Anne Barton

Anne Barton

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Development and validation of a methotrexate adherence assay.

Ann Rheum Dis 2019 Sep 5;78(9):1192-1197. Epub 2019 Jun 5.

Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2019-215446DOI Listing
September 2019

Chromatin interactions reveal novel gene targets for drug repositioning in rheumatic diseases.

Ann Rheum Dis 2019 Aug 15;78(8):1127-1134. Epub 2019 May 15.

Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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http://dx.doi.org/10.1136/annrheumdis-2018-214649DOI Listing
August 2019

Author Correction: Genotypic variability-based genome-wide association study identifies non-additive loci HLA-C and IL12B for psoriasis.

J Hum Genet 2019 Aug;64(8):831

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, M6 8HD, UK.

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http://dx.doi.org/10.1038/s10038-019-0605-5DOI Listing
August 2019

Association of pharmacological biomarkers with treatment response and long-term disability in patients with psoriatic arthritis: results from the Outcomes of Treatment in Psoriatic Arthritis Study Syndicate.

J Rheumatol 2019 Aug 1. Epub 2019 Aug 1.

Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; National Institute of Health Research Manchester Biomedical Research Centre, University of Manchester, Manchester Academic Health Science Centre, Salford Royal Foundation Trust, Manchester, United Kingdom; National Institute of Health Research Manchester Biomedical Research Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester University Foundation Trust, United Kingdom; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Address correspondence to Professor Anne Barton, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, United Kingdom, M13 9PT. Email:

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http://dx.doi.org/10.3899/jrheum.190253DOI Listing
August 2019

A Dashboard for Latent Class Trajectory Modeling: Application in Rheumatoid Arthritis.

Stud Health Technol Inform 2019 Aug;264:911-915

Centre for Health Informatics, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.3233/SHTI190356DOI Listing
August 2019

The predictors of and reasons for non-adherence in an observational cohort of patients with rheumatoid arthritis commencing methotrexate.

Rheumatology (Oxford) 2019 Jul 13. Epub 2019 Jul 13.

NIHR Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kez274DOI Listing
July 2019

Advancing research paradigms and pathophysiological pathways in psoriatic arthritis and ankylosing spondylitis: Proceedings of the 2017 Platform for the Exchange of Expertise and Research (PEER) meeting.

Semin Arthritis Rheum 2019 Jun 15;48(6):1005-1013. Epub 2018 Oct 15.

St. Vincent's University Hospital and Conway Institute for Biomolecular Research, University College Dublin School of Medicine, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.semarthrit.2018.10.008DOI Listing
June 2019

Prediction of infection risk in rheumatoid arthritis patients treated with biologics: are we any closer to risk stratification?

Curr Opin Rheumatol 2019 May;31(3):285-292

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester.

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http://dx.doi.org/10.1097/BOR.0000000000000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443047PMC
May 2019

Can serum interleukin-17 and interleukin-10 levels predict response to biologic treatments in patients with rheumatoid arthritis?

Rheumatology (Oxford) 2019 Apr 27. Epub 2019 Apr 27.

NIHR Manchester BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kez147DOI Listing
April 2019

Adding value to real-world data: the role of biomarkers.

Rheumatology (Oxford) 2019 Apr 16. Epub 2019 Apr 16.

Manchester Academic Health Science Centre, The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kez113DOI Listing
April 2019

Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.

J Immunol Res 2018 14;2018:2624981. Epub 2018 Aug 14.

MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1155/2018/2624981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112073PMC
November 2018

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins.

Genome Med 2018 09 4;10(1):64. Epub 2018 Sep 4.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13073-018-0575-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122744PMC
September 2018

Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS).

Arthritis Res Ther 2018 07 13;20(1):147. Epub 2018 Jul 13.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-018-1645-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044018PMC
July 2018

Prediction of response to methotrexate in rheumatoid arthritis.

Expert Rev Clin Immunol 2018 05 26;14(5):419-429. Epub 2018 Apr 26.

c Professor of Rheumatology, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research , The University of Manchester , Manchester , UK.

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http://dx.doi.org/10.1080/1744666X.2018.1465409DOI Listing
May 2018

Genotypic variability-based genome-wide association study identifies non-additive loci HLA-C and IL12B for psoriasis.

J Hum Genet 2018 Mar 19;63(3):289-296. Epub 2017 Dec 19.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, M6 8HD, UK.

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http://dx.doi.org/10.1038/s10038-017-0350-6DOI Listing
March 2018

Rheumatoid arthritis.

Nat Rev Dis Primers 2018 02 8;4:18001. Epub 2018 Feb 8.

Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://www.nature.com/articles/nrdp20181
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http://dx.doi.org/10.1038/nrdp.2018.1DOI Listing
February 2018

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.

Ann Rheum Dis 2017 12 12;76(12):e51. Epub 2017 May 12.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211512DOI Listing
December 2017

DNA methylation as a marker of response in rheumatoid arthritis.

Pharmacogenomics 2017 Sep 24;18(14):1323-1332. Epub 2017 Aug 24.

Arthritis Research UK Centre for Genetics & Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs-2016-0195DOI Listing
September 2017

Stratified medicine in rheumatoid arthritis-the MATURA programme.

Rheumatology (Oxford) 2017 08;56(8):1247-1250

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, London, UK.

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http://dx.doi.org/10.1093/rheumatology/kew369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850849PMC
August 2017

Precision Medicine in Rheumatoid Arthritis.

Rheum Dis Clin North Am 2017 08;43(3):377-387

Division of Musculoskeletal and Dermal Sciences, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Room 2.607, Stopford Building, Oxford Road, Manchester M13 9PT, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M139WU, UK.

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http://dx.doi.org/10.1016/j.rdc.2017.04.008DOI Listing
August 2017

A rare coding allele in is protective for psoriatic arthritis.

Ann Rheum Dis 2017 Jul 13;76(7):1321-1324. Epub 2017 May 13.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530346PMC
July 2017

Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.

Sci Rep 2017 07 13;7(1):5261. Epub 2017 Jul 13.

Arthritis Research UK Centre for Genetics and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1038/s41598-017-05447-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509675PMC
July 2017

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.

PLoS One 2016 18;11(11):e0166923. Epub 2016 Nov 18.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Siences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166923PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115837PMC
June 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

Genetics of rheumatoid arthritis susceptibility, severity, and treatment response.

Semin Immunopathol 2017 06 29;39(4):395-408. Epub 2017 May 29.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s00281-017-0630-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486781PMC
June 2017

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform.

BMC Microbiol 2017 Jan 21;17(1):23. Epub 2017 Jan 21.

NIHR Manchester Musculoskeletal Biomedical research Unit, Central Manchester Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, England.

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http://bmcmicrobiol.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12866-017-0927-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251215PMC
January 2017

Drug-specific risk and characteristics of lupus and vasculitis-like events in patients with rheumatoid arthritis treated with TNFi: results from BSRBR-RA.

RMD Open 2017 17;3(1):e000314. Epub 2017 Jan 17.

Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2016-00031
Publisher Site
http://dx.doi.org/10.1136/rmdopen-2016-000314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255894PMC
January 2017

A microcosting study of immunogenicity and tumour necrosis factor alpha inhibitor drug level tests for therapeutic drug monitoring in clinical practice.

Rheumatology (Oxford) 2016 Dec 29;55(12):2131-2137. Epub 2016 Aug 29.

Manchester Centre for Health Economics, Institute of Population Health, Manchester Academic Health Science Centre University of Manchester,

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http://dx.doi.org/10.1093/rheumatology/kew292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144665PMC
December 2016

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

Genome Biol 2016 11 1;17(1):212. Epub 2016 Nov 1.

Arthritis Research UK Centre for Genetics and Genomics, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1186/s13059-016-1078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088679PMC
November 2016

Rheumatoid arthritis patient perceptions on the value of predictive testing for treatments: a qualitative study.

BMC Musculoskelet Disord 2016 11 8;17(1):460. Epub 2016 Nov 8.

Arthritis Research UK Centre for Genetics and Genomics Centre for Musculoskeletal Research, Institution of Inflammation and Repair, University of Manchester, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1186/s12891-016-1319-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101686PMC
November 2016

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.

Arthritis Rheumatol 2016 07;68(7):1603-13

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, and University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924598PMC
July 2016

Replication of a distinct psoriatic arthritis risk variant at the IL23R locus.

Ann Rheum Dis 2016 07 25;75(7):1417-8. Epub 2016 Mar 25.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-209290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941176PMC
July 2016

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Pharmacogenomics 2016 05 16;17(7):715-20. Epub 2016 May 16.

Arthritis Research UK, Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.16.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996314PMC
May 2016

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388675PMC
March 2016

Genetic and genomic markers of anti-TNF treatment response in rheumatoid arthritis.

Biomark Med 2015 ;9(6):499-512

Arthritis Research UK Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Institute of Inflammation & Repair, University Of Manchester, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.2217/bmm.15.18DOI Listing
March 2016

One SNP at a Time: Moving beyond GWAS in Psoriasis.

J Invest Dermatol 2016 Mar 22;136(3):567-573. Epub 2016 Jan 22.

The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jid.2015.11.025DOI Listing
March 2016

Psychological factors predict adherence to methotrexate in rheumatoid arthritis; findings from a systematic review of rates, predictors and associations with patient-reported and clinical outcomes.

RMD Open 2016 20;2(1):e000171. Epub 2016 Jan 20.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester , Manchester , UK.

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http://dx.doi.org/10.1136/rmdopen-2015-000171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731843PMC
February 2016

Identifying a novel locus for psoriatic arthritis.

Rheumatology (Oxford) 2016 Jan 8;55(1):25-32. Epub 2015 Aug 8.

Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences and The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kev273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676906PMC
January 2016

Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.

Ann Rheum Dis 2016 Jan 17;75(1):317-20. Epub 2015 Sep 17.

Faculty of Medical and Human Sciences, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-207210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717396PMC
January 2016

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples.

Arthritis Res Ther 2015 Dec 14;17:359. Epub 2015 Dec 14.

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, the University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-015-0868-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704535PMC
December 2015

Association of chemokine CXC ligand 12 gene polymorphism (rs1746048) with cardiovascular mortality in patients with rheumatoid arthritis: results from the Norfolk Arthritis Register.

Ann Rheum Dis 2015 Nov 31;74(11):2099-102. Epub 2015 Aug 31.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://ard.bmj.com/content/74/11/2099.full.pdf
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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20785
Publisher Site
http://dx.doi.org/10.1136/annrheumdis-2015-207851DOI Listing
November 2015

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.

Nat Commun 2015 Nov 30;6:10069. Epub 2015 Nov 30.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/ncomms10069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674669PMC
November 2015

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.

Ann Rheum Dis 2015 Oct 28;74(10):1882-5. Epub 2015 Apr 28.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-207187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602265PMC
October 2015

Pharmacogenetics of treatment response in psoriatic arthritis.

Curr Rheumatol Rep 2015 Jul;17(7):44

Arthritis Research UK Centre for Genetics and Genomics; Centre for Musculoskeletal Research, University of Manchester, Room 2.704, Stopford Building, Oxford Road, Manchester, M13 9PT, UK,

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http://dx.doi.org/10.1007/s11926-015-0518-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435910PMC
July 2015

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Nat Genet 2015 Jul 8;47(7):839-46. Epub 2015 Jun 8.

1] JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. [2] Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754941PMC
July 2015

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Arthritis Rheumatol 2015 May;67(8):2011-9

Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843946PMC
May 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.

Rheumatology (Oxford) 2015 Mar 10;54(3):494-9. Epub 2014 Sep 10.

Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK. Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/keu358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334684PMC
March 2015

Reply: To PMID 24339425.

Arthritis Care Res (Hoboken) 2015 Mar;67(3):452-3

University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/acr.22486DOI Listing
March 2015

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Nat Commun 2015 Feb 5;6:6046. Epub 2015 Feb 5.

1] Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester M13 9PT, UK [2] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester M13 9WU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327416PMC
February 2015

The skin microbiome in psoriatic arthritis: methodology development and pilot data.

Lancet 2015 Feb;385 Suppl 1:S27

Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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February 2015

Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.

Lancet 2015 Feb;385 Suppl 1:S48

Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK.

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February 2015

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.

Ann Rheum Dis 2015 Jan 3;74(1):170-6. Epub 2013 Oct 3.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283663PMC
January 2015

Economics of stratified medicine in rheumatoid arthritis.

Curr Rheumatol Rep 2014 Dec;16(12):468

Manchester Centre for Health Economics, Institute of Population Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

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December 2014

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

The role of genetic polymorphisms regulating vitamin D levels in rheumatoid arthritis outcome: a Mendelian randomisation approach.

Ann Rheum Dis 2014 Jul 20;73(7):1430-3. Epub 2014 Mar 20.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.

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July 2014

Genetic and epigenetic predictors of responsiveness to treatment in RA.

Nat Rev Rheumatol 2014 Jun 18;10(6):329-37. Epub 2014 Feb 18.

Arthritis Research UK Centre of Excellence for Musculoskeletal Genetics, Manchester Academy of Health Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/nrrheum.2014.16DOI Listing
June 2014

The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances.

Rheumatology (Oxford) 2014 May 24;53(5):777-84. Epub 2013 Sep 24.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/rheumatology/ket319DOI Listing
May 2014

Polymorphisms in IL-1B distinguish between psoriasis of early and late onset.

J Invest Dermatol 2014 May 12;134(5):1459-1462. Epub 2013 Nov 12.

The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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May 2014

Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.

Ann Rheum Dis 2014 May 9;73(5):938-40. Epub 2013 Dec 9.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, , Manchester, UK.

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May 2014

Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register.

Ann Rheum Dis 2014 Apr 27;73(4):787-8. Epub 2013 Nov 27.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, , Manchester, UK.

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April 2014

Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.

PLoS Genet 2013 19;9(9):e1003808. Epub 2013 Sep 19.

Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom ; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778023PMC
March 2014

The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases.

Rheumatology (Oxford) 2014 Feb 14;53(2):213-22. Epub 2013 Aug 14.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/rheumatology/ket260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894670PMC
February 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

Arthritis Rheumatol 2014 Jan;66(1):24-30

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/art.38196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285161PMC
January 2014

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Cell 2013 Sep 12;155(1):57-69. Epub 2013 Sep 12.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.cell.2013.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790457PMC
September 2013

The potential use of expression profiling: implications for predicting treatment response in rheumatoid arthritis.

Ann Rheum Dis 2013 Jul 13;72(7):1118-24. Epub 2013 Mar 13.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, School of Translational Medicine, University of Manchester, Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2012-20274
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July 2013