Publications by authors named "Anna Cappa"

11Publications

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.

Authors:
Alessia Romussi Anna Cappa Paola Vianello Silvia Brambillasca Maria Rosaria Cera Roberto Dal Zuffo Giovanni Fagà Raimondo Fattori Loris Moretti Paolo Trifirò Manuela Villa Stefania Vultaggio Valentina Cecatiello Sebastiano Pasqualato Giulio Dondio Chi Wai Eric So Saverio Minucci Luca Sartori Mario Varasi Ciro Mercurio

ACS Med Chem Lett 2020 May 13;11(5):754-759. Epub 2020 Feb 13.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.

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May 2020

Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.

Authors:
Rossella Fioravanti Annalisa Romanelli Nicola Mautone Elisabetta Di Bello Annarita Rovere Davide Corinti Clemens Zwergel Sergio Valente Dante Rotili Oronza A Botrugno Paola Dessanti Stefania Vultaggio Paola Vianello Anna Cappa Claudia Binda Andrea Mattevi Saverio Minucci Ciro Mercurio Mario Varasi Antonello Mai

ChemMedChem 2020 04 14;15(7):643-658. Epub 2020 Feb 14.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy.

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April 2020

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Authors:
Paolo Trifirò Anna Cappa Silvia Brambillasca Oronza A Botrugno Maria Rosaria Cera Roberto Dal Zuffo Paola Dessanti Giuseppe Meroni Florian Thaler Manuela Villa Saverio Minucci Ciro Mercurio Mario Varasi Paola Vianello

Future Med Chem 2017 07 19;9(11):1161-1174. Epub 2017 Jul 19.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.

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July 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

Authors:
Paola Vianello Luca Sartori Federica Amigoni Anna Cappa Giovanni Fagá Raimondo Fattori Elena Legnaghi Giuseppe Ciossani Andrea Mattevi Giuseppe Meroni Loris Moretti Valentina Cecatiello Sebastiano Pasqualato Alessia Romussi Florian Thaler Paolo Trifiró Manuela Villa Oronza A Botrugno Paola Dessanti Saverio Minucci Stefania Vultaggio Elisa Zagarrí Mario Varasi Ciro Mercurio

J Med Chem 2017 03 27;60(5):1693-1715. Epub 2017 Feb 27.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology , Via Adamello 16, 20139 Milano, Italy.

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March 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

Authors:
Luca Sartori Ciro Mercurio Federica Amigoni Anna Cappa Giovanni Fagá Raimondo Fattori Elena Legnaghi Giuseppe Ciossani Andrea Mattevi Giuseppe Meroni Loris Moretti Valentina Cecatiello Sebastiano Pasqualato Alessia Romussi Florian Thaler Paolo Trifiró Manuela Villa Stefania Vultaggio Oronza A Botrugno Paola Dessanti Saverio Minucci Elisa Zagarrí Daniele Carettoni Lucia Iuzzolino Mario Varasi Paola Vianello

J Med Chem 2017 03 27;60(5):1673-1692. Epub 2017 Feb 27.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology , Via Adamello 16, 20139 Milano, Italy.

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March 2017

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Authors:
Paola Vianello Oronza A Botrugno Anna Cappa Roberto Dal Zuffo Paola Dessanti Antonello Mai Biagina Marrocco Andrea Mattevi Giuseppe Meroni Saverio Minucci Giulia Stazi Florian Thaler Paolo Trifiró Sergio Valente Manuela Villa Mario Varasi Ciro Mercurio

J Med Chem 2016 Feb 7;59(4):1501-17. Epub 2016 Jan 7.

Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology , Via Adamello 16, 20139 Milan, Italy.

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February 2016

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

Authors:
Paola Vianello Oronza A Botrugno Anna Cappa Giuseppe Ciossani Paola Dessanti Antonello Mai Andrea Mattevi Giuseppe Meroni Saverio Minucci Florian Thaler Marcello Tortorici Paolo Trifiró Sergio Valente Manuela Villa Mario Varasi Ciro Mercurio

Eur J Med Chem 2014 Oct 27;86:352-63. Epub 2014 Aug 27.

Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.

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October 2014

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Authors:
Daniele Fancelli Agnese Abate Raffaella Amici Paolo Bernardi Marco Ballarini Anna Cappa Giacomo Carenzi Andrea Colombo Cristina Contursi Fabio Di Lisa Giulio Dondio Stefania Gagliardi Eva Milanesi Saverio Minucci Gilles Pain Pier Giuseppe Pelicci Alessandra Saccani Mariangela Storto Florian Thaler Mario Varasi Manuela Villa Simon Plyte

J Med Chem 2014 Jun 11;57(12):5333-47. Epub 2014 Jun 11.

Genextra Group, Congenia s.r.l. , Via Adamello 16, 20139 Milan, Italy.

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June 2014

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.

Authors:
Florian Thaler Andrea Colombo Antonello Mai Raffaella Amici Chiara Bigogno Roberto Boggio Anna Cappa Simone Carrara Tiziana Cataudella Fulvia Fusar Eleonora Gianti Samuele Joppolo di Ventimiglia Maurizio Moroni Davide Munari Gilles Pain Nickolas Regalia Luca Sartori Stefania Vultaggio Giulio Dondio Stefania Gagliardi Saverio Minucci Ciro Mercurio Mario Varasi

J Med Chem 2010 Jan;53(2):822-39

Genextra Group, Congenia s.r.l., Via Adamello 16, 20139 Milan, Italy.

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January 2010

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.

Authors:
Francesco Leonetti Marco Catto Orazio Nicolotti Leonardo Pisani Anna Cappa Angela Stefanachi Angelo Carotti

Bioorg Med Chem 2008 Aug 14;16(15):7450-6. Epub 2008 Jun 14.

Dipartimento Farmaco-Chimico, Università di Bari, via Orabona 4, I-70125 Bari, Italy.

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August 2008

A Simple Method for the Selective Deprotection of p-Methoxybenzyl Ethers by Cerium(III) Chloride Heptahydrate and Sodium Iodide.

Authors:
Anna Cappa Enrico Marcantoni Elisabetta Torregiani Giuseppe Bartoli Maria Cristina Bellucci Marcella Bosco Letizia Sambri

J Org Chem 1999 Jul;64(15):5696-5699

Dipartimento di Chimica Organica "A. Mangini", v.le Risorgimento 4, I-40136 Bologna, Italy.

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July 1999