Publications by authors named "Anthony N Karnezis"

58Publications

Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.

Authors:
Anthony N Karnezis Shary Yuting Chen Christine Chow Winnie Yang William P D Hendricks Pilar Ramos Natalia Briones Anne-Marie Mes-Masson Tjalling Bosse C Blake Gilks Jeffrey M Trent Bernard Weissman David G Huntsman Yemin Wang

Gynecol Oncol 2020 Dec 13. Epub 2020 Dec 13.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC, Canada. Electronic address:

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December 2020

The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression.

Authors:
Cristabelle De Souza Jill A Madden Dennis Minn Vigneshwari Easwar Kumar Dennis J Montoya Roshni Nambiar Zheng Zhu Wen-Wu Xiao Neeki Tahmassebi Harikumara Kathi Nina Nelson Anthony N Karnezis Jeremy Chien

Int J Mol Sci 2020 Oct 28;21(21). Epub 2020 Oct 28.

Department of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.

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October 2020

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium.

Authors:
Filipe Correia Martins Dominique-Laurent Couturier Anna Paterson Anthony N Karnezis Christine Chow Tayyebeh M Nazeran Adekunle Odunsi Aleksandra Gentry-Maharaj Aleksandra Vrvilo Alexander Hein Aline Talhouk Ana Osorio Andreas D Hartkopf Angela Brooks-Wilson Anna DeFazio Anna Fischer Arndt Hartmann Brenda Y Hernandez Bryan M McCauley Chloe Karpinskyj Christiani B de Sousa Claus Høgdall Daniel G Tiezzi Esther Herpel Florin Andrei Taran Francesmary Modugno Gary Keeney Gregg Nelson Helen Steed Honglin Song Hugh Luk Javier Benitez Jennifer Alsop Jennifer M Koziak Jenny Lester Joseph H Rothstein Jurandyr M de Andrade Lene Lundvall Luis Paz-Ares Luis Robles-Díaz Lynne R Wilkens Maria J Garcia Maria P Intermaggio Marie-Lyne Alcaraz Mary A Brett Matthias W Beckmann Mercedes Jimenez-Linan Michael Anglesio Michael E Carney Michael Schneider Nadia Traficante Nadja Pejovic Naveena Singh Nhu Le Peter Sinn Prafull Ghatage Ramona Erber Robert Edwards Robert Vierkant Roberta B Ness Samuel Leung Sandra Orsulic Sara Y Brucker Scott H Kaufmann Sian Fereday Simon Gayther Stacey J Winham Stefan Kommoss Tanja Pejovic Teri A Longacre Valerie McGuire Valerie Rhenius Weiva Sieh Yurii B Shvetsov Alice S Whittemore Annette Staebler Beth Y Karlan Cristina Rodriguez-Antona David D Bowtell Ellen L Goode Estrid Høgdall Francisco J Candido Dos Reis Jacek Gronwald Jenny Chang-Claude Kirsten B Moysich Linda E Kelemen Linda S Cook Marc T Goodman Peter A Fasching Robin Crawford Suha Deen Usha Menon David G Huntsman Martin Köbel Susan J Ramus Paul D P Pharoah James D Brenton

Br J Cancer 2020 Sep 18;123(5):793-802. Epub 2020 Jun 18.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, England.

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September 2020

Proteomic analysis of transitional cell carcinoma-like variant of tubo-ovarian high-grade serous carcinoma.

Authors:
Basile Tessier-Cloutier Dawn R Cochrane Anthony N Karnezis Shane Colborne Jamie Magrill Aline Talhouk Jonathan Zhang Samuel Leung Christopher S Hughes Anna Piskorz Angela S Cheng Kendall Greening Andreas du Bois Jacobus Pfisterer Robert A Soslow Stefan Kommoss James D Brenton Gregg B Morin C Blake Gilks David G Huntsman Friedrich Kommoss

Hum Pathol 2020 Jul 29;101:40-52. Epub 2020 Apr 29.

Institute of Pathology, Medizin Campus Bodensee, Friedrichshafen, Germany. Electronic address:

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July 2020

Short-term organoid culture for drug sensitivity testing of high-grade serous carcinoma.

Authors:
Hui Chen Kristin Gotimer Cristabelle De Souza Clifford G Tepper Anthony N Karnezis Gary S Leiserowitz Jeremy Chien Lloyd H Smith

Gynecol Oncol 2020 06 4;157(3):783-792. Epub 2020 Apr 4.

Department of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA 95817, United States of America. Electronic address:

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June 2020

Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics.

Authors:
Joseph T Rabban Anthony N Karnezis W Patrick Devine

Histopathology 2020 Jan;76(1):11-24

Clinical Cancer Genomics Laboratory and Pathology Department, University of California San Francisco, San Francisco, CA, USA.

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January 2020

Expression of L1 retrotransposon open reading frame protein 1 in gynecologic cancers.

Authors:
Zhouchunyang Xia Dawn R Cochrane Basile Tessier-Cloutier Samuel Leung Anthony N Karnezis Angela S Cheng David A Farnell Jamie Magrill Dietmar Schmidt Stefan Kommoss Felix K F Kommoss Friederich Kommoss Jessica N McAlpine C Blake Gilks Martin Koebel Joseph T Rabban David G Huntsman

Hum Pathol 2019 10 18;92:39-47. Epub 2019 Jun 18.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 1L3, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada. Electronic address:

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October 2019

DICER1 and FOXL2 Mutation Status Correlates With Clinicopathologic Features in Ovarian Sertoli-Leydig Cell Tumors.

Authors:
Anthony N Karnezis Yemin Wang Jacqueline Keul Basile Tessier-Cloutier Jamie Magrill Stefan Kommoss Janine Senz Winnie Yang Lily Proctor Dietmar Schmidt Philip B Clement C Blake Gilks David G Huntsman Friedrich Kommoss

Am J Surg Pathol 2019 05;43(5):628-638

Institute of Pathology, im Medizin Campus Bodensee, Friedrichshafen, Germany.

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May 2019

Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type.

Authors:
Yemin Wang Shary Yuting Chen Shane Colborne Galen Lambert Chae Young Shin Nancy Dos Santos Krystal A Orlando Jessica D Lang William P D Hendricks Marcel B Bally Anthony N Karnezis Ralf Hass T Michael Underhill Gregg B Morin Jeffrey M Trent Bernard E Weissman David G Huntsman

Mol Cancer Ther 2018 12 19;17(12):2767-2779. Epub 2018 Sep 19.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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December 2018

Tubo-Ovarian Transitional Cell Carcinoma and High-grade Serous Carcinoma Show Subtly Different Immunohistochemistry Profiles.

Authors:
Jamie Magrill Anthony N Karnezis Basile Tessier-Cloutier Aline Talhouk Stefan Kommoss Dawn Cochrane Christine Chow Angela Cheng Robert Soslow Steffen Hauptmann Andreas du Bois Jacobus Pfisterer C Blake Gilks David G Huntsman Friedrich Kommoss

Int J Gynecol Pathol 2019 Nov;38(6):552-561

British Columbia Cancer Agency (J.M., A.N.K., A.T., D.C., D.G.H.) Department of Pathology, University of British Columbia (A.N.K., B.T.-C., C.C., A.C., C.B.G., D.G.H.), Vancouver, British Columbia, Canada Memorial Sloan Kettering Cancer Center, New York, New York (R.S.) Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands (S.H.) Department of Women's Health, Tübingen University Hospital, Tübingen (S.K.) Department of Gynecologic Oncology, Kliniken Essen Mitte, Essen (A.D.B.) Gynecologic Oncology Center, Kiel (J.P.) Institute of Pathology, Friedrichshafen (F.K.), Germany.

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November 2019

L1CAM further stratifies endometrial carcinoma patients with no specific molecular risk profile.

Authors:
Felix Kf Kommoss Anthony N Karnezis Friedrich Kommoss Aline Talhouk Florin-Andrei Taran Annette Staebler C Blake Gilks David G Huntsman Bernhard Krämer Sara Y Brucker Jessica N McAlpine Stefan Kommoss

Br J Cancer 2018 08 27;119(4):480-486. Epub 2018 Jul 27.

Department of Women's Health, Tübingen University Hospital, Tübingen, Germany.

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August 2018

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

Authors:
Allen W Zhang Andrew McPherson Katy Milne David R Kroeger Phineas T Hamilton Alex Miranda Tyler Funnell Nicole Little Camila P E de Souza Sonya Laan Stacey LeDoux Dawn R Cochrane Jamie L P Lim Winnie Yang Andrew Roth Maia A Smith Julie Ho Kane Tse Thomas Zeng Inna Shlafman Michael R Mayo Richard Moore Henrik Failmezger Andreas Heindl Yi Kan Wang Ali Bashashati Diljot S Grewal Scott D Brown Daniel Lai Adrian N C Wan Cydney B Nielsen Curtis Huebner Basile Tessier-Cloutier Michael S Anglesio Alexandre Bouchard-Côté Yinyin Yuan Wyeth W Wasserman C Blake Gilks Anthony N Karnezis Samuel Aparicio Jessica N McAlpine David G Huntsman Robert A Holt Brad H Nelson Sohrab P Shah

Cell 2018 06 10;173(7):1755-1769.e22. Epub 2018 May 10.

Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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June 2018

High Frequency of Ovarian Cyst Development in Vhl;Snf5 Mice.

Authors:
Yasumichi Kuwahara Leslie M Kennedy Anthony N Karnezis E Lorena Mora-Blanco Arlin B Rogers Christopher D Fletcher David G Huntsman Charles W M Roberts W Kimryn Rathmell Bernard E Weissman

Am J Pathol 2018 07 22;188(7):1510-1516. Epub 2018 Apr 22.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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July 2018

DICER1 hot-spot mutations in ovarian gynandroblastoma.

Authors:
Yemin Wang Anthony N Karnezis Jamie Magrill Basile Tessier-Cloutier Amy Lum Janine Senz C Blake Gilks W Glenn McCluggage David G Huntsman Friedrich Kommoss

Histopathology 2018 Aug 5;73(2):306-313. Epub 2018 Jun 5.

Institute of Pathology, Medizin Campus Bodensee, Friedrichshafen, Germany.

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August 2018

Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.

Authors:
Jessica D Lang William P D Hendricks Krystal A Orlando Hongwei Yin Jeffrey Kiefer Pilar Ramos Ritin Sharma Patrick Pirrotte Elizabeth A Raupach Chris Sereduk Nanyun Tang Winnie S Liang Megan Washington Salvatore J Facista Victoria L Zismann Emily M Cousins Michael B Major Yemin Wang Anthony N Karnezis Aleksandar Sekulic Ralf Hass Barbara C Vanderhyden Praveen Nair Bernard E Weissman David G Huntsman Jeffrey M Trent

Clin Cancer Res 2018 04 9;24(8):1932-1943. Epub 2018 Feb 9.

Division of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, Arizona.

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April 2018

Bartholin Gland Carcinoma: Clinicopathologic Features, Including p16 Expression and Clinical Outcome.

Authors:
Tayyebeh Nazeran Angela S Cheng Anthony N Karnezis Anna V Tinker C Blake Gilks

Int J Gynecol Pathol 2019 Mar;38(2):189-195

Department of Pathology and Laboratory Medicine (T.N., A.S.C., A.N.K., C.B.G.) Genetic Pathology Evaluation Centre (A.S.C.), University of British Columbia Division of Anatomical Pathology, Vancouver General Hospital (T.N., A.N.K., C.B.G.) Division of Medical Oncology, British Columbia Cancer Agency (A.T.), Vancouver, British Columbia, Canada.

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March 2019

Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.

Authors:
Karuna Garg Anthony N Karnezis Joseph T Rabban

Pathology 2018 Feb 17;50(2):238-256. Epub 2018 Jan 17.

University of California San Francisco, Pathology Department, San Francisco, CA, United States. Electronic address:

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February 2018

Evaluation of endometrial carcinoma prognostic immunohistochemistry markers in the context of molecular classification.

Authors:
Anthony N Karnezis Samuel Leung Jamie Magrill Melissa K McConechy Winnie Yang Christine Chow Martin Kobel Cheng-Han Lee David G Huntsman Aline Talhouk Friederich Kommoss C Blake Gilks Jessica N McAlpine

J Pathol Clin Res 2017 Oct 14;3(4):279-293. Epub 2017 Oct 14.

BC Cancer AgencyVancouverBCCanada.

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October 2017

Detection and genomic characterization of a mammary-like adenocarcinoma.

Authors:
Jasleen K Grewal Peter Eirew Martin Jones Kenrry Chiu Basile Tessier-Cloutier Anthony N Karnezis Aly Karsan Andy Mungall Chen Zhou Stephen Yip Anna V Tinker Janessa Laskin Marco Marra Steven J M Jones

Cold Spring Harb Mol Case Stud 2017 Nov 21;3(6). Epub 2017 Nov 21.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

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November 2017

Preclinical Models of Ovarian Cancer: Pathogenesis, Problems, and Implications for Prevention.

Authors:
Anthony N Karnezis Kathleen R Cho

Clin Obstet Gynecol 2017 12;60(4):789-800

*Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada †Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan.

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December 2017

Clear cell and endometrioid carcinomas: are their differences attributable to distinct cells of origin?

Authors:
Dawn R Cochrane Basile Tessier-Cloutier Katherine M Lawrence Tayyebeh Nazeran Anthony N Karnezis Clara Salamanca Angela S Cheng Jessica N McAlpine Lien N Hoang C Blake Gilks David G Huntsman

J Pathol 2017 09 7;243(1):26-36. Epub 2017 Aug 7.

Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada.

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September 2017

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.

Authors:
Yemin Wang Shary Yuting Chen Anthony N Karnezis Shane Colborne Nancy Dos Santos Jessica D Lang William Pd Hendricks Krystal A Orlando Damian Yap Friedrich Kommoss Marcel B Bally Gregg B Morin Jeffrey M Trent Bernard E Weissman David G Huntsman

J Pathol 2017 07 2;242(3):371-383. Epub 2017 Jun 2.

Department of Pathology and Laboratory Medicine, University of British Columbia and Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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July 2017

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

Authors:
Yi Kan Wang Ali Bashashati Michael S Anglesio Dawn R Cochrane Diljot S Grewal Gavin Ha Andrew McPherson Hugo M Horlings Janine Senz Leah M Prentice Anthony N Karnezis Daniel Lai Mohamed R Aniba Allen W Zhang Karey Shumansky Celia Siu Adrian Wan Melissa K McConechy Hector Li-Chang Alicia Tone Diane Provencher Manon de Ladurantaye Hubert Fleury Aikou Okamoto Satoshi Yanagida Nozomu Yanaihara Misato Saito Andrew J Mungall Richard Moore Marco A Marra C Blake Gilks Anne-Marie Mes-Masson Jessica N McAlpine Samuel Aparicio David G Huntsman Sohrab P Shah

Nat Genet 2017 Jun 24;49(6):856-865. Epub 2017 Apr 24.

Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.

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June 2017

Human papillomavirus (HPV)-independent vulvar squamous cell carcinoma has a worse prognosis than HPV-associated disease: a retrospective cohort study.

Authors:
Jessica N McAlpine Samuel C Y Leung Angela Cheng Dianne Miller Aline Talhouk C Blake Gilks Anthony N Karnezis

Histopathology 2017 Aug 23;71(2):238-246. Epub 2017 May 23.

Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, Vancouver, BC, Canada.

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August 2017

Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.

Authors:
Aline Talhouk Melissa K McConechy Samuel Leung Winnie Yang Amy Lum Janine Senz Niki Boyd Judith Pike Michael Anglesio Janice S Kwon Anthony N Karnezis David G Huntsman C Blake Gilks Jessica N McAlpine

Cancer 2017 03 6;123(5):802-813. Epub 2017 Jan 6.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2017

Of mice and women - Non-ovarian origins of "ovarian" cancer.

Authors:
Anthony N Karnezis Kathleen R Cho

Gynecol Oncol 2017 01 24;144(1):5-7. Epub 2016 Nov 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:

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January 2017

The disparate origins of ovarian cancers: pathogenesis and prevention strategies.

Authors:
Anthony N Karnezis Kathleen R Cho C Blake Gilks Celeste Leigh Pearce David G Huntsman

Nat Rev Cancer 2017 01 25;17(1):65-74. Epub 2016 Nov 25.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

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January 2017

Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse.

Authors:
Rong Wu Yali Zhai Rork Kuick Anthony N Karnezis Paloma Garcia Anum Naseem Tom C Hu Eric R Fearon Kathleen R Cho

J Pathol 2016 11;240(3):341-351

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

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November 2016

Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research.

Authors:
Christopher S Hughes Melissa K McConechy Dawn R Cochrane Tayyebeh Nazeran Anthony N Karnezis David G Huntsman Gregg B Morin

Sci Rep 2016 10 7;6:34949. Epub 2016 Oct 7.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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October 2016

Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas.

Authors:
Mackenzie Coatham Xiaodong Li Anthony N Karnezis Lien N Hoang Basile Tessier-Cloutier Bo Meng Robert A Soslow C Blake Gilks David G Huntsman Colin J R Stewart Lynne M Postovit Martin Köbel Cheng-Han Lee

Mod Pathol 2016 12 26;29(12):1586-1593. Epub 2016 Aug 26.

Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, Canada.

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December 2016

Immunophenotypic features of dedifferentiated endometrial carcinoma - insights from BRG1/INI1-deficient tumours.

Authors:
Lien N Hoang Yow-Shan Lee Anthony N Karnezis Basile Tessier-Cloutier Noorah Almandani Mackenzie Coatham C Blake Gilks Robert A Soslow Colin J R Stewart Martin Köbel Cheng-Han Lee

Histopathology 2016 Oct 5;69(4):560-9. Epub 2016 Jul 5.

Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, AB, Canada.

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October 2016

Loss of SMARCA4 (BRG1) protein expression as determined by immunohistochemistry in small-cell carcinoma of the ovary, hypercalcaemic type distinguishes these tumours from their mimics.

Authors:
Blaise A Clarke Leora Witkowski Tuyet N Ton Nu Patricia A Shaw C Blake Gilks David Huntsman Anthony N Karnezis Neil Sebire Janez Lamovec Lawrence M Roth Colin J R Stewart Martin Hasselblatt William D Foulkes W Glenn McCluggage

Histopathology 2016 Nov 28;69(5):727-738. Epub 2016 Jul 28.

Department of Pathology, Belfast Health and Social Care Trust, Royal Group of Hospitals Trust, Royal Group of Hospitals, Belfast, UK.

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November 2016

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Authors:
Leora Witkowski Catherine Goudie Pilar Ramos Talia Boshari Jean-Sebastien Brunet Anthony N Karnezis Michel Longy James A Knost Emmanouil Saloustros W Glenn McCluggage Colin J R Stewart William P D Hendricks Heather Cunliffe David G Huntsman Patricia Pautier Douglas A Levine Jeffrey M Trent Andrew Berchuck Martin Hasselblatt William D Foulkes

Gynecol Oncol 2016 06 19;141(3):454-460. Epub 2016 Mar 19.

Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Institute and Segal Cancer Center, Jewish General Hospital, Montreal, QC, Canada; Department of Medical Genetics and Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

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June 2016

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.

Authors:
Michael S Anglesio Yi Kan Wang Madlen Maassen Hugo M Horlings Ali Bashashati Janine Senz Robertson Mackenzie Diljot S Grewal Hector Li-Chang Anthony N Karnezis Brandon S Sheffield Melissa K McConechy Friedrich Kommoss Florin A Taran Annette Staebler Sohrab P Shah Diethelm Wallwiener Sara Brucker C Blake Gilks Stefan Kommoss David G Huntsman

J Natl Cancer Inst 2016 Jun 1;108(6):djv428. Epub 2016 Feb 1.

Department of Pathology and Laboratory Medicine, (MSA, HMH, JS, HLC, ANK, BSS, MKM, CBG, SK, DGH) and Department of Obstetrics and Gynaecology (MSA, DGH), University of British Columbia, Vancouver, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, Canada (YKW, AB, RM, DSG, SPS); Department of Women's Health, University Hospital Tuebingen, Tuebingen, Germany (MM, FAT, DW, SB, SK); Division of Anatomic Pathology, Synlab MVZ, Institute of Pathology, Mannheim, Germany (FK); Division of Gynecologic Pathology, Institute of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany (AS); Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, Canada (CBG).

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June 2016

Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.

Authors:
Anthony N Karnezis Lien N Hoang Mackenzie Coatham Sarah Ravn Noorah Almadani Basile Tessier-Cloutier Julie Irving Bo Meng Xiaodong Li Christine Chow Jessica McAlpine Kuan-Ting Kuo Tsui-Lien Mao Bojana Djordjevic Robert A Soslow David G Huntsman C Blake Gilks Martin Köbel Cheng-Han Lee

Mod Pathol 2016 Mar 8;29(3):302-14. Epub 2016 Jan 8.

Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, AB, Canada.

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March 2016

p16 Immunostaining Allows for Accurate Subclassification of Vulvar Squamous Cell Carcinoma Into HPV-Associated and HPV-Independent Cases.

Authors:
Angela S Cheng Anthony N Karnezis Suzanne Jordan Naveena Singh Jessica N McAlpine C Blake Gilks

Int J Gynecol Pathol 2016 Jul;35(4):385-93

Department of Cellular Pathology (S.J., N.S.), Barts Health NHS Trust, London, United Kingdom Department of Pathology and Laboratory Medicine (A.S.C., A.N.K., C.B.G.), Vancouver General Hospital Department of Obstetrics and Gynecology (J.N.M.), Division of Gynecologic Oncology, University of British Columbia, Vancouver, BC, Canada.

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July 2016

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

Authors:
Anthony N Karnezis Yemin Wang Pilar Ramos William Pd Hendricks Esther Oliva Emanuela D'Angelo Jaime Prat Marisa R Nucci Torsten O Nielsen Christine Chow Samuel Leung Friedrich Kommoss Stefan Kommoss Annacarolina Silva Brigitte M Ronnett Joseph T Rabban David D Bowtell Bernard E Weissman Jeffrey M Trent C Blake Gilks David G Huntsman

J Pathol 2016 Feb 21;238(3):389-400. Epub 2015 Dec 21.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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February 2016

Comprehensive genomic profiles of small cell lung cancer.

Authors:
Julie George Jing Shan Lim Se Jin Jang Yupeng Cun Luka Ozretić Gu Kong Frauke Leenders Xin Lu Lynnette Fernández-Cuesta Graziella Bosco Christian Müller Ilona Dahmen Nadine S Jahchan Kwon-Sik Park Dian Yang Anthony N Karnezis Dedeepya Vaka Angela Torres Maia Segura Wang Jan O Korbel Roopika Menon Sung-Min Chun Deokhoon Kim Matt Wilkerson Neil Hayes David Engelmann Brigitte Pützer Marc Bos Sebastian Michels Ignacija Vlasic Danila Seidel Berit Pinther Philipp Schaub Christian Becker Janine Altmüller Jun Yokota Takashi Kohno Reika Iwakawa Koji Tsuta Masayuki Noguchi Thomas Muley Hans Hoffmann Philipp A Schnabel Iver Petersen Yuan Chen Alex Soltermann Verena Tischler Chang-min Choi Yong-Hee Kim Pierre P Massion Yong Zou Dragana Jovanovic Milica Kontic Gavin M Wright Prudence A Russell Benjamin Solomon Ina Koch Michael Lindner Lucia A Muscarella Annamaria la Torre John K Field Marko Jakopovic Jelena Knezevic Esmeralda Castaños-Vélez Luca Roz Ugo Pastorino Odd-Terje Brustugun Marius Lund-Iversen Erik Thunnissen Jens Köhler Martin Schuler Johan Botling Martin Sandelin Montserrat Sanchez-Cespedes Helga B Salvesen Viktor Achter Ulrich Lang Magdalena Bogus Peter M Schneider Thomas Zander Sascha Ansén Michael Hallek Jürgen Wolf Martin Vingron Yasushi Yatabe William D Travis Peter Nürnberg Christian Reinhardt Sven Perner Lukas Heukamp Reinhard Büttner Stefan A Haas Elisabeth Brambilla Martin Peifer Julien Sage Roman K Thomas

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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August 2015

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.

Authors:
Michael S Anglesio Ali Bashashati Yi Kan Wang Janine Senz Gavin Ha Winnie Yang Mohamed R Aniba Leah M Prentice Hossein Farahani Hector Li Chang Anthony N Karnezis Marco A Marra Paul J Yong Martin Hirst Blake Gilks Sohrab P Shah David G Huntsman

J Pathol 2015 Jun 23;236(2):201-9. Epub 2015 Mar 23.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

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June 2015

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4.

Authors:
Pilar Ramos Anthony N Karnezis David W Craig Aleksandar Sekulic Megan L Russell William P D Hendricks Jason J Corneveaux Michael T Barrett Karey Shumansky Yidong Yang Sohrab P Shah Leah M Prentice Marco A Marra Jeffrey Kiefer Victoria L Zismann Troy A McEachron Bodour Salhia Jaime Prat Emanuela D'Angelo Blaise A Clarke Joseph G Pressey John H Farley Stephen P Anthony Richard B S Roden Heather E Cunliffe David G Huntsman Jeffrey M Trent

Nat Genet 2014 May 23;46(5):427-9. Epub 2014 Mar 23.

1] Division of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, Arizona, USA. [2] [3].

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May 2014

RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

Authors:
Zubaidah M Ramdzan Charles Vadnais Ranjana Pal Guillaume Vandal Chantal Cadieux Lam Leduy Sayeh Davoudi Laura Hulea Lu Yao Anthony N Karnezis Marilène Paquet David Dankort Alain Nepveu

PLoS Biol 2014 Mar 11;12(3):e1001807. Epub 2014 Mar 11.

Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada; Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Oncology McGill University, Montreal, Quebec, Canada.

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March 2014

Association of tumor morphology with mismatch-repair protein status in older endometrial cancer patients: implications for universal versus selective screening strategies for Lynch syndrome.

Authors:
Joseph T Rabban Sarah M Calkins Anthony N Karnezis James P Grenert Amie Blanco Beth Crawford Lee-May Chen

Am J Surg Pathol 2014 Jun;38(6):793-800

Departments of *Pathology ‡Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco †Cancer Risk Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.

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June 2014

Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).

Authors:
Pilar Ramos Anthony N Karnezis William P D Hendricks Yemin Wang Waibhav Tembe Victoria L Zismann Christophe Legendre Winnie S Liang Megan L Russell David W Craig John H Farley Bradley J Monk Stephen P Anthony Aleksandar Sekulic Heather E Cunliffe David G Huntsman Jeffrey M Trent

Rare Dis 2014 3;2(1):e967148. Epub 2014 Nov 3.

Division of Integrated Cancer Genomics; Translational Genomics Research Institute (TGen) ; Phoenix, AZ USA.

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March 2016

Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system.

Authors:
Gerald F Reis Michele M Bloomer Arie Perry Joanna J Phillips James P Grenert Anthony N Karnezis Tarik Tihan

Mod Pathol 2013 Oct 24;26(10):1279-87. Epub 2013 May 24.

Neuropathology Unit, Department of Anatomic Pathology, UCSF School of Medicine, San Francisco, CA, USA.

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October 2013

The diagnostic utility of TP53 and CDKN2A to distinguish ovarian high-grade serous carcinoma from low-grade serous ovarian tumors.

Authors:
Alon D Altman Gregg S Nelson Prafull Ghatage John B McIntyre David Capper Pamela Chu Jill G Nation Anthony N Karnezis Guangming Han Steve E Kalloger Martin Köbel

Mod Pathol 2013 Sep 5;26(9):1255-63. Epub 2013 Apr 5.

Department of Obstetrics and Gynecology, Division of Gynecological Oncology, Winnipeg Health Sciences Center, University of Manitoba, Winnipeg, MB, Canada.

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September 2013

Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.

Authors:
Nancy Dumont Bob Liu Rosa Anna Defilippis Hang Chang Joseph T Rabban Anthony N Karnezis Judy A Tjoe James Marx Bahram Parvin Thea D Tlsty

Neoplasia 2013 Mar;15(3):249-62

Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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March 2013

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Authors:
Laura Soucek Jonathan R Whitfield Nicole M Sodir Daniel Massó-Vallés Erika Serrano Anthony N Karnezis Lamorna Brown Swigart Gerard I Evan

Genes Dev 2013 Mar;27(5):504-13

Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143-0502, USA.

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March 2013

Transitional cell-like morphology in ovarian endometrioid carcinoma: morphologic, immunohistochemical, and behavioral features distinguishing it from high-grade serous carcinoma.

Authors:
Anthony N Karnezis Anil Aysal Charles J Zaloudek Joseph T Rabban

Am J Surg Pathol 2013 Jan;37(1):24-37

Department of Pathology, University of California San Francisco, San Francisco, CA 94143-0102, USA.

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January 2013

A crucial requirement for Hedgehog signaling in small cell lung cancer.

Authors:
Kwon-Sik Park Luciano G Martelotto Martin Peifer Martin L Sos Anthony N Karnezis Moe R Mahjoub Katie Bernard Jamie F Conklin Anette Szczepny Jing Yuan Ribo Guo Beatrice Ospina Jeanette Falzon Samara Bennett Tracey J Brown Ana Markovic Wendy L Devereux Cory A Ocasio James K Chen Tim Stearns Roman K Thomas Marion Dorsch Silvia Buonamici D Neil Watkins Craig D Peacock Julien Sage

Nat Med 2011 Oct 9;17(11):1504-8. Epub 2011 Oct 9.

Department of Pediatrics, Stanford University, Stanford, California, USA.

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October 2011

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.

Authors:
Colleen A Brady Dadi Jiang Stephano S Mello Thomas M Johnson Lesley A Jarvis Margaret M Kozak Daniela Kenzelmann Broz Shashwati Basak Eunice J Park Margaret E McLaughlin Anthony N Karnezis Laura D Attardi

Cell 2011 May;145(4):571-83

Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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May 2011

Endogenous Myc maintains the tumor microenvironment.

Authors:
Nicole M Sodir Lamorna Brown Swigart Anthony N Karnezis Douglas Hanahan Gerard I Evan Laura Soucek

Genes Dev 2011 May 8;25(9):907-16. Epub 2011 Apr 8.

Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA.

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May 2011

Junctional epithelial zones of the fallopian tube: cancer hotspots?

Authors:
Joseph T Rabban Anthony N Karnezis Charles J Zaloudek

Int J Gynecol Pathol 2011 Jan;30(1):1-3

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January 2011

Selective activation of p53-mediated tumour suppression in high-grade tumours.

Authors:
Melissa R Junttila Anthony N Karnezis Daniel Garcia Francesc Madriles Roderik M Kortlever Fanya Rostker Lamorna Brown Swigart David M Pham Youngho Seo Gerard I Evan Carla P Martins

Nature 2010 Nov;468(7323):567-71

University of California San Francisco, Department of Pathology and Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94143-0502, USA.

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November 2010

Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma.

Authors:
Bethany E Schaffer Kwon-Sik Park Gloria Yiu Jamie F Conklin Chenwei Lin Deborah L Burkhart Anthony N Karnezis E Alejandro Sweet-Cordero Julien Sage

Cancer Res 2010 May 20;70(10):3877-83. Epub 2010 Apr 20.

Department of Pediatrics, Stanford Medical School, Stanford, California 94305-5149, USA.

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May 2010

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.

Authors:
David Dankort David P Curley Robert A Cartlidge Betsy Nelson Anthony N Karnezis William E Damsky Mingjian J You Ronald A DePinho Martin McMahon Marcus Bosenberg

Nat Genet 2009 May 12;41(5):544-52. Epub 2009 Mar 12.

Cancer Research Institute & Department of Cell and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.

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May 2009

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.

Authors:
Minh D To Christine E Wong Anthony N Karnezis Reyno Del Rosario Roberto Di Lauro Allan Balmain

Nat Genet 2008 Oct 31;40(10):1240-4. Epub 2008 Aug 31.

University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, Cancer Research Institute, San Francisco, California 94115, USA.

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October 2008

Modelling Myc inhibition as a cancer therapy.

Authors:
Laura Soucek Jonathan Whitfield Carla P Martins Andrew J Finch Daniel J Murphy Nicole M Sodir Anthony N Karnezis Lamorna Brown Swigart Sergio Nasi Gerard I Evan

Nature 2008 Oct 17;455(7213):679-83. Epub 2008 Aug 17.

Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143-0875, USA.

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October 2008

Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer.

Authors:
Dan J Raz Jason A Zell Anthony N Karnezis Anobel Odisho S H Ignatius Ou Hoda Anton-Culver David M Jablons

J Thorac Oncol 2006 Nov;1(9):943-8

Department of Surgery, Division of Cardiothoracic Surgery and the UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94131, USA.

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November 2006