Publications by authors named "Anne Claessens"

7 Publications

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The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve.

Gynecol Endocrinol 2016 Jul 1;32(7):534-7. Epub 2016 Feb 1.

c Toronto West Fertility Center , Etobicoke , Canada .

Objective: The objective of this study is to compare the combination of dehydroepiandrosterone (DHEA) and coenzyme Q10 (CoQ10) (D + C) with DHEA alone (D) in intrauterine insemination (IUI) and in vitro fertilization (IVF) cycles among patients with decreased ovarian reserve.

Methods: We retrospectively extracted data from patients charts treated by DHEA with/without CoQ10 during IUI or IVF between February 2006 and June 2014. Prestimulation parameters included age, BMI, day 3 FSH and antral follicular count (AFC). Ovarian response parameters included total gonadotropins dosage, peak serum estradiol, number of follicles > 16 mm and fertilization rate. Clinical outcomes included clinical and ongoing pregnancy rates.

Results: Three hundred and thirty IUI cycles involved D + C compared with 467 cycles of D; 78 IVF cycles involved D + C and 175 D. In both IUI and IVF, AFC was higher with D + C compared with D (7.4 ± 5.7 versus 5.9 ± 4.7, 8.2 ± 6.3 versus 5.2 ± 5, respectively, p < 0.05). D + C resulted in a more follicles > 16 mm during IUI cycles (3.3 ± 2.3 versus 2.9 ± 2.2, respectively, p = 0.01), while lower mean total gonadotropin dosage was administered after D + C supplementation compared with D (3414 ± 1141 IUs versus 3877 ± 1143 IUs respectively, p = 0.032) in IVF cycles. Pregnancy and delivery rates were similar for both IUI and IVF.

Conclusion: D + C significantly increases AFC and improves ovarian responsiveness during IUI and IVF without a difference in clinical outcome.
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http://dx.doi.org/10.3109/09513590.2015.1137095DOI Listing
July 2016

Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination.

Fertil Steril 2009 Jun 23;91(6):2501-7. Epub 2008 May 23.

Toronto Centre For Advanced Reproductive Technologies (TCART), and Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.

Objective: To investigate the effect of a combination of letrozole and gonadotropins in advanced reproductive age infertile women who were treated with IUI.

Design: A retrospective case control study.

Setting: A private practice affiliated with an academic institute.

Patient(s): Infertile women 40 years old and older who were treated with IUI and controlled ovarian hyperstimulation (COH) using either letrozole in combination with FSH (n = 90) or FSH alone (n = 69).

Main Outcome Measure(s): Pregnancy rates (PR), mature follicles, serum levels of E(2), P, LH, endometrial thickness, rates of cycle cancellation, and FSH dose.

Result(s): Pregnancy rates were comparable between the letrozole-FSH co-treatment group and the FSH alone group. Significantly fewer cycles were cancelled in the letrozole co-treatment group. The E(2) levels and the number of follicles were significantly higher in the FSH-only group. Serum levels of LH were significantly higher in the co-treatment group on cycle day 7. The P levels were significantly higher in the FSH alone group on the day of hCG administration.

Conclusion(s): Letrozole co-treatment compared with using FSH alone has significantly modified the cycle characteristics without reducing PRs and could be of potential benefit in IUI cycles in older infertile women.
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http://dx.doi.org/10.1016/j.fertnstert.2008.03.020DOI Listing
June 2009

Don't judge a book by its cover; a quintuplet pregnancy following transfer of five poor-quality embryos.

Fertil Steril 2008 Nov 18;90(5):2007.e13-5. Epub 2008 Apr 18.

Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, Canada.

Objective: To report a case of a quintuplet pregnancy following transfer of five poor-quality cellular-stage embryos.

Design: Case report.

Setting: University of Toronto-affiliated infertility clinic.

Patient(s): A 35-year-old female with a 2-year history of secondary infertility.

Intervention(s): Intracytoplasmic sperm injection and embryo transfer.

Main Outcome Measure(s): Clinical pregnancy.

Result(s): Quintuplet implantation with five fetal hearts.

Conclusion(s): Because the transfer of five poor embryos resulted in a quintuplet implantation, we recommend that embryos with significant morphologic abnormalities, especially in younger patients, be considered as viable embryos with implantation potential.
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http://dx.doi.org/10.1016/j.fertnstert.2008.02.087DOI Listing
November 2008

Ongoing twin pregnancy after rescue intracytoplasmic sperm injection of unfertilized abnormal oocytes.

Fertil Steril 2008 Jul 7;90(1):199.e5-7. Epub 2008 Mar 7.

Toronto Centre for Advanced Reproductive Technology (TCART), Toronto, Canada.

Objective: To report a case of an ongoing twin pregnancy resulting from rescue intracytoplasmic sperm injection (ICSI) after failed fertilization of morphologically abnormal oocytes.

Design: Case report.

Setting: Tertiary center for assisted reproductive technology (ART).

Patient(s): A 28-year-old woman with primary infertility due to tubal obstruction.

Intervention(s): Rescue ICSI after failed IVF insemination.

Main Outcome Measure(s): Clinical pregnancy.

Result(s): Successful ongoing twin pregnancy.

Conclusion(s): With failed fertilization of oocytes with abnormal morphology after IVF, early rescue ICSI may increase the fertilization rates and result in an ongoing pregnancy.
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http://dx.doi.org/10.1016/j.fertnstert.2007.07.1299DOI Listing
July 2008

Successful pregnancy following double-frozen embryo transfer in a patient with repeated implantation failure.

Fertil Steril 2008 Oct 20;90(4):1199.e13-5. Epub 2008 Feb 20.

Toronto Centre for Advanced Reproductive Technology, Toronto, Canada.

Objective: To report a case of successful singleton pregnancy following a novel technique of sequential double transfer of two groups of frozen embryos at the same developmental stage (8-cell) at 5 and 7 days after the LH surge to a patient with seven previous failed assisted reproductive technology (ART) cycles.

Design: Case report.

Setting: University of Toronto affiliated infertility clinic.

Patient: A 27-year-old female with a three-year history of primary infertility.

Intervention: Double frozen embryo transfer of day-3 embryos two days apart in the luteal phase.

Main Outcome Measure(s): Successful pregnancy.

Result(s): Successful singleton pregnancy resulting in the delivery of healthy baby boy.

Conclusion: To the best of our knowledge, the patient is the first to be treated successfully with double frozen-embryo transfer.
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http://dx.doi.org/10.1016/j.fertnstert.2007.08.054DOI Listing
October 2008

The presence of pinopodes in the human endometrium does not delineate the implantation window.

Fertil Steril 2007 May 16;87(5):1015-21. Epub 2007 Jan 16.

Division of Reproductive Sciences, Samuel Lunenfeld Research Institute, and the Fran and Lawrence Bloomberg Department of Obstetrics and Gynecology, Mount Sinai Hospital, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

Objective: To assess pinopode formation in human endometrium during the luteal phase of the menstrual cycle and in the first trimester of pregnancy.

Design: Prospective clinical study.

Setting: Outpatient infertility clinics and outpatient family planning clinic.

Patient(s): Thirty-two regularly cycling infertile women, 15 regularly cycling fertile women, 9 women receiving elective termination of pregnancy, and 1 woman receiving GnRH agonist and hormone therapy addback.

Intervention(s): Endometrial tissue was collected by suction pipelle and examined by scanning electron microscopy for pinopode formation.

Main Outcome Measure(s): Endometrial tissue was scored (0, 1, 2, 3, or 4) depending on the percentage of the surface covered in pinopodes (from 0% to >20% of 100 fields).

Result(s): Pinopodes were present throughout the luteal phase of the menstrual cycle, up to the 11th week of pregnancy, and in the endometrium of the woman on GnRH agonist and hormone therapy.

Conclusion(s): Pinopodes can be detected in the progesterone-exposed endometrium for an extended period of time, in contradistinction to the perception that they are markers for the implantation window in the human endometrium.
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http://dx.doi.org/10.1016/j.fertnstert.2006.08.101DOI Listing
May 2007

Gestational carrier is an optimal method for pregnancy in patients with vaginal agenesis (Rokitansky syndrome).

Int J Fertil Womens Med 2004 Mar-Apr;49(2):79-82

Toronto Centre for Advanced Reproductive Technology, Toronto, Canada.

Objective: To evaluate the results of successful pregnancy for patients with Mayer-Rokitansky-Kuster-Hauser syndrome using a gestational carrier.

Methods: All gestational carrier patients who attended our infertility clinic between 1995 and 2002 were reviewed for this study. Of the patients, 6 women with MRKH syndrome had 12 ovarian stimulation cycles, which resulted in 12 fresh and 5 frozen embryo transfers into six gestational carriers.

Results: The mean number (+/-SD) of embryos obtained per cycle was 4.8 (+/-2.9). Either two (n = 15) or three (n = 2) embryos were transferred to the gestational carrier. Three pregnancies were achieved following fresh embryo transfer, which included one clinical pregnancy that ended in spontaneous abortion, a singleton, and a set of twins. The pregnancy rate for fresh embryo transfer was 25% per retrieval and 50% per patient. No pregnancy was achieved following frozen embryo transfer.

Conclusion: Gestational carrier is shown to be an effective treatment for patients with Mayer-Rokitansky-Kuster-Hauser syndrome.
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August 2004