Publications by authors named "Anne Welfringer-Morin"

5 Publications

  • Page 1 of 1

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) : Series of 49 French pediatric cases.

J Allergy Clin Immunol Pract 2021 Jul 28. Epub 2021 Jul 28.

Service de Dermatologie, Hôtel Dieu, Centre Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse drug reaction. It can be difficult to diagnose, even more so among children, since symptoms may mimic other commonly encountered pediatric conditions.

Objective: To describe clinical and laboratory features of DRESS syndrome in the pediatric population (≤ 18 years of age), establish causative agents and treatment modalities.

Methods: Multicenter retrospective study of probable and definite DRESS cases (RegiSCAR ≥ 4) in children hospitalized in 15 French University Hospitals between 2000 and 2020.

Results: We included 49 cases. All children had fever and rash, 69.4% had lymphadenopathy and 65.3% had facial edema. The most common organ affected was the liver (83.7%). Treatment consisted in topical corticosteroid only for 30.6%, systemic corticosteroid for 55.1%; 12.2 % received IVIg. Among culprit drugs of probable and certain probability, 65% were antibiotics and 27.5% antiepileptics, with a median time to DRESS symptom onset after initiation of 15 days (13 days with antibiotics and 21 days with antiepileptics). Twenty-seven children had allergy assessment for causative agents: 65.4% had positive tests.

Conclusions: The culprit drugs are frequently antibiotics and antiepileptic drugs and onset is often less than two weeks after the treatment starts, especially with antibiotics. Treatment with topical corticosteroids appears sufficient in the least severe cases. Treatment by systemic corticosteroid therapy remains the reference treatment in case of severe organ damage.
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http://dx.doi.org/10.1016/j.jaip.2021.07.025DOI Listing
July 2021

A 3-Year-Old Child With Fever, Severe Cheilitis, and Blisters of the Palms and Soles.

Clin Infect Dis 2021 05;72(9):1667-1668

Department of General Pediatrics and Pediatric Infectious Diseases, Necker Hospital for Sick Children, AP-HP, Université de Paris, Paris, France.

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http://dx.doi.org/10.1093/cid/ciaa1699DOI Listing
May 2021

Hypophosphatemic rickets: A rare complication of congenital melanocytic nevus syndrome.

Pediatr Dermatol 2020 May 10;37(3):541-544. Epub 2020 Mar 10.

Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), APHP, Institut Imagine, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France.

We report the case of a child who presented with a giant melanocytic nevus with numerous satellite nevi at birth and developed hypophosphatemic rickets due to excessive secretion of the FGF23 hormone. A NRAS c.182A>G (Q61R) mutation was identified in the lesional skin. The functional outcome was favorable with medical treatment.
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http://dx.doi.org/10.1111/pde.14139DOI Listing
May 2020

An unsual case of palmoplantar keratoderma.

Pediatr Dermatol 2020 Jan;37(1):e17-e19

Department of Dermatology, Reference Centre for Genodermatoses and Rare Skin Disease (MAGEC), Hopital Universitaire Necker-Enfants Malades, APHP, Paris, France.

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http://dx.doi.org/10.1111/pde.14038DOI Listing
January 2020

Severe extensive ecchymotic oedema in the buttock.

J Paediatr Child Health 2018 May;54(5):587

Department of Pediatric, Hospital Robert Debré, Paris, France.

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http://dx.doi.org/10.1111/jpc.1_13887DOI Listing
May 2018
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