Anthony R Isles

Anthony R Isles

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Anthony R Isles

Anthony R Isles

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Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.

Genes Brain Behav 2020 01 29;19(1):e12571. Epub 2019 Apr 29.

MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/gbb.12571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050506PMC
January 2020

Glutamate Transport and Preterm Brain Injury.

Front Physiol 2019 24;10:417. Epub 2019 Apr 24.

Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.3389/fphys.2019.00417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491644PMC
April 2019

Genomic Imprinting and Physiological Processes in Mammals.

Cell 2019 02;176(5):952-965

Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

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http://dx.doi.org/10.1016/j.cell.2019.01.043DOI Listing
February 2019

Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications.

Philos Trans R Soc Lond B Biol Sci 2019 02;374(1766):20180128

3 School of Psychology, Cardiff University , Tower Building, 70 Park Place, Cardiff CF10 3AT , UK.

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http://dx.doi.org/10.1098/rstb.2018.0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335461PMC
February 2019

Epigenetics, chromatin and brain development and function.

Authors:
Anthony R Isles

Brain Neurosci Adv 2018 Jan-Dec;2:2398212818812011. Epub 2018 Nov 12.

MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1177/2398212818812011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058192PMC
November 2018

Impulsive Choice in Mice Lacking Paternal Expression of Suggests Intragenomic Conflict in Behavior.

Genetics 2018 05 21;209(1):233-239. Epub 2018 Mar 21.

Behavioural Genetics Group, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, CF24 4HQ United Kingdom

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http://dx.doi.org/10.1534/genetics.118.300898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937175PMC
May 2018

Territorial Behavior and Social Stability in the Mouse Require Correct Expression of Imprinted .

Front Behav Neurosci 2018 26;12:28. Epub 2018 Feb 26.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom.

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http://dx.doi.org/10.3389/fnbeh.2018.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834910PMC
February 2018

Htr2c Splice Variants and 5HTR-Mediated Appetite.

Authors:
Anthony R Isles

Trends Endocrinol Metab 2017 08 9;28(8):542-544. Epub 2017 May 9.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.04.002DOI Listing
August 2017

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT receptor mediated appetite.

Mol Brain 2016 12 8;9(1):95. Epub 2016 Dec 8.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Pscyhology, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1186/s13041-016-0277-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144496PMC
December 2016

Methods of epigenome editing for probing the function of genomic imprinting.

Epigenomics 2016 10 14;8(10):1389-1398. Epub 2016 Sep 14.

MRC Centre for Neuropsychiatric Genetics & Genomics, Department of Psychological Medicine & Clinical Neuroscience, School of Medicine, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.

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http://dx.doi.org/10.2217/epi-2016-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066122PMC
October 2016

Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome.

Eur J Neurosci 2015 Aug 25;42(4):2105-13. Epub 2015 Jun 25.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK.

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http://dx.doi.org/10.1111/ejn.12972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949663PMC
August 2015

15q Maternal Duplication and Neurodevelopmental Disorders; UBE3A is the Key.

Authors:
Anthony R Isles

Hum Mutat 2015 Jul;36(7):iii

MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK.

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http://dx.doi.org/10.1002/humu.22656DOI Listing
July 2015

Influencing the social group: the role of imprinted genes.

Adv Genet 2014 ;86:107-34

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.

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http://dx.doi.org/10.1016/B978-0-12-800222-3.00006-1DOI Listing
May 2015

Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent?

Eur J Neurosci 2014 Jun 24;39(11):1933-42. Epub 2014 May 24.

MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.

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http://doi.wiley.com/10.1111/ejn.12607
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http://dx.doi.org/10.1111/ejn.12607DOI Listing
June 2014

An overview of measuring impulsive behavior in mice.

Curr Protoc Mouse Biol 2014 Jun 16;4(2):35-45. Epub 2014 Jun 16.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom; School of Psychology, Cardiff University, Cardiff, United Kingdom.

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http://dx.doi.org/10.1002/9780470942390.mo140015DOI Listing
June 2014

Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10.

Mamm Genome 2014 Feb 24;25(1-2):87-93. Epub 2013 Aug 24.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK.

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http://dx.doi.org/10.1007/s00335-013-9472-0DOI Listing
February 2014

Measuring risk-taking in mice: balancing the risk between seeking reward and danger.

Eur J Neurosci 2014 Feb 28;39(4):520-30. Epub 2013 Nov 28.

Behavioural Genetics Group, Neuroscience and Mental Health Research Institute, Schools of Psychology & Medicine, Cardiff University, Cardiff, CF10 3AT, UK.

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http://dx.doi.org/10.1111/ejn.12430DOI Listing
February 2014

Analysis of copy number variations at 15 schizophrenia-associated loci.

Br J Psychiatry 2014 Feb 5;204(2):108-14. Epub 2013 Dec 5.

Elliott Rees, MRes, James T. R. Walters, PhD, MRCPsych, Lyudmila Georgieva, PhD, Anthony R. Isles, PhD, MRC, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Kimberly D. Chambert, MS, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachuetts, USA; Alexander L. Richards, PhD, Gerwyn Mahoney-Davies, BSc, Sophie E. Legge, BSc, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Jennifer L. Moran, PhD, Steven A. McCarroll, PhD, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachuetts, USA; Michael C. O'Donovan, FRCPsych, PhD, Michael J. Owen, FRCPsych, PhD, George Kirov, MRCPsych, PhD, Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1192/bjp.bp.113.131052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909838PMC
February 2014

Dosage-sensitivity of imprinted genes expressed in the brain: 15q11-q13 and neuropsychiatric illness.

Biochem Soc Trans 2013 Jun;41(3):721-6

Behavioural Genetics Group, Neuroscience and Mental Health Research Institute, Schools of Medicine and Psychology, Cardiff University, Cardiff CF14 4XN, U.K.

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http://dx.doi.org/10.1042/BST20130008DOI Listing
June 2013

Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome.

Brain Res Bull 2013 Mar 17;92:41-8. Epub 2011 Sep 17.

Mediterranean Institute for Life Sciences, Mestrovicevo setaliste bb, 21000 Split, Croatia.

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http://dx.doi.org/10.1016/j.brainresbull.2011.09.009DOI Listing
March 2013

Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome.

Behav Neurosci 2012 Jun;126(3):488-92

Behavioural Genetics Group, School of Psychology, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1037/a0028155DOI Listing
June 2012

Genomic imprinting; the cost of mother's care.

Authors:
Anthony R Isles

Bioessays 2011 Dec 8;33(12):924-6. Epub 2011 Sep 8.

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1002/bies.201100115DOI Listing
December 2011

Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome.

Eur J Neurosci 2010 Jan 23;31(1):156-64. Epub 2009 Dec 23.

Laboratory of Cognitive and Behavioural Neuroscience, The Babraham Institute, Babraham Research Campus, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2009.07048.xDOI Listing
January 2010

Evolution of genomic imprinting in humans: does bipedalism have a role?

Authors:
Anthony R Isles

Trends Genet 2009 Nov;25(11):495-500

Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.

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http://dx.doi.org/10.1016/j.tig.2009.09.010DOI Listing
November 2009

Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour.

Hum Mol Genet 2009 Jun 20;18(12):2140-8. Epub 2009 Mar 20.

Behavioural Genetics Group, Department of Psychological Medicine and Neurology (School of Medicine) and School of Psychology, Cardiff University, Cardiff, UK.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddp137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685753PMC
June 2009

Feel the heat: epigenetic coding of thermotolerance in the chick (Commentary on Yossifoff et al.).

Authors:
Anthony R Isles

Eur J Neurosci 2008 Dec;28(11):2266

Behavioural Genetics Group, Department Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06544.xDOI Listing
December 2008

Epigenetics: what is it and why is it important to mental disease?

Br Med Bull 2008 15;85:35-45. Epub 2008 Feb 15.

Behavioural Genetics Group, Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

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http://dx.doi.org/10.1093/bmb/ldn004DOI Listing
October 2008

What are imprinted genes doing in the brain?

Epigenetics 2007 Oct-Dec;2(4):201-6. Epub 2007 Dec 5.

Behavioral Genetics Group, Department of Psychological Medicine and School of Psychology, School of Medicine, University of Cardiff, Cardiff, Wales, UK.

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http://dx.doi.org/10.4161/epi.2.4.5379DOI Listing
June 2008

What are imprinted genes doing in the brain?

Adv Exp Med Biol 2008 ;626:62-70

Department of Psychological Medicine, University of Cardiff, Henry Wellcome Building, Heath Park, Cardiff, Wales, UK.

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http://dx.doi.org/10.1007/978-0-387-77576-0_5DOI Listing
April 2008

Genomic imprinting effects on brain development and function.

Nat Rev Neurosci 2007 Nov;8(11):832-43

Behavioural Genetics Group, School of Psychology and Department of Psychological Medicine, School of Medicine, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.

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http://dx.doi.org/10.1038/nrn2235DOI Listing
November 2007

Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age.

Hum Mol Genet 2007 Jul 20;16(14):1708-19. Epub 2007 May 20.

Laboratory of Cognitive and Behavioural Neuroscience, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK.

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http://dx.doi.org/10.1093/hmg/ddm119DOI Listing
July 2007

X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder.

Biol Psychiatry 2007 Jun 8;61(12):1351-60. Epub 2006 Dec 8.

Laboratories of Cognitive and Behavioral Neuroscience and Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Babraham, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S000632230601012
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http://dx.doi.org/10.1016/j.biopsych.2006.08.011DOI Listing
June 2007

Genomic imprinting and the social brain.

Philos Trans R Soc Lond B Biol Sci 2006 Dec;361(1476):2229-37

Laboratory of Cognitive and Behavioural Neuroscience, The Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB2 4AT, UK.

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http://dx.doi.org/10.1098/rstb.2006.1942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764840PMC
December 2006

X-linked imprinting: effects on brain and behaviour.

Bioessays 2006 Jan;28(1):35-44

Laboratories of Cognitive and Behavioural Neuroscience and Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK.

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http://dx.doi.org/10.1002/bies.20341DOI Listing
January 2006

An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task.

Eur J Neurosci 2005 Aug;22(4):997-1000

Laboratory of Cognitive and Behavioural Neuroscience, The Babraham Institute, Babraham Research Campus, Babraham, Cambridge, CB2 4AT, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2005.04265.xDOI Listing
August 2005

Imprinted gene expression in the brain.

Neurosci Biobehav Rev 2005 May 18;29(3):421-30. Epub 2005 Jan 18.

Neurobiology and Developmental Genetics Programmes, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK.

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http://dx.doi.org/10.1016/j.neubiorev.2004.11.007DOI Listing
May 2005

Imprinted Nesp55 influences behavioral reactivity to novel environments.

Mol Cell Biol 2005 Apr;25(8):3019-26

Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom.

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http://dx.doi.org/10.1128/MCB.25.8.3019-3026.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069615PMC
April 2005

Imprinted genes and mother-offspring interactions.

Early Hum Dev 2005 Jan 19;81(1):73-7. Epub 2004 Nov 19.

Babraham Research Campus, The Babraham Institute, Cambridge CB2 4AT, United Kingdom.

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http://dx.doi.org/10.1016/j.earlhumdev.2004.10.006DOI Listing
January 2005

Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome.

Hum Mol Genet 2004 Sep 6;13(17):1849-55. Epub 2004 Jul 6.

Neurobiology and Developmental Genetics Programmes, The Babraham Institute, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddh203DOI Listing
September 2004

Common genetic effects on variation in impulsivity and activity in mice.

J Neurosci 2004 Jul;24(30):6733-40

Neurobiology and Developmental Genetics Programmes, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.1650-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729702PMC
July 2004

Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine.

Psychopharmacology (Berl) 2003 Dec 30;170(4):376-82. Epub 2003 Aug 30.

Laboratory of Cognitive and Behavioural Neuroscience, Neurobiology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK.

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http://dx.doi.org/10.1007/s00213-003-1551-6DOI Listing
December 2003

Neuroendocrinology briefings 16: genomic imprinting, hormones and behaviour.

J Neuroendocrinol 2002 May;14(5):425-6

Neurobiology and Developmental Genetics Programmes, The Babraham Institute, Cambridge, UK.

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http://dx.doi.org/10.1046/j.1365-2826.2002.00445.xDOI Listing
May 2002

A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice.

Proc Biol Sci 2002 Apr;269(1492):665-70

Sub-department of Animal Behaviour, University of Cambridge, Madingley, Cambridge CB3 8AA, UK.

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http://dx.doi.org/10.1098/rspb.2001.1911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690950PMC
April 2002