Annette Paschen

Annette Paschen

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Annette Paschen

Annette Paschen

Publications by authors named "Annette Paschen"

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60Publications

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ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope.

Eur J Immunol 2020 Feb 27;50(2):270-283. Epub 2019 Nov 27.

Friedrich Loeffler Institut für Medizinische Mikrobiologie-Virologie, Universitätsmedizin Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1002/eji.201948116DOI Listing
February 2020

Clinical and genetic analysis of melanomas arising in acral sites.

Eur J Cancer 2019 Sep 14;119:66-76. Epub 2019 Aug 14.

Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany; Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.07.008DOI Listing
September 2019

The Era of Checkpoint Inhibition: Lessons Learned from Melanoma.

Recent Results Cancer Res 2020 ;214:169-187

Department of Dermatology, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.

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http://dx.doi.org/10.1007/978-3-030-23765-3_6DOI Listing
September 2019

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells.

Int J Cancer 2019 04 9;144(7):1645-1656. Epub 2019 Jan 9.

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.

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http://doi.wiley.com/10.1002/ijc.31874
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http://dx.doi.org/10.1002/ijc.31874DOI Listing
April 2019

Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance.

Cancer Immunol Immunother 2019 Mar 11;68(3):479-488. Epub 2019 Jan 11.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Virchowstraße 179, 45147, Essen, Germany.

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http://link.springer.com/10.1007/s00262-019-02300-4
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http://dx.doi.org/10.1007/s00262-019-02300-4DOI Listing
March 2019

Tumor CDKN2A-Associated JAK2 Loss and Susceptibility to Immunotherapy Resistance.

J Natl Cancer Inst 2018 06;110(6):677-681

Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium partner site Essen/Düsseldorf, Essen, Germany (DKTK).

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http://dx.doi.org/10.1093/jnci/djx271DOI Listing
June 2018

Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.

Stem Cell Reports 2017 09 3;9(3):985-998. Epub 2017 Aug 3.

Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen 45147, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599186PMC
September 2017

Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.

Invest Ophthalmol Vis Sci 2017 07;58(9):3464-3470

Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany 8Dermatopathologie bei Mainz, Nieder-Olm, Germany.

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http://dx.doi.org/10.1167/iovs.17-21838DOI Listing
July 2017

HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.

Oncotarget 2017 Apr;8(17):28312-28327

Internal Medicine III, University Cancer Center (UCT) and Research Center for Immunotherapy (FZI), University Medical Center (UMC) of the Johannes Gutenberg University and German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Mainz, Germany.

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http://dx.doi.org/10.18632/oncotarget.16048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438652PMC
April 2017

The Influence of HLA and KIR Genes on Malignant Melanoma Development and Progression.

Arch Immunol Ther Exp (Warsz) 2016 Dec 12;64(Suppl 1):73-81. Epub 2017 Jan 12.

Department of Clinical Immunology with Stem Cell Bank, Alexandrovska University Hospital, Medical University, 1431, Sofia, Bulgaria.

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http://dx.doi.org/10.1007/s00005-016-0437-3DOI Listing
December 2016

Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency.

Cancer Res 2016 08 3;76(15):4347-58. Epub 2016 Jun 3.

Department of Dermatology, University Hospital Essen, University Duisburg-Essen and German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0008DOI Listing
August 2016

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.

Eur J Cancer 2016 05 26;59:109-112. Epub 2016 Mar 26.

Department of Dermatology, Venereology, and Allergology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, West German Cancer Center, University of Duisburg-Essen, 45122 Essen, Germany.

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http://dx.doi.org/10.1016/j.ejca.2016.02.023DOI Listing
May 2016

Frequent TERT Promoter Mutations in Ocular Surface Squamous Neoplasia.

Invest Ophthalmol Vis Sci 2015 Sep;56(10):5854-61

Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.

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http://dx.doi.org/10.1167/iovs.15-17469DOI Listing
September 2015

Deciphering the genetic evolution of T-cell resistance in melanoma.

Oncoimmunology 2015 May 3;4(5):e1005510. Epub 2015 Feb 3.

Department of Dermatology; University Hospital; University Duisburg-Essen and German Cancer Consortium (DKTK) ; Essen, Germany.

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http://dx.doi.org/10.1080/2162402X.2015.1005510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485751PMC
May 2015

Expression of stress ligands of the immunoreceptor NKG2D in melanoma: regulation and clinical significance.

Eur J Cell Biol 2014 Jan-Feb;93(1-2):49-54. Epub 2014 Feb 11.

Department of Dermatology, University Hospital, West German Cancer Center, University Duisburg-Essen, Essen and German Cancer Consortium (DKTK), Germany.

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http://dx.doi.org/10.1016/j.ejcb.2014.01.009DOI Listing
April 2015

Genetic evolution of T-cell resistance in the course of melanoma progression.

Clin Cancer Res 2014 Dec 7;20(24):6593-604. Epub 2014 Oct 7.

Department of Dermatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany. German Cancer Consortium (DKTK), Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0567DOI Listing
December 2014

Vemurafenib reverses immunosuppression by myeloid derived suppressor cells.

Int J Cancer 2013 Oct 13;133(7):1653-63. Epub 2013 Apr 13.

Department of Dermatology, University Hospital, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/ijc.28168DOI Listing
October 2013

Immunological consequences of selective BRAF inhibitors in malignant melanoma: Neutralization of myeloid-derived suppressor cells.

Oncoimmunology 2013 Aug 10;2(8):e25218. Epub 2013 Jun 10.

Department of Dermatology; University Hospital; University Duisburg-Essen; Essen, Germany.

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http://dx.doi.org/10.4161/onci.25218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805652PMC
August 2013

New developments in biomarkers for melanoma.

Curr Opin Oncol 2013 Mar;25(2):145-51

Department of Dermatology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1097/CCO.0b013e32835dafdfDOI Listing
March 2013

Dacarbazine in melanoma: from a chemotherapeutic drug to an immunomodulating agent.

J Invest Dermatol 2013 Feb;133(2):289-92

Department of Dermatology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/jid.2012.341DOI Listing
February 2013

Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes.

Cancer Immunol Immunother 2012 Sep 26;61(9):1359-71. Epub 2012 Jul 26.

Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.

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http://dx.doi.org/10.1007/s00262-012-1321-6DOI Listing
September 2012

Tumor suppressors control ULBP2, an innate surface ligand of the lymphocyte immune receptor NKG2D.

Oncoimmunology 2012 Jul;1(4):535-536

Department of Dermatology; University Hospital Essen; Essen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382901PMC
http://dx.doi.org/10.4161/onci.19406DOI Listing
July 2012

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors.

Immunogenetics 2011 Feb 18;63(2):65-71. Epub 2010 Nov 18.

Department of Clinical Analysis, Hospital Universitario Virgen de las Nieves, Granada, Spain.

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http://dx.doi.org/10.1007/s00251-010-0494-4DOI Listing
February 2011

MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells.

Mod Pathol 2010 Apr 22;23(4):511-21. Epub 2010 Jan 22.

Department of Biochemistry, University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/modpathol.2009.183DOI Listing
April 2010

Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.

Clin Cancer Res 2009 Aug 11;15(16):5208-15. Epub 2009 Aug 11.

Clinical Cooperation Unit Dermato-Oncology, German Cancer Research Center Heidelberg and University Medicine Mannheim, University Medicine Mannheim, Mannheim, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-0886DOI Listing
August 2009

Identification of different tumor escape mechanisms in several metastases from a melanoma patient undergoing immunotherapy.

Cancer Immunol Immunother 2007 Jan 19;56(1):88-94. Epub 2006 Apr 19.

Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nueves, Avda Fuerzas Armadas s/n, 18014, Granada, Spain.

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http://link.springer.com/content/pdf/10.1007/s00262-006-0166
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http://link.springer.com/10.1007/s00262-006-0166-2
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http://dx.doi.org/10.1007/s00262-006-0166-2DOI Listing
January 2007

Identification of a cross-reactive HLA-DRB1*0301-restricted CD4 T cell response directed against cholesterol-binding cytolysins from two different pathogens.

Microbes Infect 2006 Jul 30;8(8):2034-43. Epub 2006 May 30.

Skin Cancer Unit of the German Cancer Research Center (DKFZ), Faculty for Clinical Medicine Mannheim of the University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.micinf.2006.03.010DOI Listing
July 2006

A novel strategy for the discovery of MHC class II-restricted tumor antigens: identification of a melanotransferrin helper T-cell epitope.

Cancer Res 2005 Nov;65(21):10068-78

Pharmaceutical Research and Roche Center for Medical Genomics, F. Hoffmann La Roche Ltd., Basel, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1973DOI Listing
November 2005

Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

Int J Cancer 2005 Oct;116(6):944-8

Skin Cancer Unit of the German Cancer Research Center at the University Hospital of Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1002/ijc.21132DOI Listing
October 2005

Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

Int J Cancer 2005 Oct;116(6):944-8

Skin Cancer Unit of the German Cancer Research Center at the University Hospital of Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1002/ijc.21132DOI Listing
October 2005

Identification of tumor antigens and T-cell epitopes, and its clinical application.

Cancer Immunol Immunother 2004 Mar 20;53(3):196-203. Epub 2003 Dec 20.

Skin Cancer Unit (DKFZ), University Hospital Mannheim, Theodor Kutzer Ufer 1, 68135, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00262-003-0479-3DOI Listing
March 2004

Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

Int J Cancer 2005 Oct;116(6):944-8

Skin Cancer Unit of the German Cancer Research Center at the University Hospital of Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1002/ijc.21132DOI Listing
October 2005

Complete loss of HLA class I antigen expression on melanoma cells: a result of successive mutational events.

Int J Cancer 2003 Mar;103(6):759-67

Skin Cancer Unit, German Cancer Research Center, University Hospital Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1002/ijc.10906DOI Listing
March 2003

Regulation of nitrogen fixation in the phototrophic purple bacterium Rhodobacter capsulatus.

J Mol Microbiol Biotechnol 2002 May;4(3):243-8

Ruhr-Universität Bochum, Fakultät für Biologie, Lehrstuhl für Biologie der Mikroorganismen, Germany.

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May 2002

Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells.

Cancer Res 2002 May;62(10):2875-82

Skin Cancer Unit of German Cancer Research Center, University of Heidelberg, Theodor Kutzer Ufer 1, 68135 Mannheim, Germany.

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May 2002