Publications by authors named "Anne Maj van der Velden"

5 Publications

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[Psychological, neurological and cell-mediated mechanisms by mindfulness-based therapy].

Ugeskr Laeger 2019 Jul;181(30)

In this review, we present clinical studies on mindfulness-based therapy (MBT) with a focus on mediating mechanisms for its health promoting effects. These constitute awareness, self-compassion, regulation of dysfunctional patterns of thoughts and emotions, neural network and cellular processes. Among cellular processes are inflammation, oxidative stress, mitochondrial dysfunction and telomere shortening, which all contribute to the molecular pathophysiology of several of today's lifestyle diseases. Finally, we address applications, where strong evidence exists for the clinical impact of MBT.
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July 2019

The impact of mindfulness-based interventions on brain activity: A systematic review of functional magnetic resonance imaging studies.

Neurosci Biobehav Rev 2018 Jan 7;84:424-433. Epub 2017 Aug 7.

Interacting Minds Centre, Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address:

Mindfulness-based interventions are increasingly used in the treatment and prevention of mental health conditions. Despite this, the mechanisms of change for such interventions are only beginning to be understood, with a number of recent studies assessing changes in brain activity. The aim of this systematic review was to assess changes in brain functioning associated with manualised 8-session mindfulness interventions. Searches of PubMed and Scopus databases resulted in 39 papers, 7 of which were eligible for inclusion. The most consistent longitudinal effect observed was increased insular cortex activity following mindfulness-based interventions. In contrast to previous reviews, we did not find robust evidence for increased activity in specific prefrontal cortex sub-regions. These findings suggest that mindfulness interventions are associated with changes in functioning of the insula, plausibly impacting awareness of internal reactions 'in-the-moment'. The studies reviewed here demonstrated a variety of effects across populations and tasks, pointing to the need for greater consistency in future study design.
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http://dx.doi.org/10.1016/j.neubiorev.2017.08.003DOI Listing
January 2018

[Mindfulness-based cognitive therapy is efficient in the treatment of recurrent depression].

Ugeskr Laeger 2017 Jan;179(4)

Mindfulness-based cognitive therapy (MBCT) is an evidence-based psychotherapeutic intervention, which integrates elements of cognitive behavioural therapy for depression with the clinical application of mindfulness meditation. MBCT is currently recommended in several national clinical guidelines as a preventative treatment for recurrent major depressive disorder. Over the last fifteen years there has been a growing interest in MBCT and its clinical potential in the prevention of depressive episodes. In this article, we review the current status of the research in the field.
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January 2017

Neural mechanisms of mindfulness meditation: bridging clinical and neuroscience investigations.

Nat Rev Neurosci 2015 Jul 17;16(7):439. Epub 2015 Jun 17.

Interacting Minds Centre, Aarhus University, 8000 Aarhus, Denmark.

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http://dx.doi.org/10.1038/nrn3916-c1DOI Listing
July 2015

A systematic review of mechanisms of change in mindfulness-based cognitive therapy in the treatment of recurrent major depressive disorder.

Clin Psychol Rev 2015 Apr 11;37:26-39. Epub 2015 Feb 11.

Danish Center for Mindfulness at the Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

Background: The investigation of treatment mechanisms in randomized controlled trials has considerable clinical and theoretical relevance. Despite the empirical support for the effect of mindfulness-based cognitive therapy (MBCT) in the treatment of recurrent major depressive disorder (MDD), the specific mechanisms by which MBCT leads to therapeutic change remain unclear.

Objective: By means of a systematic review we evaluate how the field is progressing in its empirical investigation of mechanisms of change in MBCT for recurrent MDD.

Method: To identify relevant studies, a systematic search was conducted. Studies were coded and ranked for quality.

Results: The search produced 476 articles, of which 23 were included. In line with the theoretical premise, 12 studies found that alterations in mindfulness, rumination, worry, compassion, or meta-awareness were associated with, predicted or mediated MBCT's effect on treatment outcome. In addition, preliminary studies indicated that alterations in attention, memory specificity, self-discrepancy, emotional reactivity and momentary positive and negative affect might play a role in how MBCT exerts its clinical effects.

Conclusion: The results suggest that MBCT could work through some of the MBCT model's theoretically predicted mechanisms. However, there is a need for more rigorous designs that can assess greater levels of causal specificity.
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http://dx.doi.org/10.1016/j.cpr.2015.02.001DOI Listing
April 2015
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