Anne M Murphy

Anne M Murphy

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Anne M Murphy

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Genetic aetiologies should be considered in paediatric cases of acute heart failure presumed to be myocarditis.

Cardiol Young 2019 Jul 14;29(7):917-921. Epub 2019 Jun 14.

Department of Pediatrics, Pediatric Cardiology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1017/S1047951119001124DOI Listing
July 2019

Juvenile Idiopathic Arthritis Associated with Combined JP-HHT Syndrome: A Novel Phenotype Associated with a Novel Variant in .

J Pediatr Genet 2018 Jun 29;7(2):78-82. Epub 2017 Dec 29.

Department of Medical Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

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http://dx.doi.org/10.1055/s-0037-1609060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916806PMC
June 2018

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.

Circ Heart Fail 2017 Sep;10(9)

From the Division of Cardiology, Department of Pediatrics (Y.L., N.O., A.H., G.R.-C., A.M.M.), Division of Cardiology, Department of Medicine (G.Z., N.P., C.T., G.K., D.A.K.), Department of Pharmacology and Molecular Sciences, Department of Biomedical Engineering (D.A.K.), and Deparment of Ophthalmology (P.Z.), Johns Hopkins University, Baltimore, MD; and Istanbul Faculty of Medicine, Istanbul University, Turkey (N.O.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.003850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612410PMC
September 2017

The past, present, and future of paediatric cardiology training at the Johns Hopkins Hospital, in the tradition of Dr Helen Taussig.

Cardiol Young 2016 Dec;26(8):1494-1498

Department of Pediatrics,Division of Pediatric Cardiology,The Johns Hopkins University,Baltimore,Maryland,United States of America.

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https://www.cambridge.org/core/product/identifier/S104795111
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http://dx.doi.org/10.1017/S1047951116001761DOI Listing
December 2016

Comprehensive Versus Targeted Genetic Testing in Children with Hypertrophic Cardiomyopathy.

Pediatr Cardiol 2016 Jun 2;37(5):845-51. Epub 2016 Mar 2.

Johns Hopkins Children's Center M2319, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s00246-016-1358-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899273PMC
June 2016

Proteomics of pediatric heart failure: from traditional biomarkers to new discovery strategies.

Cardiol Young 2015 Aug;25 Suppl 2:51-7

1Department of Pediatrics,Division of Cardiology,Johns Hopkins University School of Medicine,Baltimore,Maryland,United States of America.

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http://dx.doi.org/10.1017/S1047951115000839DOI Listing
August 2015

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.

J Mol Cell Cardiol 2015 May 11;82:93-103. Epub 2015 Mar 11.

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2015.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405491PMC
May 2015

Targeted proteomics of myofilament phosphorylation and other protein posttranslational modifications.

Proteomics Clin Appl 2014 Aug;8(7-8):543-53

Department of Pediatrics/Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/prca.201400034DOI Listing
August 2014

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

Arch Biochem Biophys 2014 Jul 9;554:11-21. Epub 2014 May 9.

Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2014.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121669PMC
July 2014

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

PLoS One 2013 7;8(10):e74847. Epub 2013 Oct 7.

Laboratory for Physiology, Institute for Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands ; Johns Hopkins Bayview Proteomics Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074847PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792062PMC
June 2014

Helen Brooke Taussig: pediatric cardiology leader and innovator.

Adv Pediatr 2013 3;60(1):1-9. Epub 2013 Jul 3.

Pediatric Cardiology, Johns Hopkins University, Ross Building 1144, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.yapd.2013.04.003DOI Listing
April 2014

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Am J Physiol Heart Circ Physiol 2014 Apr 28;306(8):H1171-81. Epub 2014 Feb 28.

Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1152/ajpheart.00580.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989756PMC
April 2014

Characterization of the cardiac myosin binding protein-C phosphoproteome in healthy and failing human hearts.

J Mol Cell Cardiol 2013 Jul 22;60:116-20. Epub 2013 Apr 22.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2013.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710717PMC
July 2013

Healing hearts and minds: can antidepressants repair the heart?

Authors:
Anne M Murphy

J Mol Cell Cardiol 2012 Dec 17;53(6):749-50. Epub 2012 Sep 17.

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https://linkinghub.elsevier.com/retrieve/pii/S00222828120033
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http://dx.doi.org/10.1016/j.yjmcc.2012.09.006DOI Listing
December 2012

Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.

Circulation 2012 Oct 12;126(15):1828-37. Epub 2012 Sep 12.

Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.096388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733556PMC
October 2012

A rasopathy phenotype with severe congenital hypertrophic obstructive cardiomyopathy associated with a PTPN11 mutation and a novel variant in SOS1.

Am J Med Genet A 2012 Jun 14;158A(6):1414-21. Epub 2012 May 14.

McKusick-Nathans Institute of Genetic Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://doi.wiley.com/10.1002/ajmg.a.35363
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http://dx.doi.org/10.1002/ajmg.a.35363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101836PMC
June 2012

Molecular mechanisms of sarcomere dysfunction in dilated and hypertrophic cardiomyopathy.

Prog Pediatr Cardiol 2011 Jan;31(1):29-33

Departments of Pediatrics, Division of Cardiology, Johns Hopkins University School of Medicine.

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http://dx.doi.org/10.1016/j.ppedcard.2010.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032173PMC
January 2011

Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background.

J Mol Cell Cardiol 2010 May 15;48(5):954-63. Epub 2010 Jan 15.

Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yjmcc.2010.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854313PMC
May 2010

Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sites.

J Mol Cell Cardiol 2010 May 18;48(5):943-53. Epub 2010 Jan 18.

Department of Pediatrics/Division of Cardiology, Johns Hopkins University School of Medicine, Ross Bldg 1144/720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854165PMC
May 2010

Mammography screening for breast cancer: a view from 2 worlds.

Authors:
Anne M Murphy

JAMA 2010 Jan;303(2):166-7

Department of Pediatrics, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1001/jama.2009.1991DOI Listing
January 2010

Early childhood development: One developmental paediatrician's story.

Authors:
Anne M Murphy

Paediatr Child Health 2009 Dec;14(10):669-70

Horizon Health Network, Saint John Regional Hospital, Saint John, New Brunswick.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807810PMC
http://dx.doi.org/10.1093/pch/14.10.669DOI Listing
December 2009

Familial hypertrophic cardiomyopathy associated with cardiac beta-myosin heavy chain and troponin I mutations.

Pediatr Cardiol 2008 Jul 4;29(4):846-50. Epub 2008 Jan 4.

Department of Pediatrics, Cardiology Division, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s00246-007-9177-9DOI Listing
July 2008

Impact of modafinil on spasticity reduction and quality of life in children with CP.

Dev Med Child Neurol 2008 Jul;50(7):510-4

Atlantic Health Sciences Corporation, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://doi.wiley.com/10.1111/j.1469-8749.2008.03019.x
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http://dx.doi.org/10.1111/j.1469-8749.2008.03019.xDOI Listing
July 2008

The Blalock-Taussig-Thomas collaboration: a model for medical progress.

JAMA 2008 Jul;300(3):328-30

The Helen B. Taussig Division of Pediatric Cardiology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.30
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http://dx.doi.org/10.1001/jama.300.3.328DOI Listing
July 2008

Cardiac myofilaments: from proteome to pathophysiology.

Proteomics Clin Appl 2008 Jun;2(6):800-10

Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/prca.200780075DOI Listing
June 2008

Community and interjurisdictional legal preparedness.

J Law Med Ethics 2005 ;33(4 Suppl):73-6

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January 2008

Public health ethics in action: flu vaccine and drug allocation strategies.

J Law Med Ethics 2005 ;33(4 Suppl):102-5

Oregon Health & Science University, Portland, USA.

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January 2008

Repairing the myofilaments to heal the heart.

Am J Physiol Heart Circ Physiol 2007 Aug 6;293(2):H907-8. Epub 2007 Apr 6.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1152/ajpheart.00272.2007DOI Listing
August 2007

Nitroxyl increases force development in rat cardiac muscle.

J Physiol 2007 May 1;580(Pt.3):951-60. Epub 2007 Mar 1.

Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Tower 711, 600 N Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1113/jphysiol.2007.129254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075441PMC
May 2007

Local control in thin filament activation of cardiac muscle.

J Physiol 2007 Apr 8;580(Pt. 2):358. Epub 2007 Mar 8.

Department of Anaesthesia and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1113/jphysiol.2007.131672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075562PMC
April 2007

Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function.

Am J Physiol Heart Circ Physiol 2007 Jan 25;292(1):H318-25. Epub 2006 Aug 25.

Dept. of Pediatrics, Johns Hopkins Univ. School of Medicine, 720 Rutland Ave., Ross Bldg. 1144, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1152/ajpheart.00283.2006DOI Listing
January 2007

Heart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament.

Authors:
Anne M Murphy

Congest Heart Fail 2006 Jan-Feb;12(1):32-8; quiz 39-40

Cardiology Division, Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Building 1144, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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April 2006

Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy.

Am J Physiol Heart Circ Physiol 2005 Oct 29;289(4):H1512-8. Epub 2005 Apr 29.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00168.2005
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http://dx.doi.org/10.1152/ajpheart.00168.2005DOI Listing
October 2005

Discovery of disease-induced post-translational modifications in cardiac contractile proteins.

Curr Opin Mol Ther 2005 Jun;7(3):234-9

Johns Hopkins University School of Medicine, Department of Pediatrics, Division of Cardiology, 720 Rutland Avenue, Ross 1144, Baltimore, MD 21205, USA.

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June 2005

Emergency preparedness, response & recovery checklist: beyond the emergency management plan.

J Health Law 2004 ;37(4):503-65

MaineHealth, Family of Healthcare Services, Southern Central, Western Maine, USA.

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March 2005

Detection of a tyrosine phosphatase LAR on intestinal epithelial cells and intraepithelial lymphocytes in the human duodenum.

Mediators Inflamm 2005 Feb;2005(1):23-30

Department of Clinical medicine, Institute of Molecular medicine, Trinity Centre for Health Sciences, Saint James Hospital, Dublin 8, Ireland.

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http://www.hindawi.com/journals/mi/2005/298438/abs/
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http://dx.doi.org/10.1155/MI.2005.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513056PMC
February 2005

Another new kinase targets troponin I.

Authors:
Anne M Murphy

Circ Res 2004 Nov;95(11):1043-5

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http://dx.doi.org/10.1161/01.RES.0000150051.81155.88DOI Listing
November 2004

Augmented systolic response to the calcium sensitizer EMD-57033 in a transgenic model with troponin I truncation.

Am J Physiol Heart Circ Physiol 2004 May 23;286(5):H1785-92. Epub 2003 Dec 23.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1152/ajpheart.00170.2003DOI Listing
May 2004

Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.

Circ Res 2004 Mar 15;94(4):496-504. Epub 2004 Jan 15.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md 21205, USA.

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http://dx.doi.org/10.1161/01.RES.0000117307.57798.F5DOI Listing
March 2004

Workshop on smallpox legal preparedness: what have we learned from smallpox legal preparedness?

J Law Med Ethics 2003 ;31(4 Suppl):39-40

Office of General Counsel, Centers for Disease Control and Prevention, Atlanta, GA, USA.

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March 2004

Legal preparedness for public health emergencies: TOPOFF 2 and other lessons.

J Law Med Ethics 2003 ;31(4 Suppl):43-4

New Mexico House of Representative, Carlsbad, NM, USA.

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March 2004

When public health meets the judiciary.

J Law Med Ethics 2003 ;31(4 Suppl):54-5

Circuit Court of Cook County, Chicago, IL, USA.

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March 2004

What is public health legal preparedness?

J Law Med Ethics 2003 ;31(4):672-83

Illinois Department of Public Health, USA.

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http://deepblue.lib.umich.edu/bitstream/handle/2027.42/71834
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March 2004

C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning.

Circ Res 2003 Nov 9;93(10):917-24. Epub 2003 Oct 9.

Department of Biochemistry , Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1161/01.RES.0000099889.35340.6FDOI Listing
November 2003

125I-BMIPP and 18F-FDG uptake in a transgenic mouse model of stunned myocardium.

Eur J Nucl Med Mol Imaging 2003 Mar;30(3):431-9

Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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March 2003

Troponin I: in sickness and in health-and normal development.

Authors:
Anne M Murphy

Circ Res 2002 Sep;91(6):449-50

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http://dx.doi.org/10.1161/01.res.0000035340.44036.a0DOI Listing
September 2002

Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility.

J Clin Invest 2002 Feb;109(3):393-400

Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/JCI13359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150851PMC
February 2002