Ann Massie

Ann Massie

UNVERIFIED PROFILE

Are you Ann Massie?   Register this Author

Register author
Ann Massie

Ann Massie

Publications by authors named "Ann Massie"

Are you Ann Massie?   Register this Author

49Publications

-Reads

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.

Glia 2018 05 19;66(5):951-970. Epub 2018 Jan 19.

The Neurotransporter Group, Section of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, 0317, Norway.

View Article
May 2018

Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice.

Glia 2018 Apr 25. Epub 2018 Apr 25.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, 1090, Belgium.

View Article
April 2018

6 Hz corneal kindling in mice triggers neurobehavioral comorbidities accompanied by relevant changes in c-Fos immunoreactivity throughout the brain.

Epilepsia 2018 01 20;59(1):67-78. Epub 2017 Nov 20.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
January 2018

Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the corticosterone mouse model.

World J Biol Psychiatry 2017 Sep 27:1-12. Epub 2017 Sep 27.

a Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information , Center for Neurosciences (C4N), Vrije Universiteit Brussel , Brussels , Belgium.

View Article
September 2017

Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice.

PLoS One 2016 24;11(10):e0164721. Epub 2016 Oct 24.

Department of Neurology, University Hospital Brussels and Center for Neuroscience, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

View Article
June 2017

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system x.

Exp Neurol 2017 04 24;290:15-28. Epub 2016 Dec 24.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

View Article
April 2017

Plastic changes at corticostriatal synapses predict improved motor function in a partial lesion model of Parkinson's disease.

Brain Res Bull 2017 04 20;130:257-267. Epub 2017 Feb 20.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

View Article
April 2017

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor.

Int J Mol Sci 2017 Mar 4;18(3). Epub 2017 Mar 4.

Research Group Experimental Pharmacology (EFAR/FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel, Belgium.

View Article
March 2017

Absence of system x on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.

J Neuroinflammation 2017 01 13;14(1). Epub 2017 Jan 13.

Center for Neurosciences (C4N), Department of Pharmaceutical Biotechnology and Molecular Biology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.

View Article
January 2017

Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.

Neurosci Lett 2016 07 18;626:119-25. Epub 2016 May 18.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

View Article
July 2016

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.

J Comp Neurol 2016 Apr 23;524(5):1015-32. Epub 2015 Oct 23.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, 1090, Belgium.

View Article
April 2016

In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions.

Physiol Behav 2016 Mar 18;156:199-207. Epub 2015 Dec 18.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

View Article
March 2016

Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission.

J Neurochem 2015 Dec 29;135(6):1062-79. Epub 2015 Sep 29.

Department of Neurology, Ulm University, Oberer Eselsberg 45, Ulm, Germany.

View Article
December 2015

Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.

Neurochem Int 2015 Sep 11;88:88-96. Epub 2015 Jul 11.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

View Article
September 2015

Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds.

Epilepsy Res 2015 Sep 6;115:67-72. Epub 2015 Jun 6.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

View Article
September 2015

Neuropeptide FF receptors as novel targets for limbic seizure attenuation.

Neuropharmacology 2015 Aug 9;95:415-23. Epub 2015 May 9.

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

View Article
August 2015

Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.

Prog Neuropsychopharmacol Biol Psychiatry 2015 Jun 23;59:49-58. Epub 2015 Jan 23.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

View Article
June 2015

MPTP-induced parkinsonism in mice alters striatal and nigral xCT expression but is unaffected by the genetic loss of xCT.

Neurosci Lett 2015 Apr 10;593:1-6. Epub 2015 Mar 10.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

View Article
April 2015

Lack of effect of Theiler's murine encephalomyelitis virus infection on system xc⁻.

Neurosci Lett 2015 Apr 18;593:124-8. Epub 2015 Mar 18.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

View Article
April 2015

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.

Front Behav Neurosci 2015 31;9:68. Epub 2015 Mar 31.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.

View Article
April 2015

Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosis.

Neurosci Lett 2015 Mar 7;590:184-8. Epub 2015 Feb 7.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
March 2015

NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats.

Neuropharmacology 2014 Oct 24;85:198-205. Epub 2014 May 24.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

View Article
October 2014

Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo.

Hypertension 2013 Nov 16;62(5):920-6. Epub 2013 Sep 16.

Department of Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.

View Article
November 2013

Immune players in the CNS: the astrocyte.

J Neuroimmune Pharmacol 2013 Sep 4;8(4):824-39. Epub 2013 Jul 4.

Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel-VUB, Brussels, Belgium.

View Article
September 2013

Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?

Front Cell Neurosci 2013 Aug 30;7:139. Epub 2013 Aug 30.

Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.

View Article
August 2013

L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.

Nutr Neurosci 2013 Mar 4;16(2):78-82. Epub 2012 Dec 4.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
March 2013

The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy.

Epilepsia 2012 May 16;53(5):870-8. Epub 2012 Mar 16.

Center for Neurosciences, Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium.

View Article
May 2012

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

Epilepsy Behav 2011 Nov 1;22(3):450-60. Epub 2011 Oct 1.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
November 2011

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.

J Alzheimers Dis 2011 ;24(2):287-300

Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Centre of Pharmaceutical Research, Vrije Universiteit Brussel, Brussel, Belgium.

View Article
August 2011

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

FASEB J 2011 Apr 29;25(4):1359-69. Epub 2010 Dec 29.

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
April 2011

Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats.

Neurochem Int 2010 Nov 17;57(5):572-8. Epub 2010 Jul 17.

Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
November 2010

Biphasic and bilateral changes in striatal VGLUT1 and 2 protein expression in hemi-Parkinson rats.

Neurochem Int 2010 Sep 5;57(2):111-8. Epub 2010 May 5.

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

View Article
September 2010

The control of kainic acid-induced status epilepticus.

Epilepsy Res 2010 Jun;90(1-2):164-6

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

View Article
June 2010

vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol.

Neurochem Int 2009 Jul-Aug;55(1-3):41-4. Epub 2009 Jan 8.

Department of Pharmaceutical Chemistry, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
July 2009

High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain.

J Comp Neurol 2008 Nov;511(2):155-72

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group of Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
November 2008

Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats.

Neuroreport 2008 Oct;19(16):1589-92

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

View Article
October 2008

NMDA-mediated release of glutamate and GABA in the subthalamic nucleus is mediated by dopamine: an in vivo microdialysis study in rats.

J Neurochem 2007 Nov;103(3):1063-74

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Neuropharmacology, Vrije Universiteit Brussel, Laarbeeklaan, Brussels, Belgium.

View Article
November 2007

Acoustic stria: anatomy of physiologically characterized cells and their axonal projection patterns.

J Comp Neurol 2005 Feb;482(4):349-71

Department of Anatomy, University of Wisconsin, Medical School-Madison, 1300 University Ave., Madison, Wisconsin 53706, USA.

View Article
February 2005

Differential display implicates cyclophilin A in adult cortical plasticity.

Eur J Neurosci 2003 Jul;18(1):61-75

Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B-3000 Leuven, Belgium.

View Article
July 2003

Glutamate levels and transport in cat (Felis catus) area 17 during cortical reorganization following binocular retinal lesions.

J Neurochem 2003 Mar;84(6):1387-97

Laboratory of Neuroendocrinology and Immunological Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium.

View Article
March 2003

Molecular cloning and differential expression of the cat immediate early gene c-fos.

Brain Res Mol Brain Res 2003 Mar;111(1-2):198-210

Laboratory of Neuroendocrinology and Immunological Biotechnology, Katholieke Universiteit Leuven, Naamsestraat 59, B-3000 Leuven, Belgium.

View Article
March 2003

Retinal lesions affect extracellular glutamate levels in sensory-deprived and remote non-deprived regions of cat area 17 as revealed by in vivo microdialysis.

Brain Res 2003 Feb;962(1-2):199-206

Laboratory of Neuroendocrinology and Immunological Biotechnology, Katholieke Universiteit Leuven, Naamsestraat 59, B-3000 Leuven, Belgium.

View Article
February 2003

Distribution of the AMPA2 glutamate receptor subunit in adult cat visual cortex.

Brain Res 2003 Jan;960(1-2):1-8

Laboratory of Neuroendocrinology and Immunological Biotechnology, Katholieke Universiteit Leuven, Naamsestraat 59, B-3000, Leuven, Belgium.

View Article
January 2003