Anne Caignard

Anne Caignard

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Anne Caignard

Anne Caignard

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CD16NKG2A Natural Killer Cells Infiltrate Breast Cancer-Draining Lymph Nodes.

Cancer Immunol Res 2019 Feb 4;7(2):208-218. Epub 2018 Dec 4.

INSERM U1160, Institut Universitaire d'Hématologie, Hôpital Saint Louis, Paris, France.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0085DOI Listing
February 2019

Tumor-Derived Mesenchymal Stem Cells Use Distinct Mechanisms to Block the Activity of Natural Killer Cell Subsets.

Cell Rep 2017 Sep;20(12):2891-2905

Experimental Pathology Service, Institute of Pathology, CHUV, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 25, 1011 Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.089DOI Listing
September 2017

Patient's Natural Killer Cells in the Era of Targeted Therapies: Role for Tumor Killers.

Front Immunol 2017 12;8:683. Epub 2017 Jun 12.

INSERM U1160, Institut Universitaire d'Hématologie, Hôpital Saint Louis, Paris, France.

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http://dx.doi.org/10.3389/fimmu.2017.00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466965PMC
June 2017

Relevance of serum biomarkers associated with melanoma during follow-up of anti-CTLA-4 immunotherapy.

Int Immunopharmacol 2016 Nov 8;40:466-473. Epub 2016 Oct 8.

INSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2016.09.030DOI Listing
November 2016

Ipilimumab reshapes T cell memory subsets in melanoma patients with clinical response.

Oncoimmunology 2016 Jul 18;5(7):1136045. Epub 2016 Feb 18.

INSERM, UMR-1160, Institut Universitaire d'Hématologie, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Laboratoire d'Immunologie-Histocompatibilité, AP-HP, Hôpital Saint Louis, Paris, France.

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http://dx.doi.org/10.1080/2162402X.2015.1136045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006913PMC
July 2016

Prognostic impact of the expression of NCR1 and NCR3 NK cell receptors and PD-L1 on advanced non-small cell lung cancer.

Oncoimmunology 2017 13;6(1):e1163456. Epub 2016 May 13.

Gustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT), GRCC, Villejuif, France; University of Paris Sud XI, Kremlin Bicêtre, France; Department of Immuno-Oncology, GRCC, Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1163456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283624PMC
May 2016

Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells.

Front Immunol 2016 9;7:94. Epub 2016 Mar 9.

UMRS-1160, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; U 1160, Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Laboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

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http://dx.doi.org/10.3389/fimmu.2016.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783386PMC
March 2016

Classification of current anticancer immunotherapies.

Oncotarget 2014 Dec;5(24):12472-508

Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. INSERM, U1138, Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Pôle de Biologie, Hôpital Européen Georges Pompidou (HEGP), AP-HP, Paris, France.

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https://lirias.kuleuven.be/bitstream/123456789/502976/1/2998
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http://oncotarget.com/abstract/2998
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350348PMC
http://dx.doi.org/10.18632/oncotarget.2998DOI Listing
December 2014

Phenotypic and functional characteristics of blood natural killer cells from melanoma patients at different clinical stages.

PLoS One 2013 18;8(10):e76928. Epub 2013 Oct 18.

Cochin Institute, Institut National de la Sante et de la Recherche Medicale (INSERM) U1016, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, University Paris Descartes, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076928PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799851PMC
August 2014

Expression of IL-27 by tumor cells in invasive cutaneous and metastatic melanomas [corrected]..

PLoS One 2013 10;8(10):e75694. Epub 2013 Oct 10.

Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Université Paris Descartes, Sorbonne Paris Cité, Paris, France ; Service d'Anatomie Pathologique and Université Paris Descartes, Assistance Publique des Hôpitaux de Paris, Hôpital Cochin, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075694PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794994PMC
June 2014

When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma.

Oncoimmunology 2014 14;3:e28048. Epub 2014 Feb 14.

Institut Cochin, INSERM U1016; CNRS UMR 8104; Université Paris Descartes; Paris, France.

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http://dx.doi.org/10.4161/onci.28048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203499PMC
February 2014

Regulation of CD4(+)NKG2D(+) Th1 cells in patients with metastatic melanoma treated with sorafenib: role of IL-15Rα and NKG2D triggering.

Cancer Res 2014 Jan 6;74(1):68-80. Epub 2013 Nov 6.

Authors' Affiliations: Cancer Institute Gustave Roussy; Departments of Epidemiology and Statistics and Dermatology; Stabilité génétique et oncogenèse UMR 8200; Clinical Oncology, Melanoma Branch, Cancer Institute Gustave Roussy; Department of BioPathology, Translational Research Laboratory and Biobank, Institute Gustave Roussy; Institut National de la Santé et de la Recherche Medicale (INSERM), U1015; Center of Clinical Investigations CBT507, Biotherapy, Villejuif; INSERM U1102, Institut de Cancérologie de l'Ouest, Saint Herblain; INSERM, U892, Institut de Recherche Thérapeutique, Nantes; INSERM, U1016, Saint Vincent de Paul Hospital; INSERM U1016, CNRS UMR8104, Cochin Institute; Faculté Paris Sud-Université Paris XI, Paris, France; and IRCCS San Matteo University Hospital Foundation, Pavia, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1186DOI Listing
January 2014

Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma.

Cancer Res 2014 Jan 13;74(1):81-92. Epub 2013 Nov 13.

Authors' Affiliations: INSERM U1016, CNRS UMR 8104, Institut Cochin; APHP, Department of Dermatology, Hospital Cochin, University Paris Descartes; APHP, Department of Dermatology; APHP, Department of Surgery, Hospital Bichat, University Paris Diderot; Surgery Department, Institut Curie, rue d'Ulm-Paris; Hospital Foch, Suresnes; Centre de Recherche des Cordeliers, 15 rue de l'école de médecine; and INSERM U1015 INSERM, Institut Gustave Roussy, Villejuif, Paris, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1303DOI Listing
January 2014

Obesity and renal cancer: Role of adipokines in the tumor-immune system conflict.

Oncoimmunology 2014 Jan 16;3(1):e27810. Epub 2014 Jan 16.

Institut Cochin; INSERM U1016; CNRS UMR 8104; Université Paris Descartes; Paris, France.

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http://dx.doi.org/10.4161/onci.27810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010540PMC
January 2014

NK cells sense tumors, course of disease and treatments: Consequences for NK-based therapies.

Oncoimmunology 2012 Jan;1(1):38-47

Institut Cochin-INSERM U06; CNRS UMR 804; Université Paris Descartes; Paris, France.

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http://dx.doi.org/10.4161/onci.1.1.18312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376977PMC
January 2012

Unique functional status of natural killer cells in metastatic stage IV melanoma patients and its modulation by chemotherapy.

Clin Cancer Res 2011 May 11;17(9):2628-37. Epub 2011 Jan 11.

Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Hôpital Cochin, Nantes, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2084DOI Listing
May 2011

Interleukin-15 is a major regulator of the cell-microenvironment interactions in human renal cancer.

Bull Cancer 2011 May;98(5):32-9

Hôpital Paul-Brousse, université de Paris-Sud, Inserm UMR 1014, 14, avenue Paul-Vaillant-Couturier, 94807 Villejuif Cedex, France.

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http://dx.doi.org/10.1684/bdc.2011.1359DOI Listing
May 2011

Cytokeratin 18 expression pattern correlates with renal cell carcinoma progression: relationship with Snail.

Int J Oncol 2010 May;36(5):1145-54

INSERM, U 753, Laboratoire d'Immunologie des Tumeurs Humaines: Interaction effecteurs cytotoxiques-système tumoral, Institut Gustave Roussy, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.3892/ijo_00000597DOI Listing
May 2010

Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells.

Blood 2008 Sep 23;112(6):2381-9. Epub 2008 Jun 23.

Inserm U753, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1182/blood-2007-12-127779DOI Listing
September 2008

Chemokine receptors expression and migration potential of tumor-infiltrating and peripheral-expanded Vgamma9Vdelta2 T cells from renal cell carcinoma patients.

J Immunother 2008 Apr;31(3):313-23

Institut National de la Santé et de la Recherche Médicale U753, from Institut Fédératif de Recherche 54 Villejuif , France.

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https://insights.ovid.com/crossref?an=00002371-200804000-000
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http://dx.doi.org/10.1097/CJI.0b013e3181609988DOI Listing
April 2008

Human CD5 protects circulating tumor antigen-specific CTL from tumor-mediated activation-induced cell death.

J Immunol 2007 Jun;178(11):6821-7

Laboratoire "Immunologie des tumeurs humaines: Interaction effecteurs cytotoxiques-système tumoral," Institut National de la Santé et de la Recherche Médicale Unité 753, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.4049/jimmunol.178.11.6821DOI Listing
June 2007

Chronic myeloid leukemia and allogeneic natural killer cells: a surprising dialogue.

Expert Rev Clin Immunol 2006 Jul;2(4):627-37

Institut Gustave Roussy, Hematology Department, 94805 Villejuif, France.

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http://dx.doi.org/10.1586/1744666X.2.4.627DOI Listing
July 2006

BCR/ABL promotes dendritic cell-mediated natural killer cell activation.

Cancer Res 2005 Jul;65(14):6409-17

ERM0208 Institut National de la Sante et de la Recherche Medicale, Department of Clinical Biology, Institut Gustave Roussy, Villejuf Cedex, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2675DOI Listing
July 2005

Human NK cells lyse organ-specific endothelial cells: analysis of adhesion and cytotoxic mechanisms.

J Immunol 2005 May;174(9):5573-82

Institut National de la Santé et de la Recherche Médicale, Unité 487, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.4049/jimmunol.174.9.5573DOI Listing
May 2005

Phosphostim-activated gamma delta T cells kill autologous metastatic renal cell carcinoma.

J Immunol 2005 Feb;174(3):1338-47

Institut National de la Santé et de la Recherche Médicale Unité 487, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.4049/jimmunol.174.3.1338DOI Listing
February 2005

NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.

Blood 2004 Nov 8;104(10):3267-75. Epub 2004 Jul 8.

Immunology Unit, ERM0208 Institut National de la Santé et de la Recherche Médicale, Department of Clinical Biology, Institut Gustave Roussy, 39 rue C. Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1182/blood-2004-01-0380DOI Listing
November 2004

[Tumor/cytotoxic effector cross-talk in the control of tumor susceptibility to lysis].

Bull Cancer 2003 Aug-Sep;90(8-9):686-94

Inserm U487, IFR 54, Institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif, France.

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December 2003

CD158 receptor controls cytotoxic T-lymphocyte susceptibility to tumor-mediated activation-induced cell death by interfering with Fas signaling.

Cancer Res 2003 Nov;63(21):7475-82

Institut National de la Santé et de la Recherche Médicale (INSERM) U487, Institut Fédératif de Recherche 54, 94805 Villejuif, France.

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November 2003

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

Blood 2002 Oct;100(8):2874-81

Institut National de la Santé et de la Recherche Médicale (INSERM) U487 and Unité des Thérapies innovantes, Institut Gustave Roussy, and Institut Andre Lwoff-CNRS, Hôpital Paul Brousse, Villejuif, France.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-02-06
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http://dx.doi.org/10.1182/blood-2002-02-0643DOI Listing
October 2002

Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.

Blood 2002 Mar;99(6):2107-13

INSERM 487, Laboratoire de thérapie cellulaire, Institut Gustave Roussy, 39 rue Camille Desmoulins, F-94805 Villejuif, France.

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http://dx.doi.org/10.1182/blood.v99.6.2107DOI Listing
March 2002