Anthony T Vella

Anthony T Vella

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Anthony T Vella

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Replens prevents preterm birth by decreasing type I interferon strengthening the cervical epithelial barrier.

Am J Reprod Immunol 2020 Jan 14;83(1):e13192. Epub 2019 Oct 14.

Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.1111/aji.13192DOI Listing
January 2020

Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration.

J Control Release 2020 Jan 19;317:78-95. Epub 2019 Nov 19.

Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA; Department of Orthopedic Surgery, University of Connecticut Health, Farmington, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.11.021DOI Listing
January 2020

Evaluation of a bioengineered ACL matrix's osteointegration with BMP-2 supplementation.

PLoS One 2020 7;15(1):e0227181. Epub 2020 Jan 7.

Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946545PMC
January 2020

Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Infection.

Front Cell Infect Microbiol 2019 22;9:481. Epub 2020 Jan 22.

Department of Immunology, UConn Health School of Medicine, Farmington, CT, United States.

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http://dx.doi.org/10.3389/fcimb.2019.00481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987077PMC
January 2020

IL-17 inhibits CXCL9/10-mediated recruitment of CD8 cytotoxic T cells and regulatory T cells to colorectal tumors.

J Immunother Cancer 2019 Nov 27;7(1):324. Epub 2019 Nov 27.

Department of Immunology, School of Medicine, UConn Health, 263 Farmington Ave, Farmington, CT, 06030, USA.

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http://dx.doi.org/10.1186/s40425-019-0757-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880503PMC
November 2019

A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors.

Sci Rep 2019 Jul 26;9(1):10862. Epub 2019 Jul 26.

Center for Quantitative Medicine, School of Medicine, UConn Health, 263 Farmington Ave., Farmington, CT, USA.

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http://dx.doi.org/10.1038/s41598-019-47333-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659676PMC
July 2019

Activated T-effector seeds: cultivating atherosclerotic plaque through alternative activation.

Am J Physiol Heart Circ Physiol 2019 Jun 29;316(6):H1354-H1365. Epub 2019 Mar 29.

Department of Immunology, School of Medicine, University of Connecticut Health School of Medicine , Farmington, Connecticut.

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http://dx.doi.org/10.1152/ajpheart.00148.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620674PMC
June 2019

Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.

Am J Physiol Heart Circ Physiol 2019 Jun 12;316(6):H1480-H1494. Epub 2019 Apr 12.

Department of Immunology, University of Connecticut Health School of Medicine , Farmington, Connecticut.

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http://dx.doi.org/10.1152/ajpheart.00088.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620679PMC
June 2019

Long Noncoding RNAs in Host-Pathogen Interactions.

Trends Immunol 2019 Jun 30;40(6):492-510. Epub 2019 Apr 30.

Department of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714906193007
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http://dx.doi.org/10.1016/j.it.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556373PMC
June 2019

Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases.

JCI Insight 2019 Apr 16;5. Epub 2019 Apr 16.

Department of Immunology, School of Medicine, University of Connecticut, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.126453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542613PMC
April 2019

Understanding how combinatorial targeting of TLRs and TNFR family costimulatory members promote enhanced T cell responses.

Expert Opin Biol Ther 2018 10 12;18(10):1073-1083. Epub 2018 Sep 12.

d Department of Immunology, UConn School of Medicine , UConn Health , Farmington , CT , USA.

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http://dx.doi.org/10.1080/14712598.2018.1518422DOI Listing
October 2018

A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice.

Cancer Immunol Immunother 2018 Apr 11;67(4):605-613. Epub 2018 Jan 11.

Department of Immunology, School of Medicine, UConn Health, Farmington, CT, 06030, USA.

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http://link.springer.com/10.1007/s00262-018-2116-1
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http://dx.doi.org/10.1007/s00262-018-2116-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862768PMC
April 2018

Macrophage polarization and meta-inflammation.

Transl Res 2018 01 3;191:29-44. Epub 2017 Nov 3.

Department of Immunology, University of Connecticut, School of Medicine, Farmington, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776711PMC
January 2018

Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes.

PLoS One 2017 6;12(9):e0183887. Epub 2017 Sep 6.

Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183887PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587274PMC
October 2017

IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages.

Endocrinology 2017 09;158(9):2837-2847

Department of Immunology, School of Medicine, University of Connecticut, Farmington, Connecticut 06030.

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http://academic.oup.com/endo/article/158/9/2837/3884499/IRF6
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http://dx.doi.org/10.1210/en.2017-00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659664PMC
September 2017

Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production.

J Leukoc Biol 2017 07 21;102(1):57-69. Epub 2017 Apr 21.

Department of Immunology, School of Medicine, University of Connecticut Health, Farmington, Connecticut, USA;

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http://dx.doi.org/10.1189/jlb.1A0616-261RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470836PMC
July 2017

Therapeutic blockade of CD54 attenuates pulmonary barrier damage in T cell-induced acute lung injury.

Am J Physiol Lung Cell Mol Physiol 2017 07 4;313(1):L177-L191. Epub 2017 May 4.

Department of Immunology, School of Medicine, UConn Health, Farmington, Connecticut;

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http://dx.doi.org/10.1152/ajplung.00050.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148083PMC
July 2017

A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma.

Front Neurosci 2017 15;11:335. Epub 2017 Jun 15.

Departments of Neuroscience, University of Connecticut School of MedicineFarmington, CT, United States.

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http://dx.doi.org/10.3389/fnins.2017.00335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471332PMC
June 2017

Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2.

Cell Mol Immunol 2017 Mar 20;14(3):254-253. Epub 2015 Jul 20.

Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1038/cmi.2015.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360877PMC
March 2017

Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.

Immunotherapy 2017 01;9(1):71-82

Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

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http://dx.doi.org/10.2217/imt-2016-0097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619014PMC
January 2017

Regulatory T Cells and Cancer: A Two-Sided Story.

Immunol Invest 2016 Nov 7;45(8):797-812. Epub 2016 Sep 7.

a Department of Immunology , School of Medicine, University of Connecticut Health Center , Farmington , CT , USA.

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http://dx.doi.org/10.1080/08820139.2016.1197242DOI Listing
November 2016

Trace Levels of Staphylococcal Enterotoxin Bioactivity Are Concealed in a Mucosal Niche during Pulmonary Inflammation.

PLoS One 2015 28;10(10):e0141548. Epub 2015 Oct 28.

Department of Immunology MC3710. University of Connecticut Health, 263 Farmington Avenue, Farmington, CT 06032, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141548PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625020PMC
June 2016

Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform.

Proteomics Clin Appl 2016 Jan 16;10(1):8-24. Epub 2015 Sep 16.

Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.

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http://dx.doi.org/10.1002/prca.201500029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644731PMC
January 2016

The role of PGE2 in intestinal inflammation and tumorigenesis.

Prostaglandins Other Lipid Mediat 2015 Jan-Mar;116-117:26-36. Epub 2014 Oct 22.

Center for Molecular Medicine and Colon Cancer Prevention, University of Connecticut Health Center, Farmington, CT 06030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2014.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385488PMC
December 2015

Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.

J Immunol 2015 Dec 11;195(12):5816-26. Epub 2015 Nov 11.

Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030; and

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http://dx.doi.org/10.4049/jimmunol.1502032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670784PMC
December 2015

Why is coinfection with influenza virus and bacteria so difficult to control?

Discov Med 2015 Jan;19(102):33-40

Department of Immunology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313126PMC
January 2015

Distinctive colonic mucosal cytokine signature in new-onset, untreated pediatric Crohn disease.

J Pediatr Gastroenterol Nutr 2014 Nov;59(5):553-61

*Department of Pediatrics, Connecticut Children's Medical Center, Hartford †Department of Immunology, University of Connecticut Health Center, Farmington.

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http://dx.doi.org/10.1097/MPG.0000000000000480DOI Listing
November 2014

Therapeutic targeting of the inflammome.

Biochem Pharmacol 2014 Nov 6;92(2):184-91. Epub 2014 Sep 6.

Department of Immunology, University of Connecticut Health Center, University of Connecticut Heath Center, MC3710 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722871PMC
November 2014

Baseline serum C-reactive protein and death from colorectal cancer in the NHANES III cohort.

Int J Cancer 2014 Apr 31;134(8):1862-70. Epub 2013 Oct 31.

Department of Community Medicine & Health Care, University of Connecticut Health Center, Farmington, CT.

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http://dx.doi.org/10.1002/ijc.28504DOI Listing
April 2014

Differential proteomics identifies PDIA3 as a novel chemoprevention target in human colon cancer cells.

Mol Carcinog 2014 Feb 19;53 Suppl 1:E11-22. Epub 2012 Dec 19.

Department of Immunology, Colorectal Cancer Prevention Program University of Connecticut Health Center, Farmington, Connecticut.

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http://dx.doi.org/10.1002/mc.21986DOI Listing
February 2014

Striving for synergy: how to improve cancer immunotherapy through multiple agonist costimulation.

Immunotherapy 2013 Dec;5(12):1271-3

Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3710, USA.

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http://dx.doi.org/10.2217/imt.13.129DOI Listing
December 2013

RKIP contributes to IFN-γ synthesis by CD8+ T cells after serial TCR triggering in systemic inflammatory response syndrome.

J Immunol 2013 Jul 12;191(2):708-16. Epub 2013 Jun 12.

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.1203486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702676PMC
July 2013

Cytochrome b5 and cytokeratin 17 are biomarkers in bronchoalveolar fluid signifying onset of acute lung injury.

PLoS One 2012 6;7(7):e40184. Epub 2012 Jul 6.

University of Connecticut Health Center, Farmington, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040184PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391234PMC
March 2013

CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.

Immunol Cell Biol 2013 Feb 8;91(2):173-83. Epub 2013 Jan 8.

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030-3710, USA.

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http://dx.doi.org/10.1038/icb.2012.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570742PMC
February 2013

Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.

Oncoimmunology 2013 Jan;2(1):e22837

Department of Immunology; University of Connecticut Health Center; Farmington, CT USA.

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http://dx.doi.org/10.4161/onci.22837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583935PMC
January 2013

Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness.

Proc Natl Acad Sci U S A 2012 Jun 11;109(26):10486-91. Epub 2012 Jun 11.

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1073/pnas.1202607109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387033PMC
June 2012

Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest.

Biochem Pharmacol 2012 May 25;83(9):1217-28. Epub 2012 Jan 25.

Department of Molecular and Cell Biology, 91 North Eagleville Road, University of Connecticut, Storrs, CT 06269, United States.

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http://dx.doi.org/10.1016/j.bcp.2012.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299870PMC
May 2012

The role of microbial byproducts in protection against immunological disorders and the hygiene hypothesis.

Discov Med 2011 Nov;12(66):405-12

Department of Immunology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, Connecticut 06030, USA.

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November 2011

Duration of antigen availability influences the expansion and memory differentiation of T cells.

J Immunol 2011 Sep 20;187(5):2310-21. Epub 2011 Jul 20.

Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.1100363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159832PMC
September 2011

Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.

Cancer Prev Res (Phila) 2011 Aug 16;4(8):1198-208. Epub 2011 May 16.

Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151318PMC
August 2011

The WSX-1 pathway restrains intestinal T-cell immunity.

Int Immunol 2011 Feb 13;23(2):129-37. Epub 2011 Jan 13.

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1093/intimm/dxq464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030729PMC
February 2011

Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide.

Trends Immunol 2010 Nov 27;31(11):429-35. Epub 2010 Sep 27.

Department of Immunology, MC1319, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.it.2010.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967613PMC
November 2010

Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization.

J Leukoc Biol 2010 Jul 3;88(1):21-31. Epub 2010 Feb 3.

Department of Immunology,University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1189/jlb.0909631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892526PMC
July 2010

T cell and APC dynamics in situ control the outcome of vaccination.

J Immunol 2010 Jul 7;185(1):239-52. Epub 2010 Jun 7.

Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.0901047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997353PMC
July 2010

The systemic and pulmonary immune response to staphylococcal enterotoxins.

Toxins (Basel) 2010 07 21;2(7):1898-912. Epub 2010 Jul 21.

Department of Immunology-MC3710, University of Connecticut Heath Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.3390/toxins2071898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153275PMC
July 2010

Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death.

J Immunol 2010 May 29;184(9):4770-8. Epub 2010 Mar 29.

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0902713
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http://dx.doi.org/10.4049/jimmunol.0902713DOI Listing
May 2010

Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF.

J Immunol 2009 May;182(9):5322-30

Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.0803616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947744PMC
May 2009

Understanding how lipopolysaccharide impacts CD4 T-cell immunity.

Crit Rev Immunol 2008 ;28(4):281-99

Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549535PMC
http://dx.doi.org/10.1615/critrevimmunol.v28.i4.20DOI Listing
February 2009

The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death.

J Leukoc Biol 2009 Jan 15;85(1):175-85. Epub 2008 Oct 15.

Department of Immunology, Center for Immunotherapy of Cancer and Infectious Diseases, MC1319, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06032, USA.

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http://dx.doi.org/10.1189/jlb.0408248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626763PMC
January 2009

Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/beta.

J Immunol 2008 Dec;181(11):7670-80

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676428PMC
http://dx.doi.org/10.4049/jimmunol.181.11.7670DOI Listing
December 2008

Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.

Int Arch Allergy Immunol 2008 2;147(1):59-73. Epub 2008 May 2.

Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1159/000128660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707756PMC
September 2008

Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model.

Int Arch Allergy Immunol 2008 4;145(3):231-43. Epub 2007 Oct 4.

Department of Immunology, University of Connecticut Health Center, Farmington, Conn., USA.

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http://dx.doi.org/10.1159/000109292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576511PMC
March 2008

Effects of the physico-chemical nature of two biomimetic crystals on the innate immune response.

Int Immunopharmacol 2007 Dec 4;7(13):1617-29. Epub 2007 Sep 4.

Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1016/j.intimp.2007.08.011DOI Listing
December 2007

Utilizing endoscopic technology to reveal real-time proteomic alterations in response to chemoprevention.

Proteomics Clin Appl 2007 Dec;1(12):1660-6

Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA.

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http://dx.doi.org/10.1002/prca.200700545DOI Listing
December 2007

Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo.

J Immunol 2007 Nov;179(9):6169-75

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, McGuire Translational Research Facility, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4049/jimmunol.179.9.6169DOI Listing
November 2007

The lipopolysaccharide adjuvant effect on T cells relies on nonoverlapping contributions from the MyD88 pathway and CD11c+ cells.

J Immunol 2007 Nov;179(10):6524-35

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.179.10.6524DOI Listing
November 2007

CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent.

J Immunol 2007 Aug;179(4):2203-14

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2203DOI Listing
August 2007

TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells.

J Immunol 2007 Mar;178(5):3219-25

Department of Immunology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.178.5.3219DOI Listing
March 2007

The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma.

Immunology 2007 Jan 18;120(1):112-9. Epub 2006 Oct 18.

Department of Immunology, The University of Connecticut Health Center, Farmington, CT 06030-3105, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2006.02486.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265875PMC
January 2007

Effects of LPS-mediated bystander activation in the innate immune system.

J Leukoc Biol 2006 Dec 14;80(6):1251-61. Epub 2006 Sep 14.

University of Connecticut Health Center, 263 Farmington Ave., MC1319, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1189/jlb.0406253DOI Listing
December 2006

TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.

J Immunol 2006 Nov;177(9):6091-7

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.177.9.6091DOI Listing
November 2006

IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway.

J Immunol 2006 Jul;177(1):234-45

Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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July 2006

A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs.

Cell Immunol 2006 Jul 11;242(1):9-22. Epub 2006 Oct 11.

Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA.

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http://dx.doi.org/10.1016/j.cellimm.2006.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987380PMC
July 2006

CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches.

Immunity 2006 May;24(5):623-32

Department of Medicine, GI Division and Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, McGuire Translational Research Facility, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1016/j.immuni.2006.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855652PMC
May 2006

Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells.

Int Immunol 2006 Feb 22;18(2):325-33. Epub 2005 Dec 22.

Department of Immunology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1093/intimm/dxh371DOI Listing
February 2006

p,p'-DDE depresses the immune competence of chinook salmon (Oncorhynchus tshawytscha) leukocytes.

Fish Shellfish Immunol 2005 Aug;19(2):97-114

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.1016/j.fsi.2004.11.005DOI Listing
August 2005

Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation.

Trends Immunol 2005 Aug;26(8):440-6

Department of Immunology, School of Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06032, USA.

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http://dx.doi.org/10.1016/j.it.2005.06.003DOI Listing
August 2005

Enhanced CD4 T cell responsiveness in the absence of 4-1BB.

J Immunol 2005 Jun;174(11):6803-8

La Jolla Institute for Allergy and Immunology, Division of Molecular Immunology, San Diego, CA 92121, USA.

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http://dx.doi.org/10.4049/jimmunol.174.11.6803DOI Listing
June 2005

Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.

J Immunol 2005 Jun;174(12):7625-32

Division of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.174.12.7625DOI Listing
June 2005

Staphylococcal enterotoxins condition cells of the innate immune system for Toll-like receptor 4 stimulation.

Int Immunol 2004 Dec 25;16(12):1751-60. Epub 2004 Oct 25.

Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA.

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http://dx.doi.org/10.1093/intimm/dxh176DOI Listing
December 2004

4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.

J Immunol 2004 Sep;173(5):3002-12

Division of Immunology, University of Connecticut Health Center, Farmington 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.173.5.3002DOI Listing
September 2004

T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation.

J Immunol 2004 Jan;172(1):248-59

Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA.

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http://dx.doi.org/10.4049/jimmunol.172.1.248DOI Listing
January 2004

In vitro detection of functional humoral immunocompetence in juvenile chinook salmon (Oncorhynchus tshawytscha) using flow cytometry.

Fish Shellfish Immunol 2003 Aug;15(2):145-58

Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR, 97331, USA.

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http://dx.doi.org/10.1016/s1050-4648(02)00151-1DOI Listing
August 2003

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering.

Proc Natl Acad Sci U S A 2003 Apr 14;100(9):5348-53. Epub 2003 Apr 14.

Division of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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http://dx.doi.org/10.1073/pnas.0837611100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154348PMC
April 2003

Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity.

J Immunol 2002 May;168(9):4372-81

Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.168.9.4372DOI Listing
May 2002