Publications by authors named "Annette MacLeod"

69Publications

To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host.

Front Immunol 2020 12;11:1250. Epub 2020 Jun 12.

College of Medical, Veterinary and Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom.

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June 2020

Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population.

Infect Genet Evol 2019 07 23;71:108-115. Epub 2019 Mar 23.

Ministère de la Santé et de l'Hygiène Publique, Programme National de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Conakry, Guinea; Institut de Recherche pour le Développement (IRD), UMR IRD-CIRAD 177 INTERTRYP, Montpellier, France. Electronic address:

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July 2019

Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon.

PLoS Negl Trop Dis 2019 03 25;13(3):e0007283. Epub 2019 Mar 25.

Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

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March 2019

Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection.

PLoS Negl Trop Dis 2019 02 19;13(2):e0007189. Epub 2019 Feb 19.

The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, United Kingdom.

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February 2019

Resolving the apparent transmission paradox of African sleeping sickness.

PLoS Biol 2019 01 11;17(1):e3000105. Epub 2019 Jan 11.

Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom.

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January 2019

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

PLoS Negl Trop Dis 2018 05 14;12(5):e0006450. Epub 2018 May 14.

Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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May 2018

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.

PLoS Pathog 2018 01 18;14(1):e1006855. Epub 2018 Jan 18.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

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January 2018

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.

PLoS Negl Trop Dis 2016 08 5;10(8):e0004903. Epub 2016 Aug 5.

Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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August 2016

Population genomics reveals the origin and asexual evolution of human infective trypanosomes.

Elife 2016 Jan 26;5:e11473. Epub 2016 Jan 26.

Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom.

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January 2016

Population Genetics and Reproductive Strategies of African Trypanosomes: Revisiting Available Published Data.

PLoS Negl Trop Dis 2015 22;9(10):e0003985. Epub 2015 Oct 22.

IRD, UMR 177 IRD-CIRAD INTERTRYP, Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Bobo-Dioulasso, Burkina-Faso.

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March 2016

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome.

Parasitology 2015 Feb;142 Suppl 1:S108-19

Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences,University of Glasgow,464 Bearsden Road, Glasgow G61 1QH,UK.

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February 2015

Population genetics of Trypanosoma brucei gambiense in sleeping sickness patients with treatment failures in the focus of Mbuji-Mayi, Democratic Republic of the Congo.

Infect Genet Evol 2015 Mar 20;30:128-133. Epub 2014 Dec 20.

Centre International de Recherche-Développement sur l'Élevage en zones Subhumides (CIRDES), Unité de recherches sur les bases biologiques de la lutte intégrée, Institut de Recherche pour le Développement, Unité Mixte de Recherche IRD-CIRAD 177 INTERTRYP, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso; Institut de Recherche pour le Développement, Unité Mixte de Recherche IRD-CIRAD 177 INTERTRYP, TA A-17/G, Campus International de Baillarguet, F-34398 Montpellier, France.

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March 2015

Human African trypanosomiasis presenting at least 29 years after infection--what can this teach us about the pathogenesis and control of this neglected tropical disease?

PLoS Negl Trop Dis 2014 Dec 18;8(12):e3349. Epub 2014 Dec 18.

Hospital for Tropical Diseases, University College London Hospital, London, United Kingdom; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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December 2014

Exploiting genetic variation to discover genes involved in important disease phenotypes.

Methods Mol Biol 2015 ;1201:91-107

Wellcome Trust Centre for Molecular Parasitology, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, 464 Bearsden Road, Glasgow, G61 1QH, UK.

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July 2015

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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June 2014

Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci.

PLoS Negl Trop Dis 2013 Nov 14;7(11):e2526. Epub 2013 Nov 14.

Wellcome Trust Centre for Molecular Parasitology, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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November 2013

The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense.

PLoS Pathog 2013 3;9(10):e1003686. Epub 2013 Oct 3.

Wellcome Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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May 2014

A protocol to improve genotyping of problematic microsatellite loci of Trypanosoma brucei gambiense from body fluids.

Infect Genet Evol 2013 Dec 15;20:171-6. Epub 2013 Aug 15.

Centre International de Recherche-Développement sur l'Élevage en zones Subhumides (CIRDES), Unité de recherches sur les bases biologiques de la lutte intégrée, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso; Université Polytechnique de Bobo-Dioulasso, 01 BP 1091 Bobo-Dioulasso 01, Burkina Faso. Electronic address:

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December 2013

Human and animal Trypanosomes in Côte d'Ivoire form a single breeding population.

PLoS One 2013 2;8(7):e67852. Epub 2013 Jul 2.

Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Biological Sciences, Glasgow, United Kingdom.

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February 2014

Trypanosome resistance to human innate immunity: targeting Achilles' heel.

Trends Parasitol 2012 Dec 8;28(12):539-45. Epub 2012 Oct 8.

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

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December 2012

Novel African trypanocidal agents: membrane rigidifying peptides.

PLoS One 2012 7;7(9):e44384. Epub 2012 Sep 7.

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America.

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May 2013

Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors.

Virulence 2012 Jan-Feb;3(1):72-6. Epub 2012 Jan 1.

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.

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September 2012

Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei.

Mol Biochem Parasitol 2012 May 29;183(1):8-14. Epub 2011 Dec 29.

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

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May 2012

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1.

PLoS Negl Trop Dis 2011 Sep 6;5(9):e1287. Epub 2011 Sep 6.

College of Medical, Veterinary and Biological Sciences, Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom.

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September 2011

Trypanosome genetics: populations, phenotypes and diversity.

Vet Parasitol 2011 Sep 19;181(1):61-8. Epub 2011 Apr 19.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.

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September 2011

Population genetic structure of Guinea Trypanosoma brucei gambiense isolates according to host factors.

Infect Genet Evol 2011 Jul 14;11(5):1129-35. Epub 2011 Apr 14.

Centre International de Recherche-Développement sur l'Élevage en zones Subhumides, Unité de recherches sur les bases biologiques de la lutte intégrée, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso.

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July 2011

Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16137-41. Epub 2010 Aug 30.

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

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September 2010

The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides.

J Biol Chem 2010 Sep 8;285(37):28659-66. Epub 2010 Jul 8.

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA.

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September 2010

Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes.

BMC Genomics 2010 Feb 22;11:124. Epub 2010 Feb 22.

Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, UK.

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February 2010

Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection.

Infect Immun 2010 Mar 19;78(3):1096-108. Epub 2010 Jan 19.

Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom.

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March 2010

A major genetic locus in Trypanosoma brucei is a determinant of host pathology.

PLoS Negl Trop Dis 2009 Dec 1;3(12):e557. Epub 2009 Dec 1.

Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, Glasgow, United Kingdom.

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December 2009

Trypanosoma vivax displays a clonal population structure.

Int J Parasitol 2009 Nov 8;39(13):1475-83. Epub 2009 Jun 8.

Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, Faculty of Veterinary Medicine, University of Glasgow, Glasgow G12 8TA, United Kingdom.

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November 2009

Discovery of mating in the major African livestock pathogen Trypanosoma congolense.

PLoS One 2009 15;4(5):e5564. Epub 2009 May 15.

Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow, United Kingdom.

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August 2009

Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation.

Infect Genet Evol 2008 Dec 23;8(6):847-54. Epub 2008 Aug 23.

Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom.

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December 2008

Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map.

Genome Biol 2008 22;9(6):R103. Epub 2008 Jun 22.

Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University Place, Glasgow G12 8TA, UK.

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August 2008

The population structure of the Cryptosporidium parvum population in Scotland: a complex picture.

Infect Genet Evol 2008 Mar 9;8(2):121-9. Epub 2007 Nov 9.

Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK.

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March 2008

Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development.

Mol Biochem Parasitol 2007 Jan 15;151(1):133-6. Epub 2006 Nov 15.

Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, 120, University Place, Glasgow G12 8TA, UK.

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January 2007

The genetic map and comparative analysis with the physical map of Trypanosoma brucei.

Nucleic Acids Res 2005 27;33(21):6688-93. Epub 2005 Nov 27.

Wellcome Centre for Molecular Parasitology, Anderson College Complex, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK.

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December 2005

The genome of the African trypanosome Trypanosoma brucei.

Authors:
Matthew Berriman Elodie Ghedin Christiane Hertz-Fowler Gaëlle Blandin Hubert Renauld Daniella C Bartholomeu Nicola J Lennard Elisabet Caler Nancy E Hamlin Brian Haas Ulrike Böhme Linda Hannick Martin A Aslett Joshua Shallom Lucio Marcello Lihua Hou Bill Wickstead U Cecilia M Alsmark Claire Arrowsmith Rebecca J Atkin Andrew J Barron Frederic Bringaud Karen Brooks Mark Carrington Inna Cherevach Tracey-Jane Chillingworth Carol Churcher Louise N Clark Craig H Corton Ann Cronin Rob M Davies Jonathon Doggett Appolinaire Djikeng Tamara Feldblyum Mark C Field Audrey Fraser Ian Goodhead Zahra Hance David Harper Barbara R Harris Heidi Hauser Jessica Hostetler Al Ivens Kay Jagels David Johnson Justin Johnson Kristine Jones Arnaud X Kerhornou Hean Koo Natasha Larke Scott Landfear Christopher Larkin Vanessa Leech Alexandra Line Angela Lord Annette Macleod Paul J Mooney Sharon Moule David M A Martin Gareth W Morgan Karen Mungall Halina Norbertczak Doug Ormond Grace Pai Chris S Peacock Jeremy Peterson Michael A Quail Ester Rabbinowitsch Marie-Adele Rajandream Chris Reitter Steven L Salzberg Mandy Sanders Seth Schobel Sarah Sharp Mark Simmonds Anjana J Simpson Luke Tallon C Michael R Turner Andrew Tait Adrian R Tivey Susan Van Aken Danielle Walker David Wanless Shiliang Wang Brian White Owen White Sally Whitehead John Woodward Jennifer Wortman Mark D Adams T Martin Embley Keith Gull Elisabetta Ullu J David Barry Alan H Fairlamb Fred Opperdoes Barclay G Barrell John E Donelson Neil Hall Claire M Fraser Sara E Melville Najib M El-Sayed

Science 2005 Jul;309(5733):416-22

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.

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July 2005

Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis.

Mol Biochem Parasitol 2005 Sep;143(1):12-9

Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK.

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September 2005

Minisatellites and MVR-PCR for the individual identification of parasite isolates.

Authors:
Annette MacLeod

Methods Mol Biol 2004 ;270:187-202

Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, UK.

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July 2004

Multilocus genotyping of Cryptosporidium parvum Type 2: population genetics and sub-structuring.

Infect Genet Evol 2003 Sep;3(3):207-18

Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK.

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September 2003

Population structures and the role of genetic exchange in the zoonotic pathogen Cryptosporidium parvum.

J Mol Evol 2003 Apr;56(4):407-17

Wellcome Centre for Molecular Parasitology, Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland.

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April 2003

Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits.

Philos Trans R Soc Lond B Biol Sci 2002 Jan;357(1417):89-99

Wellcome Centre for Molecular Parasitology, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK.

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January 2002