Anthony R Green

Anthony R Green

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Notch Signaling Mediates Secondary Senescence.

Cell Rep 2019 Apr;27(4):997-1007.e5

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486482PMC
April 2019

Clonal approaches to understanding the impact of mutations on hematologic disease development.

Blood 2019 03 6;133(13):1436-1445. Epub 2019 Feb 6.

Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-11
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http://dx.doi.org/10.1182/blood-2018-11-835405DOI Listing
March 2019

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716614
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http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
October 2018

MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling.

Leukemia 2018 08 27;32(8):1826-1830. Epub 2018 Feb 27.

Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1038/s41375-018-0053-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989937PMC
August 2018

Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.

J Clin Oncol 2018 Aug 28:JCO2018788414. Epub 2018 Aug 28.

Anna L. Godfrey, Jacob Grinfeld, and Anthony R. Green, Cambridge University Hospitals National Health Service (NHS) Foundation Trust; Peter J. Campbell and Jyoti Nangalia, Wellcome Trust Sanger Institute, Hinxton; Cathy MacLean, Julia Cook, Julie Temple, and Anthony R. Green, University of Cambridge; Anthony R. Green, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge; Georgina Buck, University of Oxford, Oxford; Bridget S. Wilkins and Claire N. Harrison, Guy's and St Thomas' NHS Foundation Trust, London; Keith Wheatley, University of Birmingham, Birmingham; Mary Frances McMullin, Queen's University Belfast, Belfast, United Kingdom; Cecily Forsyth, Gosford Hospital, Gosford, and Australasian Leukaemia and Lymphoma Group, Australia; and Jean-Jacques Kiladjian, Hôpital Saint-Louis, Paris, France.

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http://dx.doi.org/10.1200/JCO.2018.78.8414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269131PMC
August 2018

Multiplexing for Oxidative Bisulfite Sequencing (oxBS-seq).

Methods Mol Biol 2018 ;1708:665-678

Epigenetics ISP, The Babraham Institute, Cambridge, CB22 3AT, UK.

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http://dx.doi.org/10.1007/978-1-4939-7481-8_34DOI Listing
July 2018

Determination of complex subclonal structures of hematological malignancies by multiplexed genotyping of blood progenitor colonies.

Exp Hematol 2018 01 9;57:60-64.e1. Epub 2017 Oct 9.

Department of Haematology, Cambridge Institute for Medical Research University of Cambridge, Cambridge CB2 0XY, United Kingdom; Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731633PMC
January 2018

Myeloproliferative neoplasms: from origins to outcomes.

Blood 2017 12;130(23):2475-2483

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, United Kingdom; and.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-06
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http://dx.doi.org/10.1182/blood-2017-06-782037DOI Listing
December 2017

Myeloproliferative neoplasms: from origins to outcomes.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):470-479

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, United Kingdom; and.

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http://dx.doi.org/10.1182/asheducation-2017.1.470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142568PMC
December 2017

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Cell Rep 2017 05;19(8):1503-1511

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK; Department of Haematology, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK; Stem Cell Institute, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457484PMC
May 2017

Order Matters: The Order of Somatic Mutations Influences Cancer Evolution.

Cold Spring Harb Perspect Med 2017 Apr 3;7(4). Epub 2017 Apr 3.

Wellcome Trust/MRC Stem Cell Institute, Hills Road, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a027060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378012PMC
April 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer Cell 2017 04;31(4):549-562.e11

Department of Medicine II, Hematology/Oncology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK; Cambridge Institute for Medical Research, Wellcome Trust/MRC Stem Cell Institute, Cambridge CB2 0XY, UK; German Cancer Research Center and German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389883PMC
April 2017

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.

Haematologica 2017 01 1;102(1):7-17. Epub 2016 Dec 1.

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2014.113845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210228PMC
January 2017

Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.

Blood 2016 05 10;127(19):2298-309. Epub 2016 Feb 10.

Department of Haematology, Cambridge Institute for Medical Research, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://www.bloodjournal.org/content/early/2016/02/10/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-08-66
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http://dx.doi.org/10.1182/blood-2015-08-664631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882783PMC
May 2016

Pathogenesis of Myeloproliferative Disorders.

Annu Rev Pathol 2016 05;11:101-26

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge CB2 0XY, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-pathol-012615-044454DOI Listing
May 2016

Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.

EMBO J 2016 Mar 23;35(6):580-94. Epub 2015 Dec 23.

Cambridge Institute for Medical Research, Wellcome Trust/MRC Stem Cell Institute, Cambridge, UK Department of Haematology, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

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http://dx.doi.org/10.15252/embj.201592383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801948PMC
March 2016

STAT1 activation in association with JAK2 exon 12 mutations.

Haematologica 2016 Jan 3;101(1):e15-9. Epub 2015 Dec 3.

Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, Addenbrooke's Hospital, UK Department of Haematology, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2015.128546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697901PMC
January 2016

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

Nat Med 2016 Jan 21;22(1):91-6. Epub 2015 Dec 21.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1038/nm.4013DOI Listing
January 2016

RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability.

Cell Rep 2015 Dec 10;13(11):2345-2352. Epub 2015 Dec 10.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Broad Institute of the Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142; Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691544PMC
December 2015

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.

Haematologica 2015 Nov 6;100(11):e438-42. Epub 2015 Aug 6.

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2015.129510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825297PMC
November 2015

The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients.

Blood 2015 Mar;125(10):1679-81

Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2014-12-618074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471770PMC
March 2015

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

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http://dx.doi.org/10.1056/NEJMoa1412098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660033PMC
February 2015

Modification of British Committee for Standards in Haematology diagnostic criteria for essential thrombocythaemia.

Br J Haematol 2014 Nov 17;167(3):421-3. Epub 2014 Jun 17.

Department of Haematology, Guy's and St Thomas, Hospitals' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/bjh.12986DOI Listing
November 2014

Nongenetic stochastic expansion of JAK2V617F-homozygous subclones in polycythemia vera?

Blood 2014 Nov;124(22):3332-4

Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2014-09-603043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239339PMC
November 2014

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms.

Exp Hematol 2014 Oct 6;42(10):841-51. Epub 2014 Sep 6.

Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.07.268DOI Listing
October 2014

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.

Proc Natl Acad Sci U S A 2014 Oct 6;111(42):15190-5. Epub 2014 Oct 6.

Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Cambridge Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom; and

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http://dx.doi.org/10.1073/pnas.1401873111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210350PMC
October 2014

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

Nature 2014 Jun 28;510(7504):268-72. Epub 2014 Apr 28.

1] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nature13228DOI Listing
June 2014

CALR mutations in myeloproliferative neoplasms: hidden behind the reticulum.

Am J Hematol 2014 May 11;89(5):453-6. Epub 2014 Mar 11.

Laboratorio Congiunto MMPC, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1002/ajh.23678DOI Listing
May 2014

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.

Blood 2014 May 1;123(20):3139-51. Epub 2014 Apr 1.

Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-06-51
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http://dx.doi.org/10.1182/blood-2013-06-510222DOI Listing
May 2014

Methods for detecting mutations in the human JAK2 gene.

Methods Mol Biol 2013 ;967:115-31

Department of Hematology, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-62703-242-1_8DOI Listing
June 2013

Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression.

Mol Cell Biol 2013 Mar 14;33(6):1254-66. Epub 2013 Jan 14.

Department of Haematology, Cambridge Institute for Medical Research & Wellcome Trust and MRC Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.01525-12
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http://dx.doi.org/10.1128/MCB.01525-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592016PMC
March 2013

Genotype-phenotype interactions in the myeloproliferative neoplasms.

Hematol Oncol Clin North Am 2012 Oct 28;26(5):993-1015. Epub 2012 Aug 28.

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S08898588120012
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http://dx.doi.org/10.1016/j.hoc.2012.07.003DOI Listing
October 2012

Janus kinase deregulation in leukemia and lymphoma.

Immunity 2012 Apr;36(4):529-41

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.03.017DOI Listing
April 2012

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms.

Blood 2011 Aug 8;118(6):1610-21. Epub 2011 Jun 8.

Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK.

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http://dx.doi.org/10.1182/blood-2011-02-335042DOI Listing
August 2011

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms.

Blood 2011 Jul 11;118(1):177-81. Epub 2011 May 11.

Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK.

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http://dx.doi.org/10.1182/blood-2010-12-327593DOI Listing
July 2011

Mouse models of myeloproliferative neoplasms: JAK of all grades.

Dis Model Mech 2011 May;4(3):311-7

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.006817
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http://dx.doi.org/10.1242/dmm.006817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097453PMC
May 2011

How I treat essential thrombocythemia.

Blood 2011 Feb 24;117(5):1472-82. Epub 2010 Nov 24.

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2010-08-270033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145107PMC
February 2011

Comparison of different criteria for the diagnosis of primary myelofibrosis reveals limited clinical utility for measurement of serum lactate dehydrogenase.

Haematologica 2010 Nov 9;95(11):1960-3. Epub 2010 Jun 9.

Department of Haematology, University of Cambridge, 1Cambridge Institute for Medical Research, Cambridge, United Kingdom.

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http://dx.doi.org/10.3324/haematol.2010.026708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966920PMC
November 2010

Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.

Cancer Cell 2010 Nov;18(5):524-35

Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.ccr.2010.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996868PMC
November 2010

Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis.

Br J Haematol 2010 Apr 11;149(2):250-7. Epub 2010 Feb 11.

Department of Haematology, Haemato-Oncology Diagnostic Service, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08083.xDOI Listing
April 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili 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Nature 2010 Apr;464(7291):993-8

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April 2010

Pathogenesis and management of essential thrombocythemia.

Hematology Am Soc Hematol Educ Program 2009 :621-8

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March 2010

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.

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Reticulin accumulation in essential thrombocythemia: prognostic significance and relationship to therapy.

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Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, QUB, 2 floor, Whitla Medical Building, 97 Lisburn Rd, Belfast BT97BL, Northern Ireland.

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N Engl J Med 2008 Dec;359(26):2778-89

Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.

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December 2008

Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders.

Haematologica 2008 Nov 24;93(11):1635-44. Epub 2008 Sep 24.

Haemato-oncology, Diagnostic Service, Department, of Haematology, Addenbrooke's, Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

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November 2008

Rapid identification of JAK2 exon 12 mutations using high resolution melting analysis.

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October 2008

A novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity.

Genome Res 2008 Sep 7;18(9):1422-32. Epub 2008 Aug 7.

University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Cambridge CB2 2XY, United Kingdom.

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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing.

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