Annamaria Biroccio

Annamaria Biroccio

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Annamaria Biroccio

Annamaria Biroccio

Publications by authors named "Annamaria Biroccio"

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BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells.

Genes (Basel) 2019 09 10;10(9). Epub 2019 Sep 10.

Oncogenomic and Epigenetic Unit, IRCSS Regina Elena National Cancer Institute, Via Elio Chianesi, 53-00144 Rome, Italy.

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http://dx.doi.org/10.3390/genes10090697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771010PMC
September 2019

Dyads of G-Quadruplex Ligands Triggering DNA Damage Response and Tumour Cell Growth Inhibition at Subnanomolar Concentration.

Chemistry 2019 Aug 1;25(47):11085-11097. Epub 2019 Aug 1.

Department of Chemistry, University of Pavia, V. le Taramelli 10, 27100, Pavia, Italy.

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http://dx.doi.org/10.1002/chem.201900766DOI Listing
August 2019

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Nat Commun 2019 07 17;10(1):3143. Epub 2019 Jul 17.

Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1038/s41467-019-11048-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637138PMC
July 2019

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.

EMBO J 2019 06 18;38(11). Epub 2019 Apr 18.

Université Côte d'Azur, Centre National de la Recherche Scientifique (CNRS) UMR7284, Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France

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http://dx.doi.org/10.15252/embj.2018100012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545744PMC
June 2019

Tailoring a lead-like compound targeting multiple G-quadruplex structures.

Eur J Med Chem 2019 Feb 27;163:295-306. Epub 2018 Nov 27.

Department of Chemical Sciences, University of Naples Federico II, 80126, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.058DOI Listing
February 2019

Emerging roles of telomeric chromatin alterations in cancer.

J Exp Clin Cancer Res 2019 Jan 17;38(1):21. Epub 2019 Jan 17.

Oncogenomic and Epigenetic Unit, IRCCS-Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1030-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337846PMC
January 2019

Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?

J Exp Clin Cancer Res 2017 12 22;36(1):189. Epub 2017 Dec 22.

Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Via Elio Chianesi, 53 -, 00144, Rome, Italy.

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http://dx.doi.org/10.1186/s13046-017-0657-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741932PMC
December 2017

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.

Biochim Biophys Acta Gen Subj 2017 May 9;1861(5 Pt B):1362-1370. Epub 2016 Nov 9.

Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.11.010DOI Listing
May 2017

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

Biochim Biophys Acta Gen Subj 2017 May 24;1861(5 Pt B):1341-1352. Epub 2017 Jan 24.

Department of Chemical Sciences, University of Naples Federico II, Naples 80126, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.01.024DOI Listing
May 2017

Patient-derived xenografts: a relevant preclinical model for drug development.

J Exp Clin Cancer Res 2016 12 5;35(1):189. Epub 2016 Dec 5.

UOSD SAFU, Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.

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http://dx.doi.org/10.1186/s13046-016-0462-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139018PMC
December 2016

A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications.

Org Biomol Chem 2016 Jul;14(30):7238-49

Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, via Gobetti 101, 40129 Bologna, Italy.

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http://dx.doi.org/10.1039/c6ob00987eDOI Listing
July 2016

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Mol Cell 2016 Feb 31;61(3):449-460. Epub 2015 Dec 31.

Genome Stability and Tumourigenesis Group, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901PMC
February 2016

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.

PLoS Genet 2015 Jun 25;11(6):e1005167. Epub 2015 Jun 25.

Dipartimento di Biologia e Biotecnologie, Sapienza-Università di Roma, Roma, Italy; Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza-Università di Roma, Roma, Italy; Istituto di Biologia e Patologia Molecolari del CNR, Sapienza-Università di Roma, Roma, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1005167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481533PMC
June 2015

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules.

ChemMedChem 2015 Apr 18;10(4):640-9. Epub 2015 Feb 18.

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131, Napoli (Italy).

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http://doi.wiley.com/10.1002/cmdc.201402552
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http://dx.doi.org/10.1002/cmdc.201402552DOI Listing
April 2015

Identification of novel interactors of human telomeric G-quadruplex DNA.

Chem Commun (Camb) 2015 Feb;51(14):2964-7

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.

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http://dx.doi.org/10.1039/c4cc07231fDOI Listing
February 2015

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage.

Org Biomol Chem 2014 Dec 3;12(47):9572-82. Epub 2014 Nov 3.

University of Rome "Sapienza", Department of Chemistry, Piazzale Aldo Moro 5, Roma 00185, Italy.

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http://dx.doi.org/10.1039/c4ob01658kDOI Listing
December 2014

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

J Exp Clin Cancer Res 2014 Oct 6;33:81. Epub 2014 Oct 6.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, via delle Messi d'Oro 156, 00158, Rome, Italy.

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http://dx.doi.org/10.1186/s13046-014-0081-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193996PMC
October 2014

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.

Nucleic Acids Res 2014 Mar 11;42(5):2945-57. Epub 2013 Dec 11.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy, Laboratory of Molecular Pathology, Department of Pharmacy, University of Naples "Federico II", Naples, Italy, Department of Clinical and Molecular Medicine, University of Rome "La Sapienza", Rome, Italy, Laboratory of Molecular Pathology, Regina Elena National Cancer Institute, Rome, Italy, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice University, CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France and Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, France.

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http://dx.doi.org/10.1093/nar/gkt1289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950687PMC
March 2014

Methods of studying telomere damage induced by quadruplex-ligand complexes.

Methods 2012 May 4;57(1):93-9. Epub 2012 Mar 4.

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.ymeth.2012.02.010DOI Listing
May 2012

Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells.

J Thorac Oncol 2011 Mar;6(3):583-91

Department for the Development of Therapeutic Programs, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1097/JTO.0b013e31820cdd6fDOI Listing
March 2011

Antiproliferative effect of Aurora kinase targeting in mesothelioma.

Lung Cancer 2010 Dec 3;70(3):271-9. Epub 2010 Apr 3.

Gene Expression Core-Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics, CNR, Naples, Italy.

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http://dx.doi.org/10.1016/j.lungcan.2010.03.005DOI Listing
December 2010

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.

Proc Natl Acad Sci U S A 2009 Feb 6;106(8):2806-11. Epub 2009 Feb 6.

Laboratories of Molecular Pathology, Experimental Chemotherapy, and Immunology, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0807158106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650347PMC
February 2009

Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells.

Mol Pharmacol 2007 Oct 12;72(4):1015-23. Epub 2007 Jul 12.

Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.03
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http://dx.doi.org/10.1124/mol.107.038687DOI Listing
October 2007

Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer.

Prostate 2007 Sep;67(13):1475-85

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1002/pros.20636DOI Listing
September 2007

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells.

Eur J Cancer 2006 Aug 5;42(12):1881-8. Epub 2006 Jun 5.

Experimental Chemotherapy Laboratory, Experimental Research Centre, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, Rome 00158, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S095980490600333
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http://dx.doi.org/10.1016/j.ejca.2006.03.010DOI Listing
August 2006

c-Myc phosphorylation is required for cellular response to oxidative stress.

Mol Cell 2006 Feb;21(4):509-19

Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Rome, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650600010
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http://dx.doi.org/10.1016/j.molcel.2006.01.009DOI Listing
February 2006

Antisense clusterin oligodeoxynucleotides increase the response of HER-2 gene amplified breast cancer cells to Trastuzumab.

J Cell Physiol 2005 Aug;204(2):463-9

Experimental Chemotherapy Laboratory, "Centro di Ricerca Sperimentale", Regina Elena Cancer Institute, Rome, Italy.

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http://doi.wiley.com/10.1002/jcp.20295
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http://dx.doi.org/10.1002/jcp.20295DOI Listing
August 2005

Potentiation of the antitumoral activity of gemcitabine and paclitaxel in combination on human breast cancer cells.

Cancer Biol Ther 2005 Aug;4(8):866-71

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.4161/cbt.4.8.1895DOI Listing
August 2005

Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents.

Neoplasia 2004 May-Jun;6(3):195-206

Experimental Chemotherapy Laboratory, Experimental Research Center, Regina Elena Cancer Institute, Rome 00158, Italy.

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http://dx.doi.org/10.1593/neo.3370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502103PMC
December 2004

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.

Mol Pharmacol 2004 Nov 10;66(5):1138-46. Epub 2004 Aug 10.

Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, University La Sapienza, Roma, Italy.

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http://dx.doi.org/10.1124/mol.104.001537DOI Listing
November 2004

Telomerase as a new target for the treatment of hormone-refractory prostate cancer.

Endocr Relat Cancer 2004 Sep;11(3):407-21

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1677/erc.1.00764DOI Listing
September 2004

Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis.

J Biol Chem 2003 Sep 24;278(37):35693-701. Epub 2003 Jun 24.

Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1074/jbc.M304597200DOI Listing
September 2003

The future of antisense therapy: combination with anticancer treatments.

Oncogene 2003 Sep;22(42):6579-88

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy.

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http://www.nature.com/articles/1206812
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http://dx.doi.org/10.1038/sj.onc.1206812DOI Listing
September 2003

Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells.

Mol Pharmacol 2003 Mar;63(3):632-8

Experimental Chemotherapy Laboratory, Centro di Ricerca Sperimentale, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1124/mol.63.3.632DOI Listing
March 2003

Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy.

J Clin Oncol 2003 Mar;21(5):927-31

Neuroscience Department, Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1200/JCO.2003.05.139DOI Listing
March 2003

Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells.

J Biol Chem 2002 Nov 10;277(46):43763-70. Epub 2002 Sep 10.

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro, 00158 Rome, Italy.

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http://dx.doi.org/10.1074/jbc.M207684200DOI Listing
November 2002

Endothelin-1 acts as a survival factor in ovarian carcinoma cells.

Clin Sci (Lond) 2002 Aug;103 Suppl 48:302S-305S

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1042/CS103S302SDOI Listing
August 2002