Anthony D Whetton

Anthony D Whetton

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Anthony D Whetton

Publications by authors named "Anthony D Whetton"

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Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel.

Br J Cancer 2019 Sep 7;121(6):483-489. Epub 2019 Aug 7.

School of Biological Sciences, Queens University Belfast, Chlorine Gardens, Belfast, BT9 5DL, UK.

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http://dx.doi.org/10.1038/s41416-019-0544-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738042PMC
September 2019

Identification of a Biomarker Panel for Early Detection of Lung Cancer Patients.

J Proteome Res 2019 Sep 21;18(9):3369-3382. Epub 2019 Aug 21.

Stoller Biomarker Discovery Centre, Institute of Cancer Sciences, Faculty of Medical and Human Sciences , University of Manchester , Manchester M13 9PL , United Kingdom.

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https://pubs.acs.org/doi/10.1021/acs.jproteome.9b00287
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http://dx.doi.org/10.1021/acs.jproteome.9b00287DOI Listing
September 2019

Oncogenic MYC amplifies mitotic perturbations.

Open Biol 2019 Aug 28;9(8):190136. Epub 2019 Aug 28.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Cancer Research Centre, 555 Wilmslow Road, Manchester M20 4GJ, UK.

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http://dx.doi.org/10.1098/rsob.190136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731591PMC
August 2019

Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease.

J Cardiothorac Surg 2018 Jun 22;13(1):76. Epub 2018 Jun 22.

Stoller Biomarker Discovery Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13019-018-0762-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013884PMC
June 2018

-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.

Blood 2018 04 5;131(14):1532-1544. Epub 2018 Feb 5.

Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1182/blood-2017-05-783845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027092PMC
April 2018

A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours.

Br J Cancer 2017 Aug 29;117(5):666-674. Epub 2017 Jun 29.

Stoller Biomarker Discovery Centre and Pathology Node, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/bjc.2017.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572165PMC
August 2017

Novel risk models for early detection and screening of ovarian cancer.

Oncotarget 2017 Jan;8(1):785-797

Stoller Biomarker Discovery Centre and Pathology Node, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.13648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352196PMC
January 2017

Protein Z: A putative novel biomarker for early detection of ovarian cancer.

Int J Cancer 2016 Jun 19;138(12):2984-92. Epub 2016 Feb 19.

Stoller Biomarker Discovery Centre and Pathology Node, Institute of Cancer Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.30020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840324PMC
June 2016

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

Nature 2016 06 8;534(7607):341-6. Epub 2016 Jun 8.

Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK.

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http://dx.doi.org/10.1038/nature18288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913876PMC
June 2016

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production.

Sci Rep 2016 05 26;6:26419. Epub 2016 May 26.

Faculty of Medical and Human Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, UK, M13 9PT.

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http://dx.doi.org/10.1038/srep26419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881047PMC
May 2016

ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

BMJ Open Respir Res 2016 17;3(1):e000114. Epub 2016 Feb 17.

Stem Cell and Leukaemia Proteomics Laboratory , University of Manchester, Manchester Academic Health Science Centre , Manchester , UK.

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http://dx.doi.org/10.1136/bmjresp-2015-000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762086PMC
February 2016

Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value.

EBioMedicine 2015 Aug 19;2(8):841-50. Epub 2015 Jun 19.

Stoller Biomarker Discovery Centre, Manchester Academic Health Science Centre, The University of Manchester, Wolfson Molecular Imaging Centre, Manchester M20 3LJ, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563120PMC
August 2015

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood.

Oncotarget 2015 May;6(13):10924-39

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484429PMC
http://dx.doi.org/10.18632/oncotarget.3454DOI Listing
May 2015

Molecular histology of lung cancer: from targets to treatments.

Cancer Treat Rev 2015 Apr 20;41(4):361-75. Epub 2015 Feb 20.

Faculty Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, Manchester M20 3LJ, UK.

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http://dx.doi.org/10.1016/j.ctrv.2015.02.008DOI Listing
April 2015

Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells.

Stem Cell Reports 2015 Mar 13;4(3):473-88. Epub 2015 Feb 13.

Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375938PMC
March 2015

BCR-ABL affects STAT5A and STAT5B differentially.

PLoS One 2014 16;9(5):e97243. Epub 2014 May 16.

Hannover Medical School, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097243PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023949PMC
January 2015

Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

Nat Protoc 2015 Jan 18;10(1):149-68. Epub 2014 Dec 18.

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://www.nature.com/articles/nprot.2015.007
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http://dx.doi.org/10.1038/nprot.2015.007DOI Listing
January 2015

THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).

Nucleic Acids Res 2014 Oct 1;42(19):12249-60. Epub 2014 Oct 1.

Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, D-30623 Hannover, Germany

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http://dx.doi.org/10.1093/nar/gku911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231767PMC
October 2014

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

Stem Cells 2014 Sep;32(9):2324-37

Paul O'Gorman Leukaemia Research Centre, College of Medical, Veterinary & Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1002/stem.1748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282530PMC
September 2014

The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets.

Cancer Treat Rev 2014 May 15;40(4):558-66. Epub 2013 Oct 15.

Faculty Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, Manchester M20 3LJ, UK.

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http://dx.doi.org/10.1016/j.ctrv.2013.10.001DOI Listing
May 2014

A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

Bioinformatics 2014 Feb 15;30(4):549-58. Epub 2013 Dec 15.

Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, University of Manchester, Manchester M20 4BX, UK, Stem Cell and Leukaemia Proteomics Laboratory, Institute of Cancer Sciences, Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, University of Manchester, Manchester M20 3LJ, UK and Centre for Biostatistics, Institute of Population Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1093/bioinformatics/btt722DOI Listing
February 2014

A label-free selected reaction monitoring workflow identifies a subset of pregnancy specific glycoproteins as potential predictive markers of early-onset pre-eclampsia.

Mol Cell Proteomics 2013 Nov 29;12(11):3148-59. Epub 2013 Jul 29.

Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom;

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http://dx.doi.org/10.1074/mcp.M112.026872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820930PMC
November 2013

A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

Mol Cell Proteomics 2013 Nov 1;12(11):3319-29. Epub 2013 Sep 1.

Stem Cell and Leukaemia Proteomics Laboratory, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, University of Manchester, 27 Palatine Rd, Manchester, M20 4QL;

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http://dx.doi.org/10.1074/mcp.M112.024604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820942PMC
November 2013

Application of the MIDAS approach for analysis of lysine acetylation sites.

Methods Mol Biol 2013 ;981:25-36

Department of Chemical and Biological Engineering, ChELSI Institute, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1007/978-1-62703-305-3_3DOI Listing
July 2013

The application of quantification techniques in proteomics for biomedical research.

Mass Spectrom Rev 2013 Jan-Feb;32(1):1-26. Epub 2012 Jul 30.

Proteomic Unit, CIC bioGUNE, CIBERehd, ProteoRed, Derio, Spain.

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http://dx.doi.org/10.1002/mas.21347DOI Listing
May 2013

BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

J Proteomics 2012 Dec 15;77:14-26. Epub 2012 Jun 15.

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health, Science Centre, The University of Manchester, Wolfson Molecular Imaging, Centre, 27 Palatine Road, Withington, Manchester, M20 3LJ, UK.

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http://dx.doi.org/10.1016/j.jprot.2012.06.003DOI Listing
December 2012

Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma.

Fam Cancer 2012 Dec;11(4):661-5

Department of Clinical Genetics and Human Genetics, University Medical Centre, Free University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10689-012-9553-3DOI Listing
December 2012

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.

Anal Chem 2012 Nov 29;84(22):9848-57. Epub 2012 Oct 29.

School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.

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http://pubs.acs.org/doi/10.1021/ac302227c
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http://dx.doi.org/10.1021/ac302227cDOI Listing
November 2012

The use of proteomics for systematic analysis of normal and transformed hematopoietic stem cells.

Curr Pharm Des 2012 ;18(13):1730-50

Stem Cell and Leukaemia Proteomics Laboratory, University of Manchester, Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, Manchester, UK.

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http://dx.doi.org/10.2174/138161212799859675DOI Listing
July 2012

An assessment of peptide enrichment methods employing mTRAQ quantification approaches.

Anal Chem 2012 Jul 19;84(13):5604-10. Epub 2012 Jun 19.

School of Cancer & Enabling Sciences, Wolfson Molecular Imaging Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1021/ac300584yDOI Listing
July 2012

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

J Proteome Res 2012 Apr 12;11(4):2103-13. Epub 2012 Mar 12.

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://pubs.acs.org/doi/10.1021/pr200636x
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http://dx.doi.org/10.1021/pr200636xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320746PMC
April 2012

The requirement for proteomics to unravel stem cell regulatory mechanisms.

J Cell Physiol 2011 Oct;226(10):2478-83

Stem Cell and Leukaemia Proteomics Laboratory, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, The University of Manchester, Christie's NHS Foundation Trust, Wolfson Molecular Imaging Centre, Withington, Manchester, UK.

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http://dx.doi.org/10.1002/jcp.22610DOI Listing
October 2011

Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

Proteomics 2010 Sep;10(18):3321-42

Stem Cell and Leukaemia Proteomics Laboratory, School of Cancer, Enabling Sciences, Manchester Academic Health Science Centre, The University of Manchester, Wolfson Molecular Imaging Centre, Withington, Manchester, UK.

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http://dx.doi.org/10.1002/pmic.201000176DOI Listing
September 2010

Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC-MS/MS.

Nat Protoc 2010 Sep 26;5(9):1574-82. Epub 2010 Aug 26.

Stem Cell & Leukaemia Proteomics Laboratory, School of Cancer and Enabling Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, Manchester, UK.

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http://www.nature.com/articles/nprot.2010.123
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http://dx.doi.org/10.1038/nprot.2010.123DOI Listing
September 2010

Development of approaches for systematic analysis of protein networks in stem cells.

Adv Enzyme Regul 2010 13;50(1):273-84. Epub 2009 Nov 13.

School of Cancer and Imaging Sciences, Manchester Academic Health Science Centre, The University of Manchester, Wolfson Molecular Imaging Centre, 27 Palatine Road, Withington, Manchester M20 3LJ, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00652571090008
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http://dx.doi.org/10.1016/j.advenzreg.2009.10.028DOI Listing
August 2010

A gel-free quantitative proteomics analysis of factors released from hypoxic-conditioned placentae.

Reprod Sci 2010 Mar 11;17(3):247-57. Epub 2009 Nov 11.

Maternal and Fetal Health Research Group, St Mary's Hospital, Manchester, UK.

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http://dx.doi.org/10.1177/1933719109351320DOI Listing
March 2010

Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.

Br J Haematol 2010 Feb 23;148(4):534-43. Epub 2009 Nov 23.

School of Cancer & Imaging Sciences, Faculty of Medical & Human Sciences, The University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07979.xDOI Listing
February 2010

A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS).

Nat Protoc 2009 14;4(6):870-7. Epub 2009 May 14.

Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/nprot.2009.57DOI Listing
September 2009

Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.

J Biol Chem 2009 Sep 1;284(36):24115-22. Epub 2009 Jul 1.

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.030361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782005PMC
September 2009

Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 May 18;877(13):1240-9. Epub 2008 Nov 18.

Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, United Kingdom.

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http://dx.doi.org/10.1016/j.jchromb.2008.11.023DOI Listing
May 2009

THOC5 couples M-CSF receptor signaling to transcription factor expression.

Cell Signal 2009 Feb 5;21(2):309-16. Epub 2008 Nov 5.

Stem Cell and Leukaemia Proteomics laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Wilmslow Road, Manchester M20 9BX, UK.

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http://dx.doi.org/10.1016/j.cellsig.2008.10.018DOI Listing
February 2009

Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

Mol Cell Proteomics 2008 May 21;7(5):853-63. Epub 2007 Oct 21.

Stem Cell and Leukaemia Proteomics Laboratory, University of Manchester, Christie Hospital, Kinnaird House, Kinnaird Road, Manchester M204QL, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M700251-MCP200DOI Listing
May 2008

THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.

Br J Haematol 2008 May 27;141(5):641-50. Epub 2008 Mar 27.

Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07090.xDOI Listing
May 2008

Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.

Mol Cell Proteomics 2008 Mar 27;7(3):459-72. Epub 2007 Nov 27.

Stem Cell and Leukemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Kinnaird House, Kinnaird Road, Manchester M20 4QL, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M700370-MCP200DOI Listing
March 2008

Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting.

Mol Cell Proteomics 2008 Mar 14;7(3):573-81. Epub 2007 Dec 14.

Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Kinnaird House, Kinnaird Road, Manchester M20 4QL, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M700292-MCP200DOI Listing
March 2008

The time is right: proteome biology of stem cells.

Cell Stem Cell 2008 Mar;2(3):215-7

Stem Cell and Leukemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Manchester M20 9BX, UK.

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March 2008

Proteome biology of stem cells: a new joint HUPO and ISSCR initiative.

Mol Cell Proteomics 2008 Jan;7(1):204-5

Department of Biomolecular Mass Spectrometry, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.

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http://dx.doi.org/10.1074/mcp.H800001-MCP200DOI Listing
January 2008

Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis.

Proteomics 2008 Jan;8(2):279-88

Human Nutrition Unit, Division of Clinical Sciences North, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK.

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http://dx.doi.org/10.1002/pmic.200700404DOI Listing
January 2008

Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells.

Protein Sci 2007 Dec 26;16(12):2711-5. Epub 2007 Oct 26.

Cancer Research UK, Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom.

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http://doi.wiley.com/10.1110/ps.072874607
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http://dx.doi.org/10.1110/ps.072874607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222818PMC
December 2007

How will haematologists use proteomics?

Blood Rev 2007 Nov 24;21(6):315-26. Epub 2007 Sep 24.

Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Kinnaird House, Kinnaird Road, Withington, Manchester, UK M20 4QL.

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http://dx.doi.org/10.1016/j.blre.2007.07.002DOI Listing
November 2007

Guanidination chemistry for qualitative and quantitative proteomics.

Rapid Commun Mass Spectrom 2006 ;20(21):3245-56

Michael Barber Centre for Mass Spectrometry and Manchester Interdisciplinary Biocentre, University of Manchester, Manchester M1 7ND, UK.

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http://dx.doi.org/10.1002/rcm.2691DOI Listing
August 2007

The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.

J Am Soc Mass Spectrom 2007 Aug 6;18(8):1423-8. Epub 2007 May 6.

Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Studies, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jasms.2007.04.021DOI Listing
August 2007

The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia.

Mol Biotechnol 2007 Jun;36(2):81-9

Division of Cancer Studies, Faculty of Medical and Human Sciences, Christie Hospital, University of Manchester, Wilmslow Road, Manchester M20 9BX, UK.

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June 2007

A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.

Blood 2006 Sep 2;108(5):1716-23. Epub 2006 May 2.

Department of Haematology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, University Floor, Tower Block, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-04-01
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http://dx.doi.org/10.1182/blood-2006-04-016113DOI Listing
September 2006

Relative quantification in proteomics: new approaches for biochemistry.

Trends Biochem Sci 2006 Aug 11;31(8):473-84. Epub 2006 Jul 11.

Stem Cell and Leukaemia Proteomics Laboratory, University of Manchester, Kinnaird House, Kinnaird Road, Withington, Manchester, M20 4QL, UK.

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http://dx.doi.org/10.1016/j.tibs.2006.06.003DOI Listing
August 2006

The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.

J Cell Sci 2006 Aug 4;119(Pt 15):3039-46. Epub 2006 Jul 4.

John Hughes Bennett Laboratory, Edinburgh Cancer Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1242/jcs.03038DOI Listing
August 2006

Systematic proteome and transcriptome analysis of stem cell populations.

Cell Cycle 2006 Aug 1;5(15):1587-91. Epub 2006 Aug 1.

Stem Cell and Leukaemia Proteomics Laboratory, University of Manchester, Kinnaird House, Manchester, UK.

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http://dx.doi.org/10.4161/cc.5.15.3101DOI Listing
August 2006

Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

Blood 2006 Jun 28;107(12):4687-94. Epub 2006 Feb 28.

Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Manchester M20 4QL, UK.

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http://dx.doi.org/10.1182/blood-2005-12-4995DOI Listing
June 2006

Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity.

Mol Cell Proteomics 2005 Aug 27;4(8):1134-44. Epub 2005 May 27.

Faculty of Medical and Human Sciences, University of Manchester, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M500113-MCP200DOI Listing
August 2005

Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

Mol Cell Proteomics 2005 Jul 22;4(7):924-35. Epub 2005 Apr 22.

Department of Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Withington, Manchester, M20 9BX, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M400193-MCP200DOI Listing
July 2005

Stem cells bank on ATM machine.

Nat Med 2004 Nov;10(11):1166-8

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http://dx.doi.org/10.1038/nm1104-1166DOI Listing
November 2004

The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.

Oncogene 2004 Aug;23(39):6581-9

Institut für Biochemie, OE 4310, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany.

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http://dx.doi.org/10.1038/sj.onc.1207841DOI Listing
August 2004

Proteomics techniques and their application to hematology.

Blood 2004 May 15;103(10):3624-34. Epub 2004 Jan 15.

Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2003-09-3295DOI Listing
May 2004

Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

Cell Signal 2004 Feb;16(2):145-56

Biological Sciences, IENS, Lancaster University, Lancaster LA1 4YQ, UK.

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http://dx.doi.org/10.1016/s0898-6568(03)00101-3DOI Listing
February 2004

Proteomic analysis of chronic lymphocytic leukemia subtypes with mutated or unmutated Ig V(H) genes.

Mol Cell Proteomics 2003 Dec 13;2(12):1331-41. Epub 2003 Oct 13.

Leukaemia Research Fund Proteomics Facility, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M300055-MCP200DOI Listing
December 2003

The potential for proteomic definition of stem cell populations.

Exp Hematol 2003 Dec;31(12):1147-59

Leukaemia Research Fund Proteomics Facility, Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, United Kingdom.

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December 2003

Molecular pathogenesis of chronic myeloid leukaemia.

Expert Rev Mol Med 2003 Nov 25;5(27):1-27. Epub 2003 Nov 25.

Leukaemia Research Fund Unit, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Sackville St, Manchester, M60 1QD, UK.

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http://dx.doi.org/10.1017/S1462399403006835DOI Listing
November 2003