Anne Tybjærg-Hansen

Anne Tybjærg-Hansen

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Anne Tybjærg-Hansen

Anne Tybjærg-Hansen

Publications by authors named "Anne Tybjærg-Hansen"

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Identification and Replication of Six Loci Associated With Gallstone Disease.

Hepatology 2019 Aug 4;70(2):597-609. Epub 2019 Mar 4.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/hep.30313DOI Listing
August 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2019 Jul;51(7):1191-1192

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-019-0447-2DOI Listing
July 2019

Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Narrative Review

Curr Vasc Pharmacol 2019 Jul 15. Epub 2019 Jul 15.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

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July 2019

Blood-brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals.

Eur J Epidemiol 2019 Jun 4;34(6):579-590. Epub 2019 Mar 4.

Department of Clinical Biochemistry KB 3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1007/s10654-019-00498-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497814PMC
June 2019

High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase-Lowering Effect of a HSD17B13 Variant.

Hepatology 2019 Jun 3. Epub 2019 Jun 3.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/hep.30799DOI Listing
June 2019

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.

Cardiovasc Diabetol 2019 Jun 4;18(1):71. Epub 2019 Jun 4.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12933-019-0864-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549355PMC
June 2019

Low LDL Cholesterol by PCSK9 Variation Reduces Cardiovascular Mortality.

J Am Coll Cardiol 2019 Jun;73(24):3102-3114

The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jacc.2019.03.517DOI Listing
June 2019

Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort.

Eur Heart J 2019 Jun 24. Epub 2019 Jun 24.

Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehz402DOI Listing
June 2019

Causal Associations in Type 2 Diabetes Development.

J Clin Endocrinol Metab 2019 Apr;104(4):1313-1324

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-01648DOI Listing
April 2019

Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Main Text.

Curr Vasc Pharmacol 2019 ;17(5):498-514

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.2174/1570161117666190507110519DOI Listing
January 2019

Postprandial Hypertriglyceridaemia Revisited in the Era of Non-fasting Lipid Profiles: Executive Summary of a 2019 Expert Panel Statement.

Curr Vasc Pharmacol 2019 ;17(5):538-540

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.2174/1570161117999190517115432DOI Listing
January 2019

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).

Atherosclerosis 2018 10;277:234-255

Imperial Centre for Cardiovascular Disease Prevention (ICCP), Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.051DOI Listing
October 2018

Response to: liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease.

Eur Heart J 2018 Sep;39(36):3399

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark.

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https://academic.oup.com/eurheartj/article/39/36/3399/499267
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http://dx.doi.org/10.1093/eurheartj/ehy250DOI Listing
September 2018

Absolute 10-year risk of dementia by age, sex and genotype: a population-based cohort study.

CMAJ 2018 Sep;190(35):E1033-E1041

Department of Clinical Biochemistry (Rasmussen, Tybjærg-Hansen, Frikke-Schmidt), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry (Rasmussen, Nordestgaard), Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.180066
Publisher Site
http://dx.doi.org/10.1503/cmaj.180066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148649PMC
September 2018

Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease.

Eur Heart J 2018 Jun;39(22):2106-2116

Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehy068DOI Listing
June 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Advances in lipid-lowering therapy through gene-silencing technologies.

Nat Rev Cardiol 2018 05 8;15(5):261-272. Epub 2018 Feb 8.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsveg 3B, 2200 Copenhagen, Denmark.

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http://www.nature.com/doifinder/10.1038/nrcardio.2018.3
Publisher Site
http://dx.doi.org/10.1038/nrcardio.2018.3DOI Listing
May 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2018 05;50(5):765-766

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-018-0050-yDOI Listing
May 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2018 05;50(5):766-767

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-018-0082-3DOI Listing
May 2018

U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies.

Eur Heart J 2018 Apr;39(14):1181-1190

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehx665DOI Listing
April 2018

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Authors:
Anubha Mahajan Jennifer Wessel Sara M Willems Wei Zhao Neil R Robertson Audrey Y Chu Wei Gan Hidetoshi Kitajima Daniel Taliun N William Rayner Xiuqing Guo Yingchang Lu Man Li Richard A Jensen Yao Hu Shaofeng Huo Kurt K Lohman Weihua Zhang James P Cook Bram Peter Prins Jason Flannick Niels Grarup Vassily Vladimirovich Trubetskoy Jasmina Kravic Young Jin Kim Denis V Rybin Hanieh Yaghootkar Martina Müller-Nurasyid Karina Meidtner Ruifang Li-Gao Tibor V Varga Jonathan Marten Jin Li Albert Vernon Smith Ping An Symen Ligthart Stefan Gustafsson Giovanni Malerba Ayse Demirkan Juan Fernandez Tajes Valgerdur Steinthorsdottir Matthias Wuttke Cécile Lecoeur Michael Preuss Lawrence F Bielak Marielisa Graff Heather M Highland Anne E Justice Dajiang J Liu Eirini Marouli Gina Marie Peloso Helen R Warren Saima Afaq Shoaib Afzal Emma Ahlqvist Peter Almgren Najaf Amin Lia B Bang Alain G Bertoni Cristina Bombieri Jette Bork-Jensen Ivan Brandslund Jennifer A Brody Noël P Burtt Mickaël Canouil Yii-Der Ida Chen Yoon Shin Cho Cramer Christensen Sophie V Eastwood Kai-Uwe Eckardt Krista Fischer Giovanni Gambaro Vilmantas Giedraitis Megan L Grove Hugoline G de Haan Sophie Hackinger Yang Hai Sohee Han Anne Tybjærg-Hansen Marie-France Hivert Bo Isomaa Susanne Jäger Marit E Jørgensen Torben Jørgensen Annemari Käräjämäki Bong-Jo Kim Sung Soo Kim Heikki A Koistinen Peter Kovacs Jennifer Kriebel Florian Kronenberg Kristi Läll Leslie A Lange Jung-Jin Lee Benjamin Lehne Huaixing Li Keng-Hung Lin Allan Linneberg Ching-Ti Liu Jun Liu Marie Loh Reedik Mägi Vasiliki Mamakou Roberta McKean-Cowdin Girish Nadkarni Matt Neville Sune F Nielsen Ioanna Ntalla Patricia A Peyser Wolfgang Rathmann Kenneth Rice Stephen S Rich Line Rode Olov Rolandsson Sebastian Schönherr Elizabeth Selvin Kerrin S Small Alena Stančáková Praveen Surendran Kent D Taylor Tanya M Teslovich Barbara Thorand Gudmar Thorleifsson Adrienne Tin Anke Tönjes Anette Varbo Daniel R Witte Andrew R Wood Pranav Yajnik Jie Yao Loïc Yengo Robin Young Philippe Amouyel Heiner Boeing Eric Boerwinkle Erwin P Bottinger Rajiv Chowdhury Francis S Collins George Dedoussis Abbas Dehghan Panos Deloukas Marco M Ferrario Jean Ferrières Jose C Florez Philippe Frossard Vilmundur Gudnason Tamara B Harris Susan R Heckbert Joanna M M Howson Martin Ingelsson Sekar Kathiresan Frank Kee Johanna Kuusisto Claudia Langenberg Lenore J Launer Cecilia M Lindgren Satu Männistö Thomas Meitinger Olle Melander Karen L Mohlke Marie Moitry Andrew D Morris Alison D Murray Renée de Mutsert Marju Orho-Melander Katharine R Owen Markus Perola Annette Peters Michael A Province Asif Rasheed Paul M Ridker Fernando Rivadineira Frits R Rosendaal Anders H Rosengren Veikko Salomaa Wayne H-H Sheu Rob Sladek Blair H Smith Konstantin Strauch André G Uitterlinden Rohit Varma Cristen J Willer Matthias Blüher Adam S Butterworth John Campbell Chambers Daniel I Chasman John Danesh Cornelia van Duijn Josée Dupuis Oscar H Franco Paul W Franks Philippe Froguel Harald Grallert Leif Groop Bok-Ghee Han Torben Hansen Andrew T Hattersley Caroline Hayward Erik Ingelsson Sharon L R Kardia Fredrik Karpe Jaspal Singh Kooner Anna Köttgen Kari Kuulasmaa Markku Laakso Xu Lin Lars Lind Yongmei Liu Ruth J F Loos Jonathan Marchini Andres Metspalu Dennis Mook-Kanamori Børge G Nordestgaard Colin N A Palmer James S Pankow Oluf Pedersen Bruce M Psaty Rainer Rauramaa Naveed Sattar Matthias B Schulze Nicole Soranzo Timothy D Spector Kari Stefansson Michael Stumvoll Unnur Thorsteinsdottir Tiinamaija Tuomi Jaakko Tuomilehto Nicholas J Wareham James G Wilson Eleftheria Zeggini Robert A Scott Inês Barroso Timothy M Frayling Mark O Goodarzi James B Meigs Michael Boehnke Danish Saleheen Andrew P Morris Jerome I Rotter Mark I McCarthy

Nat Genet 2018 04 9;50(4):559-571. Epub 2018 Apr 9.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41588-018-0084-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898373PMC
April 2018

Loss-of-Function Mutations, Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Cardiovascular Risk: Mediation- and Meta-Analyses of 137 895 Individuals.

Arterioscler Thromb Vasc Biol 2018 03 18;38(3):660-668. Epub 2018 Jan 18.

From the Department of Clinical Biochemistry, Rigshospitalet (A.B.W., A.T.-H.), Department of Clinical Biochemistry, Herlev and Gentofte Hospital (B.G.N.), and Copenhagen City Heart Study, Frederiksberg Hospital (B.G.N., A.T.-H.), Copenhagen University Hospital, University of Copenhagen, Denmark; Department of Clinical Biochemistry, Zealand University Hospital, Denmark (A.B.W.); and Copenhagen General Population Study, Herlev and Gentofte Hospital, Denmark (B.G.N., A.T.-H.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310473DOI Listing
March 2018

Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals.

Alzheimers Dement 2018 01 22;14(1):71-80. Epub 2017 Aug 22.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev, Denmark; Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.05.006DOI Listing
January 2018

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2018 01 22;50(1):26-41. Epub 2017 Dec 22.

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-017-0011-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945951PMC
January 2018

and risk of dementia and vascular disease in the Danish population.

Ann Clin Transl Neurol 2018 01 19;5(1):41-51. Epub 2017 Dec 19.

Department of Clinical Biochemistry Rigshospitalet Copenhagen Denmark.

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http://dx.doi.org/10.1002/acn3.506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771325PMC
January 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Using genetics to explore whether the cholesterol-lowering drug ezetimibe may cause an increased risk of cancer.

Int J Epidemiol 2017 12;46(6):1777-1785

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/ije/dyx096DOI Listing
December 2017

Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality.

J Thorac Oncol 2017 11 21;12(11):1664-1672. Epub 2017 Jul 21.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark; The Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.07.008DOI Listing
November 2017

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Nat Genet 2017 Oct 4;49(10):1450-1457. Epub 2017 Sep 4.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224PMC
October 2017

Effect of APOE ε Genotype on Lipoprotein(a) and the Associated Risk of Myocardial Infarction and Aortic Valve Stenosis.

J Clin Endocrinol Metab 2017 09;102(9):3390-3399

Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2017-01049DOI Listing
September 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nat Genet 2017 Jul 22;49(7):1113-1119. Epub 2017 May 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555387PMC
July 2017

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

N Engl J Med 2017 07 24;377(3):211-221. Epub 2017 May 24.

From Regeneron Genetics Center (F.E.D., C.O., C.S., O.G., S.M., C.V.V.H., S.B., L.H., A.L., J.P., N.S., A.J.M., J.D.O., J.G.R., A.R.S., I.B.B., T.M.T., G.D.Y., S.J.M., A. Baras) and Regeneron Pharmaceuticals (V.G., H.M.D., A.Z., W.S., N.S., A.J.M., S.H., A. Bouzelmat, R.Z., B.S., R.P., D.G., G.A.H., W.J.S., P.B., G.D.Y., S.J.M., J.G.) Tarrytown, NY; the Department of Medicine, Division of Translational Medicine and Human Genetics (R.L.D.), and Departments of Surgery (S.D.) and Genetics and Medicine (A.S., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, and Geisinger Health System, Danville (J.B.L., M.F.M., M.D.R., H.L.K., D.H.L., D.J.C.) - both in Pennsylvania; the Division of Endocrinology and Metabolism, Department of Internal Medicine (W.H.H.S., I.-T.L.) and Cardiovascular Center (K.-W.L.), Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), School of Medicine, Chung Shan Medical University (I.-T.L.), and the Department of Medicine, China Medical University (K.-W.L.), Taichung, and School of Medicine, National Yang-Ming University (W.H.H.S., I.-T.L., K.-W.L.), and School of Medicine, National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (X.G., J.I.R., Y.-D.I.C.); the Division of Cardiology, Department of Medicine, Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC (W.E.K., S.H.S.); the Department of Clinical Biochemistry, Rigshospitalet (A.B.W., B.G.N., A.T.-H.), the Copenhagen General Population Study (B.G.N., A.T.-H.) and Department of Clinical Biochemistry (B.G.N.), Herlev and Gentofte Hospital, and the Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, and Faculty of Health and Medical Sciences, University of Copenhagen (B.G.N., A.T.-H.) - all in Copenhagen; and TNO Metabolic Health Research, Gaubius Laboratory, Leiden, the Netherlands (A.M.H., H.M.G.P.).

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http://dx.doi.org/10.1056/NEJMoa1612790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800308PMC
July 2017

Body Mass Index and Risk of Alzheimer's Disease: A Mendelian Randomization Study of 399,536 Individuals.

J Clin Endocrinol Metab 2017 07;102(7):2310-2320

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2017-00195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505195PMC
July 2017

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.

Nat Genet 2017 Jun 24;49(6):842-847. Epub 2017 Apr 24.

The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/ng.3855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562020PMC
June 2017

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

Authors:
Ioanna Tachmazidou Dániel Süveges Josine L Min Graham R S Ritchie Julia Steinberg Klaudia Walter Valentina Iotchkova Jeremy Schwartzentruber Jie Huang Yasin Memari Shane McCarthy Andrew A Crawford Cristina Bombieri Massimiliano Cocca Aliki-Eleni Farmaki Tom R Gaunt Pekka Jousilahti Marjolein N Kooijman Benjamin Lehne Giovanni Malerba Satu Männistö Angela Matchan Carolina Medina-Gomez Sarah J Metrustry Abhishek Nag Ioanna Ntalla Lavinia Paternoster Nigel W Rayner Cinzia Sala William R Scott Hashem A Shihab Lorraine Southam Beate St Pourcain Michela Traglia Katerina Trajanoska Gialuigi Zaza Weihua Zhang María S Artigas Narinder Bansal Marianne Benn Zhongsheng Chen Petr Danecek Wei-Yu Lin Adam Locke Jian'an Luan Alisa K Manning Antonella Mulas Carlo Sidore Anne Tybjaerg-Hansen Anette Varbo Magdalena Zoledziewska Chris Finan Konstantinos Hatzikotoulas Audrey E Hendricks John P Kemp Alireza Moayyeri Kalliope Panoutsopoulou Michal Szpak Scott G Wilson Michael Boehnke Francesco Cucca Emanuele Di Angelantonio Claudia Langenberg Cecilia Lindgren Mark I McCarthy Andrew P Morris Børge G Nordestgaard Robert A Scott Martin D Tobin Nicholas J Wareham Paul Burton John C Chambers George Davey Smith George Dedoussis Janine F Felix Oscar H Franco Giovanni Gambaro Paolo Gasparini Christopher J Hammond Albert Hofman Vincent W V Jaddoe Marcus Kleber Jaspal S Kooner Markus Perola Caroline Relton Susan M Ring Fernando Rivadeneira Veikko Salomaa Timothy D Spector Oliver Stegle Daniela Toniolo André G Uitterlinden Inês Barroso Celia M T Greenwood John R B Perry Brian R Walker Adam S Butterworth Yali Xue Richard Durbin Kerrin S Small Nicole Soranzo Nicholas J Timpson Eleftheria Zeggini

Am J Hum Genet 2017 Jun 25;100(6):865-884. Epub 2017 May 25.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473732PMC
June 2017

Low LDL cholesterol, and genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

BMJ 2017 Apr 24;357:j1648. Epub 2017 Apr 24.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 3, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1136/bmj.j1648DOI Listing
April 2017

Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses.

Exp Gerontol 2017 03 4;89:69-77. Epub 2017 Jan 4.

Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark; Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2017.01.005DOI Listing
March 2017

Rare and low-frequency coding variants alter human adult height.

Authors:
Eirini Marouli Mariaelisa Graff Carolina Medina-Gomez Ken Sin Lo Andrew R Wood Troels R Kjaer Rebecca S Fine Yingchang Lu Claudia Schurmann Heather M Highland Sina Rüeger Gudmar Thorleifsson Anne E Justice David Lamparter Kathleen E Stirrups Valérie Turcot Kristin L Young Thomas W Winkler Tõnu Esko Tugce Karaderi Adam E Locke Nicholas G D Masca Maggie C Y Ng Poorva Mudgal Manuel A Rivas Sailaja Vedantam Anubha Mahajan Xiuqing Guo Goncalo Abecasis Katja K Aben Linda S Adair Dewan S Alam Eva Albrecht Kristine H Allin Matthew Allison Philippe Amouyel Emil V Appel Dominique Arveiler Folkert W Asselbergs Paul L Auer Beverley Balkau Bernhard Banas Lia E Bang Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Heiner Boeing Eric Boerwinkle Carsten A Böger Lori L Bonnycastle Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Amber A Burt Adam S Butterworth David J Carey Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox Gabriel Cuellar-Partida John Danesh Gail Davies Paul I W de Bakker Gert J de Borst Simon de Denus Mark C H de Groot Renée de Mutsert Ian J Deary George Dedoussis Ellen W Demerath Anneke I den Hollander Joe G Dennis Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Alison M Dunning Douglas F Easton Tapani Ebeling Todd L Edwards Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki Jessica D Faul Mary F Feitosa Shuang Feng Ele Ferrannini Marco M Ferrario Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Paul W Franks Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Ayush Giri Giorgia Girotto Scott D Gordon Penny Gordon-Larsen Mathias Gorski Niels Grarup Megan L Grove Vilmundur Gudnason Stefan Gustafsson Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Caroline Hayward Liang He Iris M Heid Kauko Heikkilä Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Lynne J Hocking Mette Hollensted Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Carel B Hoyng Paul L Huang Kristian Hveem M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Min A Jhun Yucheng Jia Xuejuan Jiang Stefan Johansson Marit E Jørgensen Torben Jørgensen Pekka Jousilahti J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Frank Kee Renske Keeman Lambertus A Kiemeney Hidetoshi Kitajima Kirsten B Kluivers Thomas Kocher Pirjo Komulainen Jukka Kontto Jaspal S Kooner Charles Kooperberg Peter Kovacs Jennifer Kriebel Helena Kuivaniemi Sébastien Küry Johanna Kuusisto Martina La Bianca Markku Laakso Timo A Lakka Ethan M Lange Leslie A Lange Carl D Langefeld Claudia Langenberg Eric B Larson I-Te Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Yeheng Liu Yongmei Liu Artitaya Lophatananon Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen David A Mackey Pamela A F Madden Alisa K Manning Satu Männistö Gaëlle Marenne Jonathan Marten Nicholas G Martin Angela L Mazul Karina Meidtner Andres Metspalu Paul Mitchell Karen L Mohlke Dennis O Mook-Kanamori Anna Morgan Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Matthias Nauck Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Ioanna Ntalla Jeffrey R O'Connel Heikki Oksa Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Thomas N Person Ailith Pirie Ozren Polasek Danielle Posthuma Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Paul M Ridker John D Rioux Neil Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Kevin Sandow Yadav Sapkota Naveed Sattar Marjanka K Schmidt Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati Shah Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert Vernon Smith Jennifer A Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Valgerdur Steinthorsdottir Heather M Stringham Michael Stumvoll Praveen Surendran Leen M 't Hart Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Sheila Ulivi Sander W van der Laan Andries R Van Der Leij Cornelia M van Duijn Natasja M van Schoor Jessica van Setten Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Henrik Vestergaard Veronique Vitart Thomas F Vogt Diego Vozzi Mark Walker Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Nicholas J Wareham Helen R Warren Jennifer Wessel Sara M Willems James G Wilson Daniel R Witte Michael O Woods Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao He Zheng Wei Zhou Jerome I Rotter Michael Boehnke Sekar Kathiresan Mark I McCarthy Cristen J Willer Kari Stefansson Ingrid B Borecki Dajiang J Liu Kari E North Nancy L Heard-Costa Tune H Pers Cecilia M Lindgren Claus Oxvig Zoltán Kutalik Fernando Rivadeneira Ruth J F Loos Timothy M Frayling Joel N Hirschhorn Panos Deloukas Guillaume Lettre

Nature 2017 02 1;542(7640):186-190. Epub 2017 Feb 1.

Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1038/nature21039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302847PMC
February 2017

Using Human Genetics to Predict the Effects and Side Effects of Lipoprotein(a) Lowering Drugs.

J Am Coll Cardiol 2016 12;68(25):2773-2775

Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.10.032DOI Listing
December 2016

SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a).

Circ Cardiovasc Genet 2016 Oct 20;9(5):408-418. Epub 2016 Sep 20.

From the Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD (X.Y., L.R.Y., D.M.B., R.A.M., L.C.B.); Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, MD (A.S., C.K., A.T.R.); and Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark (B.G.N., A.T.-H.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001402DOI Listing
October 2016

High body mass index and cancer risk-a Mendelian randomisation study.

Eur J Epidemiol 2016 09 9;31(9):879-92. Epub 2016 Apr 9.

The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.

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http://dx.doi.org/10.1007/s10654-016-0147-5DOI Listing
September 2016

PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis.

J Clin Endocrinol Metab 2016 09 24;101(9):3281-7. Epub 2016 May 24.

Department of Clinical Biochemistry (A.L., B.G.N., M.B., P.R.K.) and The Copenhagen General Population Study (A.L., B.G.N., M.B., A.T.-H., P.R.K.), Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen City Heart Study (B.G.N., M.B., A.T.-H.), Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry (A.T.-H.), Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences (A.L., B.G.N., A.T.-H., P.R.K.), University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2016-1206DOI Listing
September 2016

Lipoprotein(a) and familial hypercholesterolaemia - Authors' reply.

Lancet Diabetes Endocrinol 2016 09 23;4(9):730-731. Epub 2016 Jul 23.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, DK-2730 Herlev, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, DK-2730 Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(16)30147-4DOI Listing
September 2016

Components of the Metabolic Syndrome and Risk of Type 2 Diabetes.

J Clin Endocrinol Metab 2016 08 10;101(8):3212-21. Epub 2016 Jun 10.

Department of Clinical Biochemistry (S.C.W.M., M.B.), Herlev and Gentofte Hospital, 2900 Hellerup, Denmark; Department of Clinical Biochemistry (B.G.N.), Herlev and Gentofte Hospital, and The Copenhagen General Population Study (S.C.W.M., B.G.N., A.T.-H., M.B.), Herlev and Gentofte Hospital, 2730 Herlev, Denmark; Department of Clinical Biochemistry (A.T.-H.), Rigshospitalet, 2100 Copenhagen Ø, Denmark; and Copenhagen University Hospital (S.C.W.M., B.G.N., A.T.-H., M.B.), Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1210/jc.2015-3777DOI Listing
August 2016

High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study.

Lancet Diabetes Endocrinol 2016 07 13;4(7):577-87. Epub 2016 May 13.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(16)30042-0DOI Listing
July 2016

The Sialylation Pathway and Coronary Artery Disease.

N Engl J Med 2016 Jun 18;374(22):2169-71. Epub 2016 May 18.

From the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, and the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.

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http://dx.doi.org/10.1056/NEJMe1604773DOI Listing
June 2016

Plakophilin-2 c.419C>T and risk of heart failure and arrhythmias in the general population.

Eur J Hum Genet 2016 May 12;24(5):732-8. Epub 2015 Aug 12.

Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ejhg.2015.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930081PMC
May 2016

Mutations causative of familial hypercholesterolaemia: screening of 98 098 individuals from the Copenhagen General Population Study estimated a prevalence of 1 in 217.

Eur Heart J 2016 May 22;37(17):1384-94. Epub 2016 Feb 22.

The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

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http://eurheartj.oxfordjournals.org/content/ehj/37/17/1384.f
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http://dx.doi.org/10.1093/eurheartj/ehw028DOI Listing
May 2016

Change in Body Mass Index Associated With Lowest Mortality in Denmark, 1976-2013.

JAMA 2016 May;315(18):1989-96

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark2Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark3Section for Molecular Gen.

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http://dx.doi.org/10.1001/jama.2016.4666DOI Listing
May 2016

Using human genetics to predict the effects and side-effects of drugs.

Curr Opin Lipidol 2016 Apr;27(2):105-11

aDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. bDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://pdfs.journals.lww.com/co-lipidology/2016/04000/Using_
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http://dx.doi.org/10.1097/MOL.0000000000000280DOI Listing
April 2016

Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population.

Atherosclerosis 2016 Mar 29;246:63-70. Epub 2015 Dec 29.

Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.12.038DOI Listing
March 2016

Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease.

Data Brief 2016 Mar 5;6:923-32. Epub 2016 Feb 5.

Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark; Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.dib.2016.01.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753393PMC
March 2016

Increased Baseline C-Reactive Protein Concentrations Are Associated with Increased Risk of Infections: Results from 2 Large Danish Population Cohorts.

Clin Chem 2016 Feb 31;62(2):335-42. Epub 2015 Dec 31.

Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1373/clinchem.2015.249680DOI Listing
February 2016

Response to the Letter: Response to "Use of biomarkers to identify new drug targets and to predict risk of cardiometabolic outcomes" by Abasi A., et al.

J Clin Endocrinol Metab 2016 Feb;101(2):L22-3

Department of Clinical Biochemistry (H.N.H., M.B.), Gentofte Hospital, DK-2900 Gentofte, Denmark; Department of Clinical Biochemistry (B.G.N.), Herlev Hospital, DK-2730 Herlev, Denmark; The Copenhagen City Heart Study (B.G.N., G.B.J., A.T.-H., M.B.), Frederiksberg Hospital, DK-2000 Copenhagen, Denmark; Department of Clinical Biochemistry (A.T.-H.), Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences (H.N.H., B.G.N., G.B.J., A.T.-H., M.B.), Copenhagen University Hospitals, University of Copenhagen, DK-2400 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2015-4386DOI Listing
February 2016

Genetics of Coronary Artery Disease.

Circ Res 2016 Feb;118(4):564-78

From the Department of Medicine, Atherogenomics Laboratory, Division of Cardiology, Ruddy Canadian Cardiovascular Genetics Center, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (R.M.); and Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.T.-H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306566DOI Listing
February 2016

Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-Analyses.

J Clin Endocrinol Metab 2016 Jan 28;101(1):69-78. Epub 2015 Oct 28.

Department of Clinical Biochemistry (H.N.H., M.B.), Gentofte Hospital, 2900 Hellerup, Denmark; Department of Clinical Biochemistry (B.G.N.), Herlev Hospital, 2730 Herlev, Denmark; The Copenhagen City Heart Study (B.G.N., G.B.J., A.T.-H., M.B.), Frederiksberg Hospital, 2000 Frederiksberg, Denmark; Department of Clinical Biochemistry (A.T.-H.), Rigshospitalet, 2100 Copenhagen, Denmark; and Copenhagen University Hospitals (H.N.H., B.G.N., G.B.J., A.T.-H., M.B.), Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2015-2687DOI Listing
January 2016

Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications.

Ageing Res Rev 2016 Jan 15;25:24-41. Epub 2015 Nov 15.

Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2015.11.002DOI Listing
January 2016

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease.

Alzheimers Dement 2015 Dec 13;11(12):1430-1438. Epub 2015 Jun 13.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospitals, Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.04.006DOI Listing
December 2015

ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes.

PLoS One 2014 15;9(12):e114294. Epub 2014 Dec 15.

The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark; Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114294PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266606PMC
November 2015

HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study.

Diabetes 2015 Sep 13;64(9):3328-33. Epub 2015 May 13.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.2337/db14-1603DOI Listing
September 2015

Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease.

Eur Heart J 2015 Jul 4;36(25):1601-8. Epub 2015 Apr 4.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1093/eurheartj/ehv108DOI Listing
July 2015

Novel genes in LDL metabolism--a comprehensive overview.

Curr Opin Lipidol 2015 Jun;26(3):179-87

aDepartment of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital bFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/MOL.0000000000000175DOI Listing
June 2015

Subgroups at high risk for ischaemic heart disease:identification and validation in 67 000 individuals from the general population.

Int J Epidemiol 2015 Feb 30;44(1):117-28. Epub 2014 Oct 30.

Department of Clinical Biochemistry, Rigshospitalet, The Copenhagen General Population Study, Herlev Hospital, The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark, Department of Oncology, Wayne State University, Detroit, USA, Department of Clinical Biochemistry, Gentofte Hospital, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark, Department of Human Genetics, University of Michigan, Ann Arbor, USA and Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/ije/dyu215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339759PMC
February 2015

Remnant cholesterol, low-density lipoprotein cholesterol, and blood pressure as mediators from obesity to ischemic heart disease.

Circ Res 2015 Feb 19;116(4):665-73. Epub 2014 Nov 19.

From the Department of Clinical Biochemistry (A.V., B.G.N.) and The Copenhagen General Population Study (A.V., M.B., A.T.-H., B.G.N.), Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (A.V., M.B., A.T.-H., B.G.N.); Department of Clinical Biochemistry, Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark (M.B.); MRC Integrative Epidemiology Unit, Oakfield House, Oakfield Grove (G.D.S., N.J.T.) and School of Social and Community Medicine (G.D.S., N.J.T.), University of Bristol, United Kingdom; The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Frederiksberg, Denmark (A.T.-H., B.G.N.); and Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (A.T.-H.).

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http://circres.ahajournals.org/content/early/2014/11/19/CIRC
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http://dx.doi.org/10.1161/CIRCRESAHA.116.304846DOI Listing
February 2015

Plasma levels of apolipoprotein E and risk of dementia in the general population.

Ann Neurol 2015 Feb 13;77(2):301-11. Epub 2015 Jan 13.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen; Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.

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http://dx.doi.org/10.1002/ana.24326DOI Listing
February 2015

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Nature 2015 Feb 10;518(7537):102-6. Epub 2014 Dec 10.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [2] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA. [4] Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://www.nature.com/doifinder/10.1038/nature13917
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http://dx.doi.org/10.1038/nature13917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319990PMC
February 2015

Extreme concentrations of endogenous sex hormones, ischemic heart disease, and death in women.

Arterioscler Thromb Vasc Biol 2015 Feb 30;35(2):471-7. Epub 2014 Dec 30.

From the Department of Clinical Biochemistry, Gentofte Hospital (M.B., H.N.H.), Department of Clinical Biochemistry, Herlev Hospital (S.S.V., B.G.N.), Department of Clinical Biochemistry, Rigshospitalet (A.T.-H.), and The Copenhagen City Heart Study, Frederiksberg Hospital (M.B., G.B.J., A.T.-H., B.G.N.), and Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark (M.B., A.T.-H., B.G.N.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304821DOI Listing
February 2015

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Authors:
Daniel I Swerdlow David Preiss Karoline B Kuchenbaecker Michael V Holmes Jorgen E L Engmann Tina Shah Reecha Sofat Stefan Stender Paul C D Johnson Robert A Scott Maarten Leusink Niek Verweij Stephen J Sharp Yiran Guo Claudia Giambartolomei Christina Chung Anne Peasey Antoinette Amuzu KaWah Li Jutta Palmen Philip Howard Jackie A Cooper Fotios Drenos Yun R Li Gordon Lowe John Gallacher Marlene C W Stewart Ioanna Tzoulaki Sarah G Buxbaum Daphne L van der A Nita G Forouhi N Charlotte Onland-Moret Yvonne T van der Schouw Renate B Schnabel Jaroslav A Hubacek Ruzena Kubinova Migle Baceviciene Abdonas Tamosiunas Andrzej Pajak Roman Topor-Madry Urszula Stepaniak Sofia Malyutina Damiano Baldassarre Bengt Sennblad Elena Tremoli Ulf de Faire Fabrizio Veglia Ian Ford J Wouter Jukema Rudi G J Westendorp Gert Jan de Borst Pim A de Jong Ale Algra Wilko Spiering Anke H Maitland-van der Zee Olaf H Klungel Anthonius de Boer Pieter A Doevendans Charles B Eaton Jennifer G Robinson David Duggan John Kjekshus John R Downs Antonio M Gotto Anthony C Keech Roberto Marchioli Gianni Tognoni Peter S Sever Neil R Poulter David D Waters Terje R Pedersen Pierre Amarenco Haruo Nakamura John J V McMurray James D Lewsey Daniel I Chasman Paul M Ridker Aldo P Maggioni Luigi Tavazzi Kausik K Ray Sreenivasa Rao Kondapally Seshasai JoAnn E Manson Jackie F Price Peter H Whincup Richard W Morris Debbie A Lawlor George Davey Smith Yoav Ben-Shlomo Pamela J Schreiner Myriam Fornage David S Siscovick Mary Cushman Meena Kumari Nick J Wareham W M Monique Verschuren Susan Redline Sanjay R Patel John C Whittaker Anders Hamsten Joseph A Delaney Caroline Dale Tom R Gaunt Andrew Wong Diana Kuh Rebecca Hardy Sekar Kathiresan Berta A Castillo Pim van der Harst Eric J Brunner Anne Tybjaerg-Hansen Michael G Marmot Ronald M Krauss Michael Tsai Josef Coresh Ronald C Hoogeveen Bruce M Psaty Leslie A Lange Hakon Hakonarson Frank Dudbridge Steve E Humphries Philippa J Talmud Mika Kivimäki Nicholas J Timpson Claudia Langenberg Folkert W Asselbergs Mikhail Voevoda Martin Bobak Hynek Pikhart James G Wilson Alex P Reiner Brendan J Keating Aroon D Hingorani Naveed Sattar

Lancet 2015 Jan 24;385(9965):351-61. Epub 2014 Sep 24.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/S0140-6736(14)61183-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322187PMC
January 2015

Total and cause-specific mortality by moderately and markedly increased ferritin concentrations: general population study and metaanalysis.

Clin Chem 2014 Nov 25;60(11):1419-28. Epub 2014 Aug 25.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.

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http://dx.doi.org/10.1373/clinchem.2014.229013DOI Listing
November 2014

[The genome and cardiology].

Ugeskr Laeger 2014 Nov;176(46)

Rigshospitalets Enhed for Arvelige Hjerte-sygdomme, Hjertecentret, Rigshospitalet, Blegdamsvej 9, 2100 København Ø.

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November 2014

Loss-of-function mutations in APOC3 and risk of ischemic vascular disease.

N Engl J Med 2014 Jul 18;371(1):32-41. Epub 2014 Jun 18.

From Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen (A.B.J., R.F.-S., B.G.N., A.T.-H.), the Department of Clinical Biochemistry, Rigshospitalet (A.B.J., R.F.-S., A.T.-H.), the Department of Clinical Biochemistry (B.G.N.) and the Copenhagen General Population Study (R.F.-S., B.G.N., A.T.-H.), Herlev Hospital, and the Copenhagen City Heart Study, Frederiksberg Hospital (B.G.N., A.T.-H.) - all in Copenhagen.

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http://dx.doi.org/10.1056/NEJMoa1308027DOI Listing
July 2014

Low nonfasting triglycerides and reduced all-cause mortality: a mendelian randomization study.

Clin Chem 2014 May 16;60(5):737-46. Epub 2014 Jan 16.

Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark;

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http://dx.doi.org/10.1373/clinchem.2013.219881DOI Listing
May 2014

The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease.

J Am Coll Cardiol 2014 May 19;63(20):2121-2128. Epub 2014 Mar 19.

Copenhagen University Hospitals and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.12.055DOI Listing
May 2014

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.

Nat Genet 2014 Apr 16;46(4):352-6. Epub 2014 Feb 16.

McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/ng.2901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969786PMC
April 2014

Visible age-related signs and risk of ischemic heart disease in the general population: a prospective cohort study.

Circulation 2014 Mar 13;129(9):990-8. Epub 2013 Dec 13.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark (M.C., R.F.-S.,A.T.-H.); The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark (P.S., G.B.J., B.G.N., A.T.-H.); the Department of Cardiology, Hvidovre Hospital, Hvidovre, Denmark (G.B.J.); Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark (B.G.N.); and Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark (M.C., R.F.-S., P.S., G.B.J., B.G.N., A.T.-H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.001696DOI Listing
March 2014

Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.

J Am Coll Cardiol 2014 Feb 23;63(5):470-7. Epub 2013 Oct 23.

Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.09.038DOI Listing
February 2014

Response: Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies.

J Am Coll Cardiol 2013 Nov 18;62(20):1908-9. Epub 2013 Sep 18.

Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jacc.2013.08.1615DOI Listing
November 2013