Publications Authored by Ann Van den Bruel

Exploring the appropriateness of antibiotic prescribing for common respiratory tract infections in UK primary care.

Authors:

Beth Stuart Hannah Brotherwood Catherine Van't Hoff Alastair Brown Ann van den Bruel Alastair D Hay Michael Moore Paul Little

J Antimicrob Chemother 2020 Jan;75(1):236-242

University of Southampton, Primary Care Medical Group, PCPS Unit, Aldermoor Health Centre, Southampton, UK.

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http://dx.doi.org/10.1093/jac/dkz410	DOI Listing

January 2020

C-Reactive Protein for Antibiotic Use in COPD Exacerbations.

Authors:

Jan Y Verbakel Ann Van den Bruel Matthew Thompson

N Engl J Med 2019 12;381(24):2371

University of Washington, Seattle, WA.

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http://dx.doi.org/10.1056/NEJMc1912624	DOI Listing

December 2019

Relationship between microbiology of throat swab and clinical course among primary care patients with acute cough: a prospective cohort study.

Authors:

José M Ordóñez-Mena Thomas R Fanshawe Chris C Butler David Mant Denise Longhurst Peter Muir Barry Vipond Paul Little Michael Moore Beth Stuart Alastair D Hay Hannah V Thornton Matthew J Thompson Sue Smith Ann Van den Bruel Victoria Hardy Laikin Cheah Derrick Crook Kyle Knox

Fam Pract 2019 Dec 17. Epub 2019 Dec 17.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/fampra/cmz093	DOI Listing

December 2019

Development of practical recommendations for diagnostic accuracy studies in low-prevalence situations.

Authors:

Gea A Holtman Marjolein Y Berger Huibert Burger Jonathan J Deeks Norbert Donner-Banzhoff Thomas R Fanshawe Constantinos Koshiaris Mariska M Leeflang Jason L Oke Rafael Perera Johannes B Reitsma Ann Van den Bruel

J Clin Epidemiol 2019 Oct 28;114:38-48. Epub 2019 May 28.

Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, University of Oxford, Oxford OX2 6GG, UK; Academic Centre of General Practice, University of Leuven, Kapucijnenvoer 33 blok J, Bus 7001, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jclinepi.2019.05.018	DOI Listing

October 2019

C-reactive protein and neutrophil count laboratory test requests from primary care: what is the demand and would substitution by point-of-care technology be viable?

Authors:

José M Ordóñez-Mena Thomas R Fanshawe David McCartney Brian Shine Ann Van den Bruel Daniel Lasserson Gail Hayward

J Clin Pathol 2019 Jul 16;72(7):474-481. Epub 2019 Apr 16.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/jclinpath-2018-205688	DOI Listing

July 2019

The Clinical Utility of Point-of-Care Tests for Influenza in Ambulatory Care: A Systematic Review and Meta-analysis.

Authors:

Joseph Jonathan Lee Jan Y Verbakel Clare Rosemary Goyder Thanusha Ananthakumar Pui San Tan Phillip James Turner Gail Hayward Ann Van den Bruel

Clin Infect Dis 2019 Jun;69(1):24-33

Nuffield Department of Primary Care Health Sciences, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1093/cid/ciy837	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579962	PMC

June 2019

The successful uptake and sustainability of rapid infectious disease and antimicrobial resistance point-of-care testing requires a complex 'mix-and-match' implementation package.

Authors:

John P Hays Konstantinos Mitsakakis Saturnino Luz Alex van Belkum Karsten Becker Ann van den Bruel Stephan Harbarth John H Rex Gunnar Skov Simonsen Guido Werner Valentina Di Gregori Gerd Lüdke Tjeerd van Staa Jacob Moran-Gilad Till T Bachmann

Eur J Clin Microbiol Infect Dis 2019 Jun 2;38(6):1015-1022. Epub 2019 Feb 2.

Division of Infection and Pathway Medicine, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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http://dx.doi.org/10.1007/s10096-019-03492-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520316	PMC

June 2019

Predictors of Adverse Outcomes in Uncomplicated Lower Respiratory Tract Infections.

Authors:

Michael Moore Beth Stuart Mark Lown Ann Van den Bruel Sue Smith Kyle Knox Matthew J Thompson Paul Little

Ann Fam Med 2019 05;17(3):231-238

University of Southampton, Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, United Kingdom.

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http://www.annfammed.org/lookup/doi/10.1370/afm.2386	Publisher Site
http://dx.doi.org/10.1370/afm.2386	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827627	PMC

May 2019

The diagnostic performance of current tumour markers in surveillance for recurrent testicular cancer: A diagnostic test accuracy systematic review.

Authors:

Brian D Nicholson Nicholas R Jones Andrew Protheroe Johnson Joseph Nia W Roberts Ann Van den Bruel Thomas R Fanshawe

Cancer Epidemiol 2019 04 15;59:15-21. Epub 2019 Jan 15.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.canep.2019.01.001	DOI Listing

April 2019

Impact of point-of-care C reactive protein in ambulatory care: a systematic review and meta-analysis.

Authors:

Jan Y Verbakel Joseph J Lee Clare Goyder Pui San Tan Thanusha Ananthakumar Philip J Turner Gail Hayward Ann Van den Bruel

BMJ Open 2019 02 1;9(1):e025036. Epub 2019 Feb 1.

Nuffield Department of Primary Care Health Sciences, NIHR Community Healthcare MIC, University of Oxford, Oxford, UK.

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02503	Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025036	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361331	PMC

February 2019

Is stratification testing for treatment of chronic obstructive pulmonary disease exacerbations cost-effective in primary care? an early cost-utility analysis.

Authors:

Lucy Abel Helen A Dakin Nia Roberts Helen F Ashdown Chris C Butler Gail Hayward Ann Van den Bruel Philip J Turner Yaling Yang

Int J Technol Assess Health Care 2019 Jan 4;35(2):116-125. Epub 2019 Mar 4.

Nuffield Department of Primary Care Health Sciences,University of Oxford.

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http://dx.doi.org/10.1017/S0266462318003707	DOI Listing

January 2019

Frequencies and patterns of laboratory test requests from general practice: a service evaluation to inform point-of-care testing.

Authors:

Thomas R Fanshawe José M Ordóñez-Mena Philip J Turner Ann Van den Bruel Brian Shine Gail N Hayward

J Clin Pathol 2018 Dec 18;71(12):1065-1071. Epub 2018 Sep 18.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford , UK.

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http://dx.doi.org/10.1136/jclinpath-2018-205242	DOI Listing

December 2018

Point-of-care C-reactive protein to assist in primary care management of children with suspected non-serious lower respiratory tract infection: a randomised controlled trial.

Authors:

Marjolein Jc Schot Ann Van den Bruel Berna Dl Broekhuizen Jochen Wl Cals Eveline A Noteboom Walter Balemans Rogier M Hopstaken Sanne van Delft Niek J de Wit Theo Jm Verheij

BJGP Open 2018 Oct 11;2(3):bjgpopen18X101600. Epub 2018 Jul 11.

GP and Professor of Primary Care, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.3399/bjgpopen18X101600	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189779	PMC

October 2018

Early detection of multiple myeloma in primary care using blood tests: a case-control study in primary care.

Authors:

Constantinos Koshiaris Ann Van den Bruel Jason L Oke Brian D Nicholson Elizabeth Shephard Mick Braddick William Hamilton

Br J Gen Pract 2018 Sep 13;68(674):e586-e593. Epub 2018 Aug 13.

University of Exeter Medical School, Exeter.

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http://dx.doi.org/10.3399/bjgp18X698357	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104875	PMC

September 2018

Improving the quality of point-of-care testing.

Authors:

Christopher P Price Ian Smith Ann Van den Bruel

Fam Pract 2018 07;35(4):358-364

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/fampra/cmx120	DOI Listing

July 2018

Opportunities for earlier diagnosis of type 1 diabetes in children: A case-control study using routinely collected primary care records.

Authors:

Joseph Jonathan Lee Matthew James Thompson Juliet Alexandra Usher-Smith Constantinos Koshiaris Ann Van den Bruel

Prim Care Diabetes 2018 06 13;12(3):254-264. Epub 2018 Mar 13.

Nuffield Department of Primary Care Health Sciences, Radcliffe Primary Care, Radcliffe Observatory Quarter, Woodstock Rd, Oxford OX2 6GG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pcd.2018.02.002	DOI Listing

June 2018

Quantifying intervals to diagnosis in myeloma: a systematic review and meta-analysis.

Authors:

Constantinos Koshiaris Jason Oke Lucy Abel Brian D Nicholson Karthik Ramasamy Ann Van den Bruel

BMJ Open 2018 06 22;8(6):e019758. Epub 2018 Jun 22.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-01975	Publisher Site
http://dx.doi.org/10.1136/bmjopen-2017-019758	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020959	PMC

June 2018

Diagnostic evidence cooperatives: bridging the valley of death in diagnostics development.

Authors:

Ann Van den Bruel Gail Hayward

Diagn Progn Res 2018 18;2. Epub 2018 Jun 18.

1NIHR Diagnostic Evidence Cooperative Oxford, Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, 32 Woodstock Road, Oxford, OX2 6GG UK.

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http://dx.doi.org/10.1186/s41512-018-0030-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460518	PMC

June 2018

Point-of-care C reactive protein to identify serious infection in acutely ill children presenting to hospital: prospective cohort study.

Authors:

Jan Y Verbakel Marieke B Lemiengre Tine De Burghgraeve An De Sutter Bert Aertgeerts Dominique M A Bullens Bethany Shinkins Ann Van den Bruel Frank Buntinx

Arch Dis Child 2018 05 21;103(5):420-426. Epub 2017 Dec 21.

Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/archdischild-2016-312384	DOI Listing

May 2018

Point-of-care lactate testing for sepsis at presentation to health care: a systematic review of patient outcomes.

Authors:

Elizabeth Morris David McCartney Daniel Lasserson Ann Van den Bruel Rebecca Fisher Gail Hayward

Br J Gen Pract 2017 Dec 20;67(665):e859-e870. Epub 2017 Nov 20.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

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http://dx.doi.org/10.3399/bjgp17X693665	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697556	PMC

December 2017

Fractional exhaled nitric oxide monitoring in paediatric asthma management.

Authors:

Nicholas R Jones Kay Wang Yaling Yang Carl Heneghan Christopher P Price Ann Van den Bruel Annette Plüddemann

Br J Gen Pract 2017 11;67(664):531-532

Diagnostic Horizon Scan Programme, Diagnostic Evidence Co-operative Oxford, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

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http://dx.doi.org/10.3399/bjgp17X693449	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647915	PMC

November 2017

Common evidence gaps in point-of-care diagnostic test evaluation: a review of horizon scan reports.

Authors:

Jan Y Verbakel Philip J Turner Matthew J Thompson Annette Plüddemann Christopher P Price Bethany Shinkins Ann Van den Bruel

BMJ Open 2017 Sep 1;7(9):e015760. Epub 2017 Sep 1.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjopen-2016-015760	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588931	PMC

September 2017

Corticosteroids for sore throat: a clinical practice guideline.

BMJ 2017 09 20;358:j4090. Epub 2017 Sep 20.

CEBAM, Belgian Centre for Evidence-Based Medicine, Cochrane Belgium, Leuven, Belgium.

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http://dx.doi.org/10.1136/bmj.j4090	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284245	PMC

September 2017

Erratum to: Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial.

Authors:

Jan Y Verbakel Marieke B Lemiengre Tine De Burghgraeve An De Sutter Bert Aertgeerts Bethany Shinkins Rafael Perera David Mant Ann Van den Bruel Frank Buntinx

BMC Med 2017 05 2;15(1):93. Epub 2017 May 2.

Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 33 J, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12916-017-0861-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414285	PMC

May 2017

Antibiotic prescription strategies and adverse outcome for uncomplicated lower respiratory tract infections: prospective cough complication cohort (3C) study.

Authors:

Paul Little Beth Stuart Sue Smith Matthew J Thompson Kyle Knox Ann van den Bruel Mark Lown Michael Moore David Mant

BMJ 2017 May 22;357:j2148. Epub 2017 May 22.

Nuffield Department of Primary Health Care Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439222	PMC
http://dx.doi.org/10.1136/bmj.j2148	DOI Listing

May 2017

The Sore Throat Test and Treat Service: speed should not substitute science.

Authors:

Clare Goyder Jan Verbakel Gail Hayward Joseph Lee Brian D Nicholson Ann Van den Bruel

Br J Gen Pract 2017 03;67(656):110

Nuffield Department of Primary Care Health Sciences, University of Oxford.

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http://dx.doi.org/10.3399/bjgp17X689545	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325632	PMC

March 2017

Erratum to: Methods for evaluating medical tests and biomarkers.

Authors:

Gowri Gopalakrishna Miranda Langendam Rob Scholten Patrick Bossuyt Mariska Leeflang Anna Noel-Storr James Thomas Iain Marshall Byron Wallace Penny Whiting Clare Davenport Mariska Leeflang Gowri GopalaKrishna Isabel de Salis Sue Mallett Robert Wolff Penny Whiting Richard Riley Marie Westwood Jos Kleinen Gary Collins Hans Reitsma Karel Moons Antonia Zapf Annika Hoyer Katharina Kramer Oliver Kuss J Ensor J J Deeks E C Martin R D Riley Gerta Rücker Susanne Steinhauser Martin Schumacher Richard Riley Joie Ensor Kym Snell Brian Willis Thomas Debray Karel Moons Jon Deeks Gary Collins Lavinia Ferrante di Ruffano Brian Willis Clare Davenport Sue Mallett Sian Taylor-Phillips Chris Hyde Jon Deeks Sue Mallett Stuart A Taylor Gauraang Batnagar Sian Taylor-Phillips Lavinia Ferrante Di Ruffano Farah Seedat Aileen Clarke Jon Deeks Sarah Byron Frances Nixon Rebecca Albrow Thomas Walker Carla Deakin Chris Hyde Zhivko Zhelev Harriet Hunt Lavinia Ferrante di Ruffano Yaling Yang Lucy Abel James Buchanan Thomas Fanshawe Bethany Shinkins Laure Wynants Jan Verbakel Sabine Van Huffel Dirk Timmerman Ben Van Calster Mariska Leeflang Aeliko Zwinderman Patrick Bossuyt Jason Oke Jack O'Sullivan Rafael Perera Brian Nicholson Hannah L Bromley Tracy E Roberts Adele Francis Denniis Petrie G Bruce Mann Kinga Malottki Holly Smith Jon Deeks Lucinda Billingham Alice Sitch Sue Mallett Jon Deeks Oke Gerke Mie Holm-Vilstrup Eivind Antonsen Segtnan Ulrich Halekoh Poul Flemming Høilund-Carlsen Bernard G Francq Jon Deeks Alice Sitch Jac Dinnes Julie Parkes Walter Gregory Jenny Hewison Doug Altman William Rosenberg Peter Selby Julien Asselineau Paul Perez Aïssatou Paye Emilie Bessede Cécile Proust-Lima Christiana Naaktgeboren Joris de Groot Anne Rutjes Patrick Bossuyt Johannes Reitsma Karel Moons Gary Collins Emmanuel Ogundimu Jonathan Cook Yannick Le Manach Doug Altman Laure Wynants Yvonne Vergouwe Sabine Van Huffel Dirk Timmerman Ben Van Calster Romin Pajouheshnia Rolf Groenwold Karen Moons Johannes Reitsma Linda Peelen Ben Van Calster Daan Nieboer Yvonne Vergouwe Bavo De Cock Micael J Pencina Ewout W Steyerberg Jennifer Cooper Sian Taylor-Phillips Nick Parsons Chris Stinton Steve Smith Andy Dickens Rachel Jordan Alexandra Enocson David Fitzmaurice Alice Sitch Peymane Adab Bernard G Francq Charles Boachie Gaj Vidmar Karoline Freeman Martin Connock Sian Taylor-Phillips Rachel Court Aileen Clarke Joris de Groot Christiana Naaktgeboren Hans Reitsma Carl Moons Jessica Harris Andrew Mumford Zoe Plummer Kurtis Lee Barnaby Reeves Chris Rogers Veerle Verheyden Gianni D Angelini Gavin J Murphy Jeremy Huddy Melody Ni Katherine Good Graham Cooke Patrick Bossuyt George Hanna Jie Ma Doug Altman Gary Collins K G M Carl Moons Joris A H de Groot Sue Mallett Doug G Altman Johannes B Reitsma Gary S Collins Karel G M Moons Douglas G Altman Johannes B Reitsma Gary S Collins Adina Najwa Kamarudin Ruwanthi Kolamunnage-Dona Trevor Cox Melody Ni Jeremy Huddy Simone Borsci George Hanna Teresa Pérez M Carmen Pardo Angel Candela-Toha Alfonso Muriel Javier Zamora Sabina Sanghera Syed Mohiuddin Richard Martin Jenny Donovan Joanna Coast Mikyung Kelly Seo John Cairns Elizabeth Mitchell Alison Smith Judy Wright Peter Hall Michael Messenger Nicola Calder Nyantara Wickramasekera Karen Vinall-Collier Andrew Lewington Romin Pajouheshnia Johanna Damen Rolf Groenwold Karel Moons Linda Peelen Michael Messenger David Cairns Alison Smith Michelle Hutchinson Judy Wright Peter Hall Nicola Calder Cathie Sturgeon Liz Mitchel Rebecca Kift Sofia Christakoudi Manohursingh Rungall Paula Mobillo Rosa Montero Tjir-Li Tsui Sui Phin Kon Beatriz Tucker Steven Sacks Chris Farmer Terry Strom Paramit Chowdhury Irene Rebollo-Mesa Maria Hernandez-Fuentes Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Johanna A A G Damen Lotty Hooft Ewoud Schuit Thomas P A Debray Gary S Collins Ioanna Tzoulaki Camille M Lassale George C M Siontis Virginia Chiocchia Corran Roberts Michael Maia Schlüssel Stephen Gerry James A Black Pauline Heus Yvonne T van der Schouw Linda M Peelen Karel G M Moons Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Jie Ma Doug Altman Gary Collins Graeme Spence David McCartney Ann van den Bruel Daniel Lasserson Gail Hayward Werner Vach Antoinette de Jong Coreline Burggraaff Otto Hoekstra Josée Zijlstra Henrica de Vet Harriet Hunt Chris Hyde Sara Graziadio Joy Allen Louise Johnston Rachel O'Leary Michael Power Joy Allen Sara Graziadio Louise Johnson Rachel O'Leary Michael Power Ray Waters John Simpson Louise Johnston Joy Allen Sara Graziadio Rachel O'Leary Ray Waters Michael Power Sue Mallett Thomas R Fanshawe Peter Phillips Andrew Plumb Emma Helbren Steve Halligan Stuart A Taylor Alastair Gale Sue Mallett Peggy Sekula Douglas G Altman Willi Sauerbrei Sue Mallett Thomas R Fanshawe Julia R Forman Susan J Dutton Yemisi Takwoingi Elizabeth M Hensor Thomas E Nichols Bethany Shinkins Yaling Yang Lucy Abel Lavinia Ferrante Di Ruffano Thomas Fanshawe Emmanuelle Kempf Raphael Porcher Jennifer de Beyer Karel Moons Douglas Altman Hans Reitsma Sally Hopewell Willi Sauerbrei Gary Collins John Dennis Beverley Shields Angus Jones William Henley Ewan Pearson Andrew Hattersley Pauline Heus Johanna A A G Damen Romin Pajouheshnia Rob J P M Scholten Johannes B Reitsma Gary S Collins Douglas G Altman Karel G M Moons Lotty Hooft Beverley Shields John Dennis Angus Jones William Henley Ewan Pearson Andrew Hattersley Fueloep Scheibler Anne Rummer Sibylle Sturtz Robert Großelfinger Katie Banister Craig Ramsay Augusto Azuara-Blanco Jonathan Cook Charles Boachie Jennifer Burr Manjula Kumarasamy Rupert Bourne Ijeoma Uchegbu Simone Borsci Jennifer Murphy George Hanna Ijeoma Uchegbu Alex Carter Jen Murphy Melody Ni Joachim Marti Julie Eatock Ijeoma Uchegbu Julie Robotham Maria Dudareva Mark Gilchrist Alison Holmes Ijeoma Uchegbu Simone Borsci Phillip Monaghan Sarah Lord Andrew StJohn Sverre Sandberg Christa Cobbaert Lieselotte Lennartz Wilma Verhagen-Kamerbeek Christoph Ebert Patrick Bossuyt Andrea Horvath Kevin Jenniskens Christiana Naaktgeboren Johannes Reitsma Karel Moons Joris de Groot Chris Hyde Jaime Peters Bogdan Grigore Jaime Peters Chris Hyde Chris Hyde Obi Ukoumunne Jaime Peters Zhivko Zhelev Brooke Levis Andrea Benedetti Alexander W Levis John P A Ioannidis Ian Shrier Pim Cuijpers Simon Gilbody Lorie A Kloda Dean McMillan Scott B Patten Russell J Steele Roy C Ziegelstein Charles H Bombardier Flavia de Lima Osório Jesse R Fann Dwenda Gjerdingen Femke Lamers Manote Lotrakul Sonia R Loureiro Bernd Löwe Juwita Shaaban Lesley Stafford Henk C P M van Weert Mary A Whooley Linda S Williams Karin A Wittkampf Albert S Yeung Brett D Thombs Jaime Peters Chris Cooper James Buchanan Tom Nieto Claire Smith Olga Tucker Janine Dretzke Andrew Beggs Nirmala Rai Clare Davenport Sue Bayliss Simon Stevens Kym Snell Sue Mallet Jon Deeks Sudha Sundar Emma Hall Nuria Porta David Lorente Estelles Johann de Bono

Diagn Progn Res 2017 30;1:11. Epub 2017 Mar 30.

278The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1186/s41512-017-0011-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460744	PMC

March 2017

Capillary refill time in sick children: a clinical guide for general practice.

Authors:

Susannah Fleming Peter J Gill Ann Van den Bruel Matthew Thompson

Br J Gen Pract 2016 Nov;66(652):587

Department of Family Medicine, University of Washington, Seattle.

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http://dx.doi.org/10.3399/bjgp16X687925	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072914	PMC

November 2016

Clinical presentation of childhood leukaemia: a systematic review and meta-analysis.

Authors:

Rachel T Clarke Ann Van den Bruel Clare Bankhead Christopher D Mitchell Bob Phillips Matthew J Thompson

Arch Dis Child 2016 Oct;101(10):894-901

Department of Primary Care Health Sciences, University of Oxford, Oxford, UK Department of Family Medicine, University of Washington, Seattle, USA.

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http://dx.doi.org/10.1136/archdischild-2016-311251	DOI Listing

October 2016

A Modified Delphi Study to Identify Factors Associated With Clinical Deterioration in Hospitalized Children.

Authors:

Kristina Krmpotic Ann Van den Bruel Anna-Theresa Lobos

Hosp Pediatr 2016 10;6(10):616-625

Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada; and Faculty of Medicine, University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.1542/hpeds.2016-0006	DOI Listing

October 2016

Neutrophil gelatinase-associated lipocalin: primary care diagnostic technology update.

Authors:

Roya Hassanzadeh Daniel Lasserson Christopher P Price Carl Heneghan Ann Van den Bruel Annette Plüddemann

Br J Gen Pract 2016 Oct;66(651):542-3

Diagnostic Horizon Scan Programme, Diagnostic Evidence Co-operative Oxford, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033304	PMC
http://dx.doi.org/10.3399/bjgp16X687505	DOI Listing

October 2016

Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial.

Authors:

Jan Y Verbakel Marieke B Lemiengre Tine De Burghgraeve An De Sutter Bert Aertgeerts Bethany Shinkins Rafael Perera David Mant Ann Van den Bruel Frank Buntinx

BMC Med 2016 Oct 6;14(1):131. Epub 2016 Oct 6.

Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 33J, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12916-016-0679-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052874	PMC

October 2016

Point-of-care testing in UK primary care: a survey to establish clinical needs.

Authors:

Philip J Turner Ann Van den Bruel Caroline H D Jones Annette Plüddemann Carl Heneghan Matthew J Thompson Christopher P Price Jeremy Howick

Fam Pract 2016 08 5;33(4):388-94. Epub 2016 Apr 5.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK and.

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http://dx.doi.org/10.1093/fampra/cmw018	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957010	PMC

August 2016

The Diagnostic Value of Capillary Refill Time for Detecting Serious Illness in Children: A Systematic Review and Meta-Analysis.

Authors:

Susannah Fleming Peter Gill Caroline Jones James A Taylor Ann Van den Bruel Carl Heneghan Nia Roberts Matthew Thompson

PLoS One 2015 16;10(9):e0138155. Epub 2015 Sep 16.

Department of Family Medicine, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138155	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573516	PMC

May 2016

C-reactive protein point-of-care testing in acutely ill children: a mixed methods study in primary care.

Authors:

Ann Van den Bruel Caroline Jones Matthew Thompson David Mant

Arch Dis Child 2016 Apr 12;101(4):382-5. Epub 2016 Jan 12.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/archdischild-2015-309228	DOI Listing

April 2016

Creatinine point-of-care testing for detection and monitoring of chronic kidney disease: primary care diagnostic technology update.

Authors:

Oghenekome Gbinigie Christopher P Price Carl Heneghan Ann Van den Bruel Annette Plüddemann

Br J Gen Pract 2015 Nov;65(640):608-9

Diagnostic Horizon Scan Programme, Diagnostic Evidence Co-operative Oxford, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

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http://dx.doi.org/10.3399/bjgp15X687613	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617263	PMC

November 2015

Validating a decision tree for serious infection: diagnostic accuracy in acutely ill children in ambulatory care.

Authors:

Jan Y Verbakel Marieke B Lemiengre Tine De Burghgraeve An De Sutter Bert Aertgeerts Dominique M A Bullens Bethany Shinkins Ann Van den Bruel Frank Buntinx

BMJ Open 2015 Aug 7;5(8):e008657. Epub 2015 Aug 7.

Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium Research Institute Caphri, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1136/bmjopen-2015-008657	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538259	PMC

August 2015

The triumph of medicine: how overdiagnosis is turning healthy people into patients.

Authors:

Ann Van den Bruel

Fam Pract 2015 Jun;32(3):364

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https://academic.oup.com/fampra/article-lookup/doi/10.1093/f	Publisher Site
http://dx.doi.org/10.1093/fampra/cmv033	DOI Listing

June 2015

The triumph of medicine: how overdiagnosis is turning healthy people into patients.

Authors:

Ann Van den Bruel

Fam Pract 2015 Apr;32(2):127-8

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.

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http://dx.doi.org/10.1093/fampra/cmv008	DOI Listing

April 2015

Validity and reliability of measurement of capillary refill time in children: a systematic review.

Authors:

Susannah Fleming Peter Gill Caroline Jones James A Taylor Ann Van den Bruel Carl Heneghan Matthew Thompson

Arch Dis Child 2015 Mar 26;100(3):239-49. Epub 2014 Sep 26.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK Department of Family Medicine, University of Washington, Seattle, USA.

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http://dx.doi.org/10.1136/archdischild-2014-307079	DOI Listing

March 2015

What should integrated care look like ... ?

Authors:

Roger Jones Ann Van den Bruel Clare Gerada William Hamilton Tony Kendrick Graham Watt

Br J Gen Pract 2015 Mar;65(632):149-51

University of Glasgow. E-mail:

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http://dx.doi.org/10.3399/bjgp15X684193	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337298	PMC

March 2015

People's willingness to accept overdetection in cancer screening: population survey.

Authors:

Ann Van den Bruel Caroline Jones Yaling Yang Jason Oke Paul Hewitson

BMJ 2015 Mar 3;350:h980. Epub 2015 Mar 3.

Nuffield Department of Population Health, Richard Doll Building, University of Oxford, Oxford OX3 7LF, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356995	PMC
http://dx.doi.org/10.1136/bmj.h980	DOI Listing

March 2015

The predictive value of the NICE "red traffic lights" in acutely ill children.

Authors:

Evelien Kerkhof Monica Lakhanpaul Samiran Ray Jan Y Verbakel Ann Van den Bruel Matthew Thompson Marjolein Y Berger Henriette A Moll Rianne Oostenbrink

PLoS One 2014 14;9(3):e90847. Epub 2014 Mar 14.

Erasmus MC-Sophia Children's Hospital, Department of General Pediatrics, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090847	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954615	PMC

December 2014

The cost-utility of left ventricular assist devices for end-stage heart failure patients ineligible for cardiac transplantation: a systematic review and critical appraisal of economic evaluations.

Authors:

Mattias Neyt Ann Van den Bruel Yolba Smit Nicolaas De Jonge Joan Vlayen

Ann Cardiothorac Surg 2014 Sep;3(5):439-49

1 ME-TA, Medical Evaluation and Technology Assessment, Belgium ; 2 Independent researcher, the Netherlands ; 3 Department of Cardiology, University Medical Centre Utrecht, Utrecht, the Netherlands.

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http://www.annalscts.com/article/view/4752/5642	Publisher Site
http://dx.doi.org/10.3978/j.issn.2225-319X.2014.09.02	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229461	PMC

September 2014

Current and future use of point-of-care tests in primary care: an international survey in Australia, Belgium, The Netherlands, the UK and the USA.

Authors:

Jeremy Howick Jochen W L Cals Caroline Jones Christopher P Price Annette Plüddemann Carl Heneghan Marjolein Y Berger Frank Buntinx John Hickner Wilson Pace Tony Badrick Ann Van den Bruel Caroline Laurence Henk C van Weert Evie van Severen Adriana Parrella Matthew Thompson

BMJ Open 2014 Aug 8;4(8):e005611. Epub 2014 Aug 8.

Department of Family Medicine, University of Washington, Seattle, Washington, USA.

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http://bmjopen.bmj.com/cgi/doi/10.1136/bmjopen-2014-005611	Publisher Site
http://dx.doi.org/10.1136/bmjopen-2014-005611	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127935	PMC

August 2014

Research into practice: acutely ill children.

Authors:

Ann Van den Bruel Matthew Thompson

Br J Gen Pract 2014 Jun;64(623):311-3

University of Washington, Seattle, US, and senior researcher, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

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http://dx.doi.org/10.3399/bjgp14X680317	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032010	PMC

June 2014

Triage tests for identifying atrial fibrillation in primary care: a diagnostic accuracy study comparing single-lead ECG and modified BP monitors.

Authors:

Karen Kearley Mary Selwood Ann Van den Bruel Matthew Thompson David Mant Fd Richard Hobbs David Fitzmaurice Carl Heneghan

BMJ Open 2014 May 2;4(5):e004565. Epub 2014 May 2.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2013-00456	Publisher Site
http://dx.doi.org/10.1136/bmjopen-2013-004565	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025411	PMC

May 2014

The comprehensive diagnostic study: a new solution to old problems?

Authors:

Ann van den Bruel Rafael Perera

J Clin Epidemiol 2014 Feb 28;67(2):133-4. Epub 2013 Nov 28.

Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Walton Street, Oxford OX2 6NW, UK.

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http://dx.doi.org/10.1016/j.jclinepi.2013.09.007	DOI Listing

February 2014

Response to Donner-Banzhoff.

Authors:

Ann van den Bruel Rafael Perera

J Clin Epidemiol 2014 Feb 26;67(2):137. Epub 2013 Nov 26.

Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Walton Street, Oxford OX2 6NW, UK.

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http://dx.doi.org/10.1016/j.jclinepi.2013.09.006	DOI Listing

February 2014

Cost-effectiveness of continuous-flow left ventricular assist devices.

Authors:

Mattias Neyt Ann Van den Bruel Yolba Smit Nicolaas De Jonge Michiel Erasmus Diederik Van Dijk Joan Vlayen

Int J Technol Assess Health Care 2013 Jul 14;29(3):254-60. Epub 2013 Jun 14.

ME-TA, Medical Evaluation and Technology Assessment, Belgium.

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http://dx.doi.org/10.1017/S0266462313000238	DOI Listing

July 2013

Point-of-care testing for coeliac disease: primary care diagnostic technology update.

Authors:

Jaspreet Khangura Ann Van den Bruel Rafael Perera Carl Heneghan Christopher P Price Jane Wolstenholme Matthew Thompson Annette Plüddemann

Br J Gen Pract 2013 Jun;63(611):e426-8

Horizon Scanning Programme, Centre for Monitoring and Diagnosis, University of Oxford, Oxford.

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http://bjgp.org/lookup/doi/10.3399/bjgp13X668401	Publisher Site
http://dx.doi.org/10.3399/bjgp13X668401	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662461	PMC

June 2013

Health services for children in western Europe.

Authors:

Ingrid Wolfe Matthew Thompson Peter Gill Giorgio Tamburlini Mitch Blair Ann van den Bruel Jochen Ehrich Massimo Pettoello-Mantovani Staffan Janson Marina Karanikolos Martin McKee

Lancet 2013 Apr 27;381(9873):1224-34. Epub 2013 Mar 27.

European Centre on Health of Societies in Transition, London School of Hygiene & Tropical Medicine, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(12)62085-6	DOI Listing

April 2013

How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets?

Authors:

Jan Y Verbakel Ann Van den Bruel Matthew Thompson Richard Stevens Bert Aertgeerts Rianne Oostenbrink Henriette A Moll Marjolein Y Berger Monica Lakhanpaul David Mant Frank Buntinx

BMC Med 2013 Jan 15;11:10. Epub 2013 Jan 15.

Department of General Practice, KU Leuven, Kapucijnenvoer 33 blok J, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1186/1741-7015-11-10	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566974	PMC

January 2013

Clinicians' gut feeling about serious infections in children: observational study.

Authors:

Ann Van den Bruel Matthew Thompson Frank Buntinx David Mant

BMJ 2012 Sep 25;345:e6144. Epub 2012 Sep 25.

Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, Oxford OX2 6GG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458229	PMC
http://dx.doi.org/10.1136/bmj.e6144	DOI Listing

September 2012

The cost-effectiveness of tiotropium for the treatment of chronic obstructive pulmonary disease (COPD): the importance of the comparator.

Authors:

Mattias Neyt Ann Van Den Bruel

Eur J Health Econ 2012 Aug;13(4):379-80

Belgian Health Care Knowledge Centre (KCE), Kruidtuinlaan 55, 1000 Brussels, Belgium.

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http://dx.doi.org/10.1007/s10198-012-0392-9	DOI Listing

August 2012

Should we promote the tumbler test?

Authors:

David Mant Ann Van den Bruel

Arch Dis Child 2011 Jul 26;96(7):613-4. Epub 2010 Jul 26.

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http://dx.doi.org/10.1136/adc.2010.191510	DOI Listing

July 2011

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review.

Authors:

Ann Van den Bruel Matthew J Thompson Tanya Haj-Hassan Richard Stevens Henriette Moll Monica Lakhanpaul David Mant

BMJ 2011 Jun 8;342:d3082. Epub 2011 Jun 8.

Department of Primary Health Care, University of Oxford, UK.

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http://dx.doi.org/10.1136/bmj.d3082	DOI Listing

June 2011

The protective effect of ophthalmic viscoelastic devices on endothelial cell loss during cataract surgery: a meta-analysis using mixed treatment comparisons.

Authors:

Ann Van den Bruel Jeannine Gailly Stephan Devriese Nicky J Welton Alex J Shortt France Vrijens

Br J Ophthalmol 2011 Jan 3;95(1):5-10. Epub 2009 Dec 3.

Belgian Health Care Knowledge Centre, Kruidtuinlaan 55, Brussels B-1000, Belgium.

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http://dx.doi.org/10.1136/bjo.2009.158360	DOI Listing

January 2011

Dealing with low-incidence serious diseases in general practice.

Authors:

Frank Buntinx David Mant Ann Van den Bruel Norbert Donner-Banzhof Geert-Jan Dinant

Br J Gen Pract 2011 Jan;61(582):43-6

Department of General Practice, Catholic University of Leuven, Belgium.

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http://dx.doi.org/10.3399/bjgp11X548974	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020049	PMC

January 2011

Excess of mortality in patients with chest pain peaks in the first 3 days period after the incident and normalizes after 1 month.

Authors:

Rudi Bruyninckx Ann Van den Bruel Frank Buntinx Viviane Van Casteren Bert Aertgeerts

Fam Pract 2010 Dec 16;27(6):604-8. Epub 2010 Jul 16.

Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/fampra/cmq052	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980602	PMC

December 2010

Accuracy of diagnostic ultrasound in patients with suspected subacromial disorders: a systematic review and meta-analysis.

Authors:

Ramon P Ottenheijm Mariëtte J Jansen J Bart Staal Ann van den Bruel René E Weijers Rob A de Bie Geert-Jan Dinant

Arch Phys Med Rehabil 2010 Oct;91(10):1616-25

Department of General Practice, Maastricht University, The Netherlands.

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http://dx.doi.org/10.1016/j.apmr.2010.07.017	DOI Listing

October 2010

Tiotropium's cost-effectiveness for the treatment of COPD: a cost-utility analysis under real-world conditions.

Authors:

Mattias Neyt Stephan Devriese Nancy Thiry Ann Van den Bruel

BMC Pulm Med 2010 Sep 15;10:47. Epub 2010 Sep 15.

Belgian Health Care Knowledge Centre (KCE), Brussels, Belgium.

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http://dx.doi.org/10.1186/1471-2466-10-47	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954895	PMC

September 2010

Does tiotropium lower exacerbation and hospitalization frequency in COPD patients: results of a meta-analysis.

Authors:

Ann Van den Bruel Jeannine Gailly Mattias Neyt

BMC Pulm Med 2010 Sep 21;10:50. Epub 2010 Sep 21.

Belgian Health Care Knowledge Centre (KCE), Brussels, Belgium.

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http://dx.doi.org/10.1186/1471-2466-10-50	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955630	PMC

September 2010

Diagnosing serious bacterial infection in young febrile children.

Authors:

Matthew J Thompson Ann Van den Bruel

BMJ 2010 Apr 20;340:c2062. Epub 2010 Apr 20.

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http://dx.doi.org/10.1136/bmj.c2062	DOI Listing

April 2010

Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review.

Authors:

Ann Van den Bruel Tanya Haj-Hassan Matthew Thompson Frank Buntinx David Mant

Lancet 2010 Mar 2;375(9717):834-45. Epub 2010 Feb 2.

Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S014067360962000	Publisher Site
http://dx.doi.org/10.1016/S0140-6736(09)62000-6	DOI Listing