Publications by authors named "Anthony N Karnezis"

58Publications

Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.

Gynecol Oncol 2020 Dec 13. Epub 2020 Dec 13.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC, Canada. Electronic address:

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December 2020

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium.

Authors:
Filipe Correia Martins Dominique-Laurent Couturier Anna Paterson Anthony N Karnezis Christine Chow Tayyebeh M Nazeran Adekunle Odunsi Aleksandra Gentry-Maharaj Aleksandra Vrvilo Alexander Hein Aline Talhouk Ana Osorio Andreas D Hartkopf Angela Brooks-Wilson Anna DeFazio Anna Fischer Arndt Hartmann Brenda Y Hernandez Bryan M McCauley Chloe Karpinskyj Christiani B de Sousa Claus Høgdall Daniel G Tiezzi Esther Herpel Florin Andrei Taran Francesmary Modugno Gary Keeney Gregg Nelson Helen Steed Honglin Song Hugh Luk Javier Benitez Jennifer Alsop Jennifer M Koziak Jenny Lester Joseph H Rothstein Jurandyr M de Andrade Lene Lundvall Luis Paz-Ares Luis Robles-Díaz Lynne R Wilkens Maria J Garcia Maria P Intermaggio Marie-Lyne Alcaraz Mary A Brett Matthias W Beckmann Mercedes Jimenez-Linan Michael Anglesio Michael E Carney Michael Schneider Nadia Traficante Nadja Pejovic Naveena Singh Nhu Le Peter Sinn Prafull Ghatage Ramona Erber Robert Edwards Robert Vierkant Roberta B Ness Samuel Leung Sandra Orsulic Sara Y Brucker Scott H Kaufmann Sian Fereday Simon Gayther Stacey J Winham Stefan Kommoss Tanja Pejovic Teri A Longacre Valerie McGuire Valerie Rhenius Weiva Sieh Yurii B Shvetsov Alice S Whittemore Annette Staebler Beth Y Karlan Cristina Rodriguez-Antona David D Bowtell Ellen L Goode Estrid Høgdall Francisco J Candido Dos Reis Jacek Gronwald Jenny Chang-Claude Kirsten B Moysich Linda E Kelemen Linda S Cook Marc T Goodman Peter A Fasching Robin Crawford Suha Deen Usha Menon David G Huntsman Martin Köbel Susan J Ramus Paul D P Pharoah James D Brenton

Br J Cancer 2020 Sep 18;123(5):793-802. Epub 2020 Jun 18.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, England.

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September 2020

Short-term organoid culture for drug sensitivity testing of high-grade serous carcinoma.

Gynecol Oncol 2020 06 4;157(3):783-792. Epub 2020 Apr 4.

Department of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA 95817, United States of America. Electronic address:

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June 2020

Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics.

Histopathology 2020 Jan;76(1):11-24

Clinical Cancer Genomics Laboratory and Pathology Department, University of California San Francisco, San Francisco, CA, USA.

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January 2020

Expression of L1 retrotransposon open reading frame protein 1 in gynecologic cancers.

Hum Pathol 2019 10 18;92:39-47. Epub 2019 Jun 18.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 1L3, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada. Electronic address:

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October 2019

Tubo-Ovarian Transitional Cell Carcinoma and High-grade Serous Carcinoma Show Subtly Different Immunohistochemistry Profiles.

Int J Gynecol Pathol 2019 Nov;38(6):552-561

British Columbia Cancer Agency (J.M., A.N.K., A.T., D.C., D.G.H.) Department of Pathology, University of British Columbia (A.N.K., B.T.-C., C.C., A.C., C.B.G., D.G.H.), Vancouver, British Columbia, Canada Memorial Sloan Kettering Cancer Center, New York, New York (R.S.) Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands (S.H.) Department of Women's Health, Tübingen University Hospital, Tübingen (S.K.) Department of Gynecologic Oncology, Kliniken Essen Mitte, Essen (A.D.B.) Gynecologic Oncology Center, Kiel (J.P.) Institute of Pathology, Friedrichshafen (F.K.), Germany.

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November 2019

High Frequency of Ovarian Cyst Development in Vhl;Snf5 Mice.

Am J Pathol 2018 07 22;188(7):1510-1516. Epub 2018 Apr 22.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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July 2018

DICER1 hot-spot mutations in ovarian gynandroblastoma.

Histopathology 2018 Aug 5;73(2):306-313. Epub 2018 Jun 5.

Institute of Pathology, Medizin Campus Bodensee, Friedrichshafen, Germany.

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August 2018

Bartholin Gland Carcinoma: Clinicopathologic Features, Including p16 Expression and Clinical Outcome.

Int J Gynecol Pathol 2019 Mar;38(2):189-195

Department of Pathology and Laboratory Medicine (T.N., A.S.C., A.N.K., C.B.G.) Genetic Pathology Evaluation Centre (A.S.C.), University of British Columbia Division of Anatomical Pathology, Vancouver General Hospital (T.N., A.N.K., C.B.G.) Division of Medical Oncology, British Columbia Cancer Agency (A.T.), Vancouver, British Columbia, Canada.

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March 2019

Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.

Pathology 2018 Feb 17;50(2):238-256. Epub 2018 Jan 17.

University of California San Francisco, Pathology Department, San Francisco, CA, United States. Electronic address:

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February 2018

Detection and genomic characterization of a mammary-like adenocarcinoma.

Cold Spring Harb Mol Case Stud 2017 Nov 21;3(6). Epub 2017 Nov 21.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

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November 2017

Preclinical Models of Ovarian Cancer: Pathogenesis, Problems, and Implications for Prevention.

Clin Obstet Gynecol 2017 12;60(4):789-800

*Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada †Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan.

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December 2017

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.

J Pathol 2017 07 2;242(3):371-383. Epub 2017 Jun 2.

Department of Pathology and Laboratory Medicine, University of British Columbia and Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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July 2017

Human papillomavirus (HPV)-independent vulvar squamous cell carcinoma has a worse prognosis than HPV-associated disease: a retrospective cohort study.

Histopathology 2017 Aug 23;71(2):238-246. Epub 2017 May 23.

Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, Vancouver, BC, Canada.

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August 2017

Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.

Cancer 2017 03 6;123(5):802-813. Epub 2017 Jan 6.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2017

Of mice and women - Non-ovarian origins of "ovarian" cancer.

Gynecol Oncol 2017 01 24;144(1):5-7. Epub 2016 Nov 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:

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January 2017

The disparate origins of ovarian cancers: pathogenesis and prevention strategies.

Nat Rev Cancer 2017 01 25;17(1):65-74. Epub 2016 Nov 25.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

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January 2017

Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research.

Sci Rep 2016 10 7;6:34949. Epub 2016 Oct 7.

Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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October 2016

Concurrent ARID1A and ARID1B inactivation in endometrial and ovarian dedifferentiated carcinomas.

Mod Pathol 2016 12 26;29(12):1586-1593. Epub 2016 Aug 26.

Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, Canada.

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December 2016

Immunophenotypic features of dedifferentiated endometrial carcinoma - insights from BRG1/INI1-deficient tumours.

Histopathology 2016 Oct 5;69(4):560-9. Epub 2016 Jul 5.

Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, AB, Canada.

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October 2016

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Gynecol Oncol 2016 06 19;141(3):454-460. Epub 2016 Mar 19.

Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Institute and Segal Cancer Center, Jewish General Hospital, Montreal, QC, Canada; Department of Medical Genetics and Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

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June 2016

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.

J Natl Cancer Inst 2016 Jun 1;108(6):djv428. Epub 2016 Feb 1.

Department of Pathology and Laboratory Medicine, (MSA, HMH, JS, HLC, ANK, BSS, MKM, CBG, SK, DGH) and Department of Obstetrics and Gynaecology (MSA, DGH), University of British Columbia, Vancouver, Canada; Department of Molecular Oncology, British Columbia Cancer Agency Cancer Research Centre, Vancouver, Canada (YKW, AB, RM, DSG, SPS); Department of Women's Health, University Hospital Tuebingen, Tuebingen, Germany (MM, FAT, DW, SB, SK); Division of Anatomic Pathology, Synlab MVZ, Institute of Pathology, Mannheim, Germany (FK); Division of Gynecologic Pathology, Institute of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany (AS); Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, Canada (CBG).

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June 2016

p16 Immunostaining Allows for Accurate Subclassification of Vulvar Squamous Cell Carcinoma Into HPV-Associated and HPV-Independent Cases.

Int J Gynecol Pathol 2016 Jul;35(4):385-93

Department of Cellular Pathology (S.J., N.S.), Barts Health NHS Trust, London, United Kingdom Department of Pathology and Laboratory Medicine (A.S.C., A.N.K., C.B.G.), Vancouver General Hospital Department of Obstetrics and Gynecology (J.N.M.), Division of Gynecologic Oncology, University of British Columbia, Vancouver, BC, Canada.

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July 2016

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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August 2015

RAS transformation requires CUX1-dependent repair of oxidative DNA damage.

PLoS Biol 2014 Mar 11;12(3):e1001807. Epub 2014 Mar 11.

Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada; Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Oncology McGill University, Montreal, Quebec, Canada.

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March 2014

Association of tumor morphology with mismatch-repair protein status in older endometrial cancer patients: implications for universal versus selective screening strategies for Lynch syndrome.

Am J Surg Pathol 2014 Jun;38(6):793-800

Departments of *Pathology ‡Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco †Cancer Risk Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.

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June 2014

Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system.

Mod Pathol 2013 Oct 24;26(10):1279-87. Epub 2013 May 24.

Neuropathology Unit, Department of Anatomic Pathology, UCSF School of Medicine, San Francisco, CA, USA.

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October 2013

The diagnostic utility of TP53 and CDKN2A to distinguish ovarian high-grade serous carcinoma from low-grade serous ovarian tumors.

Mod Pathol 2013 Sep 5;26(9):1255-63. Epub 2013 Apr 5.

Department of Obstetrics and Gynecology, Division of Gynecological Oncology, Winnipeg Health Sciences Center, University of Manitoba, Winnipeg, MB, Canada.

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September 2013

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Genes Dev 2013 Mar;27(5):504-13

Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143-0502, USA.

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March 2013

Endogenous Myc maintains the tumor microenvironment.

Genes Dev 2011 May 8;25(9):907-16. Epub 2011 Apr 8.

Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA.

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May 2011

Selective activation of p53-mediated tumour suppression in high-grade tumours.

Nature 2010 Nov;468(7323):567-71

University of California San Francisco, Department of Pathology and Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94143-0502, USA.

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November 2010

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.

Nat Genet 2009 May 12;41(5):544-52. Epub 2009 Mar 12.

Cancer Research Institute & Department of Cell and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.

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May 2009

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.

Nat Genet 2008 Oct 31;40(10):1240-4. Epub 2008 Aug 31.

University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, Cancer Research Institute, San Francisco, California 94115, USA.

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October 2008

Modelling Myc inhibition as a cancer therapy.

Nature 2008 Oct 17;455(7213):679-83. Epub 2008 Aug 17.

Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143-0875, USA.

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October 2008

Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer.

J Thorac Oncol 2006 Nov;1(9):943-8

Department of Surgery, Division of Cardiothoracic Surgery and the UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94131, USA.

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November 2006