Publications by authors named "Anthony J Chalmers"

53Publications

Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells.

Adv Radiat Oncol 2020 Sep-Oct;5(5):994-1005. Epub 2020 Jun 29.

Wolfson Wohl Translational Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.adro.2020.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557210PMC
June 2020

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma.

Cell Signal 2020 Aug 19;72:109638. Epub 2020 Apr 19.

CRUK Beatson Institute, Glasgow, UK; Division of Cellular and Molecular Medicine, School of Medicine, University of Dundee, Dundee, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2020.109638DOI Listing
August 2020

Mesothelioma Cells Depend on the Antiapoptotic Protein Bcl-xL for Survival and Are Sensitized to Ionizing Radiation by BH3-Mimetics.

Int J Radiat Oncol Biol Phys 2020 03 28;106(4):867-877. Epub 2019 Nov 28.

Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2019.11.029DOI Listing
March 2020

Radiation Responses of 2D and 3D Glioblastoma Cells: A Novel, 3D-specific Radioprotective Role of VEGF/Akt Signaling through Functional Activation of NHEJ.

Mol Cancer Ther 2020 02 31;19(2):575-589. Epub 2019 Oct 31.

Wolfson Wohl Translational Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-18-1320DOI Listing
February 2020

Targeting DNA repair in gliomas.

Curr Opin Neurol 2019 12;32(6):878-885

Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WCO.0000000000000760DOI Listing
December 2019

Patient-specific 3D-printed glioblastomas.

Nat Biomed Eng 2019 07;3(7):498-499

Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41551-019-0379-2DOI Listing
July 2019

Glioblastoma's Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy Research.

Cancers (Basel) 2019 Jan 4;11(1). Epub 2019 Jan 4.

Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11010044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356812PMC
January 2019

Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma.

Front Immunol 2018 26;9:1679. Epub 2018 Jul 26.

Department of Radiation Oncology, University Hospital of Northern Norway, Tromsø, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077256PMC
September 2019

An F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent.

J Med Chem 2018 05 19;61(9):4103-4114. Epub 2018 Apr 19.

West of Scotland PET Centre , Greater Glasgow and Clyde NHS Trust , Glasgow G12 0YN , U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.8b00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007963PMC
May 2018

GBM radiosensitizers: dead in the water…or just the beginning?

J Neurooncol 2017 Sep 31;134(3):513-521. Epub 2017 Jul 31.

Radiation Oncology Department, Duke University School of Medicine, Durham, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11060-017-2427-7DOI Listing
September 2017

Multiple boli arterial spin labeling for high signal-to-noise rodent brain perfusion imaging.

Magn Reson Med 2018 02 17;79(2):1020-1030. Epub 2017 May 17.

Glasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mrm.26706DOI Listing
February 2018

PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells.

Cancer Res 2016 12 26;76(23):7001-7011. Epub 2016 Sep 26.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-1134DOI Listing
December 2016

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses.

Neuro Oncol 2017 02;19(2):229-241

Wolfson Wohl Translational Cancer Research Center, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/now164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463789PMC
February 2017

Glioblastoma in the elderly - How do we choose who to treat?

J Geriatr Oncol 2016 11 29;7(6):453-456. Epub 2016 Jul 29.

Sussex Cancer Centre, Brighton BN2 5BE, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jgo.2016.07.005DOI Listing
November 2016

Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.

J Med Chem 2015 Nov 27;58(21):8683-93. Epub 2015 Oct 27.

West of Scotland PET Centre, Greater Glasgow and Clyde NHS Trust, Glasgow G12 0YN, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.5b01324DOI Listing
November 2015

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.

Cancer Res 2015 Oct 17;75(20):4416-28. Epub 2015 Aug 17.

Translational Radiation Biology, Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/early/2015/10/01/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-3790DOI Listing
October 2015

A novel F-labelled high affinity agent for PET imaging of the translocator protein.

Chem Sci 2015 Aug 27;6(8):4772-4777. Epub 2015 May 27.

WestCHEM , School of Chemistry , University of Glasgow , The Joseph Black Building , Glasgow G12 8QQ , UK . Email: ; ; Tel: +44 (0)141 330 5936.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C5SC01647A
Publisher Site
http://dx.doi.org/10.1039/c5sc01647aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667507PMC
August 2015

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.

Mol Cell 2015 Mar 19;57(5):860-872. Epub 2015 Feb 19.

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2015.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352766PMC
March 2015

mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells.

Mol Cancer 2014 Jun 8;13:144. Epub 2014 Jun 8.

Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1476-4598-13-144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061125PMC
June 2014

Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.

Stem Cell Res 2014 Jul 11;13(1):135-43. Epub 2014 May 11.

Institute of Cancer Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085484PMC
July 2014

The potential of PARP inhibitors in neuro-oncology.

CNS Oncol 2012 Sep;1(1):85-97

Institute of Cancer Sciences, University of Glasgow, Switchback Road, Bearsden, Glasgow G12 8QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/cns.12.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176825PMC
September 2012

Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit'?

Mol Oncol 2011 Aug 20;5(4):374-86. Epub 2011 May 20.

Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molonc.2011.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528310PMC
August 2011

A UK-wide survey of follow-up practices for patients with high-grade glioma treated with radical intent.

J Eval Clin Pract 2011 Feb 8;17(1):1-6. Epub 2010 Dec 8.

Cancer Research UK Psychosocial Oncology Group, Brighton & Sussex Medical School, Brighton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2753.2009.01292.xDOI Listing
February 2011

Overcoming resistance of glioblastoma to conventional cytotoxic therapies by the addition of PARP inhibitors.

Anticancer Agents Med Chem 2010 Sep;10(7):520-33

Genome Damage and Stability Centre, Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/187152010793498627DOI Listing
September 2010

Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets.

Semin Radiat Oncol 2010 Oct;20(4):274-81

Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10534296100004
Publisher Site
http://dx.doi.org/10.1016/j.semradonc.2010.06.001DOI Listing
October 2010

Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.

Int J Radiat Oncol Biol Phys 2009 Dec;75(5):1511-9

Brighton and Sussex Medical School, University of Sussex, Falmer, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2009.07.1703DOI Listing
December 2009

The potential role and application of PARP inhibitors in cancer treatment.

Br Med Bull 2009 9;89:23-40. Epub 2009 Feb 9.

Genome Damage and Stability Centre, University of Sussex, Brighton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bmb/ldp005DOI Listing
October 2009

Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential.

Int J Radiat Oncol Biol Phys 2008 Nov;72(4):1188-97

Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2008.07.031DOI Listing
November 2008

A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose.

Theor Biol Med Model 2007 Jul 19;4:25. Epub 2007 Jul 19.

Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1742-4682-4-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950494PMC
July 2007

Radioresistant glioma stem cells--therapeutic obstacle or promising target?

DNA Repair (Amst) 2007 Sep 7;6(9):1391-4. Epub 2007 May 7.

Brighton and Sussex Medical School, Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2007.03.019DOI Listing
September 2007