Anthony P Ford

Anthony P Ford

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Anthony P Ford

Anthony P Ford

Publications by authors named "Anthony P Ford"

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Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation.

Br J Pharmacol 2019 Jul 11;176(13):2279-2291. Epub 2019 May 11.

Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bph.14677
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http://dx.doi.org/10.1111/bph.14677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555852PMC
July 2019

Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate.

J Allergy Clin Immunol 2016 07 11;138(1):249-261.e12. Epub 2016 Jan 11.

Respiratory Pharmacology Group, Airway Disease Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929136PMC
July 2016

Hypertension: a problem of organ blood flow supply-demand mismatch.

Future Cardiol 2016 05 19;12(3):339-49. Epub 2016 Apr 19.

School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.2217/fca.16.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926521PMC
May 2016

P2X3 receptors and sensitization of autonomic reflexes.

Auton Neurosci 2015 Sep 25;191:16-24. Epub 2015 Apr 25.

School of Physiology & Pharmacology, Bristol CardioVascular, University of Bristol, Bristol, BS8 1TD, UK.

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http://dx.doi.org/10.1016/j.autneu.2015.04.005DOI Listing
September 2015

Inhibition of urothelial P2X3 receptors prevents desensitization of purinergic detrusor contractions in the rat bladder.

BJU Int 2015 Aug 25;116(2):293-301. Epub 2015 Mar 25.

Houston Methodist Research Institute, Houston, TX, USA.

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http://dx.doi.org/10.1111/bju.13003DOI Listing
August 2015

P2X3 receptor antagonist in chronic cough--Authors' reply.

Lancet 2015 Jul;386(9990):244-5

Afferent Pharmaceuticals, San Mateo, CA, USA.

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http://dx.doi.org/10.1016/S0140-6736(15)61275-2DOI Listing
July 2015

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.

Lancet 2015 Mar 25;385(9974):1198-205. Epub 2014 Nov 25.

Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK. Electronic address:

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140673614
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http://linkinghub.elsevier.com/retrieve/pii/S014067361461255
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http://dx.doi.org/10.1016/S0140-6736(14)61255-1DOI Listing
March 2015

Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.

J Physiol 2015 Mar 20;593(5):1113-25. Epub 2015 Jan 20.

Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA; Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1113/jphysiol.2014.281014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358674PMC
March 2015

Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers.

Acta Neuropathol Commun 2014 Jun 5;2:62. Epub 2014 Jun 5.

Bluestone Center for Clinical Research, New York University, 421 First Avenue, 233 W, New York, NY 10010, USA.

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http://dx.doi.org/10.1186/2051-5960-2-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229781PMC
June 2014

The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders.

Front Cell Neurosci 2013 Dec 19;7:267. Epub 2013 Dec 19.

Allergy and Clinical Immunology, Johns Hopkins University School of Medicine Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fncel.2013.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867694PMC
December 2013

Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors.

BJU Int 2012 Oct 30;110(8 Pt B):E409-14. Epub 2012 Apr 30.

Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11189.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537156PMC
October 2012

A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres.

J Physiol 2012 Aug 11;590(16):4109-20. Epub 2012 Jun 11.

Johns Hopkins University School of Medicine, The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle 1A62, Baltimore, MD21224, USA.

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http://dx.doi.org/10.1113/jphysiol.2012.233460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476651PMC
August 2012

P2X3 antagonists: novel therapeutics for afferent sensitization and chronic pain.

Authors:
Anthony P Ford

Pain Manag 2012 May;2(3):267-77

Afferent Pharmaceuticals, 2755 Campus Drive, Suite 100, San Mateo, CA 94403, USA.

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http://dx.doi.org/10.2217/pmt.12.16DOI Listing
May 2012

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.

Authors:
Anthony P Ford

Purinergic Signal 2012 Feb 18;8(Suppl 1):3-26. Epub 2011 Nov 18.

Afferent Pharmaceuticals, 2755 Campus Dr., Suite 100, San Mateo, CA, 94403, USA,

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http://dx.doi.org/10.1007/s11302-011-9271-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265711PMC
February 2012

ATP and P2X purinoceptors in urinary tract disorders.

Handb Exp Pharmacol 2011 (202):485-526

Afferent Pharmaceuticals, San Mateo, CA 94403, USA.

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http://link.springer.com/10.1007/978-3-642-16499-6_22
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http://dx.doi.org/10.1007/978-3-642-16499-6_22DOI Listing
May 2011

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.

Brain 2010 Sep;133(9):2549-64

Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King’s College London, London, UK.

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http://dx.doi.org/10.1093/brain/awq194DOI Listing
September 2010

Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.

J Neurosci 2010 Mar;30(12):4503-7

King's College London, Neurorestoration Group, Wolfson Centre for Age-Related Diseases, Wolfson Wing, Hodgkin Building, Guy's Campus, London SE1 1UL, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.6132-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882023PMC
March 2010

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.

Bioorg Med Chem Lett 2010 Feb 16;20(3):1031-6. Epub 2009 Dec 16.

Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.12.044DOI Listing
February 2010

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.

Bioorg Med Chem Lett 2009 Mar 7;19(6):1628-31. Epub 2009 Feb 7.

Department of Medicinal Chemistry, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.003DOI Listing
March 2009

The role of metabotropic glutamate receptor mGlu5 in control of micturition and bladder nociception.

Neurosci Lett 2009 Jan 14;450(1):12-7. Epub 2008 Nov 14.

Department of Physiology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.

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http://dx.doi.org/10.1016/j.neulet.2008.11.026DOI Listing
January 2009

Expression and function of rat urothelial P2Y receptors.

Am J Physiol Renal Physiol 2008 Apr 23;294(4):F821-9. Epub 2008 Jan 23.

A1207 Scaife Hall, Dept. of Medicine, Univ. of Pittsburgh, 3550 Terrace St., Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1152/ajprenal.00321.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760272PMC
April 2008

Pharmacology of P2X channels.

Pflugers Arch 2006 Aug 29;452(5):513-37. Epub 2006 Apr 29.

Department of Biochemical Pharmacology, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1007/s00424-006-0070-9DOI Listing
August 2006

Purinoceptors as therapeutic targets for lower urinary tract dysfunction.

Br J Pharmacol 2006 Feb;147 Suppl 2:S132-43

Department of Biochemical Pharmacology, Roche Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1038/sj.bjp.0706637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751490PMC
February 2006

Effect of neurokinins on canine prostate cell physiology.

Prostate 2005 Jun;63(4):358-68

Department of Urology, NYU School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1002/pros.20195DOI Listing
June 2005

Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red.

Br J Pharmacol 2005 Jun;145(3):313-22

University College London, Department of Physiology, Royal Free Campus, Rowland Hill Street, Hampstead, London NW3 2PF, UK.

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http://dx.doi.org/10.1038/sj.bjp.0706187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576146PMC
June 2005

Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification.

Bioorg Med Chem Lett 2005 Mar;15(6):1697-700

Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94303, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.01.039DOI Listing
March 2005

Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium.

J Physiol 2005 Feb 2;562(Pt 3):859-71. Epub 2004 Dec 2.

A1207 Scaife Hall, Department of Medicine-Renal Division, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1113/jphysiol.2004.071159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665539PMC
February 2005

Pharmacological and functional characterization of bradykinin B2 receptor in human prostate.

Eur J Pharmacol 2004 Nov;504(3):155-67

Roche Pharmaceuticals, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.ejphar.2004.10.004DOI Listing
November 2004

Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies.

Neuropharmacology 2004 Jun;46(7):1039-48

Autonomic Neuroscience Institute, Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.1016/j.neuropharm.2004.01.009DOI Listing
June 2004

Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia.

J Neurosci 2003 Dec;23(36):11315-21

Autonomic Neuroscience Institute and Department of Physiology, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740514PMC
December 2003

P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine.

J Physiol 2003 Nov 22;552(Pt 3):809-21. Epub 2003 Aug 22.

Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1113/jphysiol.2003.047944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343442PMC
November 2003

Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp.

J Orofac Pain 2003 ;17(3):245-50

Department of Oral and Maxillofacial Surgery, Guy's Tower, Guy's Hospital, London, United Kingdom.

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November 2003

Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit.

J Physiol 2003 Aug 17;551(Pt 1):309-22. Epub 2003 Jun 17.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1113/jphysiol.2003.044172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343160PMC
August 2003

P2X receptors and their role in female idiopathic detrusor instability.

J Urol 2002 Jan;167(1):157-64

Department of Gynaecology, Autonomic Neuroscience Institute, Guy's, Kings and St. Thomas' Medical School, Kings College London, London, UK.

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January 2002