Anthony Ford

Anthony Ford

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Anthony Ford

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The Role of MicroRNA in Paediatric Acute Lymphoblastic Leukaemia: Challenges for Diagnosis and Therapy.

J Oncol 2019 13;2019:8941471. Epub 2019 Oct 13.

Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1155/2019/8941471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815594PMC
October 2019

Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.

PLoS Negl Trop Dis 2019 09 11;13(9):e0007222. Epub 2019 Sep 11.

Program in Public Health, College of Health Sciences, University of California at Irvine, Irvine, CA, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0007222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756552PMC
September 2019

Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation.

Br J Pharmacol 2019 Jul 11;176(13):2279-2291. Epub 2019 May 11.

Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bph.14677
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http://dx.doi.org/10.1111/bph.14677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555852PMC
July 2019

Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability.

Mol Cell 2019 05 21;74(3):584-597.e9. Epub 2019 Mar 21.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509286PMC
May 2019

Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.

Pediatr Blood Cancer 2018 11 3;65(11):e27310. Epub 2018 Jul 3.

Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1002/pbc.27310DOI Listing
November 2018

The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?

Biochim Biophys Acta Rev Cancer 2017 Dec 19;1868(2):521-526. Epub 2017 Oct 19.

Molecular Cancer Study Group, Research Centre, Instituto Nacional de Câncer (INCA), Rua André Cavalcanti 37, 2° floor, Rio de Janeiro, RJ 20231050, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.10.005DOI Listing
December 2017

ETV6-RUNX1 Acute Lymphoblastic Leukaemia in Identical Twins.

Adv Exp Med Biol 2017 ;962:217-228

Centre for Evolution and Cancer, The Institute of Cancer Research, London, SM2 5NG, UK.

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http://dx.doi.org/10.1007/978-981-10-3233-2_14DOI Listing
September 2017

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

Stem Cell Reports 2016 10 22;7(4):602-618. Epub 2016 Sep 22.

Josep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Casanova 143, 08036 Barcelona, Spain; Department of Biomedicine, School of Medicine, University of Barcelona, 08036 Barcelona, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063541PMC
October 2016

Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate.

J Allergy Clin Immunol 2016 07 11;138(1):249-261.e12. Epub 2016 Jan 11.

Respiratory Pharmacology Group, Airway Disease Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929136PMC
July 2016

Hypertension: a problem of organ blood flow supply-demand mismatch.

Future Cardiol 2016 05 19;12(3):339-49. Epub 2016 Apr 19.

School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.2217/fca.16.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926521PMC
May 2016

PAX5 alterations in genetically unclassified childhood Precursor B-cell acute lymphoblastic leukaemia.

Br J Haematol 2015 Oct 26;171(2):263-272. Epub 2015 Jun 26.

Haematology Cellular and Molecular Diagnostic Service, Great Ormond Street Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.13543DOI Listing
October 2015

P2X3 receptors and sensitization of autonomic reflexes.

Auton Neurosci 2015 Sep 25;191:16-24. Epub 2015 Apr 25.

School of Physiology & Pharmacology, Bristol CardioVascular, University of Bristol, Bristol, BS8 1TD, UK.

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http://dx.doi.org/10.1016/j.autneu.2015.04.005DOI Listing
September 2015

Inhibition of urothelial P2X3 receptors prevents desensitization of purinergic detrusor contractions in the rat bladder.

BJU Int 2015 Aug 25;116(2):293-301. Epub 2015 Mar 25.

Houston Methodist Research Institute, Houston, TX, USA.

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http://dx.doi.org/10.1111/bju.13003DOI Listing
August 2015

P2X3 receptor antagonist in chronic cough--Authors' reply.

Lancet 2015 Jul;386(9990):244-5

Afferent Pharmaceuticals, San Mateo, CA, USA.

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http://dx.doi.org/10.1016/S0140-6736(15)61275-2DOI Listing
July 2015

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.

Lancet 2015 Mar 25;385(9974):1198-205. Epub 2014 Nov 25.

Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK. Electronic address:

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140673614
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http://linkinghub.elsevier.com/retrieve/pii/S014067361461255
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http://dx.doi.org/10.1016/S0140-6736(14)61255-1DOI Listing
March 2015

Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.

J Physiol 2015 Mar 20;593(5):1113-25. Epub 2015 Jan 20.

Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA; Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1113/jphysiol.2014.281014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358674PMC
March 2015

Concordant B-cell precursor acute lymphoblastic leukemia in non-twinned siblings.

Blood Cells Mol Dis 2015 Jan 20;54(1):110-5. Epub 2014 Aug 20.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1016/j.bcmd.2014.07.011DOI Listing
January 2015

Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers.

Acta Neuropathol Commun 2014 Jun 5;2:62. Epub 2014 Jun 5.

Bluestone Center for Clinical Research, New York University, 421 First Avenue, 233 W, New York, NY 10010, USA.

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http://dx.doi.org/10.1186/2051-5960-2-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229781PMC
June 2014

The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders.

Front Cell Neurosci 2013 Dec 19;7:267. Epub 2013 Dec 19.

Allergy and Clinical Immunology, Johns Hopkins University School of Medicine Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fncel.2013.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867694PMC
December 2013

Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors.

BJU Int 2012 Oct 30;110(8 Pt B):E409-14. Epub 2012 Apr 30.

Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11189.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537156PMC
October 2012

A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres.

J Physiol 2012 Aug 11;590(16):4109-20. Epub 2012 Jun 11.

Johns Hopkins University School of Medicine, The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle 1A62, Baltimore, MD21224, USA.

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http://dx.doi.org/10.1113/jphysiol.2012.233460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476651PMC
August 2012

P2X3 antagonists: novel therapeutics for afferent sensitization and chronic pain.

Authors:
Anthony P Ford

Pain Manag 2012 May;2(3):267-77

Afferent Pharmaceuticals, 2755 Campus Drive, Suite 100, San Mateo, CA 94403, USA.

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http://dx.doi.org/10.2217/pmt.12.16DOI Listing
May 2012

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.

Authors:
Anthony P Ford

Purinergic Signal 2012 Feb 18;8(Suppl 1):3-26. Epub 2011 Nov 18.

Afferent Pharmaceuticals, 2755 Campus Dr., Suite 100, San Mateo, CA, 94403, USA,

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http://dx.doi.org/10.1007/s11302-011-9271-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265711PMC
February 2012

ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor.

Blood 2011 Nov 7;118(18):4910-8. Epub 2011 Sep 7.

Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1182/blood-2011-05-354266DOI Listing
November 2011

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia.

Blood 2011 Jun 11;117(23):6247-54. Epub 2011 Apr 11.

Section of Haemato-Oncology, Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1182/blood-2010-10-314674DOI Listing
June 2011

ATP and P2X purinoceptors in urinary tract disorders.

Handb Exp Pharmacol 2011 (202):485-526

Afferent Pharmaceuticals, San Mateo, CA 94403, USA.

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http://link.springer.com/10.1007/978-3-642-16499-6_22
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http://dx.doi.org/10.1007/978-3-642-16499-6_22DOI Listing
May 2011

Fusion genes in cord blood.

Blood 2011 Jan;117(1):369-70; author reply 370-1

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http://dx.doi.org/10.1182/blood-2010-09-309351DOI Listing
January 2011

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats.

Brain 2010 Sep;133(9):2549-64

Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King’s College London, London, UK.

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http://dx.doi.org/10.1093/brain/awq194DOI Listing
September 2010

Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord.

J Neurosci 2010 Mar;30(12):4503-7

King's College London, Neurorestoration Group, Wolfson Centre for Age-Related Diseases, Wolfson Wing, Hodgkin Building, Guy's Campus, London SE1 1UL, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.6132-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882023PMC
March 2010

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.

Bioorg Med Chem Lett 2010 Feb 16;20(3):1031-6. Epub 2009 Dec 16.

Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.12.044DOI Listing
February 2010

Immunologically silent cancer clone transmission from mother to offspring.

Proc Natl Acad Sci U S A 2009 Oct 12;106(42):17882-5. Epub 2009 Oct 12.

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138519, Japan.

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http://dx.doi.org/10.1073/pnas.0904658106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764945PMC
October 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

J Clin Invest 2009 Apr 16;119(4):826-36. Epub 2009 Mar 16.

Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://www.jci.org/articles/view/36428
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http://dx.doi.org/10.1172/JCI36428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662549PMC
April 2009

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.

Bioorg Med Chem Lett 2009 Mar 7;19(6):1628-31. Epub 2009 Feb 7.

Department of Medicinal Chemistry, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.02.003DOI Listing
March 2009

The role of metabotropic glutamate receptor mGlu5 in control of micturition and bladder nociception.

Neurosci Lett 2009 Jan 14;450(1):12-7. Epub 2008 Nov 14.

Department of Physiology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.

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http://dx.doi.org/10.1016/j.neulet.2008.11.026DOI Listing
January 2009

Expression and function of rat urothelial P2Y receptors.

Am J Physiol Renal Physiol 2008 Apr 23;294(4):F821-9. Epub 2008 Jan 23.

A1207 Scaife Hall, Dept. of Medicine, Univ. of Pittsburgh, 3550 Terrace St., Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1152/ajprenal.00321.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760272PMC
April 2008

The identification of (ETV6)/RUNX1-regulated genes in lymphopoiesis using histone deacetylase inhibitors in ETV6/RUNX1-positive lymphoid leukemic cells.

Clin Cancer Res 2007 Mar 26;13(6):1726-35. Epub 2007 Feb 26.

Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology/Oncology, 2nd Medical School, Charles University Prague, Prague, Czech Republic.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-2569DOI Listing
March 2007

Pharmacology of P2X channels.

Pflugers Arch 2006 Aug 29;452(5):513-37. Epub 2006 Apr 29.

Department of Biochemical Pharmacology, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1007/s00424-006-0070-9DOI Listing
August 2006

Therapeutic opportunities and targets in childhood leukemia.

Clin Transl Oncol 2006 Aug;8(8):560-5

Section of Haemato-Oncology, Institute of Cancer Research, Sutton, United Kingdom.

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http://dx.doi.org/10.1007/s12094-006-0061-5DOI Listing
August 2006

Purinoceptors as therapeutic targets for lower urinary tract dysfunction.

Br J Pharmacol 2006 Feb;147 Suppl 2:S132-43

Department of Biochemical Pharmacology, Roche Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1038/sj.bjp.0706637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751490PMC
February 2006

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.

Oncogene 2005 Nov;24(51):7579-91

Molecular Pathology Group, Heinrich-Pette-Institut für Experimentelle Immunologie und Virologie, D-20251 Hamburg, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208931DOI Listing
November 2005

Effect of neurokinins on canine prostate cell physiology.

Prostate 2005 Jun;63(4):358-68

Department of Urology, NYU School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1002/pros.20195DOI Listing
June 2005

Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red.

Br J Pharmacol 2005 Jun;145(3):313-22

University College London, Department of Physiology, Royal Free Campus, Rowland Hill Street, Hampstead, London NW3 2PF, UK.

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http://dx.doi.org/10.1038/sj.bjp.0706187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576146PMC
June 2005

Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification.

Bioorg Med Chem Lett 2005 Mar;15(6):1697-700

Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94303, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.01.039DOI Listing
March 2005

Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium.

J Physiol 2005 Feb 2;562(Pt 3):859-71. Epub 2004 Dec 2.

A1207 Scaife Hall, Department of Medicine-Renal Division, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1113/jphysiol.2004.071159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665539PMC
February 2005

MLL translocations with concurrent 3' deletions: interpretation of FISH results.

Genes Chromosomes Cancer 2004 Nov;41(3):266-71

Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, United Kingdom.

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http://dx.doi.org/10.1002/gcc.20082DOI Listing
November 2004

Pharmacological and functional characterization of bradykinin B2 receptor in human prostate.

Eur J Pharmacol 2004 Nov;504(3):155-67

Roche Pharmaceuticals, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.ejphar.2004.10.004DOI Listing
November 2004

TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia.

Clin Cancer Res 2004 Aug;10(16):5355-60

Leukemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0584DOI Listing
August 2004

Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies.

Neuropharmacology 2004 Jun;46(7):1039-48

Autonomic Neuroscience Institute, Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.

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http://dx.doi.org/10.1016/j.neuropharm.2004.01.009DOI Listing
June 2004

Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia.

J Neurosci 2003 Dec;23(36):11315-21

Autonomic Neuroscience Institute and Department of Physiology, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740514PMC
December 2003

Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets.

Leuk Lymphoma 2003 Dec;44(12):2099-102

CLIP--Childhood Leukaemia Investigation, Prague, Czech Republic.

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http://dx.doi.org/10.1080/1042819031000123393DOI Listing
December 2003

P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine.

J Physiol 2003 Nov 22;552(Pt 3):809-21. Epub 2003 Aug 22.

Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1113/jphysiol.2003.047944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343442PMC
November 2003

Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp.

J Orofac Pain 2003 ;17(3):245-50

Department of Oral and Maxillofacial Surgery, Guy's Tower, Guy's Hospital, London, United Kingdom.

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November 2003

Leukemia in twins: lessons in natural history.

Blood 2003 Oct 5;102(7):2321-33. Epub 2003 Jun 5.

Leukemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, London SW3 6JB, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-12-38
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http://dx.doi.org/10.1182/blood-2002-12-3817DOI Listing
October 2003

Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit.

J Physiol 2003 Aug 17;551(Pt 1):309-22. Epub 2003 Jun 17.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1113/jphysiol.2003.044172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343160PMC
August 2003

Expression profile of wild-type ETV6 in childhood acute leukaemia.

Br J Haematol 2003 Jul;122(1):94-8

Children's Cancer Group, and Medical Oncology Unit, Cancer Research UK, St Bartholomew's and The London, Queen Mary School of Medicine and Dentistry, London, UK.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04399.xDOI Listing
July 2003

Chromosome translocations and covert leukemic clones are generated during normal fetal development.

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8242-7. Epub 2002 Jun 4.

Leukaemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK.

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http://dx.doi.org/10.1073/pnas.112218799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123052PMC
June 2002

P2X receptors and their role in female idiopathic detrusor instability.

J Urol 2002 Jan;167(1):157-64

Department of Gynaecology, Autonomic Neuroscience Institute, Guy's, Kings and St. Thomas' Medical School, Kings College London, London, UK.

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January 2002