Ann Van Eeckhaut

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Ann Van Eeckhaut

Publications by authors named "Ann Van Eeckhaut"

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42Publications

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Synthesis and Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

ACS Med Chem Lett 2018 May 23;9(5):496-501. Epub 2018 Apr 23.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

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May 2018

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents.

Glia 2018 Apr 23. Epub 2018 Apr 23.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research group Experimental Pharmacology (EFAR), Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, 1090, Belgium.

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April 2018

Development of potent and proteolytically stable human neuromedin U receptor agonists.

Eur J Med Chem 2018 Jan 14;144:887-897. Epub 2017 Dec 14.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address:

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January 2018

Testosterone boosts physical activity in male mice via dopaminergic pathways.

Sci Rep 2018 Jan 17;8(1):957. Epub 2018 Jan 17.

Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Herestraat 49 PO box 902, 3000, Leuven, Belgium.

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January 2018

Running Opposes the Effects of Social Isolation on Synaptic Plasticity and Transmission in a Rat Model of Depression.

PLoS One 2016 20;11(10):e0165071. Epub 2016 Oct 20.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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June 2017

Glutamate released in the preoptic area during sexual behavior controls local estrogen synthesis in male quail.

Psychoneuroendocrinology 2017 May 8;79:49-58. Epub 2017 Feb 8.

GIGA Neurosciences, Research Group in Behavioral Neuroendocrinology, Neuroendocrinology unit, University of Liège, 15 Avenue Hippocrate (B36), 4000 Liège, Belgium.

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May 2017

LC-method development for the quantification of neuromedin-like peptides. Emphasis on column choice and mobile phase composition.

J Pharm Biomed Anal 2017 Apr 11;137:104-112. Epub 2017 Jan 11.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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April 2017

In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system.

J Pharm Pharmacol 2017 Mar 30;69(3):314-324. Epub 2017 Jan 30.

Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.

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March 2017

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor.

Int J Mol Sci 2017 Mar 4;18(3). Epub 2017 Mar 4.

Research Group Experimental Pharmacology (EFAR/FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel, Belgium.

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March 2017

Challenges for the in vivo quantification of brain neuropeptides using microdialysis sampling and LC-MS.

Bioanalysis 2016 Sep 24;8(18):1965-85. Epub 2016 Aug 24.

Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.

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September 2016

An improved microbore UHPLC method with electrochemical detection for the simultaneous determination of low monoamine levels in in vivo brain microdialysis samples.

J Pharm Biomed Anal 2016 Aug 13;127:136-46. Epub 2016 Jan 13.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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August 2016

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT.

Neuropharmacology 2016 08 1;107:460-470. Epub 2016 Apr 1.

Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address:

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August 2016

Mixed α/β-Peptides as a Class of Short Amphipathic Peptide Hydrogelators with Enhanced Proteolytic Stability.

Biomacromolecules 2016 Feb 25;17(2):437-45. Epub 2016 Jan 25.

Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel , Laarbeeklaan 103, B-1090 Brussels, Belgium.

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February 2016

Miniaturized ultra-high performance liquid chromatography coupled to electrochemical detection: Investigation of system performance for neurochemical analysis.

J Chromatogr A 2016 Jan 2;1427:69-78. Epub 2015 Dec 2.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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January 2016

An ultrasensitive nano UHPLC-ESI-MS/MS method for the quantification of three neuromedin-like peptides in microdialysates.

Bioanalysis 2015 ;7(5):605-19

Department of Pharmaceutical Chemistry & Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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December 2015

Interinstrumental method transfer of a capillary electrophoretic separation of angiotensin II and five derivatives: Evaluation and update of earlier developed guidelines.

Electrophoresis 2015 Nov 7;36(21-22):2658-2664. Epub 2015 Sep 7.

Department of Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

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November 2015

Toward greener analytical techniques for the absolute quantification of peptides in pharmaceutical and biological samples.

J Pharm Biomed Anal 2015 Sep 30;113:181-8. Epub 2015 Mar 30.

Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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September 2015

Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.

Neurochem Int 2015 Sep 11;88:88-96. Epub 2015 Jul 11.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

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September 2015

Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds.

Epilepsy Res 2015 Sep 6;115:67-72. Epub 2015 Jun 6.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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September 2015

Reassessment of the antioxidative mixture for the challenging electrochemical determination of dopamine, noradrenaline and serotonin in microdialysis samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 Aug 2;998-999:63-71. Epub 2015 Jul 2.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Jette, Belgium. Electronic address:

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August 2015

Affinity capillary electrophoresis to evaluate the complex formation between poliovirus and nanobodies.

J Sep Sci 2014 Dec 12;37(24):3729-37. Epub 2014 Nov 12.

Department of Pharmaceutical Biotechnology and Molecular Biology, Vrije Universiteit Brussel, Brussels, Belgium; Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

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December 2014

NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats.

Neuropharmacology 2014 Oct 24;85:198-205. Epub 2014 May 24.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

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October 2014

Strategies to reduce aspecific adsorption of peptides and proteins in liquid chromatography-mass spectrometry based bioanalyses: an overview.

J Chromatogr A 2014 Sep 30;1358:1-13. Epub 2014 Jun 30.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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September 2014

Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.

CNS Neurosci Ther 2014 Jul 31;20(7):662-70. Epub 2014 Mar 31.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

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July 2014

Ion-pair ultra-high performance liquid chromatographic analysis of monoamines: peak-splitting at high flow rates.

J Chromatogr A 2013 Dec 29;1321:73-9. Epub 2013 Oct 29.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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December 2013

Determination of reboxetine in rat brain microdialysates and plasma samples using liquid chromatography coupled to fluorescence detection.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Jun 16;898:53-61. Epub 2012 Apr 16.

Vrije Universiteit Brussel, Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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June 2012

Microbore liquid chromatography with UV detection to study the in vivo passage of compound 21, a non-peptidergic AT₂ receptor agonist, to the striatum in rats.

J Neurosci Methods 2011 Nov 22;202(2):137-42. Epub 2011 Jun 22.

Vrije Universiteit Brussel, Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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November 2011

The absolute quantification of endogenous levels of brain neuropeptides in vivo using LC-MS/MS.

Bioanalysis 2011 Jun;3(11):1271-85

Vrije Universiteit Brussel, Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Center for Neuroscience, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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June 2011

Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Aug 13;877(23):2198-207. Epub 2009 Jan 13.

Vrije Universiteit Brussel, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Laarbeeklaan 103, 1090 Brussels, Belgium.

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August 2009

Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection.

Sensors (Basel) 2008 Aug 28;8(8):5171-5185. Epub 2008 Aug 28.

Experimental Neuropharmacology Research Group, Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussel, Belgium.

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August 2008

Capillary and nano-liquid chromatography-tandem mass spectrometry for the quantification of small molecules in microdialysis samples: comparison with microbore dimensions.

J Chromatogr A 2006 Oct 30;1131(1-2):166-75. Epub 2006 Aug 30.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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October 2006

Chiral separations by capillary electrophoresis: Recent developments and applications.

Electrophoresis 2006 Jul;27(14):2880-95

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium.

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July 2006

Chiral separation of cetirizine by capillary electrophoresis.

Electrophoresis 2006 Jun;27(12):2376-85

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium.

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June 2006

Use of microbore LC-MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Feb 28;831(1-2):205-12. Epub 2005 Dec 28.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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February 2006

Separation of neutral dihydropyridines and their enantiomers using electrokinetic chromatography.

J Pharm Biomed Anal 2004 Nov;36(4):799-805

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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November 2004

Influence of methanol on the enantioresolution of antihistamines with carboxymethyl-beta-cyclodextrin in capillary electrophoresis.

Electrophoresis 2004 Aug;25(16):2838-47

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium.

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August 2004

Differential effects of organic modifiers on the enantioseparation of dimetindene maleate with carboxymethyl-beta-cyclodextrin in capillary electrophoresis.

J Sep Sci 2004 Jan;27(1-2):21-7

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Pharmaceutical Institute, Vrije Universiteit Brussel, Brussels, Belgium.

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January 2004

Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate.

J Chromatogr A 2002 Jun;958(1-2):291-7

Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Belgium.

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June 2002