Anna Csiszar

Anna Csiszar

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Anna Csiszar

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Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans.

Geroscience 2019 Nov 2. Epub 2019 Nov 2.

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00122-xDOI Listing
November 2019

Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.

Geroscience 2019 Nov 2. Epub 2019 Nov 2.

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00101-2DOI Listing
November 2019

Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice.

Geroscience 2019 Nov 5. Epub 2019 Nov 5.

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00110-1DOI Listing
November 2019

Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice.

Geroscience 2019 Oct 23. Epub 2019 Oct 23.

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience, Department of Biochemistry, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://link.springer.com/10.1007/s11357-019-00111-0
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http://dx.doi.org/10.1007/s11357-019-00111-0DOI Listing
October 2019

Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice.

Geroscience 2019 Oct 25. Epub 2019 Oct 25.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11357-019-00102-1DOI Listing
October 2019

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases.

Geroscience 2019 Oct 26. Epub 2019 Oct 26.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11357-019-00107-wDOI Listing
October 2019

Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation.

Front Genet 2019 20;10:898. Epub 2019 Sep 20.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

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http://dx.doi.org/10.3389/fgene.2019.00898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764114PMC
September 2019

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.

Geroscience 2019 Aug 28;41(4):419-439. Epub 2019 Aug 28.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00095-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815288PMC
August 2019

Lysyl oxidases as driving forces behind age-related macrovascular rigidity.

Am J Physiol Heart Circ Physiol 2019 Jul 17;317(1):H37-H38. Epub 2019 May 17.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma.

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http://dx.doi.org/10.1152/ajpheart.00264.2019DOI Listing
July 2019

Role of endothelial NAD deficiency in age-related vascular dysfunction.

Am J Physiol Heart Circ Physiol 2019 Jun 15;316(6):H1253-H1266. Epub 2019 Mar 15.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma.

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https://www.physiology.org/doi/10.1152/ajpheart.00039.2019
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http://dx.doi.org/10.1152/ajpheart.00039.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620681PMC
June 2019

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Redox Biol 2019 06 10;24:101192. Epub 2019 Apr 10.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary; Department of Public Health, Semmelweis University, Budapest, Hungary; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477631PMC
June 2019

Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment.

Am J Physiol Heart Circ Physiol 2019 May 8;316(5):H1124-H1140. Epub 2019 Mar 8.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma.

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http://dx.doi.org/10.1152/ajpheart.00776.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580383PMC
May 2019

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.

Geroscience 2019 May 29. Epub 2019 May 29.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00074-2DOI Listing
May 2019

Age-related decline in peripheral vascular health predicts cognitive impairment.

Geroscience 2019 04 27;41(2):125-136. Epub 2019 Apr 27.

Translational Geroscience Laboratory, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00063-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544701PMC
April 2019

Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.

Geroscience 2019 04 29;41(2):209-227. Epub 2019 Apr 29.

Department of Geriatric Medicine Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-019-00064-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544731PMC
April 2019

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.

Geroscience 2018 12 23;40(5-6):513-521. Epub 2018 Nov 23.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11357-018-0047-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294722PMC
December 2018

Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.

Neurobiol Aging 2018 11 10;71:1-12. Epub 2018 Jul 10.

Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162181PMC
November 2018

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.

Nat Rev Cardiol 2018 09;15(9):555-565

Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1038/s41569-018-0030-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612360PMC
September 2018

Mechanisms of Vascular Aging.

Circ Res 2018 09;123(7):849-867

From the Vascular Cognitive Impairment Laboratory, Reynolds Oklahoma Center on Aging (Z.U., S.T., A.C.), University of Oklahoma Health Sciences Center, Oklahoma City.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31137
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http://dx.doi.org/10.1161/CIRCRESAHA.118.311378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248882PMC
September 2018

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.

Redox Biol 2018 07 6;17:47-58. Epub 2018 Apr 6.

Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006677PMC
July 2018

Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction.

Geroscience 2018 Jun 18. Epub 2018 Jun 18.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1315, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-018-0028-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060194PMC
June 2018

Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease.

Angiology 2018 May 24;69(5):416-423. Epub 2017 Aug 24.

1 Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.

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http://dx.doi.org/10.1177/0003319717726934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004123PMC
May 2018

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.

Geroscience 2018 04 24;40(2):123-137. Epub 2018 Apr 24.

Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10TH Street, SLY-BRC 1303, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-018-0019-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964055PMC
April 2018

Connective tissue growth factor (CTGF) in age-related vascular pathologies.

Geroscience 2017 12 5;39(5-6):491-498. Epub 2017 Sep 5.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-017-9995-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745206PMC
December 2017

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.

Geroscience 2017 12 14;39(5-6):601-614. Epub 2017 Dec 14.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11357-017-0003-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745218PMC
December 2017

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.

Exp Gerontol 2017 08 12;94:52-58. Epub 2016 Nov 12.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429210PMC
August 2017

Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment.

Geroscience 2017 Aug 29;39(4):385-406. Epub 2017 Jun 29.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-017-9981-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636782PMC
August 2017

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease.

Geroscience 2017 Aug 29;39(4):359-372. Epub 2017 Aug 29.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11357-017-9991-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636770PMC
August 2017

Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease.

J Vasc Surg 2017 06 1;65(6):1762-1768. Epub 2017 Mar 1.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla.

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http://dx.doi.org/10.1016/j.jvs.2016.12.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438884PMC
June 2017

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.

Aging Cell 2017 06 14;16(3):469-479. Epub 2017 Mar 14.

Reynolds Oklahoma Center on Aging, Translational Geroscience Laboratory, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1111/acel.12583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418199PMC
June 2017

Cerebral microhemorrhages: mechanisms, consequences, and prevention.

Am J Physiol Heart Circ Physiol 2017 Jun 17;312(6):H1128-H1143. Epub 2017 Mar 17.

Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

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http://www.physiology.org/doi/10.1152/ajpheart.00780.2016
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http://dx.doi.org/10.1152/ajpheart.00780.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495931PMC
June 2017

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.

Geroscience 2017 04 13;39(2):129-145. Epub 2017 Apr 13.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, SLY-BRC 1303, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-017-9971-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411370PMC
April 2017

Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.

Geroscience 2017 02 4;39(1):33-42. Epub 2017 Feb 4.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1007/s11357-017-9964-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352588PMC
February 2017

Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.

Age (Dordr) 2016 Jun 6;38(3):64. Epub 2016 Jun 6.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), 1122 N.E. 13th Street, O'Donoghue Research Building, Suite 1200, Oklahoma City, OK, 73117, USA.

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http://dx.doi.org/10.1007/s11357-016-9925-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005916PMC
June 2016

Pharmacological Strategies to Retard Cardiovascular Aging.

Circ Res 2016 05;118(10):1626-42

From the Experimental Gerontology Section, Translational Gerontology Branch (I.A., C.D.G., M.B., R.d.C.) and Laboratory of Cardiovascular Science (E.G.L.), National Institute on Aging, National Institutes of Health, Baltimore, MD; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy (C.D.G.); and Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK (A.C., Z.U.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.307475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894351PMC
May 2016

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.

J Bone Miner Res 2016 Feb 3;31(2):443-54. Epub 2015 Sep 3.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1002/jbmr.2689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854536PMC
February 2016

Biotin-conjugated fusogenic liposomes for high-quality cell purification.

J Biomater Appl 2016 Jan 15;30(6):846-56. Epub 2015 Oct 15.

Institute of Complex Systems, ICS-7: Biomechanics, Forschungszentrum Jülich GmbH, Jülich, Germany

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http://dx.doi.org/10.1177/0885328215603026DOI Listing
January 2016

Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.

J Gerontol A Biol Sci Med Sci 2016 Jan 20;71(1):13-20. Epub 2015 Nov 20.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center.

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http://dx.doi.org/10.1093/gerona/glv206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851715PMC
January 2016

IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.

Aging Cell 2015 Dec 14;14(6):1034-44. Epub 2015 Jul 14.

Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1111/acel.12372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693458PMC
December 2015

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.

Am J Physiol Heart Circ Physiol 2015 Dec 9;309(11):H1837-45. Epub 2015 Oct 9.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Szentagothai Research Center, Medical School, University of Pecs, Pecs, Hungary; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

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http://dx.doi.org/10.1152/ajpheart.00463.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698379PMC
December 2015

INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE.

J Clin Transl Endocrinol 2015 Dec;2(4):137-143

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK.

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http://dx.doi.org/10.1016/j.jcte.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730895PMC
December 2015

Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.

J Gerontol A Biol Sci Med Sci 2015 Nov 28;70(11):1355-9. Epub 2015 Jan 28.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center. Department of Pathophysiology and Gerontology, Medical School and Szentágothai Research Center, University of Pecs, Hungary. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center.

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http://dx.doi.org/10.1093/gerona/glu244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612385PMC
November 2015

Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.

J Cereb Blood Flow Metab 2015 Nov 15;35(11):1871-81. Epub 2015 Jul 15.

Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/jcbfm.2015.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635246PMC
November 2015

Endothelial Cell Inflammation and Antioxidant Capacity are Associated With Exercise Performance and Microcirculation in Patients With Symptomatic Peripheral Artery Disease.

Angiology 2015 Oct 20;66(9):867-74. Epub 2015 Jan 20.

Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1177/0003319714566863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004125PMC
October 2015

Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

J Gerontol A Biol Sci Med Sci 2015 Jun 18;70(6):665-74. Epub 2014 Aug 18.

Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center. Department of Pathophysiology and Gerontology, Medical School and Szentagothai Research Center, University of Pécs, Hungary. Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center.

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http://dx.doi.org/10.1093/gerona/glu116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447801PMC
June 2015

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.

Aging Cell 2015 Jun 9;14(3):400-8. Epub 2015 Feb 9.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA; Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Szigeti Street 12, 7624, Pecs, Hungary.

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http://doi.wiley.com/10.1111/acel.12315
Publisher Site
http://dx.doi.org/10.1111/acel.12315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406669PMC
June 2015

Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.

J Vasc Surg 2015 May 3;61(5):1249-57. Epub 2014 Apr 3.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla.

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http://dx.doi.org/10.1016/j.jvs.2014.02.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185015PMC
May 2015

Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries.

J Cereb Blood Flow Metab 2015 Mar 31;35(4):527-30. Epub 2015 Mar 31.

1] Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology and Szentagothai Research Center, University of Pecs, Pecs, Hungary [3] Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [4] The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420893PMC
March 2015

A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal.

J Gerontol A Biol Sci Med Sci 2014 Dec 17;69(12):1448-61. Epub 2013 Dec 17.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center. School of Ocean Sciences, Bangor University, Menai Bridge, Anglesey, UK.

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http://dx.doi.org/10.1093/gerona/glt201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271020PMC
December 2014

IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.

J Cereb Blood Flow Metab 2014 Dec 24;34(12):1887-97. Epub 2014 Sep 24.

1] Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA [2] Department of Pathophysiology and Gerontology, Medical School and Szentagothai Research Center, University of Pecs, Pecs, Hungary [3] The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269740PMC
December 2014

Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.

J Gerontol A Biol Sci Med Sci 2014 Nov 3;69(11):1339-52. Epub 2014 Jun 3.

Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center. Department of Pathophysiology and Gerontology, Medical School and Szentágothai Research Center, University of Pecs, Hungary. Department of Physiology, University of Oklahoma Health Sciences Center.

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http://dx.doi.org/10.1093/gerona/glu080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204615PMC
November 2014

Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.

J Gerontol A Biol Sci Med Sci 2014 Nov 6;69(11):1353-62. Epub 2014 Aug 6.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.

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http://dx.doi.org/10.1093/gerona/glu118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271094PMC
November 2014

Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.

J Gerontol A Biol Sci Med Sci 2014 Oct 22;69(10):1212-26. Epub 2013 Nov 22.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City. Department of Pathophysiology and Gerontology, Medical School and Szentágothai Research Center, University of Pecs, Hungary. The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City.

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http://dx.doi.org/10.1093/gerona/glt177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172034PMC
October 2014

Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease.

Angiology 2014 Sep 3;65(8):683-90. Epub 2013 Sep 3.

Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.

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http://dx.doi.org/10.1177/0003319713501376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043949PMC
September 2014

Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.

Am J Physiol Heart Circ Physiol 2014 Sep 18;307(6):H858-68. Epub 2014 Jul 18.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and

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http://www.physiology.org/doi/10.1152/ajpheart.00308.2014
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http://dx.doi.org/10.1152/ajpheart.00308.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166745PMC
September 2014

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats.

Am J Physiol Heart Circ Physiol 2014 Aug 6;307(3):H292-306. Epub 2014 Jun 6.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pathophysiology and Gerontology, Medical School and Szentagothai Research Center University of Pecs, Pecs, Hungary;

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http://dx.doi.org/10.1152/ajpheart.00307.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121647PMC
August 2014

Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease.

Int J Vasc Med 2014 20;2014:160534. Epub 2014 May 20.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK 73117, USA.

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http://dx.doi.org/10.1155/2014/160534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054861PMC
June 2014

Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications.

J Vasc Res 2013 1;50(6):445-57. Epub 2013 Oct 1.

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss., USA.

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https://www.karger.com/Article/FullText/354227
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http://dx.doi.org/10.1159/000354227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309372PMC
January 2014

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.

Am J Physiol Heart Circ Physiol 2013 Dec 4;305(12):H1698-708. Epub 2013 Oct 4.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;

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http://www.physiology.org/doi/10.1152/ajpheart.00377.2013
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http://dx.doi.org/10.1152/ajpheart.00377.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882550PMC
December 2013

Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.

J Cereb Blood Flow Metab 2013 Nov 14;33(11):1732-42. Epub 2013 Aug 14.

Donald W Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/jcbfm.2013.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824186PMC
November 2013

Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.

Am J Physiol Heart Circ Physiol 2013 Oct 16;305(8):H1120-30. Epub 2013 Aug 16.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;

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http://dx.doi.org/10.1152/ajpheart.00288.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798788PMC
October 2013

Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

J Gerontol A Biol Sci Med Sci 2013 Aug 13;68(8):877-91. Epub 2012 Dec 13.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/gls242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712357PMC
August 2013

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.

Am J Physiol Heart Circ Physiol 2013 Aug 7;305(4):H459-76. Epub 2013 Jun 7.

Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, Italy;

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http://dx.doi.org/10.1152/ajpheart.00936.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891249PMC
August 2013

Insulin-like growth factor-1 in CNS and cerebrovascular aging.

Front Aging Neurosci 2013 2;5:27. Epub 2013 Jul 2.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center Oklahoma City, OK, USA.

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http://dx.doi.org/10.3389/fnagi.2013.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698444PMC
July 2013

Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.

J Gerontol A Biol Sci Med Sci 2013 Jun 26;68(6):652-60. Epub 2012 Nov 26.

Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/gls232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660118PMC
June 2013

Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).

J Gerontol A Biol Sci Med Sci 2013 Apr 17;68(4):359-67. Epub 2012 Aug 17.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N. E. 10th Street – BRC 1303, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1093/gerona/gls159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732095PMC
April 2013

Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

J Gerontol A Biol Sci Med Sci 2013 Mar 17;68(3):235-49. Epub 2012 Aug 17.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N. E. 10th Street - BRC 1303, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/gls158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605906PMC
March 2013

Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.

J Gerontol A Biol Sci Med Sci 2012 Aug 4;67(8):811-20. Epub 2012 Jan 4.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 North East 10th Street, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/glr228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536544PMC
August 2012

Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging.

J Gerontol A Biol Sci Med Sci 2012 Aug 4;67(8):821-9. Epub 2012 Jan 4.

Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street-BRC 1303, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/glr229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403863PMC
August 2012

Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?

J Gerontol A Biol Sci Med Sci 2012 Aug 4;67(8):841-52. Epub 2012 Jan 4.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, 975 NE 10th Street, BRC-1315A, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/glr216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403864PMC
August 2012

Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia.

PLoS One 2012 18;7(1):e30444. Epub 2012 Jan 18.

Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030444PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261195PMC
July 2012

Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.

J Gerontol A Biol Sci Med Sci 2012 Jun 10;67(6):553-64. Epub 2011 Nov 10.

Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/glr197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348491PMC
June 2012

The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.

J Gerontol A Biol Sci Med Sci 2012 Jun 26;67(6):599-610. Epub 2012 Mar 26.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1093/gerona/gls072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348495PMC
June 2012

Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.

J Gerontol A Biol Sci Med Sci 2012 Jun 20;67(6):587-98. Epub 2012 Apr 20.

Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Stanton L. Young Biomedical Research Center 1303, 975 NE 10th Street, Oklahoma City, OK 74104, USA.

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http://dx.doi.org/10.1093/gerona/gls115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348498PMC
June 2012