Anne J Lenaerts

Anne J Lenaerts

UNVERIFIED PROFILE

Are you Anne J Lenaerts?   Register this Author

Register author
Anne J Lenaerts

Anne J Lenaerts

Publications by authors named "Anne J Lenaerts"

Are you Anne J Lenaerts?   Register this Author

64Publications

829Reads

22Profile Views

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.

Tuberculosis (Edinb) 2019 01 31;114:119-122. Epub 2018 Dec 31.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362843PMC
January 2019

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models.

J Antimicrob Chemother 2017 03;72(3):770-777

Mycobacterial Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkw467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400088PMC
March 2017

Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.

Bioorg Med Chem Lett 2016 Jan 7;26(2):388-391. Epub 2015 Dec 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706794PMC
January 2016

Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models.

Antimicrob Agents Chemother 2015 Nov 24;59(11):6904-12. Epub 2015 Aug 24.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA

View Article

Download full-text PDF

Source
http://aac.asm.org/content/early/2015/08/18/AAC.00459-15.ful
Web Search
http://aac.asm.org/content/59/11/6904.full.pdf
Web Search
http://aac.asm.org/lookup/doi/10.1128/AAC.00459-15
Publisher Site
http://dx.doi.org/10.1128/AAC.00459-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604395PMC
November 2015

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.

Sci Rep 2015 Sep 14;5:13985. Epub 2015 Sep 14.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep13985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568539PMC
September 2015

Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model.

J Pharmacokinet Pharmacodyn 2015 Aug 31;42(4):375-89. Epub 2015 May 31.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10928-015-9419-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506877PMC
August 2015

Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models.

Antimicrob Agents Chemother 2015 Jul 27;59(7):4026-30. Epub 2015 Apr 27.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00105-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468727PMC
July 2015

Nonclinical models for antituberculosis drug development: a landscape analysis.

J Infect Dis 2015 Jun;211 Suppl 3:S83-95

Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://jid.oxfordjournals.org/content/211/suppl_3/S83.full.p
Web Search
http://jid.oxfordjournals.org/lookup/doi/10.1093/infdis/jiv1
Publisher Site
http://dx.doi.org/10.1093/infdis/jiv183DOI Listing
June 2015

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

Dis Model Mech 2015 Jun 30;8(6):591-602. Epub 2015 Mar 30.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.019570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457037PMC
June 2015

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis.

Dis Model Mech 2015 Jun 30;8(6):603-10. Epub 2015 Mar 30.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.019513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457036PMC
June 2015

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

PLoS One 2014 5;9(2):e87909. Epub 2014 Feb 5.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America ; Biomedical Sciences Program, Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914891PMC
November 2014

Isolation and purification of Mycobacterium tuberculosis from H37Rv infected guinea pig lungs.

Tuberculosis (Edinb) 2014 Sep 30;94(5):525-30. Epub 2014 Jun 30.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2014.05.003DOI Listing
September 2014

Improving acid-fast fluorescent staining for the detection of mycobacteria using a new nucleic acid staining approach.

Tuberculosis (Edinb) 2014 Sep 28;94(5):511-8. Epub 2014 Jul 28.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tube.2014.07.004DOI Listing
September 2014

A physiologically based pharmacokinetic model of rifampin in mice.

Antimicrob Agents Chemother 2013 Apr 28;57(4):1763-71. Epub 2013 Jan 28.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01567-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623338PMC
April 2013

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2012 Nov 30;92(6):453-88. Epub 2012 Aug 30.

Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60621-7231, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S147297921200140
Publisher Site
http://dx.doi.org/10.1016/j.tube.2012.07.003DOI Listing
November 2012

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties.

Bioorg Med Chem 2012 Oct 28;20(20):6063-72. Epub 2012 Aug 28.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2012.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582038PMC
October 2012

Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery.

Antimicrob Agents Chemother 2012 Jul 30;56(7):3957-9. Epub 2012 Apr 30.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00464-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393411PMC
July 2012

Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2012 Jun 2;56(6):3181-95. Epub 2012 Apr 2.

Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.

View Article

Download full-text PDF

Source
http://aac.asm.org/content/56/6/3181.full.pdf
Web Search
http://aac.asm.org/cgi/doi/10.1128/AAC.00217-12
Publisher Site
http://dx.doi.org/10.1128/AAC.00217-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370740PMC
June 2012

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer.

Infect Agent Cancer 2012 Jun 18;7(1):14. Epub 2012 Jun 18.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), CP-6109, 13083-865, Campinas, SP, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-9378-7-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408364PMC
June 2012

Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis.

J Med Chem 2012 Apr 6;55(8):3739-55. Epub 2012 Apr 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 881 Madison, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm201608gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375340PMC
April 2012

Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2012 Feb 5;56(2):731-8. Epub 2011 Dec 5.

Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.05701-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264252PMC
February 2012

A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct.

Antimicrob Agents Chemother 2012 Jan 28;56(1):28-35. Epub 2011 Oct 28.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.

View Article

Download full-text PDF

Source
http://aac.asm.org/lookup/doi/10.1128/AAC.05486-11
Publisher Site
http://dx.doi.org/10.1128/AAC.05486-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256082PMC
January 2012

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.

Bioorg Med Chem 2011 Dec 5;19(23):7120-8. Epub 2011 Oct 5.

Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S096808961100797
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2011.09.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216299PMC
December 2011

Lipoarabinomannan localization and abundance during growth of Mycobacterium smegmatis.

J Bacteriol 2011 Oct 12;193(20):5802-9. Epub 2011 Aug 12.

Mycobacteria Research Laboratories, Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.05299-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187192PMC
October 2011

Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2011 Mar 6;55(3):1237-47. Epub 2010 Dec 6.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00595-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067068PMC
March 2011

Torticollis in mice intravenously infected with Mycobacterium tuberculosis.

J Am Assoc Lab Anim Sci 2011 Mar;50(2):244-7

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061426PMC
March 2011

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis.

Antimicrob Agents Chemother 2010 May 16;54(5):1820-33. Epub 2010 Feb 16.

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523-1682, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01521-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863665PMC
May 2010

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

Bioorg Med Chem 2009 May 9;17(10):3588-94. Epub 2009 Apr 9.

Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2009.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756498PMC
May 2009

Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.

Antimicrob Agents Chemother 2009 Jan 13;53(1):306-8. Epub 2008 Oct 13.

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01346-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612139PMC
January 2009

Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2008 Nov 11;52(11):4137-40. Epub 2008 Aug 11.

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00196-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573095PMC
November 2008

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.

J Antimicrob Chemother 2008 Sep 23;62(3):547-54. Epub 2008 May 23.

Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), Universidad de Navarra, C/Irunlarrea s/n, 31080 Pamplona, Spain.

View Article

Download full-text PDF

Source
https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/
Publisher Site
http://dx.doi.org/10.1093/jac/dkn214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574959PMC
September 2008

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.

Antimicrob Agents Chemother 2008 Sep 14;52(9):3321-6. Epub 2008 Jul 14.

Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada, Universidad de Navarra, Irunlarrea, Pamplona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00379-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533452PMC
September 2008

Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.

Antimicrob Agents Chemother 2008 Apr 11;52(4):1513-5. Epub 2008 Feb 11.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00897-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292560PMC
April 2008

Preclinical testing of new drugs for tuberculosis: current challenges.

Trends Microbiol 2008 Feb 7;16(2):48-54. Epub 2008 Jan 7.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tim.2007.12.002DOI Listing
February 2008

Discovery of novel isoxazolines as anti-tuberculosis agents.

Bioorg Med Chem Lett 2007 Dec 15;17(23):6638-42. Epub 2007 Sep 15.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140235PMC
December 2007

Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

Antimicrob Agents Chemother 2007 Sep 21;51(9):3338-45. Epub 2007 May 21.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00276-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043239PMC
September 2007

In vivo adaptation of the Wayne model of latent tuberculosis.

Infect Immun 2007 May 5;75(5):2621-5. Epub 2007 Feb 5.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/IAI.00918-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865751PMC
May 2007

Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability.

Bioorg Med Chem Lett 2006 May 10;16(10):2584-9. Epub 2006 Mar 10.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Ave., Rm 327, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2006.02.048DOI Listing
May 2006

Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents.

J Med Chem 2005 Dec;48(26):8261-9

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm050765nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527484PMC
December 2005

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2005 Oct;49(10):4335-8

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523-1682, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.49.10.4335-4338.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251542PMC
October 2005

Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs.

Int J Antimicrob Agents 2005 Aug;26(2):152-8

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S092485790500139
Publisher Site
http://dx.doi.org/10.1016/j.ijantimicag.2005.04.011DOI Listing
August 2005

Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates.

Tuberculosis (Edinb) 2004 ;84(6):361-4

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S147297920400028
Publisher Site
http://dx.doi.org/10.1016/j.tube.2004.03.002DOI Listing
May 2005

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents.

J Med Chem 2004 Oct;47(21):5276-83

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Room 327, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm049972yDOI Listing
October 2004

Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice.

Antimicrob Agents Chemother 2003 Feb;47(2):783-5

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151769PMC
http://dx.doi.org/10.1128/aac.47.2.783-785.2003DOI Listing
February 2003