Annie Huang

Annie Huang

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Annie Huang

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Re-irradiation for children with recurrent medulloblastoma in Toronto, Canada: a 20-year experience.

J Neurooncol 2019 Oct 29;145(1):107-114. Epub 2019 Aug 29.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-019-03272-2DOI Listing
October 2019

Repeat irradiation for children with supratentorial high-grade glioma.

Pediatr Blood Cancer 2019 Sep 17;66(9):e27881. Epub 2019 Jun 17.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27881DOI Listing
September 2019

Atypical Teratoid/Rhabdoid Sellar Tumor in an Adult with a Familial History of a Germline SMARCB1 Mutation: Case Report and Review of the Literature.

World Neurosurg 2019 Jul 17;127:336-345. Epub 2019 Apr 17.

Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.wneu.2019.04.083DOI Listing
July 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 Jul;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Evolution of the activation domain in a Hox transcription factor.

Int J Dev Biol 2018 ;62(11-12):745-753

Department of Biosciences, Rice University, Houston, TX, USA.

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http://dx.doi.org/10.1387/ijdb.180151sbDOI Listing
May 2019

Presacral Medulloepithelioma: Case Report and Literature Review.

J Pediatr Hematol Oncol 2019 Apr 15. Epub 2019 Apr 15.

Division of Haematology/Oncology.

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http://dx.doi.org/10.1097/MPH.0000000000001460DOI Listing
April 2019

Second rhabdoid tumor 8 years after treatment of atypical teratoid/rhabdoid tumor in a child with germline SMARCB1 mutation.

Pediatr Blood Cancer 2019 Mar 4;66(3):e27546. Epub 2018 Nov 4.

Pediatric Brain Tumour Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pbc.27546
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http://dx.doi.org/10.1002/pbc.27546DOI Listing
March 2019

Tails of a Super Histone.

Cancer Cell 2019 01;35(1):7-9

Arthur and Sonia Labatt Brain Tumour Research Centre, Department of Pediatrics/Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5S3H7, Canada; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S3H7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.12.005DOI Listing
January 2019

Clinical Improvement According to RAPID3 in Patients With Polymyalgia Rheumatica: A Longitudinal Analysis From Routine Care.

J Clin Rheumatol 2018 Oct;24(7):390-392

From the Division of Rheumatology, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1097/RHU.0000000000000701DOI Listing
October 2018

Molecular Classification and Management of Rare Pediatric Embryonal Brain Tumors.

Curr Oncol Rep 2018 07 11;20(9):69. Epub 2018 Jul 11.

Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, M5G1X8, Canada.

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http://dx.doi.org/10.1007/s11912-018-0717-7DOI Listing
July 2018

Atypical Teratoid Rhabdoid Tumour : From Tumours to Therapies.

J Korean Neurosurg Soc 2018 May 1;61(3):302-311. Epub 2018 May 1.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.3340/jkns.2018.0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957315PMC
May 2018

miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway.

J Hematol Oncol 2018 05 29;11(1):70. Epub 2018 May 29.

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, People's Republic of China.

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http://dx.doi.org/10.1186/s13045-018-0618-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975545PMC
May 2018

Atypical Teratoid Rhabdoid Tumor Diagnosis after Partial Resection of Dysembryoplastic Neuroepithelial Tumor: Case Report and Review of the Literature.

Pediatr Neurosurg 2016 16;51(4):191-8. Epub 2016 Mar 16.

Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000443405DOI Listing
April 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Trends in General Anesthesia Utilization by Board-Certified Pediatric Dentists.

Pediatr Dent 2018 Mar;40(2):124-130

School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa., USA.

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March 2018

TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling.

Carcinogenesis 2018 02;39(2):214-224

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1093/carcin/bgx125DOI Listing
February 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.

Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2016.71.8726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791837PMC
September 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

Assessment of fatigue in routine care on a Multidimensional Health Assessment Questionnaire (MDHAQ): a cross-sectional study of associations with RAPID3 and other variables in different rheumatic diseases.

Clin Exp Rheumatol 2016 Sep-Oct;34(5):901-909. Epub 2016 Jul 6.

Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.

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January 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.

J Clin Oncol 2016 10;34(29):3537-3543

Alvaro Lassaletta, Cynthia E. Hawkins, Rahul Krishnatry, Matthew Mistry, Anthony Arnoldo, Vijay Ramaswamy, Annie Huang, Ute Bartels, Uri Tabori, and Eric Bouffet, The Hospital for Sick Children, Toronto; Katrin Scheinemann, McMaster Children's Hospital; Shayna M. Zelcer, Children's Hospital of Western Ontario, London; Gregory Russell Pond, Ontario Clinical Oncology Group, McMaster University, Hamilton; Daniel Keene and Donna L. Johnston, Children's Hospital of Eastern Ontario, Ottawa, Ontario; Juliette Hukin and Ken Poskitt, British Columbia Children's Hospital, Vancouver, British Columbia; Beverley A. Wilson, University of Alberta Hospital; Lucie Lafay-Cousin, Alberta Children's Hospital, Calgary; David D. Eisenstat, Stollery Children's Hospital, Edmonton; Alberta; Nada Jabado, McGill University; Anne Sophie Carret, Hospital Sainte Justine, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec, Québec; and David D. Eisenstat, Cancer Care Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1200/JCO.2016.68.1585DOI Listing
October 2016

MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells.

Cell Rep 2016 10;17(5):1255-1264

Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.081DOI Listing
October 2016

Patient-reported outcomes in trials of patients with polymyalgia rheumatica: a systematic literature review.

Rheumatol Int 2016 Jul 14;36(7):897-904. Epub 2016 Jan 14.

Division of Rheumatology, Rush University Medical Center, 1611 West Harrison Street, Suite 510, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s00296-015-3416-9DOI Listing
July 2016

MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway.

J Neurooncol 2016 05 12;128(1):35-45. Epub 2016 Mar 12.

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://link.springer.com/10.1007/s11060-016-2095-z
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http://dx.doi.org/10.1007/s11060-016-2095-zDOI Listing
May 2016

JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.

Cancer Res 2016 05 24;76(9):2802-12. Epub 2016 Mar 24.

Department of Paediatrics, Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/canres/76/9/2802.f
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http://cancerres.aacrjournals.org/content/canres/early/2016/
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-15-2194DOI Listing
May 2016

Rare Presentation of Supratentorial Primitive Neuroectodermal Tumors Mimicking Bifocal Germ Cell Tumors: 2 Case Reports.

J Pediatr Hematol Oncol 2016 Mar;38(2):e67-70

*Department of Pediatrics, Division of Hematology/Oncology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand Divisions of †Haematology/Oncology §Pathology, The Hospital for Sick Children, University of Toronto, Toronto, ON ‡Department of Haematology/Oncology, CHU de Quebec, QC, Canada.

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http://dx.doi.org/10.1097/MPH.0000000000000402DOI Listing
March 2016

Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?

Neuro Oncol 2016 Feb 20;18(2):291-7. Epub 2015 Jan 20.

Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada (V.R., J.A., U.B., U.T., A.H., D.M., N.L., E.B.); Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada (V.R., M.R., X.W., M.D.T.); Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada (V.R., M.R., X.W., A.H., C.H., M.D.T); Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada (V.R., M.R., X.W., M.D.T.); Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (C.H.); Department of Radiation Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada (N.L.).

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http://dx.doi.org/10.1093/neuonc/nou357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724171PMC
February 2016

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment.

Am J Pathol 2016 Feb 12;186(2):446-59. Epub 2015 Dec 12.

Research Institute of the McGill University Health Centre, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808154PMC
February 2016

Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients.

Anesth Prog 2015 ;62(3):91-9

Graduate Clinic Director of Pediatric Dentistry, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.2344/0003-3006-62.3.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581021PMC
January 2016

A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma.

J Neurooncol 2015 May 4;122(3):471-80. Epub 2015 Mar 4.

The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1007/s11060-015-1744-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436849PMC
May 2015

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.

Lancet Oncol 2015 May 14;16(5):569-82. Epub 2015 Apr 14.

Division of Hematology-Oncology, University of Toronto, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)70114-2DOI Listing
May 2015

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

J Proteomics 2015 Apr 18;118:95-111. Epub 2014 Oct 18.

Princess Margaret Cancer Centre, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, ON Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18743919140046
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http://dx.doi.org/10.1016/j.jprot.2014.09.029DOI Listing
April 2015

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.

J Clin Oncol 2015 Mar 9;33(9):1015-22. Epub 2015 Feb 9.

Matthew Mistry, Nataliya Zhukova, Daniele Merico, Rahul Krishnatry, Mary Shago, James Stavropoulos, Noa Alon, Peter N. Ray, Vilma Navickiene, Joshua Mangerel, Marc Remke, Vijay Ramaswamy, Ana Guerreiro Stucklin, Martin Li, Edwin J. Young, Cindy Zhang, Pedro Castelo-Branco, Doua Bakry, Suzanne Laughlin, James T. Rutka, Peter B. Dirks, Michael D. Taylor, Mark Greenberg, David Malkin, Annie Huang, Eric Bouffet, Cynthia E. Hawkins, and Uri Tabori; The Hospital for Sick Children; Matthew Mistry, Patricia Rakopoulos, Rahul Krishnatry, Joshua Mangerel, Pawel Buczkowicz, Ana Guerreiro Stucklin, Doua Bakry, Adam Shlien, Mark Greenberg, David Malkin, Annie Huang, Eric Bouffet, Cynthia E. Hawkins, and Uri Tabori, University of Toronto; Jason D. Pole, Pediatric Oncology Group of Ontario, Toronto, Ontario; Jennifer Chan, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Pedro Castelo-Branco, Universidade do Algarve, Faro, Portugal; Keith L. Ligon, Dana-Farber/Boston Children's Cancer Center, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2014.58.3922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356711PMC
March 2015

DNMTs as potential therapeutic targets in high-risk pediatric embryonal brain tumors.

Expert Opin Ther Targets 2014 Oct 21;18(10):1103-7. Epub 2014 Aug 21.

The Hospital for Sick Children, Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Hematology-Oncology, Department of Pediatrics, Program in Cell Biology , 555 University Avenue, Toronto, Ontario, M5G 1X8 , Canada

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http://dx.doi.org/10.1517/14728222.2014.938052DOI Listing
October 2014

Advances in managing medulloblastoma and intracranial primitive neuro-ectodermal tumors.

F1000Prime Rep 2014 8;6:56. Epub 2014 Jul 8.

Division of Haematology/Oncology, The Hospital for Sick Children 555 University Avenue Toronto, Ontario M5G 1X8 Canada.

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http://f1000.com/prime/reports/m/6/56
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http://dx.doi.org/10.12703/P6-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108954PMC
September 2014

A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children.

Neuro Oncol 2014 Jun 26;16(6):787-99. Epub 2014 Jan 26.

Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana (Z.L., X.N.L); Laboratory of Molecular Neuro-Oncology, Texas Children's Cancer Center, Houston, Texas (Z.L., X.Z., Y.W., H.M., M.K., L.Q., X.N.L.); Texas Children's Cancer Center, Houston, Texas (P.A.B., T.K.M., J.M.S., L.P., C.C.L., M.C.); Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas (A.A.); Division of Hematology-Oncology, Arthur and Sonia Labatt Brain Tumor Research Center, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (D.P., K.C. H., A.H.).

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http://dx.doi.org/10.1093/neuonc/not244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022216PMC
June 2014

Chronic residual lesions in metastatic medulloblastoma patients.

J Pediatr Hematol Oncol 2014 Jan;36(1):71-5

*Neuro-Oncology Program, Division of Paediatric Haematology and Oncology, The Hospital for Sick Children, University of Toronto ‡Department of Radiation Oncology, Princess Margaret Hospital §Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada †Department of Pediatrics, Hadassah Medical Center, Division of Pediatric Hematology and Oncology, Jerusalem, Israel.

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http://dx.doi.org/10.1097/MPH.0b013e3182843b40DOI Listing
January 2014

Favorable survival and metabolic outcome for children with diencephalic syndrome using a radiation-sparing approach.

J Neurooncol 2014 Jan 12;116(1):195-204. Epub 2013 Nov 12.

Division of Haematology/Oncology, Department of Pediatric Neuro-Oncology, Hospital for Sick Children, University Avenue, University of Toronto, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s11060-013-1284-2DOI Listing
January 2014

A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes.

Neuro Oncol 2014 Jan 4;16(1):62-71. Epub 2013 Dec 4.

Corresponding authors: Jennifer A. Chan, MD, Department of Pathology & Laboratory Medicine, University of Calgary, HRIC 2A25, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. Annie Huang, MD, PhD, Division of Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, TMDT, 11-401P, 101 College St., Toronto, Ontario, Canada M5G 1L7

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http://dx.doi.org/10.1093/neuonc/not162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870842PMC
January 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines.

Am J Pathol 2013 Oct 3;183(4):1209-1222. Epub 2013 Aug 3.

Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791687PMC
October 2013

Successful treatment of a recurrent choroid plexus carcinoma with surgery followed by high-dose chemotherapy and stem cell rescue.

Pediatr Hematol Oncol 2013 Aug 9;30(5):386-91. Epub 2013 Jan 9.

Neuro-oncology Program, Division of Haematology-Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.3109/08880018.2012.756089DOI Listing
August 2013

Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma.

Brain Pathol 2013 May 11;23(3):244-53. Epub 2012 Oct 11.

Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00633.xDOI Listing
May 2013

Optic pathway gliomas in adolescence--time to challenge treatment choices?

Neuro Oncol 2013 Mar 7;15(3):391-400. Epub 2013 Jan 7.

The Hospital for Sick Children, Division of Haematology/Oncology, 555 University Avenue, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/neuonc/nos312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578487PMC
March 2013

Early cisplatin induced ototoxicity profile may predict the need for hearing support in children with medulloblastoma.

Pediatr Blood Cancer 2013 Feb 21;60(2):287-92. Epub 2012 Sep 21.

Division of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, Calgary, Canada.

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http://dx.doi.org/10.1002/pbc.24307DOI Listing
February 2013

Pulmonary hypertensive vasculopathy following tandem autologous transplantation in pediatric patients with central nervous system tumors.

Biol Blood Marrow Transplant 2013 Feb 26;19(2):235-9. Epub 2012 Sep 26.

Blood and Marrow Transplantation Section, Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2012.09.011DOI Listing
February 2013

Atypical teratoid rhabdoid tumors (ATRTs): the British Columbia's Children's Hospital's experience, 1986-2006.

Brain Pathol 2012 Sep 13;22(5):625-35. Epub 2012 Feb 13.

Division of Hematology, Oncology and Bone Marrow Transplantation, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/j.1750-3639.2011.00561.xDOI Listing
September 2012

Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation.

Int J Radiat Oncol Biol Phys 2012 Aug 13;83(5):1541-8. Epub 2012 Jan 13.

Department of Hematology/Oncology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2011.10.039DOI Listing
August 2012

Favorable outcome with conservative treatment for children with low grade brainstem tumors.

Pediatr Blood Cancer 2012 Apr 25;58(4):556-60. Epub 2011 May 25.

Pediatric Brain Tumor Program, Division of Pediatric Hematology and Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.23200DOI Listing
April 2012

Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas.

Pediatr Blood Cancer 2011 Jul 1;57(1):84-8. Epub 2010 Dec 1.

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/pbc.22917DOI Listing
July 2011

A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma.

Eur J Cancer 2010 Dec 23;46(18):3271-9. Epub 2010 Jul 23.

Department of Paediatrics Division of Haematology/Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ejca.2010.06.115DOI Listing
December 2010

Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.

Cancer Res 2010 Oct 28;70(20):8199-210. Epub 2010 Sep 28.

Sonia and Arthur Labatt Brain Tumor Research Centre, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada M5G 1X8.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-4562DOI Listing
October 2010

Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy.

J Pediatr Hematol Oncol 2010 Jul;32(5):e182-6

Bone Marrow Transplant Program, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1097/MPH.0b013e3181dce1a2DOI Listing
July 2010

Possibilities of new therapeutic strategies in brain tumors.

Cancer Treat Rev 2010 Jun 25;36(4):335-41. Epub 2010 Feb 25.

The Hospital for Sick Children, Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S03057372100002
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http://dx.doi.org/10.1016/j.ctrv.2010.02.009DOI Listing
June 2010

Challenges in management of patients with intracranial germ cell tumor and diabetes insipidus treated with cisplatin and/or ifosfamide based chemotherapy.

J Neurooncol 2010 May 10;97(3):393-9. Epub 2009 Oct 10.

Division of Haematology/Oncology/Neuro-Oncology, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s11060-009-0033-zDOI Listing
May 2010

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.

J Clin Oncol 2010 Mar 8;28(8):1337-44. Epub 2010 Feb 8.

Division of Pathology andHaematology, The Labatt Brain Tumor Research Centre, The Hospital for Sick Children,Toronto, Ontario, Canada.

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http://ascopubs.org/doi/10.1200/JCO.2009.25.5463
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http://dx.doi.org/10.1200/JCO.2009.25.5463DOI Listing
March 2010

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

J Biol Chem 2010 Feb 21;285(9):6770-80. Epub 2009 Dec 21.

Program in Cell Biology and the Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1074/jbc.M109.082347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825471PMC
February 2010

Ependymoma: lessons from the past, prospects for the future.

Childs Nerv Syst 2009 Nov 27;25(11):1383-4; author reply 1385. Epub 2009 Jun 27.

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http://dx.doi.org/10.1007/s00381-009-0915-6DOI Listing
November 2009

Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article.

J Neurosurg Pediatr 2009 Sep;4(3):254-61

Division of Hematology/Oncology, McMaster Children's Hospital, Hamilton.

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http://dx.doi.org/10.3171/2009.4.PEDS08411DOI Listing
September 2009

Diffuse intrinsic brainstem tumors in neonates. Report of two cases.

J Neurosurg Pediatr 2008 May;1(5):382-5

Division of Hematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/PED/2008/1/5/382DOI Listing
May 2008

Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report.

J Neurooncol 2008 Jan 10;86(1):101-8. Epub 2007 Jul 10.

Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada, K1H 8L1.

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http://dx.doi.org/10.1007/s11060-007-9440-1DOI Listing
January 2008

Tumors of the central nervous system in the first year of life.

Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1074-82

Paediatric Brain Tumour Program, Division of Paediatric Oncology/Haematology, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/pbc.21351DOI Listing
December 2007

Neuroradiological findings of bleomycin leakage in cystic craniopharyngioma. Report of three cases.

J Neurosurg 2007 Oct;107(4 Suppl):318-23

Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/PED-07/10/318DOI Listing
October 2007

Error monitoring is associated with the clinical state of schizophrenia.

Aust N Z J Psychiatry 2007 Sep;41(9):773-4

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September 2007

Supratentorial primitive neuroectodermal tumors in young children.

J Clin Oncol 2006 Dec;24(35):5609; author reply 5609-10

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http://dx.doi.org/10.1200/JCO.2006.09.1033DOI Listing
December 2006

Limited-field radiation for bifocal germinoma.

Int J Radiat Oncol Biol Phys 2006 Jun 10;65(2):486-92. Epub 2006 Mar 10.

Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S036030160503079
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http://dx.doi.org/10.1016/j.ijrobp.2005.12.011DOI Listing
June 2006

Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma.

Neurosurg Focus 2005 Nov 15;19(5):E3. Epub 2005 Nov 15.

Arthur and Sonia Labatt Brain Tumor Research Centre, Cancer Research Program, Division of Hematology and Oncology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.

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November 2005

KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers.

Oncogene 2005 Jul;24(30):4741-53

Division of Cancer Informatics, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1038/sj.onc.1208641DOI Listing
July 2005