Anthony Maxwell

Nightingale Breast Screening Centre & Prevent Breast Cancer Unit Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.

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December 2020

Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance.

Authors:

Natassja G Bush Isabel Diez-Santos Lauren R Abbott Anthony Maxwell

Molecules 2020 Dec 1;25(23). Epub 2020 Dec 1.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

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December 2020

Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients.

Authors:

Anthony J Maxwell Jiahui Ding Yuan You Zhong Dong Hussein Chehade Ayesha Alvero Yechiel Mor Sorin Draghici Gil Mor

J Leukoc Biol 2021 01 26;109(1):35-47. Epub 2020 Nov 26.

C.S. Mott Center for Human Growth and Development, Department of Obstetrics, Gynecology, Wayne State University, Detroit, Michigan, USA.

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January 2021

A novel decatenation assay for DNA topoisomerases using a singly-linked catenated substrate.

Authors:

Nidda F Waraich Shruti Jain Sean D Colloms William Marshall Stark Nicolas P Burton Anthony Maxwell

Biotechniques 2020 11 1;69(5):356-362. Epub 2020 Oct 1.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

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November 2020

Impalpable breast lesion localisation, a logistical challenge: results of the UK iBRA-NET national practice questionnaire.

Authors:

Santosh K Somasundaram Shelley Potter Suzanne Elgammal Anthony J Maxwell Amtul S Sami Sue K Down Rajiv V Dave James Harvey

Breast Cancer Res Treat 2021 Jan 10;185(1):13-20. Epub 2020 Sep 10.

The Nightingale Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK.

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January 2021

Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.

Authors:

Sara R Henderson Clare E M Stevenson Brandon Malone Yelyzaveta Zholnerovych Lesley A Mitchenall Mark Pichowicz David H McGarry Ian R Cooper Cedric Charrier Anne-Marie Salisbury David M Lawson Anthony Maxwell

J Antimicrob Chemother 2020 Oct;75(10):2835-2842

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

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October 2020

What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420).

BMC Cancer 2020 Jun 18;20(1):570. Epub 2020 Jun 18.

NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England.

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June 2020

Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques.

Authors:

Shannon J McKie Anthony Maxwell Keir C Neuman

Genes (Basel) 2020 01 13;11(1). Epub 2020 Jan 13.

Laboratory of Single Molecule Biophysics, NHLBI, Bethesda, MD 20892, USA.

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January 2020

How do women experience a false-positive test result from breast screening? A systematic review and thematic synthesis of qualitative studies.

Authors:

Hannah Long Joanna M Brooks Michelle Harvie Anthony Maxwell David P French

Br J Cancer 2019 08 23;121(4):351-358. Epub 2019 Jul 23.

Manchester Centre for Health Psychology, School of Health Sciences, University of Manchester, Manchester, M13 9PL, United Kingdom.

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August 2019

DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.

Authors:

Benjamin D Bax Garib Murshudov Anthony Maxwell Thomas Germe

J Mol Biol 2019 08 10;431(18):3427-3449. Epub 2019 Jul 10.

Dept. Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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August 2019

Is the future magnetic? Magseed localisation for non palpable breast cancer. A multi-centre non randomised control study.

Authors:

Konstantinos Zacharioudakis Sue Down Zaheerah Bholah Sum Lee Taherah Khan Anthony J Maxwell Miles Howe James Harvey

Eur J Surg Oncol 2019 Nov 26;45(11):2016-2021. Epub 2019 Jun 26.

The Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.

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November 2019

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.

Authors:

Scott McAuley Alan Huynh Alison Howells Chris Walpole Anthony Maxwell Justin R Nodwell

Cell Chem Biol 2019 09 3;26(9):1274-1282.e4. Epub 2019 Jul 3.

Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada. Electronic address:

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September 2019

The Molecular Basis of Antibiotic Action and Resistance.

Authors:

Anthony Maxwell Christopher G Dowson James Spencer

J Mol Biol 2019 08 29;431(18):3367-3369. Epub 2019 Jun 29.

School of Cellular and Molecular Medicine, University of Bristol Biomedical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom. Electronic address:

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August 2019

New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.

Authors:

Sarah Narramore Clare E M Stevenson Anthony Maxwell David M Lawson Colin W G Fishwick

Bioorg Med Chem 2019 08 14;27(16):3546-3550. Epub 2019 Jun 14.

School of Chemistry and the Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address:

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August 2019

The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents.

Authors:

Frederic Collin Anthony Maxwell

J Mol Biol 2019 08 8;431(18):3400-3426. Epub 2019 Jun 8.

Department Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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August 2019

Functionalised bicyclic tetramates derived from cysteine as antibacterial agents.

Authors:

Tharindi D Panduwawala Sarosh Iqbal Amber L Thompson Miroslav Genov Alexander Pretsch Dagmar Pretsch Shuang Liu Richard H Ebright Alison Howells Anthony Maxwell Mark G Moloney

Org Biomol Chem 2019 06;17(22):5615-5632

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK.

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June 2019

Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants.

Authors:

D Gareth R Evans Elaine F Harkness Adam R Brentnall Elke M van Veen Susan M Astley Helen Byers Sarah Sampson Jake Southworth Paula Stavrinos Sacha J Howell Anthony J Maxwell Anthony Howell William G Newman Jack Cuzick

Breast Cancer Res Treat 2019 Jul 2;176(1):141-148. Epub 2019 Apr 2.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square, Barts and The London, Queen Mary University of London, London, UK.

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July 2019

The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress.

Authors:

Xiaojing Li Yujiao Zhang Xintong Zhou Xinling Hu Yixuan Zhou Di Liu Anthony Maxwell Kaixia Mi

Mol Microbiol 2019 06 27;111(6):1529-1543. Epub 2019 Mar 27.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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June 2019

Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.

Authors:

Dmitry Ghilarov Clare E M Stevenson Dmitrii Y Travin Julia Piskunova Marina Serebryakova Anthony Maxwell David M Lawson Konstantin Severinov

Mol Cell 2019 02 17;73(4):749-762.e5. Epub 2019 Jan 17.

Centre for Life Sciences, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia; Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia; Waksman Institute for Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. Electronic address:

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February 2019

Oxytetracycline reduces the diversity of tetracycline-resistance genes in the Galleria mellonella gut microbiome.

Authors:

Katarzyna Ignasiak Anthony Maxwell

BMC Microbiol 2018 12 29;18(1):228. Epub 2018 Dec 29.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, UK.

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December 2018

Single-molecule imaging of DNA gyrase activity in living Escherichia coli.

Authors:

Mathew Stracy Adam J M Wollman Elzbieta Kaja Jacek Gapinski Ji-Eun Lee Victoria A Leek Shannon J McKie Lesley A Mitchenall Anthony Maxwell David J Sherratt Mark C Leake Pawel Zawadzki

Nucleic Acids Res 2019 01;47(1):210-220

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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January 2019

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

Tuberculosis (Edinb) 2018 09 11;112:98-109. Epub 2018 Aug 11.

Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC 27606, USA; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA 94403, USA. Electronic address:

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September 2018

Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project.

Authors:

Alastair M Thompson Karen Clements Shan Cheung Sarah E Pinder Gill Lawrence Elinor Sawyer Olive Kearins Graham R Ball Ian Tomlinson Andrew Hanby Jeremy St J Thomas Anthony J Maxwell Matthew G Wallis David J Dodwell

Eur J Cancer 2018 09 6;101:210-219. Epub 2018 Aug 6.

Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK. Electronic address:

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September 2018

Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.

Authors:

Shankar S Iyer Thomas Gensollen Amit Gandhi Sungwhan F Oh Joana F Neves Frederic Collin Richard Lavin Carme Serra Jonathan Glickman Punyanganie S A de Silva R Balfour Sartor Gurdyal Besra Russell Hauser Anthony Maxwell Amadeu Llebaria Richard S Blumberg

Cell 2018 05;173(5):1123-1134.e11

Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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May 2018

Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.

Authors:

Frédéric Jeannot Thomas Taillier Pierre Despeyroux Stéphane Renard Astrid Rey Michaël Mourez Christoph Poeverlein Imène Khichane Marc-Antoine Perrin Stéphanie Versluys Robert A Stavenger Jianzhong Huang Thomas Germe Anthony Maxwell Sha Cao Douglas L Huseby Diarmaid Hughes Eric Bacqué

J Med Chem 2018 04 10;61(8):3565-3581. Epub 2018 Apr 10.

Therapeutic Area Infectious Diseases , Sanofi R&D , 1541 Avenue Marcel Mérieux , 69280 Marcy L'Etoile , France.

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April 2018

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.

Authors:

Thomas Germe Judit Vörös Frederic Jeannot Thomas Taillier Robert A Stavenger Eric Bacqué Anthony Maxwell Benjamin D Bax

Nucleic Acids Res 2018 05;46(8):4325

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

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May 2018

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