Anthony Howell

Anthony Howell

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Anthony Howell

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Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants.

Breast Cancer Res Treat 2019 Jul 2;176(1):141-148. Epub 2019 Apr 2.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square, Barts and The London, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1007/s10549-019-05210-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548748PMC
July 2019

Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy.

Breast 2019 Jun 15;45:1-6. Epub 2019 Feb 15.

Prevent Breast Cancer Research Unit, Manchester University Hospital NHS Foundation Trust, Manchester UK.

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http://dx.doi.org/10.1016/j.breast.2019.02.006DOI Listing
June 2019

A case-control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density.

Int J Cancer 2019 Jun 28. Epub 2019 Jun 28.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32541DOI Listing
June 2019

Genome-wide association study of germline variants and breast cancer-specific mortality.

Authors:
Maria Escala-Garcia Qi Guo Thilo Dörk Sander Canisius Renske Keeman Joe Dennis Jonathan Beesley Julie Lecarpentier Manjeet K Bolla Qin Wang Jean Abraham Irene L Andrulis Hoda Anton-Culver Volker Arndt Paul L Auer Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Bram Boeckx Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Hermann Brenner Adam Brentnall Louise Brinton Per Broberg Ian W Brock Sara Y Brucker Barbara Burwinkel Carlos Caldas Trinidad Caldés Daniele Campa Federico Canzian Angel Carracedo Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Georgia Chenevix-Trench Ting-Yuan David Cheng Suet-Feung Chin Christine L Clarke Emilie Cordina-Duverger Fergus J Couch David G Cox Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Janet A Dunn Alison M Dunning Lorraine Durcan Miriam Dwek Helena M Earl Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Jonine Figueroa Dieter Flesch-Janys Henrik Flyger Marike Gabrielson Manuela Gago-Dominguez Eva Galle Susan M Gapstur Montserrat García-Closas José A García-Sáenz Mia M Gaudet Angela George Vassilios Georgoulias Graham G Giles Gord Glendon David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Susan Hankinson Elaine F Harkness Patricia A Harrington Steven N Hart Jaana M Hartikainen Alexander Hein Peter Hillemanns Louise Hiller Bernd Holleczek Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Wolfgang Janni Esther M John Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Maria Kabisch Katarzyna Kaczmarek Michael J Kerin Sofia Khan Elza Khusnutdinova Johanna I Kiiski Cari M Kitahara Julia A Knight Yon-Dschun Ko Linetta B Koppert Veli-Matti Kosma Peter Kraft Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Lian Li Annika Lindblom Sara Lindström Martha Linet Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jan Lubiński Michael P Lux Robert J MacInnis Melanie Maierthaler Tom Maishman Enes Makalic Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Pooja Middha Nicola Miller Roger L Milne Fernando Moreno Anna Marie Mulligan Claire Mulot Rami Nassir Susan L Neuhausen William T Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Christos Petridis Mila Pinchev Karoliona Prajzendanc Ross Prentice Nadege Presneau Darya Prokofieva Katri Pylkäs Brigitte Rack Paolo Radice Dhanya Ramachandran Gadi Rennert Hedy S Rennert Valerie Rhenius Atocha Romero Rebecca Roylance Emmanouil Saloustros Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Lukas Schwentner Rodney J Scott Christopher Scott Caroline Seynaeve Mitul Shah Jacques Simard Ann Smeets Christof Sohn Melissa C Southey Anthony J Swerdlow Aline Talhouk Rulla M Tamimi William J Tapper Manuel R Teixeira Maria Tengström Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Diana Torres Thérèse Truong Constance Turman Clare Turnbull Hans-Ulrich Ulmer Michael Untch Celine Vachon Christi J van Asperen Ans M W van den Ouweland Elke M van Veen Camilla Wendt Alice S Whittemore Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Yan Zhang Douglas F Easton Peter A Fasching Heli Nevanlinna Diana M Eccles Paul D P Pharoah Marjanka K Schmidt

Br J Cancer 2019 Mar 21;120(6):647-657. Epub 2019 Feb 21.

The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.

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http://www.nature.com/articles/s41416-019-0393-x
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http://dx.doi.org/10.1038/s41416-019-0393-xDOI Listing
March 2019

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Authors:
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal Andrew Lee Jonathan P Tyrer Ting-Huei Chen Qin Wang Manjeet K Bolla Xin Yang Muriel A Adank Thomas Ahearn Kristiina Aittomäki Jamie Allen Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Volker Arndt Kristan J Aronson Paul L Auer Päivi Auvinen Myrto Barrdahl Laura E Beane Freeman Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam Brentnall Ian W Brock Angela Brooks-Wilson Sara Y Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D Carter Jose E Castelao Stephen J Chanock Rowan Chlebowski Hans Christiansen Christine L Clarke J Margriet Collée Emilie Cordina-Duverger Sten Cornelissen Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Thilo Dörk Isabel Dos-Santos-Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana M Eccles Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Peter A Fasching Jonine Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago-Dominguez Susan M Gapstur José A García-Sáenz Mia M Gaudet Vassilios Georgoulias Graham G Giles Irina R Gilyazova Gord Glendon Mark S Goldberg David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Susan E Hankinson Elaine F Harkness Steven N Hart Wei He Alexander Hein Jane Heyworth Peter Hillemanns Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Milena Jakimovska Anna Jakubowska Wolfgang Janni Esther M John Nichola Johnson Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Katarzyna Kaczmarek Vesa Kataja Renske Keeman Michael J Kerin Elza Khusnutdinova Johanna I Kiiski Julia A Knight Yon-Dschun Ko Veli-Matti Kosma Stella Koutros Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Jenna Lilyquist Annika Lindblom Sara Lindström Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jirong Long Jan Lubiński Michael P Lux Robert J MacInnis Tom Maishman Enes Makalic Ivana Maleva Kostovska Arto Mannermaa Siranoush Manoukian Sara Margolin John W M Martens Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Usha Menon Pooja Middha Nicola Miller Fernando Moreno Anna Marie Mulligan Claire Mulot Victor M Muñoz-Garzon Susan L Neuhausen Heli Nevanlinna Patrick Neven William G Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Kenneth Offit Janet E Olson Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Julian Peto Mila Pinchev Dijana Plaseska-Karanfilska Eric C Polley Ross Prentice Nadege Presneau Darya Prokofyeva Kristen Purrington Katri Pylkäs Brigitte Rack Paolo Radice Rohini Rau-Murthy Gad Rennert Hedy S Rennert Valerie Rhenius Mark Robson Atocha Romero Kathryn J Ruddy Matthias Ruebner Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Peter Schürmann Lukas Schwentner Christopher Scott Rodney J Scott Caroline Seynaeve Mitul Shah Mark E Sherman Martha J Shrubsole Xiao-Ou Shu Susan Slager Ann Smeets Christof Sohn Penny Soucy Melissa C Southey John J Spinelli Christa Stegmaier Jennifer Stone Anthony J Swerdlow Rulla M Tamimi William J Tapper Jack A Taylor Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Thérèse Truong Maria Tzardi Hans-Ulrich Ulmer Michael Untch Celine M Vachon Elke M van Veen Joseph Vijai Clarice R Weinberg Camilla Wendt Alice S Whittemore Hans Wildiers Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Drakoulis Yannoukakos Yan Zhang Wei Zheng Argyrios Ziogas Alison M Dunning Deborah J Thompson Georgia Chenevix-Trench Jenny Chang-Claude Marjanka K Schmidt Per Hall Roger L Milne Paul D P Pharoah Antonis C Antoniou Nilanjan Chatterjee Peter Kraft Montserrat García-Closas Jacques Simard Douglas F Easton

Am J Hum Genet 2019 Jan 13;104(1):21-34. Epub 2018 Dec 13.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183040
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http://dx.doi.org/10.1016/j.ajhg.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323553PMC
January 2019

Lifestyle behaviours and health measures of women at increased risk of breast cancer taking chemoprevention.

Eur J Cancer Prev 2018 Nov 15. Epub 2018 Nov 15.

Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester.

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http://dx.doi.org/10.1097/CEJ.0000000000000493DOI Listing
November 2018

Penetrance estimates for , (also applied to Lynch syndrome) based on presymptomatic testing: a new unbiased method to assess risk?

J Med Genet 2018 Jul 26;55(7):442-448. Epub 2018 Feb 26.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1136/jmedgenet-2017-105223DOI Listing
July 2018

Personalized prevention in high risk individuals: Managing hormones and beyond.

Breast 2018 Jun 30;39:139-147. Epub 2018 Mar 30.

Prevent Breast Cancer and Nightingale Breast Screening Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Manchester, UK; Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK; Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.breast.2018.03.009DOI Listing
June 2018

Psychological impact of providing women with personalised 10-year breast cancer risk estimates.

Br J Cancer 2018 06 8;118(12):1648-1657. Epub 2018 May 8.

Prevent Breast Cancer Centre and Nightingale Breast Screening Centre, University Hospital of South Manchester, Manchester, M23 9LT, UK.

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http://dx.doi.org/10.1038/s41416-018-0069-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008295PMC
June 2018

Intermittent energy restriction for weight loss: Spontaneous reduction of energy intake on unrestricted days.

Food Sci Nutr 2018 May 21;6(3):674-680. Epub 2018 Feb 21.

Prevent Breast Cancer Research Unit Manchester University Hospital NHS Foundation Trust Manchester UK.

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http://dx.doi.org/10.1002/fsn3.586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980333PMC
May 2018

Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction.

JAMA Oncol 2018 Apr;4(4):476-482

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England.

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http://dx.doi.org/10.1001/jamaoncol.2017.4881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885189PMC
April 2018

Psychosocial issues of a population approach to high genetic risk identification: Behavioural, emotional and informed choice issues.

Breast 2018 Feb 21;37:148-153. Epub 2017 Nov 21.

Prevent Breast Cancer Centre and Nightingale Breast Screening Centre, University Hospital of South Manchester, Manchester, M23 9LT, UK; Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Manchester, M20 4BX, UK; Department of Genomic Medicine, Institute of Human Development, Manchester Academic Health Science Centre (MAHSC), Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL, UK; Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, University Manchester, Manchester, M13 9NT, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S09609776173077
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http://dx.doi.org/10.1016/j.breast.2017.11.008DOI Listing
February 2018

Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK.

BMC Public Health 2018 01 25;18(1):178. Epub 2018 Jan 25.

Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1186/s12889-018-5090-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784727PMC
January 2018

A randomised trial of screening with digital breast tomosynthesis plus conventional digital 2D mammography versus 2D mammography alone in younger higher risk women.

Eur J Radiol 2017 Sep 30;94:133-139. Epub 2017 Jun 30.

Medical Statistics, University Hospital of South Manchester, Manchester, M23 9LT, UK; Centre for Biostatistics, School of Health Sciences, University of Manchester, Manchester, M13 9PL, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X173027
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http://dx.doi.org/10.1016/j.ejrad.2017.06.018DOI Listing
September 2017

Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I).

J Clin Oncol 2017 08 29;35(23):2666-2673. Epub 2017 Jun 29.

Samuel George Smith, Leeds Institute of Health Science, University of Leeds, Leeds; Samuel George Smith, Ivana Sestak, and Jack Cuzick, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London; Anthony Howell, Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom; and John Forbes, Calvary Mater Newcastle Hospital, Newcastle, Australia.

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http://dx.doi.org/10.1200/JCO.2016.71.7439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549455PMC
August 2017

Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials.

J Clin Oncol 2017 Mar 28;35(7):743-750. Epub 2016 Dec 28.

Jack Cuzick, Adam R. Brentnall, Caroline Reuter, and Ivana Sestak, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London; Corrinne Segal, The Institute of Cancer Research; Corrinne Segal, Simone Detre, Elena Lopez-Knowles, and Mitchell Dowsett, Royal Marsden Hospital; Trevor J. Powles, Cancer Centre London, London; Helen Byers and William G. Newman, University of Manchester and Central Manchester Foundation Trust; and Anthony Howell, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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http://ascopubs.org/doi/10.1200/JCO.2016.69.8944
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http://dx.doi.org/10.1200/JCO.2016.69.8944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455424PMC
March 2017

The impact of a panel of 18 SNPs on breast cancer risk in women attending a UK familial screening clinic: a case-control study.

J Med Genet 2017 02 28;54(2):111-113. Epub 2016 Oct 28.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2016-104125DOI Listing
February 2017

Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects-A Narrative Review of Human and Animal Evidence.

Behav Sci (Basel) 2017 Jan 19;7(1). Epub 2017 Jan 19.

The Nightingale Centre, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UK.

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http://www.mdpi.com/2076-328X/7/1/4
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http://dx.doi.org/10.3390/bs7010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371748PMC
January 2017

How to Manage the Obese Patient With Cancer.

J Clin Oncol 2016 12 7;34(35):4284-4294. Epub 2016 Nov 7.

Andrew G. Renehan, Sacha Howell, and Anthony Howell, University of Manchester; Michelle Harvie and Anthony Howell, University Hospital of South Manchester NHS Foundation Trust, Manchester; Ramsey I. Cutress, University Hospitals Southampton; Ramsey I. Cutress, University of Southampton, Southampton, United Kingdom; Michael Leitzmann, University of Regensburg, Regensburg; and Tobias Pischon, Max Delbrück Center for Molecular Medicine (MDC), Berlin-Buch, Germany.

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http://dx.doi.org/10.1200/JCO.2016.69.1899DOI Listing
December 2016

No strong evidence for increased risk of breast cancer 8-26 years after multiple mammograms in their 30s in females at moderate and high familial risk.

Br J Radiol 2016 21;89(1059):20150960. Epub 2016 Jan 21.

1 Genesis Prevention Centre and Nightingale Breast Screening Centre, University Hospital of South Manchester, Wythenshawe, Manchester, UK.

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http://www.birpublications.org/doi/10.1259/bjr.20150960
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http://dx.doi.org/10.1259/bjr.20150960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986504PMC
July 2016

Breast cancer risk feedback to women in the UK NHS breast screening population.

Br J Cancer 2016 04 29;114(9):1045-52. Epub 2016 Mar 29.

Genesis Breast Cancer Prevention Centre and Nightingale Breast Screening Centre, University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.

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http://dx.doi.org/10.1038/bjc.2016.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984905PMC
April 2016

Epithelial and stromal microRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation.

PLoS One 2014 14;9(8):e105099. Epub 2014 Aug 14.

Center for Molecular Pathology, Skåne University Hospital, Department of Laboratory Medicine Malmö, Lund University, Malmö, Sweden; Breakthrough Breast Cancer Research Unit, Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Paterson Institute for Cancer Research, The Christie National Health Service Foundation Trust, Manchester, United Kingdom; Sahlgrenska Cancer Center, Department of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105099PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133372PMC
March 2016

Can diet and lifestyle prevent breast cancer: what is the evidence?

Am Soc Clin Oncol Educ Book 2015 :e66-73

From the Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.14694/EdBook_AM.2015.35.e66DOI Listing
February 2016

Anastrozole-Induced Carpal Tunnel Syndrome: Results From the International Breast Cancer Intervention Study II Prevention Trial.

J Clin Oncol 2016 Jan 23;34(2):139-43. Epub 2015 Nov 23.

Francesco Spagnolo, Ivana Sestak, and Jack Cuzick, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London; Anthony Howell, Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester, Manchester, United Kingdom; and John F. Forbes, Department of Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, New South Wales, Australia.

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http://dx.doi.org/10.1200/JCO.2015.63.4972DOI Listing
January 2016

Tumour characteristics and survival in familial breast cancer prospectively diagnosed by annual mammography.

Breast Cancer Res Treat 2015 Jul 3;152(1):87-94. Epub 2015 Jun 3.

Nightingale and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, United Kingdom.

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http://dx.doi.org/10.1007/s10549-015-3448-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468806PMC
July 2015

Can the breast screening appointment be used to provide risk assessment and prevention advice?

Breast Cancer Res 2015 Jul 9;17:84. Epub 2015 Jul 9.

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13058-015-0595-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496847PMC
July 2015

Estrogen Receptor Expression in 21-Gene Recurrence Score Predicts Increased Late Recurrence for Estrogen-Positive/HER2-Negative Breast Cancer.

Clin Cancer Res 2015 Jun;21(12):2763-70

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2842DOI Listing
June 2015

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: connecting fibrosis, inflammation, and stemness for cancer prevention.

Cell Cycle 2014 5;13(4):580-99. Epub 2013 Dec 5.

Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UK.

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http://dx.doi.org/10.4161/cc.27379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988118PMC
April 2015

Beliefs about weight and breast cancer: an interview study with high risk women following a 12 month weight loss intervention.

Hered Cancer Clin Pract 2015 9;13(1). Epub 2015 Jan 9.

Nightingale & Genesis Breast Cancer Prevention Centre, University Hospital South Manchester NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT UK.

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http://dx.doi.org/10.1186/s13053-014-0023-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314794PMC
February 2015

Breast cancer risk in young women in the national breast screening programme: implications for applying NICE guidelines for additional screening and chemoprevention.

Cancer Prev Res (Phila) 2014 Oct 21;7(10):993-1001. Epub 2014 Jul 21.

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, United Kingdom. Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Christie Hospital, Withington, Manchester, United Kingdom.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0037DOI Listing
October 2014

Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?

BMC Med Inform Decis Mak 2014 Oct 1;14:87. Epub 2014 Oct 1.

Institute of Population Health, Centre for Health Informatics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/1472-6947-14-87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197237PMC
October 2014

Long-term prospective clinical follow-up after BRCA1/2 presymptomatic testing: BRCA2 risks higher than in adjusted retrospective studies.

J Med Genet 2014 Sep 22;51(9):573-80. Epub 2014 Jul 22.

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Manchester, UK Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Christie Hospital, Manchester, UK The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1136/jmedgenet-2014-102336DOI Listing
September 2014

Breast cancer risk assessment in 8,824 women attending a family history evaluation and screening programme.

Fam Cancer 2014 Jun;13(2):189-96

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, M23 9LT, UK,

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http://dx.doi.org/10.1007/s10689-013-9694-zDOI Listing
June 2014

Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral.

Breast Cancer Res Treat 2013 Dec 20;142(3):611-8. Epub 2013 Nov 20.

Centre for Health Informatics, Institute of Population Health, The University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1007/s10549-013-2765-xDOI Listing
December 2013

Increased rate of phenocopies in all age groups in BRCA1/BRCA2 mutation kindred, but increased prospective breast cancer risk is confined to BRCA2 mutation carriers.

Cancer Epidemiol Biomarkers Prev 2013 Dec 27;22(12):2269-76. Epub 2013 Nov 27.

Authors' Affiliations: Department of Genetic Medicine, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital; Genesis Prevention Centre, University Hospital of South Manchester Southmoor Road; Centre for Health Informatics, Institute of Population Health, The University of Manchester, Manchester; and Centre for Rare Diseases and Personalised Medicine, School of Clinical and Experimental Medicine, University of Birmingham College of Medical and Dental Sciences, and West Midlands Regional Genetics Service, Birmingham, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0316-TDOI Listing
December 2013

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Breast Cancer Res 2013 Oct 1;15(5):R92. Epub 2013 Oct 1.

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http://dx.doi.org/10.1186/bcr3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907091PMC
October 2013

Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer.

Cell Cycle 2013 Sep 27;12(18):2935-6. Epub 2013 Aug 27.

Manchester Breast Centre & Breakthrough Breast Cancer Research Unit; Faculty Institute of Cancer Sciences; University of Manchester; Manchester, UK.

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http://dx.doi.org/10.4161/cc.26280DOI Listing
September 2013

Carbonic anhydrase 9 (CA9) and redox signaling in cancer-associated fibroblasts: therapeutic implications.

Cell Cycle 2013 Aug 30;12(16):2534-5. Epub 2013 Jul 30.

Manchester Breast Centre & Breakthrough Breast Cancer Research Unit, Faculty Institute of Cancer Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.4161/cc.25842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865039PMC
August 2013

Contralateral mastectomy improves survival in women with BRCA1/2-associated breast cancer.

Breast Cancer Res Treat 2013 Jul 20;140(1):135-42. Epub 2013 Jun 20.

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Southmoor Road, Wythenshawe, Manchester, UK.

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http://dx.doi.org/10.1007/s10549-013-2583-1DOI Listing
July 2013

Ovarian cancer among 8,005 women from a breast cancer family history clinic: no increased risk of invasive ovarian cancer in families testing negative for BRCA1 and BRCA2.

J Med Genet 2013 Jun 28;50(6):368-72. Epub 2013 Mar 28.

Centre for Health Informatics, Institute of Population Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/jmedgenet-2013-101607DOI Listing
June 2013

Breast cancer prevention: SERMs come of age.

Lancet 2013 May 30;381(9880):1795-7. Epub 2013 Apr 30.

Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/S0140-6736(13)60443-2DOI Listing
May 2013

The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.

Cell Cycle 2012 Nov 9;11(21):3972-82. Epub 2012 Oct 9.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.22227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507493PMC
November 2012

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.

Cell Cycle 2012 Nov 9;11(22):4167-73. Epub 2012 Oct 9.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.22316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524212PMC
November 2012

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance.

Cell Cycle 2012 Nov 15;11(22):4174-80. Epub 2012 Oct 15.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.22376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524213PMC
November 2012

Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.

Cell Cycle 2012 Nov 19;11(21):3956-63. Epub 2012 Sep 19.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.22136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507491PMC
November 2012

Ketone body utilization drives tumor growth and metastasis.

Cell Cycle 2012 Nov 19;11(21):3964-71. Epub 2012 Sep 19.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.22137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507492PMC
November 2012

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.

Cell Cycle 2012 Sep 16;11(17):3280-9. Epub 2012 Aug 16.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology & Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.21643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466527PMC
September 2012

Weight change associated with anastrozole and tamoxifen treatment in postmenopausal women with or at high risk of developing breast cancer.

Breast Cancer Res Treat 2012 Jul 16;134(2):727-34. Epub 2012 May 16.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University, Charterhouse Square, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1007/s10549-012-2085-6DOI Listing
July 2012

Polymorphisms of CYP19A1 and response to aromatase inhibitors in metastatic breast cancer patients.

Breast Cancer Res Treat 2012 Jun 15;133(3):1191-8. Epub 2012 Mar 15.

Department of Medical Oncology, University of Manchester and The Christie NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1007/s10549-012-2010-zDOI Listing
June 2012

Oestrogen and breast cancer: results from the WHI trial.

Lancet Oncol 2012 May 7;13(5):437-8. Epub 2012 Mar 7.

Genesis Prevention Centre, University Hospital of South Manchester, Southmoor Road, Manchester, UK.

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http://dx.doi.org/10.1016/S1470-2045(12)70110-9DOI Listing
May 2012

Energy restriction and the prevention of breast cancer.

Proc Nutr Soc 2012 May 14;71(2):263-75. Epub 2012 Mar 14.

Nightingale Centre, University Hospital of South Manchester, Manchester M23 9LT, UK.

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http://dx.doi.org/10.1017/S0029665112000195DOI Listing
May 2012

Genesis and outcome of a breast cancer trial to develop the aromatase inhibitor anastrozole.

Authors:
Anthony Howell

Clin Chem 2012 Apr 14;58(4):782-3. Epub 2012 Feb 14.

Manchester Breast Centre, The Christie NHS Foundation Trust, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1373/clinchem.2011.181206DOI Listing
April 2012

Breast cancer risk for noncarriers of family-specific BRCA1 and BRCA2 mutations: more trouble with phenocopies.

J Clin Oncol 2012 Apr 27;30(10):1142-3; author reply 1143-4. Epub 2012 Feb 27.

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http://dx.doi.org/10.1200/JCO.2011.40.8021DOI Listing
April 2012

Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study.

Breast Cancer Res 2012 Apr 4;14(2):R57. Epub 2012 Apr 4.

Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1186/bcr3161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446392PMC
April 2012

Are we ready for online tools in decision making for BRCA1/2 mutation carriers?

J Clin Oncol 2012 Feb 9;30(5):471-3. Epub 2012 Jan 9.

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http://dx.doi.org/10.1200/JCO.2011.40.1562DOI Listing
February 2012

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.

Cancer Biol Ther 2011 Dec 15;12(12):1101-13. Epub 2011 Dec 15.

Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cbt.12.12.18703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335944PMC
December 2011