Anthony Letai

Anthony Letai

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Anthony Letai

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Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.

Nat Commun 2019 Nov 14;10(1):5157. Epub 2019 Nov 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, 02115, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12477-yDOI Listing
November 2019

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics.

Cell Death Differ 2019 Jul 22. Epub 2019 Jul 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41418-019-0391-9DOI Listing
July 2019

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.

Nat Rev Mol Cell Biol 2019 Mar;20(3):175-193

John B. Little Center for Radiation Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41580-018-0089-8DOI Listing
March 2019

BCL-2 inhibition in AML: an unexpected bonus?

Blood 2018 09 23;132(10):1007-1012. Epub 2018 Jul 23.

Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1182/blood-2018-03-828269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235069PMC
September 2018

Targeting B-Cell Lymphoma 2: A Lethal Shortcut in Del(17p) Chronic Lymphocytic Leukemia.

Authors:
Anthony Letai

J Clin Oncol 2018 07 22;36(19):1991-1993. Epub 2018 May 22.

Anthony Letai, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2018.78.2763DOI Listing
July 2018

Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy.

BMC Gastroenterol 2018 Jun 22;18(1):94. Epub 2018 Jun 22.

Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Building 10; 4-3952, 10 Center Drive, MSC 1201, Bethesda, MD, 20892-1201, USA.

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http://dx.doi.org/10.1186/s12876-018-0823-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013848PMC
June 2018

To Prime, or Not to Prime: That Is the Question.

Cold Spring Harb Symp Quant Biol 2016 3;81:131-140. Epub 2016 Nov 3.

Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2016.81.030841DOI Listing
February 2018

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Sci Transl Med 2017 Dec;9(420)

Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aal3765DOI Listing
December 2017

BCL-X directly modulates RAS signalling to favour cancer cell stemness.

Nat Commun 2017 10 24;8(1):1123. Epub 2017 Oct 24.

Team 8 "Stress adaptation and tumor escape", CRCINA - Institut de Recherche en Santé de l'Université de Nantes-Angers - IRT, BP 70721, 8 quai Moncousu, Nantes, 44007, France.

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http://dx.doi.org/10.1038/s41467-017-01079-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654832PMC
October 2017

Functional precision cancer medicine-moving beyond pure genomics.

Authors:
Anthony Letai

Nat Med 2017 Sep;23(9):1028-1035

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4389DOI Listing
September 2017

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.

Elife 2017 06 8;6. Epub 2017 Jun 8.

Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.25541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464773PMC
June 2017

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages.

Nature 2017 03 8;543(7645):428-432. Epub 2017 Mar 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature21409DOI Listing
March 2017

S63845, an MCL-1 Selective BH3 Mimetic: Another Arrow in Our Quiver.

Authors:
Anthony Letai

Cancer Cell 2016 Dec;30(6):834-835

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.016DOI Listing
December 2016

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance.

Cell Rep 2016 12;17(12):3347-3358

CRCNA, INSERM, CNRS, Université d'Angers, Université de Nantes, 44035 Nantes, France; ICO René Gauducheau, 44805 Saint Herblain, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.064DOI Listing
December 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

Blood 2016 06 11;127(25):3215-24. Epub 2016 Apr 11.

Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia; Department of Clinical Hematology and Bone Marrow Transplantation, The Royal Melbourne Hospital, Parkville, VIC, Australia;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2016-01-68
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http://dx.doi.org/10.1182/blood-2016-01-688796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920022PMC
June 2016

BOK: Oddball of the BCL-2 Family.

Trends Cell Biol 2016 06 3;26(6):389-390. Epub 2016 May 3.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.04.007DOI Listing
June 2016

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

ACS Chem Biol 2016 05 19;11(5):1238-44. Epub 2016 Feb 19.

Department of Biology, Massachusetts Institute of Technology , 77 Massachusetts Ave. Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acschembio.5b01002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874891PMC
May 2016

Dynamic BH3 profiling-poking cancer cells with a stick.

Mol Cell Oncol 2016 May 10;3(3):e1040144. Epub 2016 Mar 10.

Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA, USA.

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http://dx.doi.org/10.1080/23723556.2015.1040144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909438PMC
May 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Mitochondria-Judges and Executioners of Cell Death Sentences.

Mol Cell 2016 Mar;61(5):695-704

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806554PMC
March 2016

Precision medicine for cancer with next-generation functional diagnostics.

Nat Rev Cancer 2015 Dec 5;15(12):747-56. Epub 2015 Nov 5.

Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nrc4015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970460PMC
December 2015

Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!

Authors:
Anthony Letai

Clin Cancer Res 2015 Nov;21(22):5015-20

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1204DOI Listing
November 2015

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.

Blood 2015 Sep 20;126(13):1555-64. Epub 2015 Jul 20.

Department of Molecular and Cellular Pharmacology and Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, Miami, FL;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-01-62
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http://dx.doi.org/10.1182/blood-2015-01-624585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582332PMC
September 2015

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

J Mol Biol 2015 Mar 14;427(6 Pt B):1241-1253. Epub 2014 Nov 14.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357494PMC
March 2015

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

Sci Signal 2014 Dec 23;7(357):ra122. Epub 2014 Dec 23.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/scisignal.2005301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353591PMC
December 2014

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

Haematologica 2014 Sep 23;99(9):1499-508. Epub 2014 May 23.

Division of Hematologic Malignancies and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA Harvard Medical School, Boston, MA, USA Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA Harvard Stem Cell Institute, Boston, MA, USA

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http://dx.doi.org/10.3324/haematol.2014.104166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562540PMC
September 2014

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

ACS Chem Biol 2014 Sep 23;9(9):1962-8. Epub 2014 Jul 23.

Department of Biology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/cb500340wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168798PMC
September 2014

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.

Cancer Res 2014 Jun 27;74(11):3146-56. Epub 2014 Mar 27.

Authors' Affiliations: Massachusetts General Hospital Cancer Center, Charlestown; Department of Medicine, Harvard Medical School; Department of Medical Oncology, Dana-Farber Cancer Institute; and Department of Pathology, Massachusetts General Hospital, Boston, MassachusettsAuthors' Affiliations: Massachusetts General Hospital Cancer Center, Charlestown; Department of Medicine, Harvard Medical School; Department of Medical Oncology, Dana-Farber Cancer Institute; and Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046322PMC
June 2014

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

Dev Cell 2014 May;29(4):377-91

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081014PMC
May 2014

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.

Cancer Discov 2014 Mar 17;4(3):362-75. Epub 2013 Dec 17.

Departments of 1Leukemia, 2Pediatrics, and 3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; 4Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 6The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio; 7AbbVie Inc., North Chicago, Illinois; and 8Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; 9Department of Internal Medicine III, University Hospital of Ulm, Ulm; 10MLL Munich Leukemia Laboratory, Munich, Germany.

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http://research4.dfci.harvard.edu/letai/Publications/2013-12
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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
Publisher Site
http://dx.doi.org/10.1158/2159-8290.CD-13-0609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975047PMC
March 2014

Mitochondria: gatekeepers of response to chemotherapy.

Trends Cell Biol 2013 Dec 21;23(12):612-9. Epub 2013 Sep 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.tcb.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842421PMC
December 2013

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

Cell Stem Cell 2013 Oct 15;13(4):483-91. Epub 2013 Aug 15.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stem.2013.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109647PMC
October 2013

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.

Mol Cell 2013 Sep;51(6):751-65

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.08.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164233PMC
September 2013

Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition.

Leuk Lymphoma 2013 Aug 29;54(8):1823-5. Epub 2013 May 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3109/10428194.2013.796051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557771PMC
August 2013

BH3 profiling in whole cells by fluorimeter or FACS.

Methods 2013 Jun 20;61(2):156-64. Epub 2013 Apr 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10462023130011
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http://dx.doi.org/10.1016/j.ymeth.2013.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686919PMC
June 2013

BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions.

Cancer Lett 2013 May 8;332(2):202-5. Epub 2012 Jan 8.

Chemistry Department, Elon University, McMichael Science Building 311, Elon, NC 27244, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835110076
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http://dx.doi.org/10.1016/j.canlet.2011.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770266PMC
May 2013

BCL-2 inhibition: stemming the tide of myeloid malignancies.

Cell Stem Cell 2013 Mar;12(3):269-70

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.stem.2013.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705714PMC
March 2013

ABT-199: taking dead aim at BCL-2.

Cancer Cell 2013 Feb;23(2):139-41

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693952PMC
February 2013

Targeting the B-cell lymphoma/leukemia 2 family in cancer.

J Clin Oncol 2012 Sep 29;30(25):3127-35. Epub 2012 May 29.

Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA.

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http://dx.doi.org/10.1200/JCO.2011.37.0981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979238PMC
September 2012

Who put the "A" in Atg12: autophagy or apoptosis?

Mol Cell 2011 Dec;44(6):844-5

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765110094
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http://dx.doi.org/10.1016/j.molcel.2011.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943165PMC
December 2011

Targeting Bcl-2 in CLL: cui bono?

Authors:
Anthony Letai

Blood 2011 Sep;118(13):3453-4

Dana-Farber Cancer Institute, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-08-37
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http://dx.doi.org/10.1182/blood-2011-08-370346DOI Listing
September 2011

A new face of BCL-2 inhibition in CLL.

Authors:
Anthony Letai

Blood 2011 Mar;117(10):2750-1

Dana-Farber Cancer Institute, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-32
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http://dx.doi.org/10.1182/blood-2011-01-328658DOI Listing
March 2011

A new face of BCL-2 inhibition in CLL.

Authors:
Anthony Letai

Blood 2011 Mar;117(10):2750-1

Dana-Farber Cancer Institute, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-32
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http://dx.doi.org/10.1182/blood-2011-01-328658DOI Listing
March 2011

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

Proc Natl Acad Sci U S A 2010 Jul 6;107(29):12895-900. Epub 2010 Jul 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0914878107
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http://dx.doi.org/10.1073/pnas.0914878107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900PMC
July 2010