Publications by authors named "Ansgar Schuffenhauer"

38Publications

Discovery of Potent, Highly Selective, and Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

J Med Chem 2020 12 30;63(23):14576-14593. Epub 2020 Nov 30.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2020

Evolution of Novartis' Small Molecule Screening Deck Design.

J Med Chem 2020 12 3;63(23):14425-14447. Epub 2020 Nov 3.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2020

Systematic Chemogenetic Library Assembly.

Cell Chem Biol 2020 Sep 23;27(9):1124-1129. Epub 2020 Jul 23.

Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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September 2020

Gene-signature-derived ICs/ECs reflect the potency of causative upstream targets and downstream phenotypes.

Authors:

Steffen Renner Christian Bergsdorf Rochdi Bouhelal Magdalena Koziczak-Holbro Andrea Marco Amati Valerie Techer-Etienne Ludivine Flotte Nicole Reymann Karen Kapur Sebastian Hoersch Edward James Oakeley Ansgar Schuffenhauer Hanspeter Gubler Eugen Lounkine Pierre Farmer

Sci Rep 2020 06 15;10(1):9670. Epub 2020 Jun 15.

Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.

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June 2020

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

Authors:

Achim Schlapbach Laszlo Revesz Carole Pissot Soldermann Thomas Zoller Catherine H Régnier Frédéric Bornancin Thomas Radimerski Jutta Blank Ansgar Schuffenhauer Martin Renatus Paulus Erbel Samu Melkko Richard Heng Oliver Simic Ralf Endres Markus Wartmann Jean Quancard

Bioorg Med Chem Lett 2018 07 9;28(12):2153-2158. Epub 2018 May 9.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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July 2018

Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen.

Authors:

Xian Zhang Marjo Götte Yvonne Ibig-Rehm Ansgar Schuffenhauer Marion Kamke Dan Beisner Danilo Guerini Daniela Siebert Ghislain M C Bonamy Daniela Gabriel Ursula Bodendorf

SLAS Discov 2017 Oct 21;22(9):1106-1119. Epub 2017 Jul 21.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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October 2017

Dark chemical matter as a promising starting point for drug lead discovery.

Authors:

Anne Mai Wassermann Eugen Lounkine Dominic Hoepfner Gaelle Le Goff Frederick J King Christian Studer John M Peltier Melissa L Grippo Vivian Prindle Jianshi Tao Ansgar Schuffenhauer Iain M Wallace Shanni Chen Philipp Krastel Amanda Cobos-Correa Christian N Parker John W Davies Meir Glick

Nat Chem Biol 2015 Dec 19;11(12):958-66. Epub 2015 Oct 19.

Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA.

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December 2015

High-Throughput Screening Using iPSC-Derived Neuronal Progenitors to Identify Compounds Counteracting Epigenetic Gene Silencing in Fragile X Syndrome.

Authors:

Markus Kaufmann Ansgar Schuffenhauer Isabelle Fruh Jessica Klein Anke Thiemeyer Pierre Rigo Baltazar Gomez-Mancilla Valerie Heidinger-Millot Tewis Bouwmeester Ulrich Schopfer Matthias Mueller Barna D Fodor Amanda Cobos-Correa

J Biomol Screen 2015 Oct 29;20(9):1101-11. Epub 2015 May 29.

Center of Proteomic Chemistry, Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland

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October 2015

Glucocorticoid receptor ligands modulate Cardiovirus encephalomyocarditis virus internal ribosome entry site activity.

Authors:

Marie-Cecile Didiot Claudia Agarinis Thibault Varin Hua Wu Thomas Nelson Douglas W Selinger Frederick King Ansgar Schuffenhauer Christian N Parker

Assay Drug Dev Technol 2013 Jul 1;11(6):355-66. Epub 2013 Aug 1.

Novartis Institute for Biomedical Research, Basel, Switzerland.

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July 2013

Identification of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation.

Authors:

Marie-Cecile Didiot Jeffrey Hewett Thibault Varin Felix Freuler Douglas Selinger Hanspeter Nick Juergen Reinhardt Alan Buckler Vic Myer Ansgar Schuffenhauer Chantale T Guy Christian N Parker

J Biomol Screen 2013 Apr 13;18(4):407-19. Epub 2012 Nov 13.

Novartis Institutes for Biomedical Research, Basel, CH-4056 Switzerland.

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April 2013

Latent hit series hidden in high-throughput screening data.

Authors:

Thibault Varin Marie-Cecile Didiot Christian N Parker Ansgar Schuffenhauer

J Med Chem 2012 Feb 23;55(3):1161-70. Epub 2012 Jan 23.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.

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February 2012

Rule-Based Classification of Chemical Structures by Scaffold.

Authors:

Ansgar Schuffenhauer Thibault Varin

Mol Inform 2011 Aug 16;30(8):646-64. Epub 2011 Aug 16.

Novartis Institutes for BioMedical Research, CPC/LFP, WSJ-88.11.11, Postfach, Basel, Switzerland, CH-4002; phone:+41 61 32 45385.

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August 2011

Mining for bioactive scaffolds with scaffold networks: improved compound set enrichment from primary screening data.

Authors:

Thibault Varin Ansgar Schuffenhauer Peter Ertl Steffen Renner

J Chem Inf Model 2011 Jul 15;51(7):1528-38. Epub 2011 Jun 15.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.

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July 2011

Recent trends and observations in the design of high-quality screening collections.

Authors:

Steffen Renner Maxim Popov Ansgar Schuffenhauer Hans-Joerg Roth Werner Breitenstein Andreas Marzinzik Ian Lewis Philipp Krastel Florian Nigsch Jeremy Jenkins Edgar Jacoby

Future Med Chem 2011 Apr;3(6):751-66

Novartis Institutes for BioMedical Research, Center for Proteomic Chemistry, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.

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April 2011

MultiMCS: a fast algorithm for the maximum common substructure problem on multiple molecules.

Authors:

Ramesh Hariharan Anand Janakiraman Ramaswamy Nilakantan Bhupender Singh Sajith Varghese Gregory Landrum Ansgar Schuffenhauer

J Chem Inf Model 2011 Apr 29;51(4):788-806. Epub 2011 Mar 29.

Strand Life Sciences, Fifth Floor, Kirloskar Business Park, Bellary Road, Hebbal, Bangalore 560024, India.

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April 2011

Compound set enrichment: a novel approach to analysis of primary HTS data.

Authors:

Thibault Varin Hanspeter Gubler Christian N Parker Ji-Hu Zhang Pichai Raman Peter Ertl Ansgar Schuffenhauer

J Chem Inf Model 2010 Dec 12;50(12):2067-78. Epub 2010 Nov 12.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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December 2010

The scaffold tree: an efficient navigation in the scaffold universe.

Authors:

Peter Ertl Ansgar Schuffenhauer Steffen Renner

Methods Mol Biol 2011 ;672:245-60

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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February 2011

Bioactivity-guided mapping and navigation of chemical space.

Authors:

Steffen Renner Willem A L van Otterlo Marta Dominguez Seoane Sabine Möcklinghoff Bettina Hofmann Stefan Wetzel Ansgar Schuffenhauer Peter Ertl Tudor I Oprea Dieter Steinhilber Luc Brunsveld Daniel Rauh Herbert Waldmann

Nat Chem Biol 2009 Aug 28;5(8):585-92. Epub 2009 Jun 28.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.

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August 2009

Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions.

Authors:

Peter Ertl Ansgar Schuffenhauer

J Cheminform 2009 Jun 10;1(1). Epub 2009 Jun 10.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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June 2009

Cheminformatics analysis of natural products: lessons from nature inspiring the design of new drugs.

Authors:

Peter Ertl Ansgar Schuffenhauer

Prog Drug Res 2008 ;66:217, 219-35

Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.

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May 2008