Anne B Young

Anne B Young

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Anne B Young

Anne B Young

Publications by authors named "Anne B Young"

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Sex may influence motor phenotype in a novel rodent model of cerebral palsy.

Neurobiol Dis 2020 Feb 10;134:104711. Epub 2019 Dec 10.

Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nbd.2019.104711DOI Listing
February 2020

Phenotype-genotype discrepancies in the prospective Huntington at-risk observational study.

Ann Clin Transl Neurol 2019 Jun 1;6(6):1046-1052. Epub 2019 May 1.

Massachusetts General Hospital Boston Massachusetts.

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http://dx.doi.org/10.1002/acn3.781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562068PMC
June 2019

Sex may influence motor phenotype in a novel rodent model of cerebral palsy.

Neurobiol Dis 2020 Feb 10;134:104711. Epub 2019 Dec 10.

Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nbd.2019.104711DOI Listing
February 2020

The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.

Adv Neurobiol 2017 ;15:129-161

Centre for Brain Research, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

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http://dx.doi.org/10.1007/978-3-319-57193-5_5DOI Listing
November 2018

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.

J Huntingtons Dis 2016 12;5(4):347-355

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-160226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181668PMC
December 2016

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.

J Huntingtons Dis 2016 12;5(4):347-355

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-160226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181668PMC
December 2016

HTRF analysis of soluble huntingtin in PHAROS PBMCs.

Neurology 2013 Sep 21;81(13):1134-40. Epub 2013 Aug 21.

From the Massachusetts General Hospital (M.M.-L., R.E.G., J.J.R., H.D.R., S.M., A.B.Y., S.M.H.), MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, MA; University of Rochester Medical Center (S.E., D.O.), Department of Biostatistics and Computational Biology, Rochester, NY; Veterans Administration Hospital (W.M.), Bedford, MA; and Program for Regulatory Science & Medicine (I.S.), Georgetown University, Washington, DC.

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http://dx.doi.org/10.1212/WNL.0b013e3182a55edeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795598PMC
September 2013

Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.

J Biol Chem 2012 Apr 27;287(16):13487-99. Epub 2012 Feb 27.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M111.286609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339996PMC
April 2012

Metabotropic glutamate receptor 1 (mGluR1): antibody specificity and receptor expression in cultured primary neurons.

J Neurosci Methods 2012 Mar 2;204(2):221-6. Epub 2011 Dec 2.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, 114 16th Street B114-2000, Boston, MA 02129, United States.

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http://dx.doi.org/10.1016/j.jneumeth.2011.11.014DOI Listing
March 2012

Milestones in huntington disease.

Mov Disord 2011 May;26(6):1127-33

Program for Regulatory Science and Medicine, Georgetown University, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1002/mds.23685DOI Listing
May 2011

Four decades of neurodegenerative disease research: how far we have come!

Authors:
Anne B Young

J Neurosci 2009 Oct;29(41):12722-8

Neurology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3767-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807668PMC
October 2009

Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5.

J Neurochem 2009 Jul 30;110(2):557-69. Epub 2009 Apr 30.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, 02129, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06139.xDOI Listing
July 2009

Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.

Proc Natl Acad Sci U S A 2009 Feb 26;106(8):2892-6. Epub 2009 Jan 26.

Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0812822106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650361PMC
February 2009

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Proc Natl Acad Sci U S A 2007 Oct 9;104(42):16685-9. Epub 2007 Oct 9.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0707842104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034257PMC
October 2007

Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells.

Chem Biol 2006 Jul;13(7):765-70

Massachusetts General Institute for Neurodegenerative Disease and Harvard Medical School, Department of Neurology, Massachusetts General Hospital, Charlestown, 02129, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107455210600180
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http://dx.doi.org/10.1016/j.chembiol.2006.05.012DOI Listing
July 2006

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Proc Natl Acad Sci U S A 2006 Mar 6;103(11):4246-51. Epub 2006 Mar 6.

Center for Cancer Research, Massachusetts Institute of Technology, Room E18-505, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0511256103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449678PMC
March 2006

Interrater agreement in the assessment of motor manifestations of Huntington's disease.

Mov Disord 2005 Mar;20(3):293-7

Oregon Health and Science University, Portland, Oregon 97239-3098, USA.

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http://dx.doi.org/10.1002/mds.20332DOI Listing
March 2005

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.

Hum Mol Genet 2005 Jan 17;14(2):179-89. Epub 2004 Nov 17.

Department of Neurology, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddi014DOI Listing
January 2005

Changes in the expression of the NR2B subunit during aging in macaque monkeys.

Neurobiol Aging 2004 Feb;25(2):201-8

Program in Molecular, Cellular, and Integrative Neurosciences, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1016/s0197-4580(03)00091-5DOI Listing
February 2004

Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology.

Brain Res Mol Brain Res 2003 Nov;119(1):28-36

Department of Neurology, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital, 114 16th Street, B114-2000, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2003.08.009DOI Listing
November 2003

Huntingtin in health and disease.

Authors:
Anne B Young

J Clin Invest 2003 Feb;111(3):299-302

Neurology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://www.jci.org/articles/view/17742
Publisher Site
http://dx.doi.org/10.1172/JCI17742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151871PMC
February 2003

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Hum Mol Genet 2002 Aug;11(17):1939-51

Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4.

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http://dx.doi.org/10.1093/hmg/11.17.1939DOI Listing
August 2002

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

Science 2002 Jun 2;296(5576):2238-43. Epub 2002 May 2.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Center for Aging, Genetics and Neurodegeneration, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.1072613DOI Listing
June 2002

Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease.

Brain Res Mol Brain Res 2002 Jun;102(1-2):118-28

Department of Neurology and Center for Aging, Genetics, and Neurodegeneration, Neurology/B114-2001, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/s0169-328x(02)00216-4DOI Listing
June 2002

Age-related changes in the protein expression of subunits of the NMDA receptor.

Brain Res Mol Brain Res 2002 Feb;99(1):40-5

Department of Anatomy and Neurobiology, Program in Cellular, Molecular, and Integrative Neurosciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1016/s0169-328x(01)00344-8DOI Listing
February 2002