Ann W Morgan

Ann W Morgan

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Ann W Morgan

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Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for and CD39.

Authors:
Athina Spiliopoulou Marco Colombo Darren Plant Nisha Nair Jing Cui Marieke Jh Coenen Katsunori Ikari Hisashi Yamanaka Saedis Saevarsdottir Leonid Padyukov S Louis Bridges Robert P Kimberly Yukinori Okada Piet L Cm van Riel Gertjan Wolbink Irene E van der Horst-Bruinsma Niek de Vries Paul P Tak Koichiro Ohmura Helena Canhão Henk-Jan Guchelaar Tom Wj Huizinga Lindsey A Criswell Soumya Raychaudhuri Michael E Weinblatt Anthony G Wilson Xavier Mariette John D Isaacs Ann W Morgan Costantino Pitzalis Anne Barton Paul McKeigue

Ann Rheum Dis 2019 Aug 29;78(8):1055-1061. Epub 2019 Apr 29.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21487
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http://dx.doi.org/10.1136/annrheumdis-2018-214877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669378PMC
August 2019

Giant cell arteritis: new concepts, treatments and the unmet need that remains.

Authors:
Fiona Coath Kate Gillbert Bridget Griffiths Frances Hall Lesley Kay Peter Lanyon Raashid Luqmani Sarah L Mackie Justin C Mason John Mills Susan Mollan Ann W Morgan Chetan Mukhtyar Vanessa Quick Richard Watts Bhaskar Dasgupta

Rheumatology (Oxford) 2019 Jul;58(7):1123-1125

Rheumatology, Southend University Hospital NHS Trust, Westcliff-on-Sea, UK.

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key326DOI Listing
July 2019

Giant cell arteritis: new concepts, treatments and the unmet need that remains.

Authors:
Fiona Coath Kate Gillbert Bridget Griffiths Frances Hall Lesley Kay Peter Lanyon Raashid Luqmani Sarah L Mackie Justin C Mason John Mills Susan Mollan Ann W Morgan Chetan Mukhtyar Vanessa Quick Richard Watts Bhaskar Dasgupta

Rheumatology (Oxford) 2019 Jul;58(7):1316

Rheumatology, Southend University Hospital NHS Trust, Westcliff-on-Sea, UK.

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http://dx.doi.org/10.1093/rheumatology/key411DOI Listing
July 2019

Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England.

Authors:
Jianhua Wu Adam Keeley Christian Mallen Ann W Morgan Mar Pujades-Rodriguez

CMAJ 2019 Jun;191(25):E680-E688

School of Dentistry (Wu), University of Leeds; Leeds Institute for Data Analytics (Keeley, Morgan, Pujades-Rodriguez), University of Leeds, Leeds, UK; Arthritis Research UK Primary Care Centre (Mallen), University of Keele, Staffordshire, UK; Leeds Institute of Cardiovascular and Metabolic Medicine (Morgan), School of Medicine, University of Leeds; NIHR Leeds Biomedical Research Centre (Morgan), Leeds Teaching Hospitals NHS Trust; Leeds Institute of Health Sciences (Pujades-Rodriguez), School of Medicine, University of Leeds, Leeds, UK

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http://dx.doi.org/10.1503/cmaj.190178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592810PMC
June 2019

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility.

Authors:
David González-Serna Elio G Carmona Norberto Ortego-Centeno Carmen P Simeón Roser Solans José Hernández-Rodríguez Carlos Tolosa Santos Castañeda Javier Narváez Ferran Martinez-Valle Torsten Witte Thomas Neumann Julia Holle Lorenzo Beretta Luigi Boiardi Giacomo Emmi Marco A Cimmino Augusto Vaglio Ariane L Herrick Christopher P Denton Carlo Salvarani María C Cid Ann W Morgan Carmen Fonseca Miguel A González-Gay Javier Martín Ana Márquez

PLoS One 2018 26;13(12):e0209343. Epub 2018 Dec 26.

Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, PTS Granada, Granada, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306228PMC
May 2019

Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England.

Authors:
Teumzghi F Mebrahtu Ann W Morgan Adam Keeley Paul D Baxter Paul M Stewart Mar Pujades-Rodriguez

J Clin Endocrinol Metab 2019 Apr 22. Epub 2019 Apr 22.

Leeds Institute of Health Sciences, School of Medicine, University of Leeds, UK.

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656418PMC
April 2019

Improvement in cardiovascular biomarkers sustained at 4 years following an initial treat-to-target strategy in early rheumatoid arthritis.

Authors:
Isabel Mortimer Lesley-Anne Bissell Elizabeth M A Hensor Lukasz Kozera Sarah L Mackie Agata N Burska Jackie L Nam Helen Keen Edith Villeneuve Helena Donica Maya H Buch Philip G Conaghan Paul Emery Ann W Morgan Jacqueline Andrews

Rheumatology (Oxford) 2019 Apr 16. Epub 2019 Apr 16.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1093/rheumatology/kez114DOI Listing
April 2019

Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis.

Authors:
Elizabeth M A Hensor Paul McKeigue Stephanie F Ling Marco Colombo Jennifer H Barrett Jackie L Nam Jane Freeston Maya H Buch Athina Spiliopoulou Felix Agakov Stephen Kelly Myles J Lewis Suzanne M M Verstappen Alexander J MacGregor Sebastien Viatte Anne Barton Costantino Pitzalis Paul Emery Philip G Conaghan Ann W Morgan

Rheumatology (Oxford) 2019 Mar 1. Epub 2019 Mar 1.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds.

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http://dx.doi.org/10.1093/rheumatology/kez049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649844PMC
March 2019

Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data.

Authors:
Svetlana Cherlin Darren Plant John C Taylor Marco Colombo Athina Spiliopoulou Evan Tzanis Ann W Morgan Michael R Barnes Paul McKeigue Jennifer H Barrett Costantino Pitzalis Anne Barton Matura Consortium Heather J Cordell

Genet Epidemiol 2018 12 12;42(8):754-771. Epub 2018 Oct 12.

NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/gepi.22159
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http://dx.doi.org/10.1002/gepi.22159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334178PMC
December 2018

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Authors:
Jonathan Massey Darren Plant Kimme Hyrich Ann W Morgan Anthony G Wilson Athina Spiliopoulou Marco Colombo Paul McKeigue John Isaacs Heather Cordell Costantino Pitzalis Anne Barton

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.

Authors:
John C Taylor Tim Bongartz Jonathan Massey Borbala Mifsud Athina Spiliopoulou Ian C Scott Jianmei Wang Michael Morgan Darren Plant Marco Colombo Peter Orchard Sarah Twigg Iain B McInnes Duncan Porter Jane E Freeston Jackie L Nam Heather J Cordell John D Isaacs Jenna L Strathdee Donna Arnett Maria J H de Hair Paul P Tak Stella Aslibekyan Ronald F van Vollenhoven Leonid Padyukov S Louis Bridges Costantino Pitzalis Andrew P Cope Suzanne M M Verstappen Paul Emery Michael R Barnes Felix Agakov Paul McKeigue Taisei Mushiroda Michiaki Kubo Richard Weinshilboum Anne Barton Ann W Morgan Jennifer H Barrett

Pharmacogenomics J 2018 07 25;18(4):528-538. Epub 2018 May 25.

Leeds Institute of Cancer and Pathology, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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http://dx.doi.org/10.1038/s41397-018-0025-5DOI Listing
July 2018

Cross-phenotype analysis of Immunochip data identifies as a relevant for the development of systemic vasculitis.

Authors:
Lourdes Ortiz-Fernández Francisco David Carmona Raquel López-Mejías Maria Francisca González-Escribano Paul A Lyons Ann W Morgan Amr H Sawalha Peter A Merkel Kenneth G C Smith Miguel A González-Gay Javier Martín

Ann Rheum Dis 2018 04 27;77(4):589-595. Epub 2018 Jan 27.

Instituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain.

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http://dx.doi.org/10.1136/annrheumdis-2017-212372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849568PMC
April 2018

Effect of Fatigue, Older Age, Higher Body Mass Index, and Female Sex on Disability in Early Rheumatoid Arthritis in the Treatment-to-Target Era.

Authors:
Sarah Twigg Elizabeth M A Hensor Jane Freeston Ai Lyn Tan Paul Emery Alan Tennant Ann W Morgan

Arthritis Care Res (Hoboken) 2018 03 9;70(3):361-368. Epub 2018 Feb 9.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, and NIHR-Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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http://dx.doi.org/10.1002/acr.23281DOI Listing
March 2018

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.

Authors:
James I Robinson Euan W Baxter Robin L Owen Maren Thomsen Darren C Tomlinson Mark P Waterhouse Stephanie J Win Joanne E Nettleship Christian Tiede Richard J Foster Raymond J Owens Colin W G Fishwick Sarah A Harris Adrian Goldman Michael J McPherson Ann W Morgan

Proc Natl Acad Sci U S A 2018 01 15;115(1):E72-E81. Epub 2017 Dec 15.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1707856115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776790PMC
January 2018

Patient-reported Outcomes as Predictors of Change in Disease Activity and Disability in Early Rheumatoid Arthritis: Results from the Yorkshire Early Arthritis Register.

Authors:
Sarah Twigg Elizabeth M A Hensor Paul Emery Alan Tennant Ann W Morgan

J Rheumatol 2017 Sep 1;44(9):1331-1340. Epub 2017 Jul 1.

From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), School of Medicine, University of Leeds; National Institute for Health Research - Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds Teaching Hospitals UK National Health Service (NHS) Trust, Leeds, UK; Swiss Paraplegic Research, Nottwil, Switzerland.

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http://dx.doi.org/10.3899/jrheum.161214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582137PMC
September 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Authors:
Samantha Louise Smith Darren Plant Stephen Eyre Kimme Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

Achieving consensus on minimum data items (including core outcome domains) for a longitudinal observational cohort study in rheumatoid arthritis.

Authors:
Elena Nikiphorou Sarah L Mackie John Kirwan Martin Boers John Isaacs Ann W Morgan Adam Young

Rheumatology (Oxford) 2017 04;56(4):550-555

Rheumatology Department, St Albans City Hospital, St. Albans, UK.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/kew416DOI Listing
April 2017

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Authors:
Meghna Jani John D Isaacs Ann W Morgan Anthony G Wilson Darren Plant Kimme L Hyrich Hector Chinoy Anne Barton

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.

Authors:
F David Carmona Augusto Vaglio Sarah L Mackie José Hernández-Rodríguez Paul A Monach Santos Castañeda Roser Solans Inmaculada C Morado Javier Narváez Marc Ramentol-Sintas Colin T Pease Bhaskar Dasgupta Richard Watts Nader Khalidi Carol A Langford Steven Ytterberg Luigi Boiardi Lorenzo Beretta Marcello Govoni Giacomo Emmi Francesco Bonatti Marco A Cimmino Torsten Witte Thomas Neumann Julia Holle Verena Schönau Laurent Sailler Thomas Papo Julien Haroche Alfred Mahr Luc Mouthon Øyvind Molberg Andreas P Diamantopoulos Alexandre Voskuyl Elisabeth Brouwer Thomas Daikeler Christoph T Berger Eamonn S Molloy Lorraine O'Neill Daniel Blockmans Benedicte A Lie Paul Mclaren Timothy J Vyse Cisca Wijmenga Yannick Allanore Bobby P C Koeleman Jennifer H Barrett María C Cid Carlo Salvarani Peter A Merkel Ann W Morgan Miguel A González-Gay Javier Martín

Am J Hum Genet 2017 Jan 29;100(1):64-74. Epub 2016 Dec 29.

Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain.

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http://dx.doi.org/10.1016/j.ajhg.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223025PMC
January 2017

Improvement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study.

Authors:
Lesley-Anne Bissell Elizabeth M A Hensor Lukasz Kozera Sarah L Mackie Agata N Burska Jacqueline L Nam Helen Keen Edith Villeneuve Helena Donica Maya H Buch Philip G Conaghan Jacqueline Andrews Paul Emery Ann W Morgan

Rheumatology (Oxford) 2016 Dec 16;55(12):2181-2190. Epub 2016 Sep 16.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds & NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK,

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http://dx.doi.org/10.1093/rheumatology/kew306DOI Listing
December 2016

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Authors:
Meghna Jani John D Isaacs Ann W Morgan Anthony G Wilson Darren Plant Kimme L Hyrich Hector Chinoy Anne Barton

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Authors:
Darren Plant Amy Webster Nisha Nair James Oliver Samantha L Smith Steven Eyre Kimme L Hyrich Anthony G Wilson Ann W Morgan John D Isaacs Jane Worthington Anne Barton

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Authors:
Samantha Louise Smith Darren Plant Xiu Hue Lee Jonathan Massey Kimme Hyrich Ann W Morgan Anthony G Wilson John Isaacs Anne Barton

Pharmacogenomics 2016 05 16;17(7):715-20. Epub 2016 May 16.

Arthritis Research UK, Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.16.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996314PMC
May 2016

Description and Validation of Histological Patterns and Proposal of a Dynamic Model of Inflammatory Infiltration in Giant-cell Arteritis.

Authors:
José Hernández-Rodríguez Giuseppe Murgia Irama Villar Elías Campo Sarah L Mackie Aruna Chakrabarty Elizabeth M A Hensor Ann W Morgan Carme Font Sergio Prieto-González Georgina Espígol-Frigolé Josep M Grau Maria C Cid

Medicine (Baltimore) 2016 Feb;95(8):e2368

From the Vasculitis Research Unit, Department of Autoimmune Diseases (JHR, GM, IV, CF, SPG, GEF, MCC); Department of Anatomic Pathology, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (EC); Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust (SLM, EMAH, AWM); Leeds Teaching Hospitals NHS Trust, Leeds, UK (AC); Department of Internal Medicine, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (JMG).

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http://pdfs.journals.lww.com/md-journal/2016/02230/Descripti
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MD.0000000000002368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778989PMC
February 2016

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples.

Authors:
Samantha Louise Smith Stephen Eyre Annie Yarwood Kimme Hyrich Ann W Morgan A G Wilson John Isaacs Darren Plant Anne Barton

Arthritis Res Ther 2015 Dec 14;17:359. Epub 2015 Dec 14.

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, the University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-015-0868-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704535PMC
December 2015

Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Authors:
John Bowes Ashley Budu-Aggrey Ulrike Huffmeier Steffen Uebe Kathryn Steel Harry L Hebert Chris Wallace Jonathon Massey Ian N Bruce James Bluett Marie Feletar Ann W Morgan Helena Marzo-Ortega Gary Donohoe Derek W Morris Philip Helliwell Anthony W Ryan David Kane Richard B Warren Eleanor Korendowych Gerd-Marie Alenius Emiliano Giardina Jonathan Packham Ross McManus Oliver FitzGerald Neil McHugh Matthew A Brown Pauline Ho Frank Behrens Harald Burkhardt Andre Reis Anne Barton

Nat Commun 2015 Jul 6;6:7741. Epub 2015 Jul 6.

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http://dx.doi.org/10.1038/ncomms8741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784513PMC
July 2015

Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation.

Authors:
Sarah Louise Mackie John C Taylor Lubna Haroon-Rashid Stephen Martin Bhaskar Dasgupta Andrew Gough Michael Green Lesley Hordon Stephen Jarrett Colin T Pease Jennifer H Barrett Richard Watts Ann W Morgan

Arthritis Res Ther 2015 Jul 30;17:195. Epub 2015 Jul 30.

School of Medicine and NIHR-Leeds Biomedical Research Unit, Chapel Allerton Hospital, Leeds, LS7 4SA, West Yorkshire, UK.

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http://dx.doi.org/10.1186/s13075-015-0692-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520081PMC
July 2015

Curry-assisted diagnosis in the rheumatology clinic.

Authors:
Sarah L Donaldson Maura Cobine-Davies Ann W Morgan Andrew Gough Sarah L Mackie

Oxf Med Case Reports 2015 Jun 1;2015(6):297-9. Epub 2015 Jun 1.

Leeds Institute of Rheumatic and Musculoskeletal Medicine , University of Leeds , Leeds , UK.

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http://dx.doi.org/10.1093/omcr/omv040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455788PMC
June 2015

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Authors:
Meghna Jani Hector Chinoy Richard B Warren Christopher E M Griffiths Darren Plant Bo Fu Ann W Morgan Anthony G Wilson John D Isaacs KimmeL Hyrich Anne Barton

Arthritis Rheumatol 2015 May;67(8):2011-9

Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://doi.wiley.com/10.1002/art.39169
Publisher Site
http://dx.doi.org/10.1002/art.39169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843946PMC
May 2015

Validity and reliability of the Persian version of Behçet's disease quality-of-life (BD-QoL) questionnaire: a cross-cultural adaptation.

Authors:
Mahdi Vojdanian Seyedeh Tahereh Faezi Alan Tennant Ann W Morgan Pedram Paragomi Mostafa Qorbani Maryam Mattaji Fereydoun Davatchi

Rheumatol Int 2015 Apr 13;35(4):677-84. Epub 2014 Sep 13.

Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, North Kargar Avenue, Tehran, Iran.

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http://dx.doi.org/10.1007/s00296-014-3128-6DOI Listing
April 2015

A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.

Authors:
F David Carmona Sarah L Mackie Jose-Ezequiel Martín John C Taylor Augusto Vaglio Stephen Eyre Lara Bossini-Castillo Santos Castañeda Maria C Cid José Hernández-Rodríguez Sergio Prieto-González Roser Solans Marc Ramentol-Sintas M Francisca González-Escribano Lourdes Ortiz-Fernández Inmaculada C Morado Javier Narváez José A Miranda-Filloy Lorenzo Beretta Claudio Lunardi Marco A Cimmino Davide Gianfreda Daniele Santilli Giuseppe A Ramirez Alessandra Soriano Francesco Muratore Giulia Pazzola Olga Addimanda Cisca Wijmenga Torsten Witte Jan H Schirmer Frank Moosig Verena Schönau Andre Franke Øyvind Palm Øyvind Molberg Andreas P Diamantopoulos Simon Carette David Cuthbertson Lindsy J Forbess Gary S Hoffman Nader A Khalidi Curry L Koening Carol A Langford Carol A McAlear Larry Moreland Paul A Monach Christian Pagnoux Philip Seo Robert Spiera Antoine G Sreih Kenneth J Warrington Steven R Ytterberg Peter K Gregersen Colin T Pease Andrew Gough Michael Green Lesley Hordon Stephen Jarrett Richard Watts Sarah Levy Yusuf Patel Sanjeet Kamath Bhaskar Dasgupta Jane Worthington Bobby P C Koeleman Paul I W de Bakker Jennifer H Barrett Carlo Salvarani Peter A Merkel Miguel A González-Gay Ann W Morgan Javier Martín

Am J Hum Genet 2015 Apr 26;96(4):565-80. Epub 2015 Mar 26.

Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain.

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http://dx.doi.org/10.1016/j.ajhg.2015.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385191PMC
April 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

Authors:
Sebastien Viatte Darren Plant Buhm Han Bo Fu Annie Yarwood Wendy Thomson Deborah P M Symmons Jane Worthington Adam Young Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Soumya Raychaudhuri Anne Barton

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.

Authors:
James Bluett Catharine Morgan Layla Thurston Darren Plant Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Lis Cordingley Anne Barton

Rheumatology (Oxford) 2015 Mar 10;54(3):494-9. Epub 2014 Sep 10.

Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK. Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/keu358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334684PMC
March 2015

Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study.

Authors:
Ariana Montes Eva Perez-Pampin Federico Navarro-Sarabia Virginia Moreira Arturo Rodríguez de la Serna Berta Magallares Yiannis Vasilopoulos Theologia Sarafidou Antonio Fernández-Nebro María Del Carmen Ordóñez Javier Narváez Juan D Cañete Ana Marquez Dora Pascual-Salcedo Beatriz Joven Patricia Carreira Manuel J Moreno-Ramos Rafael Caliz Miguel Angel Ferrer Rosa Garcia-Portales Francisco J Blanco Cesar Magro Enrique Raya Lara Valor Juan J Alegre-Sancho Alejandro Balsa Javier Martin Darren Plant John Isaacs Ann W Morgan Anne Barton Anthony G Wilson Juan J Gómez-Reino Antonio Gonzalez

Arthritis Res Ther 2015 Mar 18;17:63. Epub 2015 Mar 18.

Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1186/s13075-015-0571-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411723PMC
March 2015

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Authors:
John Bowes Ashley Budu-Aggrey Ulrike Huffmeier Steffen Uebe Kathryn Steel Harry L Hebert Chris Wallace Jonathan Massey Ian N Bruce James Bluett Marie Feletar Ann W Morgan Helena Marzo-Ortega Gary Donohoe Derek W Morris Philip Helliwell Anthony W Ryan David Kane Richard B Warren Eleanor Korendowych Gerd-Marie Alenius Emiliano Giardina Jonathan Packham Ross McManus Oliver FitzGerald Neil McHugh Matthew A Brown Pauline Ho Frank Behrens Harald Burkhardt Andre Reis Anne Barton

Nat Commun 2015 Feb 5;6:6046. Epub 2015 Feb 5.

1] Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester M13 9PT, UK [2] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester M13 9WU, UK.

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http://dx.doi.org/10.1038/ncomms7046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327416PMC
February 2015

Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.

Authors:
Meghna Jani Hector Chinoy Richard B Warren Christopher E M Griffiths Darren Plant Ann W Morgan Anthony G Wilson Kimme L Hyrich John Isaacs Anne Barton

Lancet 2015 Feb;385 Suppl 1:S48

Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK.

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February 2015

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment.

Authors:
Rebeccah J Mathews James I Robinson Michele Battellino Chi Wong John C Taylor Steve Eyre Sarah M Churchman Anthony G Wilson John D Isaacs Kimme Hyrich Anne Barton Darren Plant Sinisa Savic Graham P Cook Piercarlo Sarzi-Puttini Paul Emery Jennifer H Barrett Ann W Morgan Michael F McDermott

Ann Rheum Dis 2014 Jun 17;73(6):1202-10. Epub 2013 May 17.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, Chapel Allerton Hospital, UK.

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http://dx.doi.org/10.1136/annrheumdis-2013-203276DOI Listing
June 2014

Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis.

Authors:
Lis Cordingley Rita Prajapati Darren Plant Deborah Maskell Catharine Morgan Faisal R Ali Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Arthritis Care Res (Hoboken) 2014 Jun;66(6):861-8

Manchester Academy of Health Sciences and University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/acr.22249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153952PMC
June 2014

Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.

Authors:
Annie Yarwood Sebastien Viatte Darren Plant Ann W Morgan John Isaacs Anthony G Wilson Kimme Hyrich Steve Eyre Anne Barton

Ann Rheum Dis 2014 May 9;73(5):938-40. Epub 2013 Dec 9.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, , Manchester, UK.

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May 2014

Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.

Authors:
Ian C Scott Seth D Seegobin Sophia Steer Rachael Tan Paola Forabosco Anne Hinks Stephen Eyre Ann W Morgan Anthony G Wilson Lynne J Hocking Paul Wordsworth Anne Barton Jane Worthington Andrew P Cope Cathryn M Lewis

PLoS Genet 2013 19;9(9):e1003808. Epub 2013 Sep 19.

Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom ; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778023PMC
March 2014

MTHFR functional genetic variation and methotrexate treatment response in rheumatoid arthritis: a meta-analysis.

Authors:
Michael D Morgan Nashwa Al-Shaarawy Steve Martin James I Robinson Sarah Twigg Awadalla A Magdy Aziza Sayed Omar Maivel H Ghattas Paul Emery Jennifer H Barrett Ann W Morgan

Pharmacogenomics 2014 Mar;15(4):467-75

Leeds Institute of Rheumatic & Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UK.

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March 2014

Should I send my patient with previous giant cell arteritis for imaging of the thoracic aorta? A systematic literature review and meta-analysis.

Authors:
Sarah Louise Mackie Elizabeth M A Hensor Ann W Morgan Colin T Pease

Ann Rheum Dis 2014 Jan 22;73(1):143-8. Epub 2012 Dec 22.

NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, , Leeds, West Yorkshire, UK.

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January 2014

Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

Authors:
Gisela Orozco Sebastien Viatte John Bowes Paul Martin Anthony G Wilson Ann W Morgan Sophia Steer Paul Wordsworth Lynne J Hocking Anne Barton Jane Worthington Stephen Eyre

Arthritis Rheumatol 2014 Jan;66(1):24-30

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/art.38196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285161PMC
January 2014

Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data.

Authors:
Kate McAllister Annie Yarwood John Bowes Gisela Orozco Sebastian Viatte Dorothée Diogo Lynne J Hocking Sophia Steer Paul Wordsworth A G Wilson Ann W Morgan Joel M Kremer Dimitrios Pappas Peter Gregersen Lars Klareskog Robert Plenge Anne Barton Jeffrey Greenberg Jane Worthington Stephen Eyre

Arthritis Rheum 2013 Dec;65(12):3058-62

University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, and Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/art.38183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034583PMC
December 2013

Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis.

Authors:
M Dawn Teare Rachel Knevel Michael D Morgan Agnieszka Kleszcz Paul Emery David J Moore Philip Conaghan Tom W J Huizinga Ann W Morgan Annette H M van der Helm-van Mil Anthony G Wilson

Arthritis Rheum 2013 Oct;65(10):2555-61

University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1002/art.38064DOI Listing
October 2013

Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis.

Authors:
Lyndsey H Taylor Sarah Twigg Jane Worthington Paul Emery Ann W Morgan Anthony G Wilson M Dawn Teare

J Rheumatol 2013 Jul 1;40(7):1048-53. Epub 2013 May 1.

School of Health and Related Research, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.3899/jrheum.120784DOI Listing
July 2013

Informed conditioning on clinical covariates increases power in case-control association studies.

Authors:
Noah Zaitlen Sara Lindström Bogdan Pasaniuc Marilyn Cornelis Giulio Genovese Samuela Pollack Anne Barton Heike Bickeböller Donald W Bowden Steve Eyre Barry I Freedman David J Friedman John K Field Leif Groop Aage Haugen Joachim Heinrich Brian E Henderson Pamela J Hicks Lynne J Hocking Laurence N Kolonel Maria Teresa Landi Carl D Langefeld Loic Le Marchand Michael Meister Ann W Morgan Olaide Y Raji Angela Risch Albert Rosenberger David Scherf Sophia Steer Martin Walshaw Kevin M Waters Anthony G Wilson Paul Wordsworth Shanbeh Zienolddiny Eric Tchetgen Tchetgen Christopher Haiman David J Hunter Robert M Plenge Jane Worthington David C Christiani Debra A Schaumberg Daniel I Chasman David Altshuler Benjamin Voight Peter Kraft Nick Patterson Alkes L Price

PLoS Genet 2012 8;8(11):e1003032. Epub 2012 Nov 8.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493452PMC
May 2013

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.

Authors:
Jing Cui Eli A Stahl Saedis Saevarsdottir Corinne Miceli Dorothee Diogo Gosia Trynka Towfique Raj Maša Umiċeviċ Mirkov Helena Canhao Katsunori Ikari Chikashi Terao Yukinori Okada Sara Wedrén Johan Askling Hisashi Yamanaka Shigeki Momohara Atsuo Taniguchi Koichiro Ohmura Fumihiko Matsuda Tsuneyo Mimori Namrata Gupta Manik Kuchroo Ann W Morgan John D Isaacs Anthony G Wilson Kimme L Hyrich Marieke Herenius Marieke E Doorenspleet Paul-Peter Tak J Bart A Crusius Irene E van der Horst-Bruinsma Gert Jan Wolbink Piet L C M van Riel Mart van de Laar Henk-Jan Guchelaar Nancy A Shadick Cornelia F Allaart Tom W J Huizinga Rene E M Toes Robert P Kimberly S Louis Bridges Lindsey A Criswell Larry W Moreland João Eurico Fonseca Niek de Vries Barbara E Stranger Philip L De Jager Soumya Raychaudhuri Michael E Weinblatt Peter K Gregersen Xavier Mariette Anne Barton Leonid Padyukov Marieke J H Coenen Elizabeth W Karlson Robert M Plenge

PLoS Genet 2013 Mar 28;9(3):e1003394. Epub 2013 Mar 28.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610685PMC
March 2013

Relationship between area-level socio-economic deprivation and autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study.

Authors:
Sarah L Mackie John C Taylor Sarah Twigg Stephen G Martin Sophia Steer Jane Worthington Anne Barton Anthony G Wilson Lynne Hocking Adam Young Paul Emery Jennifer H Barrett Ann W Morgan

Ann Rheum Dis 2012 Oct 22;71(10):1640-5. Epub 2012 Mar 22.

NIHR-Leeds Biomedical Research Unit, Leeds Institute of Molecular Medicine, Level 8, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1136/annrheumdis-2011-201003DOI Listing
October 2012

Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.

Authors:
Darren Plant Ibrahim Ibrahim Mark Lunt Stephen Eyre Edward Flynn Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Arthritis Res Ther 2012 Oct 7;14(5):R214. Epub 2012 Oct 7.

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http://dx.doi.org/10.1186/ar4052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580526PMC
October 2012

Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

Authors:
John Bowes Pauline Ho Edward Flynn Faisal Ali Helena Marzo-Ortega Laura C Coates Richard B Warren Ross McManus Anthony W Ryan David Kane Eleanor Korendowych Neil McHugh Oliver FitzGerald Jonathon Packham Ann W Morgan Ian N Bruce Anne Barton

Ann Rheum Dis 2012 Aug 10;71(8):1350-4. Epub 2012 Feb 10.

Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2011-20080
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http://dx.doi.org/10.1136/annrheumdis-2011-200802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396450PMC
August 2012

Outrunning free radicals in room-temperature macromolecular crystallography.

Authors:
Robin L Owen Danny Axford Joanne E Nettleship Raymond J Owens James I Robinson Ann W Morgan Andrew S Doré Guillaume Lebon Christopher G Tate Elizabeth E Fry Jingshan Ren David I Stuart Gwyndaf Evans

Acta Crystallogr D Biol Crystallogr 2012 Jul 15;68(Pt 7):810-8. Epub 2012 Jun 15.

Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.

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http://dx.doi.org/10.1107/S0907444912012553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791751PMC
July 2012

FcγRIIIa expression on monocytes in rheumatoid arthritis: role in immune-complex stimulated TNF production and non-response to methotrexate therapy.

Authors:
Dawn L Cooper Stephen G Martin James I Robinson Sarah L Mackie Christopher J Charles Jackie Nam John D Isaacs Paul Emery Ann W Morgan

PLoS One 2012 3;7(1):e28918. Epub 2012 Jan 3.

NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250404PMC
May 2012

In situ macromolecular crystallography using microbeams.

Authors:
Danny Axford Robin L Owen Jun Aishima James Foadi Ann W Morgan James I Robinson Joanne E Nettleship Raymond J Owens Isabel Moraes Elizabeth E Fry Jonathan M Grimes Karl Harlos Abhay Kotecha Jingshan Ren Geoff Sutton Thomas S Walter David I Stuart Gwyndaf Evans

Acta Crystallogr D Biol Crystallogr 2012 May 17;68(Pt 5):592-600. Epub 2012 Apr 17.

Life Science Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, England.

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http://dx.doi.org/10.1107/S0907444912006749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791750PMC
May 2012

Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.

Authors:
James I Robinson Ian M Carr Dawn L Cooper Lubna H Rashid Stephen G Martin Paul Emery John D Isaacs Anne Barton Anthony G Wilson Jennifer H Barrett Ann W Morgan

Hum Mutat 2012 Apr 28;33(4):741-9. Epub 2012 Feb 28.

NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1002/humu.22031DOI Listing
April 2012

Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort.

Authors:
Darren Plant Rita Prajapati Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Arthritis Rheum 2012 Mar;64(3):665-70

Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.33381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427899PMC
March 2012

Investigation of IL1, VEGF, PPARG and MEFV genes in psoriatic arthritis susceptibility.

Authors:
John Bowes Pauline Ho Edward Flynn Salma Salah Neil McHugh Oliver FitzGerald Jonathan Packham Ann W Morgan Philip S Helliwell Ian N Bruce Anne Barton

Ann Rheum Dis 2012 Feb 28;71(2):313-4. Epub 2011 Jul 28.

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http://dx.doi.org/10.1136/ard.2011.154690DOI Listing
February 2012

Cardiovascular risk and rheumatoid arthritis--the next step: differentiating true soluble biomarkers of cardiovascular risk from surrogate measures of inflammation.

Authors:
Lukasz Kozera Jacqueline Andrews Ann W Morgan

Rheumatology (Oxford) 2011 Nov 13;50(11):1944-54. Epub 2011 Jul 13.

NIHR - Leeds Musculoskeletal Biomedical Research Unit, LeedsInstitute of Molecular Medicine, University of Leeds, Leeds, UK.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/ker232DOI Listing
November 2011

Ischaemic manifestations in giant cell arteritis are associated with area level socio-economic deprivation, but not cardiovascular risk factors.

Authors:
Sarah L Mackie Bhaskar Dasgupta Lesley Hordon Andrew Gough Michael Green Jane Hollywood Shouma Dutta Victoria Bejarano Stephen Jarrett Ann W Morgan Colin T Pease

Rheumatology (Oxford) 2011 Nov 22;50(11):2014-22. Epub 2011 Aug 22.

NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Chapel Allerton Hospital, Leeds LS7 4SA, UK.

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http://dx.doi.org/10.1093/rheumatology/ker265DOI Listing
November 2011

Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis.

Authors:
John Bowes Gisela Orozco Edward Flynn Pauline Ho Rasha Brier Helena Marzo-Ortega Laura Coates Ross McManus Anthony W Ryan David Kane Eleanor Korendowych Neil McHugh Oliver FitzGerald Jonathan Packham Ann W Morgan Ian N Bruce Anne Barton

Ann Rheum Dis 2011 Sep 29;70(9):1641-4. Epub 2011 May 29.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/ard.2011.150102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147229PMC
September 2011

Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.

Authors:
John Bowes Steve Eyre Edward Flynn Pauline Ho Salma Salah Richard B Warren Helena Marzo-Ortega Laura Coates Ross McManus Anthony W Ryan David Kane Eleanor Korendowych Neil McHugh Oliver FitzGerald Jonathan Packham Ann W Morgan Christopher E M Griffiths Ian N Bruce Jane Worthington Anne Barton

Ann Rheum Dis 2011 Jun 23;70(6):1016-9. Epub 2011 Feb 23.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/ard.2010.143123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086035PMC
June 2011

Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.

Authors:
Stephen Eyre Anne Hinks John Bowes Edward Flynn Paul Martin Anthony G Wilson Ann W Morgan Paul Emery Sophia Steer Lynne J Hocking David M Reid Pille Harrison Paul Wordsworth Wendy Thomson Jane Worthington Anne Barton

Arthritis Res Ther 2010 20;12(5):R175. Epub 2010 Sep 20.

Arthritis Research UK, Epidemiology Unit, Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991006PMC
March 2011

Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.

Authors:
Darren Plant John Bowes Catherine Potter Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Arthritis Rheum 2011 Mar;63(3):645-53

University of Manchester, Manchester, UK.

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http://doi.wiley.com/10.1002/art.30130
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084508PMC
March 2011

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.

Authors:
Gisela Orozco Steve Eyre Anne Hinks John Bowes Ann W Morgan Anthony G Wilson Paul Wordsworth Sophia Steer Lynne Hocking Wendy Thomson Jane Worthington Anne Barton

Ann Rheum Dis 2011 Mar 10;70(3):463-8. Epub 2010 Nov 10.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1136/ard.2010.137174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033530PMC
March 2011

Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.

Authors:
Lydia R Coulthard John C Taylor Steve Eyre James I Robinson Anthony G Wilson John D Isaacs Kimme Hyrich Paul Emery Anne Barton Jennifer H Barrett Ann W Morgan Michael F McDermott

Ann Rheum Dis 2011 Jan 30;70(1):98-103. Epub 2010 Aug 30.

NIHR-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1136/ard.2010.133249DOI Listing
January 2011

Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis.

Authors:
John Bowes Edward Flynn Pauline Ho Batool Aly Ann W Morgan Helena Marzo-Ortega Laura Coates Ross McManus Anthony W Ryan David Kane Eleanor Korendowych Neil McHugh Oliver FitzGerald Jonathan Packham Ian N Bruce Anne Barton

Ann Rheum Dis 2010 Dec 19;69(12):2199-203. Epub 2010 Jul 19.

Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/ard.2010.130575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002763PMC
December 2010

Persistently moderate DAS-28 is not benign: loss of function occurs in early RA despite step-up DMARD therapy.

Authors:
Philip G Conaghan Elizabeth M A Hensor Anne-Maree Keenan Ann W Morgan Paul Emery

Rheumatology (Oxford) 2010 Oct 11;49(10):1894-9. Epub 2010 Jun 11.

Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds, UK.

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http://dx.doi.org/10.1093/rheumatology/keq178DOI Listing
October 2010

Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.

Authors:
Ann W Morgan James I Robinson Philip G Conaghan Stephen G Martin Elizabeth M A Hensor Michael D Morgan Lori Steiner Henry A Erlich Hock-Chye Gooi Anne Barton Jane Worthington Paul Emery

Arthritis Res Ther 2010 30;12(2):R57. Epub 2010 Mar 30.

NIHR - Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK.

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http://dx.doi.org/10.1186/ar2969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888207PMC
September 2010

Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population.

Authors:
Stephen Eyre Anne Hinks Edward Flynn Paul Martin Anthony G Wilson James R Maxwell Ann W Morgan Paul Emery Sophia Steer Lynne J Hocking David M Reid Pille Harrison Paul Wordsworth Wendy Thomson Jane Worthington Anne Barton

Ann Rheum Dis 2010 Aug 27;69(8):1572-3. Epub 2009 Nov 27.

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http://ard.bmj.com/cgi/doi/10.1136/ard.2009.122887
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http://dx.doi.org/10.1136/ard.2009.122887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009391PMC
August 2010

No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort.

Authors:
Stephen Eyre Edward Flynn Paul Martin Anne Hinks Anthony G Wilson Ann W Morgan Paul Emery Sophia Steer Lynne J Hocking David M Reid Pille Harrison Paul Wordsworth Wendy Thomson Jane Worthington Anne Barton

Ann Rheum Dis 2010 Jul 11;69(7):1407-8. Epub 2009 Nov 11.

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http://dx.doi.org/10.1136/ard.2009.120428DOI Listing
July 2010

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

Authors:
Jing Cui Saedis Saevarsdottir Brian Thomson Leonid Padyukov Annette H M van der Helm-van Mil Joanne Nititham Laura B Hughes Niek de Vries Soumya Raychaudhuri Lars Alfredsson Johan Askling Sara Wedrén Bo Ding Candace Guiducci Gert Jan Wolbink J Bart A Crusius Irene E van der Horst-Bruinsma Marieke Herenius Michael E Weinblatt Nancy A Shadick Jane Worthington Franak Batliwalla Marlena Kern Ann W Morgan Anthony G Wilson John D Isaacs Kimme Hyrich Michael F Seldin Larry W Moreland Timothy W Behrens Cornelia F Allaart Lindsey A Criswell Tom W J Huizinga Paul P Tak S Louis Bridges Rene E M Toes Anne Barton Lars Klareskog Peter K Gregersen Elizabeth W Karlson Robert M Plenge

Arthritis Rheum 2010 Jul;62(7):1849-61

Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/art.27457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652476PMC
July 2010

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.

Authors:
Catherine Potter Heather J Cordell Anne Barton Ann K Daly Kimme L Hyrich Derek A Mann Ann W Morgan Anthony G Wilson John D Isaacs

Ann Rheum Dis 2010 Jul 6;69(7):1315-20. Epub 2010 May 6.

Musculoskeletal Research Group, Institute of Cellular Medicine, University of Newcastle, 4th Floor Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1136/ard.2009.117309DOI Listing
July 2010

Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease.

Authors:
James I Robinson Jennifer H Barrett John C Taylor Marc Naven Diane Corscadden Anne Barton Anthony G Wilson Paul Emery John D Isaacs Ann W Morgan

Ann Rheum Dis 2010 Jun 20;69(6):1054-7. Epub 2009 Aug 20.

NIHR-Leeds Musculoskeletal Biomedical Research Unit, St James's University Hospital, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1136/ard.2009.110874DOI Listing
June 2010

Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

Authors:
Rachael J L Tan Laura J Gibbons Catherine Potter Kimme L Hyrich Ann W Morgan Anthony G Wilson John D Isaacs Anne Barton

Ann Rheum Dis 2010 Jun 5;69(6):1029-35. Epub 2010 May 5.

Arthritis Research Campaign Epidemiology Unit, Stopford Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1136/ard.2009.118406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930850PMC
June 2010

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Authors:
Eli A Stahl Soumya Raychaudhuri Elaine F Remmers Gang Xie Stephen Eyre Brian P Thomson Yonghong Li Fina A S Kurreeman Alexandra Zhernakova Anne Hinks Candace Guiducci Robert Chen Lars Alfredsson Christopher I Amos Kristin G Ardlie Anne Barton John Bowes Elisabeth Brouwer Noel P Burtt Joseph J Catanese Jonathan Coblyn Marieke J H Coenen Karen H Costenbader Lindsey A Criswell J Bart A Crusius Jing Cui Paul I W de Bakker Philip L De Jager Bo Ding Paul Emery Edward Flynn Pille Harrison Lynne J Hocking Tom W J Huizinga Daniel L Kastner Xiayi Ke Annette T Lee Xiangdong Liu Paul Martin Ann W Morgan Leonid Padyukov Marcel D Posthumus Timothy R D J Radstake David M Reid Mark Seielstad Michael F Seldin Nancy A Shadick Sophia Steer Paul P Tak Wendy Thomson Annette H M van der Helm-van Mil Irene E van der Horst-Bruinsma C Ellen van der Schoot Piet L C M van Riel Michael E Weinblatt Anthony G Wilson Gert Jan Wolbink B Paul Wordsworth Cisca Wijmenga Elizabeth W Karlson Rene E M Toes Niek de Vries Ann B Begovich Jane Worthington Katherine A Siminovitch Peter K Gregersen Lars Klareskog Robert M Plenge

Nat Genet 2010 Jun 9;42(6):508-14. Epub 2010 May 9.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243840PMC
June 2010

Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.

Authors:
Gisela Orozco Steve Eyre Anne Hinks Xiayi Ke Anthony G Wilson Deborah E Bax Ann W Morgan Paul Emery Sophia Steer Lynne Hocking David M Reid Paul Wordsworth Pille Harrison Wendy Thomson Anne Barton Jane Worthington

Ann Rheum Dis 2010 May 11;69(5):813-6. Epub 2009 May 11.

Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1136/ard.2009.109579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009392PMC
May 2010

Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response.

Authors:
Catherine Potter Laura J Gibbons John D Bowes Heather J Cordell Kimme Hyrich John D Isaacs Ann W Morgan Anthony G Wilson Anne Barton

Pharmacogenet Genomics 2010 May;20(5):338-41

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University.

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http://dx.doi.org/10.1097/FPC.0b013e32833878d7DOI Listing
May 2010

PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population.

Authors:
Marian L Burr Haris Naseem Anne Hinks Steve Eyre Laura J Gibbons John Bowes Anthony G Wilson James Maxwell Ann W Morgan Paul Emery Sophia Steer Lynne Hocking David M Reid Paul Wordsworth Pille Harrison Wendy Thomson Jane Worthington Anne Barton

Ann Rheum Dis 2010 Apr 25;69(4):666-70. Epub 2009 May 25.

arc-Epidemiology Unit, University of Manchester, Oxford Road, Manchester, UK.

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http://dx.doi.org/10.1136/ard.2009.111294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927647PMC
April 2010

Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis.

Authors:
Batool Hassan James R Maxwell Kimme L Hyrich Anne Barton Jane Worthington John D Isaacs Ann W Morgan Anthony G Wilson

Rheumatology (Oxford) 2010 Jan 19;49(1):43-7. Epub 2009 Nov 19.

Academic Rheumatology Group, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1093/rheumatology/kep372DOI Listing
January 2010

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Authors:
Soumya Raychaudhuri Brian P Thomson Elaine F Remmers Stephen Eyre Anne Hinks Candace Guiducci Joseph J Catanese Gang Xie Eli A Stahl Robert Chen Lars Alfredsson Christopher I Amos Kristin G Ardlie Anne Barton John Bowes Noel P Burtt Monica Chang Jonathan Coblyn Karen H Costenbader Lindsey A Criswell J Bart A Crusius Jing Cui Phillip L De Jager Bo Ding Paul Emery Edward Flynn Pille Harrison Lynne J Hocking Tom W J Huizinga Daniel L Kastner Xiayi Ke Fina A S Kurreeman Annette T Lee Xiangdong Liu Yonghong Li Paul Martin Ann W Morgan Leonid Padyukov David M Reid Mark Seielstad Michael F Seldin Nancy A Shadick Sophia Steer Paul P Tak Wendy Thomson Annette H M van der Helm-van Mil Irene E van der Horst-Bruinsma Michael E Weinblatt Anthony G Wilson Gert Jan Wolbink Paul Wordsworth David Altshuler Elizabeth W Karlson Rene E M Toes Niek de Vries Ann B Begovich Katherine A Siminovitch Jane Worthington Lars Klareskog Peter K Gregersen Mark J Daly Robert M Plenge

Nat Genet 2009 Dec 8;41(12):1313-8. Epub 2009 Nov 8.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142887PMC
December 2009

Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.

Authors:
Annie McClure Mark Lunt Steve Eyre Xiayi Ke Wendy Thomson Anne Hinks John Bowes Laura Gibbons Darren Plant Anthony G Wilson Ioanna Marinou Ann W Morgan Paul Emery Sophia Steer Lynne J Hocking David M Reid Paul Wordsworth Pille Harrison Jane Worthington Anne Barton

Rheumatology (Oxford) 2009 Nov 9;48(11):1369-74. Epub 2009 Sep 9.

ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kep272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762544PMC
November 2009

Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.

Authors:
Ann W Morgan Wendy Thomson Stephen G Martin Angela M Carter Henry A Erlich Anne Barton Lynne Hocking David M Reid Pille Harrison Paul Wordsworth Sophia Steer Jane Worthington Paul Emery Anthony G Wilson Jennifer H Barrett

Arthritis Rheum 2009 Sep;60(9):2565-76

Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St. James' University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/art.24752DOI Listing
September 2009

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

Authors:
Anne Barton Steve Eyre Xiayi Ke Anne Hinks John Bowes Edward Flynn Paul Martin Anthony G Wilson Ann W Morgan Paul Emery Sophia Steer Lynne J Hocking David M Reid Pille Harrison Paul Wordsworth Wendy Thomson Jane Worthington

Hum Mol Genet 2009 Jul 9;18(13):2518-22. Epub 2009 Apr 9.

University of Manchester, Manchester, UK.

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http://hmg.oxfordjournals.org/content/18/13/2518.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddp177
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http://dx.doi.org/10.1093/hmg/ddp177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694689PMC
July 2009

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.

Authors:
Gisela Orozco Anne Hinks Steve Eyre Xiayi Ke Laura J Gibbons John Bowes Edward Flynn Paul Martin Anthony G Wilson Deborah E Bax Ann W Morgan Paul Emery Sophia Steer Lynne Hocking David M Reid Paul Wordsworth Pille Harrison Wendy Thomson Anne Barton Jane Worthington

Hum Mol Genet 2009 Jul 5;18(14):2693-9. Epub 2009 May 5.

arc-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/hmg/ddp193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701332PMC
July 2009

Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients.

Authors:
John D Bowes Catherine Potter Laura J Gibbons Kimme Hyrich Darren Plant Ann W Morgan Anthony G Wilson John D Isaacs Jane Worthington Anne Barton

Pharmacogenet Genomics 2009 Apr;19(4):319-23

Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1097/FPC.0b013e328328d51fDOI Listing
April 2009

Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis.

Authors:
James R Maxwell Catherine Potter Kimme L Hyrich Anne Barton Jane Worthington John D Isaacs Ann W Morgan Anthony G Wilson

Hum Mol Genet 2008 Nov 19;17(22):3532-8. Epub 2008 Aug 19.

Academic Rheumatology Group, University of Sheffield, D Floor Medical School, Sheffield, UK.

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http://hmg.oxfordjournals.org/content/17/22/3532.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddn245
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http://dx.doi.org/10.1093/hmg/ddn245DOI Listing
November 2008

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

Authors:
Anne Barton Wendy Thomson Xiayi Ke Steve Eyre Anne Hinks John Bowes Darren Plant Laura J Gibbons Anthony G Wilson Deborah E Bax Ann W Morgan Paul Emery Sophia Steer Lynne Hocking David M Reid Paul Wordsworth Pille Harrison Jane Worthington

Nat Genet 2008 Oct 14;40(10):1156-9. Epub 2008 Sep 14.

Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK.

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http://ard.bmj.com/content/71/7/1117.full.pdf
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http://www.nature.com/doifinder/10.1038/ng.218
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http://dx.doi.org/10.1038/ng.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662493PMC
October 2008

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.

Authors:
Lisa C Willcocks Paul A Lyons Menna R Clatworthy James I Robinson Wanling Yang Stephen A Newland Vincent Plagnol Naomi N McGovern Alison M Condliffe Edwin R Chilvers Dwomoa Adu Elaine C Jolly Richard Watts Yu Lung Lau Ann W Morgan Gerard Nash Kenneth G C Smith

J Exp Med 2008 Jul 16;205(7):1573-82. Epub 2008 Jun 16.

Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY, England, UK.

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http://dx.doi.org/10.1084/jem.20072413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442635PMC
July 2008

The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort.

Authors:
Ann W Morgan Lubna Haroon-Rashid Stephen G Martin Hock-Chye Gooi Jane Worthington Wendy Thomson Jennifer H Barrett Paul Emery

Arthritis Rheum 2008 May;58(5):1275-83

University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1002/art.23432DOI Listing
May 2008

The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.

Authors:
Yasser M El-Sherbiny Josephine L Meade Tim D Holmes Dennis McGonagle Sarah L Mackie Ann W Morgan Gordon Cook Sylvia Feyler Stephen J Richards Faith E Davies Gareth J Morgan Graham P Cook

Cancer Res 2007 Sep;67(18):8444-9

Leeds Institute of Molecular Medicine, University of Leeds, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4230DOI Listing
September 2007

Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis.

Authors:
Ann W Morgan Jim I Robinson Jennifer H Barrett Javier Martin Amy Walker Sarah J Babbage William E R Ollier Miguel A Gonzalez-Gay John D Isaacs

Arthritis Res Ther 2006 ;8(4):R109

Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1186/ar1996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779375PMC
February 2007

Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.

Authors:
Ann W Morgan Jennifer H Barrett Bridget Griffiths Deepak Subramanian Jim I Robinson Viki H Keyte Manir Ali Elizabeth A Jones Robert W Old Frederique Ponchel Arthur W Boylston R Deva Situnayake Alexander F Markham Paul Emery John D Isaacs

Arthritis Res Ther 2006 ;8(1):R5

Institute of Molecular Medicine, Epidemiology and Cancer Research, University of Leeds, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1186/ar1847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526569PMC
January 2007

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia.

Authors:
Frederique Ponchel Robert J Verburg Sarah J Bingham Andrew K Brown John Moore Andrew Protheroe Kath Short Catherine A Lawson Ann W Morgan Mark Quinn Maya Buch Sarah L Field Sarah L Maltby Aurelie Masurel Susan H Douglas Liz Straszynski Ursula Fearon Douglas J Veale Poulam Patel Dennis McGonagle John Snowden Alexander F Markham David Ma Jacob M van Laar Helen A Papadaki Paul Emery John D Isaacs

Arthritis Res Ther 2005 16;7(1):R80-92. Epub 2004 Nov 16.

Molecular Medicine Unit, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1186/ar1452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064881PMC
March 2006

Diagnosing late onset rheumatoid arthritis, polymyalgia rheumatica, and temporal arteritis in patients presenting with polymyalgic symptoms. A prospective longterm evaluation.

Authors:
Colin T Pease Glenn Haugeberg Ann W Morgan Bridget Montague Elizabeth M A Hensor Bipin B Bhakta

J Rheumatol 2005 Jun;32(6):1043-6

Academic Unit of Musculoskeletal and Rehabilitation Medicine, University of Leeds, Leeds, UK.

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June 2005

Fc gamma receptors are critical modulators of inflammation within the synovium: comment on the article by Blom et al.

Authors:
Ann W Morgan Paul Emery John D Isaacs

Arthritis Rheum 2004 Apr;50(4):1352-3; author reply 1353-4

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http://doi.wiley.com/10.1002/art.20142
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http://dx.doi.org/10.1002/art.20142DOI Listing
April 2004

Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis.

Authors:
Frederique Ponchel Ann W Morgan Sarah J Bingham Mark Quinn Maya Buch Robert J Verburg Judy Henwood Susan H Douglas Aurelie Masurel Philip Conaghan Moji Gesinde Julia Taylor Alexander F Markham Paul Emery Jacob M van Laar John D Isaacs

Blood 2002 Dec 8;100(13):4550-6. Epub 2002 Aug 8.

Molecular Medicine Unit, The University of Leeds, St James's University Hospital, United Kingdom.

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http://dx.doi.org/10.1182/blood-2002-03-0671DOI Listing
December 2002

Unique TCR beta-subunit variable gene haplotypes in Africans.

Authors:
Ian J Donaldson Jahan Shefta Cathy A Lawson James R Bushnell Ann W Morgan John D Isaacs Danielle Carpenter Marie-Anne Shaw Ingegerd Rooth Rupert J Quinnell Alimuddin M Zumla William R Ollier Chifumbe Z Chintu Gabriel P Muyinda Adrian S Hill Arthur W Boylston

Immunogenetics 2002 Feb 1;53(10-11):884-93. Epub 2002 Feb 1.

Molecular Medicine Unit, Level 6, Clinical Sciences Building, St. James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1007/s00251-001-0406-8DOI Listing
February 2002