Publications by authors named "Antónia Furtado"

23 Publications

  • Page 1 of 1

Necrotizing infundibulo-hypophysitis: case-report and literature review.

Br J Neurosurg 2021 Jun 21:1-4. Epub 2021 Jun 21.

Department of Neurosurgery, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Purpose: We describe a rare case of histopathologic-proven necrotizing infundibulo-hypophysitis (NIH).

Clinical History: A 40-year-old female presented with coexistence of central diabetes insipidus and hypopituitarism. Imaging disclosed a thickened infundibulum and a diffusely enlarged pituitary mass with gadolinium rim enhancement pattern. Microsurgical endonasal transsphenoidal resection was performed. The presence of extensive liquefactive necrosis, surrounded by lymphoplasmocytic inflammatory infiltrate, allowed for the diagnosis of NIH. Follow-up cranial imaging 10 months after surgery showed no evidence of reappearance of the lesion. There was no progression to panhypopituitarism.

Conclusion: Surgery and histopathological confirmation are the key diagnostic feature in NIH. The current case is the fifth report of NIH and the first one with an indolent course and without progression to panhypopituitarism so far.
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http://dx.doi.org/10.1080/02688697.2021.1940857DOI Listing
June 2021

Gastrointestinal and renal involvement in systemic vasculitis.

Rev Esp Enferm Dig 2020 Dec;112(12):952-953

Gastroenterology, Centro Hospitalar Vila Nova de Gaia e Espinho, Portugal.

Vasculitis can also present with GI or solid organ involvement. IgA and ANCA associated vasculitis are more likely to have GI involvement. A 56-year-old female was admitted to the ER due to nausea, vomiting, epigastric pain and fever. The patient had a medical history of acromegaly and chronic kidney disease of an undetermined etiology, elevated C-reactive protein and renal dysfunction. Abdominal-CT revealed duodenal parietal thickening and pancreatic head edema. On esophagogastroduodenoscopy (EGD), duodenal mucosa had a diffusely nodular aspect with ulcerated areas. The following differential diagnosis were made, infectious enteritis, Whipple disease, infiltrative disorder and GI vasculitis. After discussion between a multidisciplinary team of Gastroenterology and Nephrology, they decided to initiate oral glucocorticoids due to worsening of the renal function, which lead to the resolution of digestive symptoms and renal function stabilization. Myeloperoxidase antineutrophilic-cytoplasmic antibodies (MPO-ANCA) were subsequently positive and histology confirmed duodenal involvement by vasculitis. The patient was asymptomatic after 4-weeks, with endoscopic healing and renal function stabilization. GI involvement limited to the duodenum in the setting of ANCA-MPO vasculitis is a rare condition. Moreover, histopathologic confirmation of vasculitis in endoscopic biopsy samples is exceptional.
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http://dx.doi.org/10.17235/reed.2020.6965/2020DOI Listing
December 2020

Adult-Onset Still's Disease in a Patient With a Previous Diagnosis of Acute Sarcoidosis: A Rare Association.

J Clin Rheumatol 2020 Jun 9. Epub 2020 Jun 9.

From the *Department of Rheumatology, Centro Hospitalar e Universitário de São João, Porto Departments of †Rheumatology ‡Pathology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Espinho §Department of Rheumatology, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

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http://dx.doi.org/10.1097/RHU.0000000000001404DOI Listing
June 2020

Adult vulvar Langerhans cell histiocytosis: a rare presentation.

Int J Dermatol 2020 Feb 11;59(2):e40-e41. Epub 2019 Oct 11.

Dermatology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova De Gaia, Portugal.

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http://dx.doi.org/10.1111/ijd.14679DOI Listing
February 2020

Bullous Pemphigoid-like Skin Eruption during Treatment with Rivaroxaban: A Clinical Case Study.

Eur J Case Rep Intern Med 2018 21;5(3):000724. Epub 2018 Mar 21.

Serviço de Anatomia Patológica, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Little has been documented about hypersensitivity reactions caused by treatment with rivaroxaban. This paper reports a bullous pemphigoid-like skin eruption that occurred in a 76-year-old female patient during rivaroxaban treatment. This case highlights the vigilance required by healthcare workers in recognising potential adverse effects of newly marketed drugs and in making medication changes when necessary. A bullous pemphigoid-like eruption due to treatment with rivaroxaban has not, to the best of the Authors' knowledge, been reported previously in the literature.

Learning Points: Rivaroxaban can cause a bullous eruption apparently similar to epithelial toxic necrolysis (or to Stevens-Johnson syndrome).There is an apparent similarity between skin adverse events caused by the different anticoagulants.The anticoagulant responsible for the skin side-effects can be identified on clinical grounds by the correct differential diagnosis.
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http://dx.doi.org/10.12890/2018_000724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346955PMC
March 2018

Neutrophilic eccrine hidradenitis in a patient with FOLFOX chemotherapy.

Acta Dermatovenerol Alp Pannonica Adriat 2018 12;27(4):207-209

Dermatology Department, Vila Nova de Gaia Central Hospital, Vila Nova de Gaia, Portugal.

This case study describes a 37-year-old Caucasian male with pruritic papules and plaques-some with central erosion-on the arms, neck, and trunk that appeared after chemotherapy with FOLFOX (folinic acid, fluorouacil, and oxiliplatin) for colon cancer. A histological examination showed features of neutrophilic eccrine hidradenitis. To the best of our knowledge, this is the first reported case of neutrophilic eccrine hidradenitis due to FOLFOX.
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December 2018

Colon-Limited Leukocytoclastic Vasculitis.

Am J Gastroenterol 2018 08;113(8):1114

Department of Gastroenterology, Centro Hospitalar Vila Nova de Gaia Espinho, Vila Nova Gaia, Portugal. Department of Pathology, Centro Hospitalar Vila Nova de Gaia Espinho, Vila Nova Gaia, Portugal.

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http://dx.doi.org/10.1038/s41395-018-0081-0DOI Listing
August 2018

Posterior fossa metastasis of lung carcinoid tumor: case report.

Br J Neurosurg 2021 Jun 2;35(3):364-366. Epub 2018 Apr 2.

Serviço de Neurocirurgia, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Portugal.

Carcinoid tumors are generally indolent neoplasms. Brain metastases are rare and when present, yield a poor prognosis. We present the case of a 76-year old female surgically treated for an atypical bronchial carcinoid, staged as T2aN0M0G2. Without further adjuvant treatment she remained stable for four years, when she presented with headaches and gait imbalance. Brain MRI revealed a midline, intra-axial infratentorial lesion that was completely removal, of which histolology confirmed a carcinoid metastasis. At 14 months of follow-up, the patient showed no signs of systemic disease or brain recurrence, and thus no adjuvant radiotherapy was prescribed.
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http://dx.doi.org/10.1080/02688697.2018.1457774DOI Listing
June 2021

A case of a mixed adenoneuroendocrine tumor of the colon.

Rev Esp Enferm Dig 2017 Sep;109(9):673

Anatomic Pathology, Centro Hospitalar de Gaia/Espinho.

Neuroendocrine cells often coexist with exocrine neoplasms of the gut and each component is normally present in a variable range. Despite this frequent association, mixed exocrine-neuroendocrine carcinomas are rare. This entity is known as adenoneuroendocrine carcinoma (MANEC) and each of its malignant components represents at least 30%. In contrast, there are only a few reports of another rare association of an adenoma and a well differentiated neuroendocrine tumor (NET) in the colon and rectum. The term mixed adenoneuroendocrine tumor (MANET) was suggested due to its indolent behavior and distinct morphological characteristics with mild to moderate nuclear atypia and low number of mitoses1. However, it is not included in the recent World Health Organization (WHO) classification of tumors of the digestive system.
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http://dx.doi.org/10.17235/reed.2017.5008/2017DOI Listing
September 2017

Cytomegalovirus duodenitis in immunocompetent patients: what else should we look for?

BMJ Case Rep 2017 Jun 13;2017. Epub 2017 Jun 13.

Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.

Cytomegalovirus (CMV) infection is a well-recognised complication of immunodeficiency, although the burden of CMV disease in immunocompetent adults is still unknown. We present the case of a 54-year-old male patient admitted due to severe diarrhoea, epigastric pain and fever. Initial diagnostic workup revealed pericardial and pleural effusion, enlarged abdominal lymph nodes and mild elevation of liver enzymes. CMV serology was IgM positive, and upper endoscopy revealed proximal enteritis. Histology and immunohistochemistry of duodenal samples confirmed CMV disease. An extensive investigation of possible immunodeficiency was conducted with positron emission tomography (PET) scan revealing an abnormal hypermetabolic pulmonary nodule. The patient underwent a right superior lobectomy which, on analysis, confirmed an atypical bronchopulmonary carcinoid tumour. We report this case to reinforce the importance of considering CMV infection as a differential diagnosis in apparent immunocompetent patients and to emphasise the importance of looking for any condition that may cause any degree of immune dysfunction.
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http://dx.doi.org/10.1136/bcr-2017-219679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534848PMC
June 2017

Esophagitis dissecans superficialis associated with severe clindamycin toxicity.

J Gastrointestin Liver Dis 2014 Dec;23(4):363

Department of Gastroenterology, Centro Hospitalar Vila Nova de Gaia, Espinho, Portugal.

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http://dx.doi.org/10.15403/jgld.2014.1121.234.edasDOI Listing
December 2014

Giant left middle fossa VII nerve schwannoma associated with amnesia.

Neurology 2013 Aug;81(6):602

Department of Neuroradiology, C. Hospitalar Vila Nova Gaia/Espinho and Faculty of Medicine of Porto University, Portugal.

The facial nerve is the third most frequent location of intracranial schwannomas, with facial paresis the most common sign.(1,2) A 77-year-old woman presented with amnesia; the Mini-Mental State Examination score was 26, with normal cranial nerve function. A giant multicystic VII nerve schwannoma was identified in the left middle fossa, with components of the tumor in the temporal bone facial canal, geniculate ganglion, and internal auditory canal (figure). Compression of the hippocampus may have accounted for the clinical presentation. The middle fossa component of the tumor was resected for mass effect relief, with iatrogenic facial palsy.
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http://dx.doi.org/10.1212/WNL.0b013e31829e6eecDOI Listing
August 2013

An infant with a tumor on the maxillary gingiva.

Pediatr Dermatol 2011 Sep-Oct;28(5):577, 578

Department of Pediatrics Pediatric, Centro Hospitalar Vila Nova de Gaia/Espinho, Santa Maria da Feira, Portugal.

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http://dx.doi.org/10.1111/j.1525-1470.2011.1581.xDOI Listing
February 2012

Granuloma faciale of the scalp.

Dermatol Online J 2011 Apr 15;17(4). Epub 2011 Apr 15.

Centro Hospitalar Vila Nova de Gaia.

Granuloma faciale (GF) is an uncommon dermatosis with characteristic clinicopathological features. Extrafacial isolated GF is extremely rare. Pulsed dye laser (PDL) is a treatment option for GF to minimize the risk of scarring. We report a case of a 78-year-old male with an extensive GF of the scalp successfully treated with pulsed dye laser (PDL).
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April 2011

Ovarian ependymomas of extra-axial type or central immunophenotypes.

Hum Pathol 2011 Mar 30;42(3):403-8. Epub 2010 Dec 30.

Department of Pathology of Universities of Targu Mures, Targu Mures, Romania.

We report the differential clinicopathologic and immunophenotypical features of 2 pure ovarian ependymomas of extra-axial type with a predominant microcystic, anaplastic pattern occurring in patients aged 22 and 32 years and a unique myxopapillary pigmented ependymoma that originated within an ovarian mature cystic teratoma in a 35-year-old woman. The latter had a central nervous system phenotype different from that previously reported in ovarian ependymomas of extra-axial types, being negative for estrogen and progesterone receptors, epithelial membrane antigen and cytokeratin 34βE12, cell adhesion molecule 5.2, and cytokeratin 7. Furthermore, its benign behavior contrasted with the aggressive course of the other 2 ependymomas of extra-axial types, in which peritoneal invasion was present at the time of diagnosis. These findings illustrate that both central and extra-axial types of ependymoma show phenotypic variations that may point to either a derivation from different precursors or differentiation along diverse pathways. Thus, whereas ependymomas of extra-axial types would represent neometaplastic phenomena, those originated from the nervous tissue of teratomas resemble central nervous system ependymomas. Moreover, the dissimilarities between central and peripheral types of ependymoma would parallel the phenotypic differences present in primitive neural tumors of the female genital tract.
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http://dx.doi.org/10.1016/j.humpath.2010.07.017DOI Listing
March 2011

Eruptive keloids: spontaneous reactivation after 60 years.

Dermatol Online J 2009 Apr 15;15(4). Epub 2009 Apr 15.

Serviço de Dermatologia e Venereologia do CHVNG.

An 84-year-old man with keloids since early adulthood, was referred to our clinic because of the recent appearance of erythematous, tumid plaques upon the old keloids and upon uninvolved skin. The plaques were located mainly on the trunk in a linear distribution. On the back there were round, nodular, erythematous nodules and plaques, with central crusts, that had just appeared on normal skin. A skin biopsy was performed on the plaques that appeared over the older lesions. The histological appearance was consistent with keloid. Similar histology was found in a biopsy taken from a plaque that had erupted on normal skin.
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April 2009

Chromoblastomycosis associated with Fonsecaea pedrosoi in a carpenter handling exotic woods.

Dermatol Online J 2008 Feb 28;14(2). Epub 2008 Feb 28.

Serviço de Dermatologia do Centro Hospitalar V.N. de Gaia (CHVNG), Portugal.

Chromoblastomycosis is a rare, hard to diagnose disease that arises mostly in the tropics, especially in humid areas, affecting mainly males and rural workers. It is characterized by verrucous plaques or nodules that are slow growing and attributed to infection by different pigmented (dematiaceous) fungi. Usually the infection develops after injury, being primarily located on the lower extremities. The authors present the case of a healthy, 60-year-old man observed with a one year history of an erythematous violaceous 5cm tumor located on the right thigh. A biopsy specimen for histopathology revealed single or clustered brown pigmented cells, with a single or double septum and thick cell walls. Cultural smears showed growth of Fonsecaea Pedrosoi. The patient was treated with oral itraconazole (200mg per day), with a good response and clinical cure in 6 months that left only an atrophic scar.
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February 2008

Papillary adenocarcinoma of the thymus: case report and review of the literature.

Int J Surg Pathol 2010 Dec 8;18(6):530-3. Epub 2008 Jul 8.

Anatomic Pathology Service, Vila Nova de Gaia-Espinho Medical Center, Portugal.

A 44-year-old male with a mediastinal mass measuring 3.5 × 3.5 × 3 cm was diagnosed with papillary adenocarcinoma of the thymus. Other origins of papillary adenocarcinoma were excluded by clinical, imaging, and immunocytochemical methods before assuming this diagnosis. Residual thymus was seen under the microscope. Focal CD5 immunoreactivity was present. There was no associated thymoma. The patient underwent surgery, radiotherapy, and chemotherapy. He disclosed systemic recurrence at 18 months (subcutaneous nodule). He is alive after 24 months of follow-up with active disease. There had been only 7 cases of this rare entity published before.
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http://dx.doi.org/10.1177/1066896908319776DOI Listing
December 2010

[Review of breast pathology: diagnosed by fine needle aspiration and correlation between cytological and histological findings].

Acta Med Port 2007 Nov-Dec;20(6):491-4. Epub 2008 Feb 13.

Serviço de Anatomia Patológica, Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia.

The 980 exams concerning breast pathology performed in an 18-month period, including 626 fine needle aspiration biopsies, were reviewed. A diagnosis was made in 78.2% of fine needle aspiration biopsies, and in the remaining 21.8% they were considered insufficient for diagnosis. It was possible to establish a correlation with histological findings in 109 cases. There was accordance in 87.2% of the cases, a discrepancy in 6.4% of the cases neither with false positives nor false negatives, and in the remaining cases fine needle aspiration biopsy was considered insufficient for diagnosis despite the presence of a lesion in histological sections. The advantages and pitfalls of fine needle aspiration are discussed, and we consider this technique important in the initial approach to patients with breast disorders.
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June 2008

[Pleomorphic carcinoma of the lung in a patient with Mounier-Kuhn syndrome].

Rev Port Pneumol 2006 Sep-Oct;12(5):621-8

Interna Complementar de Pneumologia, Centro Hospitalar de Vila Nova de Gaia, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia.

Pleomorphic carcinoma of the lung (PLC) is a rare malignant tumour presenting with a poor clinical outcome. It is included in the group of non-small cell lung carcinomas that contain sarcoma or sarcoma-like components (spindle cells/giant cells). Because of its rarity and diagnostic difficulties, the authors report a case of PLC in a 44 year-old patient, smoker, with the initial clinical presentation of a dorsal tumoural mass. As the time of diagnosis the tumour was in stage IV (TNM), the patient was treated only with supportive therapy and died five months later. During clinical evaluation, a Mounier-Kuhn Syndrome was confirmed. Clinical-imagiological aspects of this situation are reported as well as cytological and immunocytochemical features.
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http://dx.doi.org/10.1016/s0873-2159(15)30450-5DOI Listing
March 2007

Bronchopulmonary sequestration--a 12-year experience.

Rev Port Pneumol 2006 Sep-Oct;12(5):489-501

Interna Complementar de Pneumologia, Centro Hospitalar de Vila Nova de Gaia, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia.

Bronchopulmonary sequestration (BPS) is a rare malformation of the lower respiratory tract. It consists of a non-functioning mass of lung tissue that lacks normal communication with the tracheobronchial tree and that receives arterial blood supply from the systemic circulation. It is classified as intralobar (ILS) or extralobar (ELS) according to its location within or outside the normal lung. Most sequestrations are intralobar (75%) and occur predominantly in the left lower lobe.
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March 2007

[Endobronchial granular cell tumor - what approach to take].

Rev Port Pneumol 2006 Jul-Aug;12(4):463-70

Serviço de Pneumologia, Cetro Hospitalar de villa Nova de Gaia Rua Conceição Fernandes 4434-502 Vila Nova de Gaia.

Granular cell tumor is a mesenchymal neoplasm almost always benign, with tendency to recurrence. Although it is more frequent in in the head and neck it has been described in almost all areas of the body. Its occurrence in the lung is extremely rare. The authors describe two cases of endobronchial granular cell tumours, discuss the particularities of this pathology as well as the treatment options, with particular attention to the use of endobronchial excision and criotherapy.
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http://dx.doi.org/10.1016/s0873-2159(15)30447-5DOI Listing
December 2006
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