Publications by authors named "Anthony Maxwell"

133 Publications

DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis.

Bioessays 2021 Jan 22:e2000286. Epub 2021 Jan 22.

Department Biological Chemistry, John Innes Centre, Norwich, UK.

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January 2021

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.

Nat Commun 2021 01 8;12(1):150. Epub 2021 Jan 8.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

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January 2021

Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance.

Molecules 2020 Dec 1;25(23). Epub 2020 Dec 1.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

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December 2020

Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients.

J Leukoc Biol 2021 01 26;109(1):35-47. Epub 2020 Nov 26.

C.S. Mott Center for Human Growth and Development, Department of Obstetrics, Gynecology, Wayne State University, Detroit, Michigan, USA.

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January 2021

A novel decatenation assay for DNA topoisomerases using a singly-linked catenated substrate.

Biotechniques 2020 11 1;69(5):356-362. Epub 2020 Oct 1.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

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November 2020

Impalpable breast lesion localisation, a logistical challenge: results of the UK iBRA-NET national practice questionnaire.

Breast Cancer Res Treat 2021 Jan 10;185(1):13-20. Epub 2020 Sep 10.

The Nightingale Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK.

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January 2021

Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques.

Genes (Basel) 2020 01 13;11(1). Epub 2020 Jan 13.

Laboratory of Single Molecule Biophysics, NHLBI, Bethesda, MD 20892, USA.

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January 2020

How do women experience a false-positive test result from breast screening? A systematic review and thematic synthesis of qualitative studies.

Br J Cancer 2019 08 23;121(4):351-358. Epub 2019 Jul 23.

Manchester Centre for Health Psychology, School of Health Sciences, University of Manchester, Manchester, M13 9PL, United Kingdom.

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August 2019

DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.

J Mol Biol 2019 08 10;431(18):3427-3449. Epub 2019 Jul 10.

Dept. Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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August 2019

Is the future magnetic? Magseed localisation for non palpable breast cancer. A multi-centre non randomised control study.

Eur J Surg Oncol 2019 Nov 26;45(11):2016-2021. Epub 2019 Jun 26.

The Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.

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November 2019

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.

Cell Chem Biol 2019 09 3;26(9):1274-1282.e4. Epub 2019 Jul 3.

Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada. Electronic address:

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September 2019

The Molecular Basis of Antibiotic Action and Resistance.

J Mol Biol 2019 08 29;431(18):3367-3369. Epub 2019 Jun 29.

School of Cellular and Molecular Medicine, University of Bristol Biomedical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom. Electronic address:

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August 2019

New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.

Bioorg Med Chem 2019 08 14;27(16):3546-3550. Epub 2019 Jun 14.

School of Chemistry and the Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. Electronic address:

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August 2019

The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents.

J Mol Biol 2019 08 8;431(18):3400-3426. Epub 2019 Jun 8.

Department Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:

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August 2019

Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants.

Breast Cancer Res Treat 2019 Jul 2;176(1):141-148. Epub 2019 Apr 2.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square, Barts and The London, Queen Mary University of London, London, UK.

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July 2019

The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress.

Mol Microbiol 2019 06 27;111(6):1529-1543. Epub 2019 Mar 27.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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June 2019

Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.

Mol Cell 2019 02 17;73(4):749-762.e5. Epub 2019 Jan 17.

Centre for Life Sciences, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia; Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia; Waksman Institute for Microbiology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. Electronic address:

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February 2019

Oxytetracycline reduces the diversity of tetracycline-resistance genes in the Galleria mellonella gut microbiome.

BMC Microbiol 2018 12 29;18(1):228. Epub 2018 Dec 29.

Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, UK.

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December 2018

Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project.

Eur J Cancer 2018 09 6;101:210-219. Epub 2018 Aug 6.

Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK. Electronic address:

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September 2018