Publications by authors named "Anne-Marie Cleton-Jansen"

100Publications

What's new in bone forming tumours of the skeleton?

Virchows Arch 2020 Jan 18;476(1):147-157. Epub 2019 Nov 18.

Department of Pathology, Leiden University Medical Center, P.O. Box 9600, L1-Q, 2300 RC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s00428-019-02683-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969005PMC
January 2020

Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature.

Skeletal Radiol 2019 Jul 2;48(7):1059-1067. Epub 2019 Jan 2.

Department of Radiology, C-2-S, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00256-018-3135-xDOI Listing
July 2019

Molecular Pathology of Bone Tumors.

J Mol Diagn 2019 03 18;21(2):171-182. Epub 2018 Dec 18.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.11.002DOI Listing
March 2019

Therapy-induced enrichment of cancer stem-like cells in solid human tumors: Where do we stand?

Pharmacol Res 2018 11 11;137:193-204. Epub 2018 Oct 11.

Institute of Pharmacology and Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Azinhaga de Sta. Comba, Celas, 3000-354 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal; CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183106
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http://dx.doi.org/10.1016/j.phrs.2018.10.011DOI Listing
November 2018

Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis.

Clin Sarcoma Res 2018 23;8:16. Epub 2018 Aug 23.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-018-0104-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106748PMC
August 2018

Molecular Analysis of Gene Fusions in Bone and Soft Tissue Tumors by Anchored Multiplex PCR-Based Targeted Next-Generation Sequencing.

J Mol Diagn 2018 09 20;20(5):653-663. Epub 2018 Aug 20.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.05.007DOI Listing
September 2018

Immune checkpoint inhibitors in sarcomas: in quest of predictive biomarkers.

Lab Invest 2018 01 20;98(1):41-50. Epub 2017 Nov 20.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/labinvest.2017.128DOI Listing
January 2018

IWR-1, a tankyrase inhibitor, attenuates Wnt/β-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft.

Cancer Lett 2018 02 8;414:1-15. Epub 2017 Nov 8.

Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Azinhaga de Sta. Comba, Celas, 3000-354, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal; CIMAGO, University of Coimbra, Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.11.004DOI Listing
February 2018

NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.

Mol Cancer Res 2017 12 31;15(12):1714-1721. Epub 2017 Aug 31.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0293DOI Listing
December 2017

Increased Risk of Breast Cancer at a Young Age in Women with Fibrous Dysplasia.

J Bone Miner Res 2018 01 20;33(1):84-90. Epub 2017 Sep 20.

Department of Medicine, Division of Endocrinology, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/jbmr.3286DOI Listing
January 2018

A researcher's perspective on the quantity of osteosarcoma studies.

J Bone Oncol 2017 Jun 7;7:29-31. Epub 2017 Apr 7.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jbo.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403790PMC
June 2017

Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy.

Cancer Immunol Immunother 2017 01 16;66(1):119-128. Epub 2016 Nov 16.

Department of Pathology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00262-016-1925-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222929PMC
January 2017

Tissue factor associates with survival and regulates tumour progression in osteosarcoma.

Thromb Haemost 2016 05 14;115(5):1025-33. Epub 2016 Jan 14.

Henri H. Versteeg, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands, Tel.: +31 715263872, Fax: +31 71526755, E-mail:

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http://dx.doi.org/10.1160/TH15-07-0541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428546PMC
May 2016

Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling.

Cancer Lett 2016 Jan 11;370(2):286-95. Epub 2015 Nov 11.

Pharmacology and Experimental Therapeutics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal; Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.013DOI Listing
January 2016

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin.

Oncotarget 2015 Nov;6(34):36113-25

Division of Toxicology, Leiden/Academic Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.5333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742165PMC
November 2015

Radiation-induced Sarcomas Occurring in Desmoid-type Fibromatosis Are Not Always Derived From the Primary Tumor.

Am J Surg Pathol 2015 Dec;39(12):1701-7

Departments of *Medical Oncology †Pathology ∥Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands ‡Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Centre, Nashville, TN §Department of Pathology, Sarcoma Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX ¶Robert J. Tomsich Pathology and Laboratory Medicine Institute, and Molecular Genetics, Cleveland Clinic, Taussig Cancer Centre and Lerner Research Institute, Cleveland, OH.

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http://dx.doi.org/10.1097/PAS.0000000000000510DOI Listing
December 2015

Osteosarcoma Stem Cells Have Active Wnt/β-catenin and Overexpress SOX2 and KLF4.

J Cell Physiol 2016 04 9;231(4):876-86. Epub 2015 Sep 9.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/jcp.25179DOI Listing
April 2016

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.

J Pathol 2015 Jul 30;236(3):348-59. Epub 2015 Mar 30.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands.

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http://dx.doi.org/10.1002/path.4528DOI Listing
July 2015

Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma.

Hematol Oncol Clin North Am 2013 Oct 26;27(5):1021-48. Epub 2013 Aug 26.

Department of Pathology, Leiden University Medical Center, PO Box 9600, L1-Q, Leiden RC 2300, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S08898588130010
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http://dx.doi.org/10.1016/j.hoc.2013.07.012DOI Listing
October 2013

CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study.

Cancer 2013 Oct 31;119(20):3696-702. Epub 2013 Jul 31.

Sarcoma Service, Department of Surgery, Scientific Institute for Research, Hospitalization, and Health Care (IRCCS) Foundation, National Cancer Institute, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.28271DOI Listing
October 2013

Mesenchymal stem cell transformation and sarcoma genesis.

Clin Sarcoma Res 2013 Jul 23;3(1):10. Epub 2013 Jul 23.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333ZA, the Netherlands.

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http://dx.doi.org/10.1186/2045-3329-3-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724575PMC
July 2013

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity.

Hum Pathol 2013 Aug 19;44(8):1597-604. Epub 2013 Mar 19.

Department of Pathology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.humpath.2013.01.006DOI Listing
August 2013

Genome-wide analyses on high-grade osteosarcoma: making sense of a genomically most unstable tumor.

Int J Cancer 2013 Dec 16;133(11):2512-21. Epub 2013 Mar 16.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ijc.28124DOI Listing
December 2013

Mutations affecting BRAF, EGFR, PIK3CA, and KRAS are not associated with sporadic vestibular schwannomas.

Virchows Arch 2013 Feb 8;462(2):211-7. Epub 2012 Dec 8.

Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00428-012-1342-8DOI Listing
February 2013

Modulation of the osteosarcoma expression phenotype by microRNAs.

PLoS One 2012 25;7(10):e48086. Epub 2012 Oct 25.

The EuroBoNet Network of Excellence on Bone Tumours, Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048086PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485010PMC
May 2013

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.

BMC Cancer 2012 Oct 22;12:488. Epub 2012 Oct 22.

Research Centre for Experimental Orthopaedics, Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1471-2407-12-488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495847PMC
October 2012

The activities of Smad and Gli mediated signalling pathways in high-grade conventional osteosarcoma.

Eur J Cancer 2012 Dec 4;48(18):3429-38. Epub 2012 Aug 4.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2012.06.018DOI Listing
December 2012

Immunotherapy: Is it different for sarcomas?

Oncoimmunology 2012 Mar;1(2):255-257

Department of Pathology; Leiden University Medical Center; Leiden, The Netherlands.

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http://dx.doi.org/10.4161/onci.1.2.18345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376989PMC
March 2012

Molecular pathology and its diagnostic use in bone tumors.

Cancer Genet 2012 May;205(5):193-204

Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1016/j.cancergen.2012.04.001DOI Listing
May 2012

Osteosarcoma models: from cell lines to zebrafish.

Sarcoma 2012 15;2012:417271. Epub 2012 Mar 15.

Department of Pathology, Leiden University Medical Center, Leiden, P.O. Box 9500, L1-Q, 23000 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1155/2012/417271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329665PMC
August 2012

Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data.

Genes Chromosomes Cancer 2012 Jul 27;51(7):696-706. Epub 2012 Mar 27.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.21956DOI Listing
July 2012

An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration.

J Pathol 2012 Jun 19;227(2):245-53. Epub 2012 Mar 19.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/path.3998DOI Listing
June 2012

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.

Lab Invest 2011 Aug 25;91(8):1195-205. Epub 2011 Apr 25.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/labinvest.2011.72DOI Listing
August 2011

Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.

Genes Chromosomes Cancer 2010 Dec;49(12):1095-103

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.20817DOI Listing
December 2010

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4.

FASEB J 2010 Dec 28;24(12):4648-59. Epub 2010 Jul 28.

Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, Oxford, OX3 7LD, UK.

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http://dx.doi.org/10.1096/fj.10-162230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992372PMC
December 2010

Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma.

J Pathol 2010 Jan;220(1):24-33

Department of Pathology, School of Medicine, Shandong University, Jinan 250012, PR China.

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http://dx.doi.org/10.1002/path.2628DOI Listing
January 2010

Aberrant heparan sulfate proteoglycan localization, despite normal exostosin, in central chondrosarcoma.

Am J Pathol 2009 Mar 29;174(3):979-88. Epub 2009 Jan 29.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.2353/ajpath.2009.080623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665757PMC
March 2009

Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi.

Eur J Nucl Med Mol Imaging 2007 Nov 1;34(11):1793-803. Epub 2007 Jun 1.

Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00259-007-0480-8DOI Listing
November 2007

The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions.

J Natl Cancer Inst 2007 Mar;99(5):396-406

Department of Pathology, Leiden University Medical Center, PO Box 9600 L1-Q, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/jnci/djk067DOI Listing
March 2007

FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex.

Cancer Res 2005 Dec;65(24):11304-13

Breast Cancer Genetics Group, Dame Roma Mitchell Cancer Research Laboratories, Department of Medicine, University of Adelaide and Hanson Institute, Institute of Medical and Veterinary Science Adelaide, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0936DOI Listing
December 2005

Expression analysis of candidate breast tumour suppressor genes on chromosome 16q.

Breast Cancer Res 2005 18;7(6):R998-1004. Epub 2005 Oct 18.

Department of Pathology, Leiden University Medical Center, Albiniusdreef 2, 2333ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1186/bcr1337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410740PMC
February 2006

Multiplex ligation-dependent probe amplification for the detection of 1p and 19q chromosomal loss in oligodendroglial tumors.

Brain Pathol 2005 Jul;15(3):192-7

Department of Pathology, Leiden University Medical Center, P.O. box 9600, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1750-3639.2005.tb00520.xDOI Listing
July 2005

Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment.

Lancet Oncol 2005 Aug;6(8):599-607

Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.

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http://dx.doi.org/10.1016/S1470-2045(05)70282-5DOI Listing
August 2005

The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting.

Virchows Arch 2005 Apr 3;446(4):430-7. Epub 2005 Mar 3.

Department of Pathology, Leiden University Medical Centre, L1-Q, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://link.springer.com/10.1007/s00428-005-1208-4
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http://dx.doi.org/10.1007/s00428-005-1208-4DOI Listing
April 2005

Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.

J Pathol 2005 Mar;205(4):476-82

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/path.1723DOI Listing
March 2005