Publications by authors named "Anna K Mapp"

70Publications

Unexpected specificity within dynamic transcriptional protein-protein complexes.

Proc Natl Acad Sci U S A 2020 Oct 19. Epub 2020 Oct 19.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109;

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http://dx.doi.org/10.1073/pnas.2013244117DOI Listing
October 2020

Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα.

ACS Med Chem Lett 2020 Oct 21;11(10):1913-1918. Epub 2020 May 21.

Department of Chemistry, Willard-Henry-Dow Laboratory, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549252PMC
October 2020

Selective Modulation of Dynamic Protein Complexes.

Cell Chem Biol 2020 Aug 11;27(8):986-997. Epub 2020 Aug 11.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469457PMC
August 2020

Electron-deficient p-benzoyl-l-phenylalanine derivatives increase covalent chemical capture yields for protein-protein interactions.

Protein Sci 2019 06 29;28(6):1163-1170. Epub 2019 Apr 29.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/pro.3621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511736PMC
June 2019

Collision-Induced Unfolding Reveals Unique Fingerprints for Remote Protein Interaction Sites in the KIX Regulation Domain.

J Am Soc Mass Spectrom 2019 Jan 22;30(1):94-102. Epub 2018 Aug 22.

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s13361-018-2043-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320266PMC
January 2019

Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide.

Chem Commun (Camb) 2018 Aug;54(67):9286-9289

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

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http://dx.doi.org/10.1039/c8cc04530eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163058PMC
August 2018

Modulating the masters: chemical tools to dissect CBP and p300 function.

Curr Opin Chem Biol 2018 08 17;45:195-203. Epub 2018 Jul 17.

Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469456PMC
August 2018

Covalent Chemical Cochaperones of the p300/CBP GACKIX Domain.

Chembiochem 2018 09 5;19(18):1907-1912. Epub 2018 Sep 5.

University of Michigan, Life Sciences Institute, 210 Washentaw Avenue, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1002/cbic.201800173DOI Listing
September 2018

Protein cross-linking capillary electrophoresis at increased throughput for a range of protein-protein interactions.

Analyst 2018 Apr;143(8):1805-1812

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. and Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1039/C7AN02098HDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902653PMC
April 2018

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

J Biol Chem 2018 02 18;293(7):2370-2380. Epub 2017 Dec 18.

the Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94158

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http://dx.doi.org/10.1074/jbc.RA117.000634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818200PMC
February 2018

From Fuzzy to Function: The New Frontier of Protein-Protein Interactions.

Acc Chem Res 2017 03;50(3):584-589

Life Sciences Institute, University of Michigan , Ann Arbor, Michigan 48109-2216, United States.

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http://dx.doi.org/10.1021/acs.accounts.6b00565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786153PMC
March 2017

A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein-Protein Interactions.

Chembiochem 2017 Jan 14;18(2):181-184. Epub 2016 Dec 14.

Chemistry Department, University of Michigan, 930 N. University Avenue, Ann Arbor, MI, 48109, USA.

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http://doi.wiley.com/10.1002/cbic.201600578
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http://dx.doi.org/10.1002/cbic.201600578DOI Listing
January 2017

A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling.

Angew Chem Int Ed Engl 2016 11 28;55(48):14997-15001. Epub 2016 Oct 28.

Department of Chemistry, University of Michigan, Ann Arbor, USA.

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http://doi.wiley.com/10.1002/anie.201607990
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http://dx.doi.org/10.1002/anie.201607990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587901PMC
November 2016

Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture.

J Am Chem Soc 2016 09 20;138(38):12629-35. Epub 2016 Sep 20.

The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/jacs.6b07680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217703PMC
September 2016

TRIC: Capturing the direct cellular targets of promoter-bound transcriptional activators.

Protein Sci 2016 08 13;25(8):1371-7. Epub 2016 Jun 13.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/pro.2951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972194PMC
August 2016

Targeting transcription is no longer a quixotic quest.

Nat Chem Biol 2015 Dec;11(12):891-4

Life Sciences Institute and the Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076862PMC
http://dx.doi.org/10.1038/nchembio.1962DOI Listing
December 2015

Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks.

Front Bioeng Biotechnol 2015 24;3:119. Epub 2015 Aug 24.

Program in Chemical Biology, Life Sciences Institute, University of Michigan , Ann Arbor, MI , USA ; Department of Pharmaceutical Chemistry, Institute for Neurodegenerative Diseases, University of California San Francisco , San Francisco, CA , USA.

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http://dx.doi.org/10.3389/fbioe.2015.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547496PMC
September 2015

miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma.

Mol Cancer Ther 2015 Oct 30;14(10):2313-20. Epub 2015 Jul 30.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-1071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596782PMC
October 2015

Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.

Proc Natl Acad Sci U S A 2014 Aug 21;111(33):12061-6. Epub 2014 Jul 21.

Program in Chemical Biology,Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109Departments of Chemistry and

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http://dx.doi.org/10.1073/pnas.1406033111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143068PMC
August 2014

Prepaying the entropic cost for allosteric regulation in KIX.

Proc Natl Acad Sci U S A 2014 Aug 7;111(33):12067-72. Epub 2014 Jul 7.

Departments of Chemistry andBiophysics, and

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http://dx.doi.org/10.1073/pnas.1405831111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143015PMC
August 2014

FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions.

Medchemcomm 2014 Mar;5:370-375

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States ; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States ; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1039/C3MD00356FDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005387PMC
March 2014

Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor.

Mol Endocrinol 2014 Feb 1;28(2):249-59. Epub 2014 Jan 1.

Department of Chemistry (J.W.H.,Y.I., J.P.C., A.K.M.), University of Michigan, and Department of Pharmacology (O.C.-R., J.A.I.-L.), University of Michigan Medical School, Ann Arbor, Michigan 48109; and Department of Chemistry and Biochemistry (A.R.V.D.), Fairfield University, Fairfield, Connecticut 06824.

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http://dx.doi.org/10.1210/me.2013-1343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896636PMC
February 2014

Direct measurements of oscillatory glycolysis in pancreatic islet β-cells using novel fluorescence resonance energy transfer (FRET) biosensors for pyruvate kinase M2 activity.

J Biol Chem 2013 Nov 7;288(46):33312-22. Epub 2013 Oct 7.

From the Department of Pharmacology and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan 48105.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.508127
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http://dx.doi.org/10.1074/jbc.M113.508127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829177PMC
November 2013

Genetic and chemical targeting of epithelial-restricted with serine box reduces EGF receptor and potentiates the efficacy of afatinib.

Mol Cancer Ther 2013 Aug 30;12(8):1515-25. Epub 2013 May 30.

Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746004PMC
August 2013

Ordering a dynamic protein via a small-molecule stabilizer.

J Am Chem Soc 2013 Mar 22;135(9):3363-6. Epub 2013 Feb 22.

Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/ja3122334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607081PMC
March 2013

Fine-tuning multiprotein complexes using small molecules.

ACS Chem Biol 2012 Aug 23;7(8):1311-20. Epub 2012 Jul 23.

Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1021/cb300255pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517816PMC
August 2012

Synergistic enhancement of the potency and selectivity of small molecule transcriptional inhibitors.

ACS Med Chem Lett 2012 Jan;3(1):30-34

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1021/ml200186rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285112PMC
January 2012

Transforming ligands into transcriptional regulators: building blocks for bifunctional molecules.

Chem Soc Rev 2011 Aug 23;40(8):4286-94. Epub 2011 Jun 23.

Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1039/c1cs15050bDOI Listing
August 2011

Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator.

J Biol Chem 2011 May 12;286(18):16238-45. Epub 2011 Feb 12.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M110.207589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091231PMC
May 2011

Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators.

Biopolymers 2011 Jan;95(1):17-23

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1002/bip.21548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535496PMC
January 2011

Palladium-catalyzed [3,3]-rearrangement for the facile synthesis of allenamides.

Org Lett 2010 Jun;12(11):2574-7

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ol1007845DOI Listing
June 2010

Transcriptional switches: chemical approaches to gene regulation.

J Biol Chem 2010 Apr 10;285(15):11033-8. Epub 2010 Feb 10.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.R109.075044
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http://dx.doi.org/10.1074/jbc.R109.075044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856975PMC
April 2010

Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.

Bioorg Med Chem Lett 2009 Nov 1;19(21):6233-6. Epub 2009 Sep 1.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.08.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782467PMC
November 2009

Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator.

J Am Chem Soc 2009 Oct;131(40):14240-2

Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja904378zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182099PMC
October 2009

Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer.

Cancer Res 2009 Jul 30;69(14):5829-34. Epub 2009 Jun 30.

Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757013PMC
July 2009

Tra1 as a screening target for transcriptional activation domain discovery.

Bioorg Med Chem Lett 2009 Jul 18;19(14):3733-5. Epub 2009 May 18.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322765PMC
July 2009

Research into selective biomarkers of erythrocyte exposure to organophosphorus compounds.

Anal Biochem 2009 Sep 2;392(2):155-61. Epub 2009 Jun 2.

Department of Biological Chemistry, University of Michigan, 3301D MSRB III, Ann Arbor, MI 48109-0606, USA.

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http://dx.doi.org/10.1016/j.ab.2009.05.049DOI Listing
September 2009

Expanding the repertoire of small molecule transcriptional activation domains.

Bioorg Med Chem 2009 Feb 16;17(3):1034-43. Epub 2008 Feb 16.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.02.045DOI Listing
February 2009

Transcriptional up-regulation in cells mediated by a small molecule.

J Am Chem Soc 2007 Sep 11;129(35):10654-5. Epub 2007 Aug 11.

Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0736865
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http://dx.doi.org/10.1021/ja0736865DOI Listing
September 2007

Disrupting mediator with a short peptide ligand.

Chembiochem 2007 Jul;8(11):1233-6

Department of Medicinal Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1002/cbic.200700062DOI Listing
July 2007

A TAD further: exogenous control of gene activation.

ACS Chem Biol 2007 Jan;2(1):62-75

Department of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/cb600463wDOI Listing
January 2007

Graduate education chemical biology at the University of Michigan.

ACS Chem Biol 2006 Sep;1(8):487-8

Chemical Biology Doctoral Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.

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http://dx.doi.org/10.1021/cb600315rDOI Listing
September 2006

[3,3]-rearrangements of phosphonium ylides.

J Am Chem Soc 2006 Apr;128(14):4576-7

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja058746qDOI Listing
April 2006

Stereochemical promiscuity in artificial transcriptional activators.

J Am Chem Soc 2005 Sep;127(36):12456-7

Department of Chemistry and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja0536567DOI Listing
September 2005

Chemical approaches to transcriptional regulation.

Curr Opin Chem Biol 2005 Oct;9(5):467-74

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S136759310500109
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http://dx.doi.org/10.1016/j.cbpa.2005.08.012DOI Listing
October 2005

Artificial transcriptional activation domains.

Chembiochem 2005 Aug;6(8):1311-5

Department of Chemistry, University of Michigan, 930 N University Avenue, Ann Arbor, MI 48109-1055, USA.

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http://doi.wiley.com/10.1002/cbic.200500036
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http://dx.doi.org/10.1002/cbic.200500036DOI Listing
August 2005

Unraveling the mechanism of a potent transcriptional activator.

J Biol Chem 2005 Aug 10;280(33):29689-98. Epub 2005 May 10.

Department of Biochemistry, University of Wisconsin, Madison, 53706, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M504895200
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http://dx.doi.org/10.1074/jbc.M504895200DOI Listing
August 2005

Thermal and catalyzed [3,3]-phosphorimidate rearrangements.

J Am Chem Soc 2005 May;127(18):6712-8

Departments of Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1021/ja050759gDOI Listing
May 2005

Succinct synthesis of beta-amino acids via chiral isoxazolines.

J Am Chem Soc 2005 Apr;127(15):5376-83

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

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http://dx.doi.org/10.1021/ja0431713DOI Listing
April 2005

Functional specificity of artificial transcriptional activators.

Chem Biol 2005 Mar;12(3):313-21

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107455210500036
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http://dx.doi.org/10.1016/j.chembiol.2005.01.014DOI Listing
March 2005

Finding their groove; bifunctional molecules arrest growth of cancer cells.

Authors:
Anna K Mapp

Chem Biol 2004 Nov;11(11):1480-2

Department of Chemistry, University of Michigan, Ann Arbor, MI 48104, USA.

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http://dx.doi.org/10.1016/j.chembiol.2004.11.002DOI Listing
November 2004

A small molecule transcriptional activation domain.

J Am Chem Soc 2004 Sep;126(34):10504-5

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0473889
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http://dx.doi.org/10.1021/ja0473889DOI Listing
September 2004

A phosphorimidate rearrangement for the facile and selective preparation of allylic amines.

J Am Chem Soc 2004 May;126(17):5364-5

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja0490469DOI Listing
May 2004

Targeting the transcriptional machinery with unique artificial transcriptional activators.

J Am Chem Soc 2003 Oct;125(41):12390-1

Departments of Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja036685vDOI Listing
October 2003

Regulating transcription: a chemical perspective.

Authors:
Anna K Mapp

Org Biomol Chem 2003 Jul;1(13):2217-20

Department of Chemistry and Department of Medicinal Chemistry, University of Michigan, MI, USA.

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http://dx.doi.org/10.1039/b302656fDOI Listing
July 2003

A concise approach to structurally diverse beta-amino acids.

J Am Chem Soc 2003 Jun;125(23):6846-7

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ja0298747DOI Listing
June 2003

Modular design of artificial transcription factors.

Curr Opin Chem Biol 2002 Dec;6(6):765-72

Department of Biochemistry and The Genome Center, 433 Babcock Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/s1367-5931(02)00377-0DOI Listing
December 2002

Total Synthesis of Myxalamide A.

J Org Chem 1999 Jan;64(1):23-27

Department of Chemistry, University of California, Berkeley, California 94720.

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http://dx.doi.org/10.1021/jo9813742DOI Listing
January 1999