Ann J Feeney

Ann J Feeney

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Ann J Feeney

Ann J Feeney

Publications by authors named "Ann J Feeney"

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Enhancers as regulators of antigen receptor loci three-dimensional chromatin structure.

Transcription 2020 Feb 12;11(1):37-51. Epub 2019 Dec 12.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1080/21541264.2019.1699383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053977PMC
February 2020

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells.

Front Immunol 2018 13;9:2074. Epub 2018 Sep 13.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02074
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http://dx.doi.org/10.3389/fimmu.2018.02074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146092PMC
September 2019

New insights emerge as antibody repertoire diversification meets chromosome conformation.

F1000Res 2019 28;8. Epub 2019 Mar 28.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.12688/f1000research.17358.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439775PMC
March 2019

A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire.

Mol Cell 2019 01 15;73(1):48-60.e5. Epub 2018 Nov 15.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183084
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http://dx.doi.org/10.1016/j.molcel.2018.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610861PMC
January 2019

Cutting Edge: Proper Orientation of CTCF Sites in Cer Is Required for Normal Jκ-Distal and Jκ-Proximal Vκ Gene Usage.

J Immunol 2018 09 3;201(6):1633-1638. Epub 2018 Aug 3.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.4049/jimmunol.1800785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125182PMC
September 2018

YY1 plays an essential role at all stages of B-cell differentiation.

Proc Natl Acad Sci U S A 2016 07 22;113(27):E3911-20. Epub 2016 Jun 22.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037;

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http://www.pnas.org/content/113/27/E3911.full.pdf
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http://dx.doi.org/10.1073/pnas.1606297113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941496PMC
July 2016

A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation.

Genes Dev 2015 Aug;29(16):1683-95

Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, Maryland 21224, USA;

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http://dx.doi.org/10.1101/gad.263871.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561478PMC
August 2015

CTCF and ncRNA Regulate the Three-Dimensional Structure of Antigen Receptor Loci to Facilitate V(D)J Recombination.

Front Immunol 2014 11;5:49. Epub 2014 Feb 11.

Department of Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920468PMC
June 2014

Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.

J Immunol 2014 Feb 18;192(3):1064-70. Epub 2013 Dec 18.

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.4049/jimmunol.1302800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096788PMC
February 2014

Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny.

Genes Dev 2013 Nov;27(22):2439-44

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA;

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http://dx.doi.org/10.1101/gad.227165.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841733PMC
November 2013

Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.

J Immunol 2013 Sep 29;191(5):2393-402. Epub 2013 Jul 29.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1301279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778908PMC
September 2013

Unifying model for molecular determinants of the preselection Vβ repertoire.

Proc Natl Acad Sci U S A 2013 Aug 5;110(34):E3206-15. Epub 2013 Aug 5.

Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1304048110
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http://dx.doi.org/10.1073/pnas.1304048110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752219PMC
August 2013

Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.

Proc Natl Acad Sci U S A 2012 Dec 19;109(50):E3493-502. Epub 2012 Nov 19.

Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1214131109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528579PMC
December 2012

Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.

Proc Natl Acad Sci U S A 2012 Oct 1;109(42):17004-9. Epub 2012 Oct 1.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1208398109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479473PMC
October 2012

Editorial overview. Lymphocyte development.

Curr Opin Immunol 2012 Apr 20;24(2):129-31. Epub 2012 Mar 20.

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http://dx.doi.org/10.1016/j.coi.2012.03.003DOI Listing
April 2012

CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement.

Cell Res 2012 Feb 22;22(2):280-2. Epub 2011 Nov 22.

The Scripps Research Institute, Department of Immunology and Microbial Science, IMM22, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/cr.2011.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271585PMC
February 2012

Epigenetic regulation of antigen receptor gene rearrangement.

Authors:
Ann J Feeney

Curr Opin Immunol 2011 Apr 7;23(2):171-7. Epub 2011 Jan 7.

Department of Immunology and Microbial Science, IMM22, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 920137, USA.

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http://dx.doi.org/10.1016/j.coi.2010.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073619PMC
April 2011

Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes.

Semin Immunol 2010 Dec 15;22(6):346-52. Epub 2010 Sep 15.

The Scripps Research Institute, Department of Immunology and Microbial Science, IMM-22, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.

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http://dx.doi.org/10.1016/j.smim.2010.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981695PMC
December 2010

Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7869-74. Epub 2010 Apr 12.

Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1073/pnas.1003525107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867885PMC
April 2010

Genetic and epigenetic control of V gene rearrangement frequency.

Authors:
Ann J Feeney

Adv Exp Med Biol 2009 ;650:73-81

The Scripps Research Institute, Department of Immunology, IMM22, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/978-1-4419-0296-2_6DOI Listing
October 2009

The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling.

J Immunol 2009 Feb;182(3):1362-9

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804480PMC
http://dx.doi.org/10.4049/jimmunol.182.3.1362DOI Listing
February 2009

Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development.

J Immunol 2009 Jan;182(1):44-8

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625297PMC
http://dx.doi.org/10.4049/jimmunol.182.1.44DOI Listing
January 2009

Repertoire-based selection into the marginal zone compartment during B cell development.

J Exp Med 2008 Sep 18;205(9):2043-52. Epub 2008 Aug 18.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20080559
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http://dx.doi.org/10.1084/jem.20080559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526199PMC
September 2008

Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.

Proc Natl Acad Sci U S A 2008 Jun 17;105(25):8685-90. Epub 2008 Jun 17.

Department of Immunology, DNA Array Core Facility, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0711758105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438410PMC
June 2008

Reduced receptor editing in lupus-prone MRL/lpr mice.

J Exp Med 2007 Nov 29;204(12):2853-64. Epub 2007 Oct 29.

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1084/jem.20071268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118512PMC
November 2007

Chromatin accessibility and epigenetic modifications differ between frequently and infrequently rearranging VH genes.

Mol Immunol 2007 Apr 10;44(10):2675-85. Epub 2007 Jan 10.

The Scripps Research Institute, Department of Immunology IMM-22, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.molimm.2006.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570232PMC
April 2007

Quantifying chromatin accessibility of individual gene family members by combining ligation-mediated PCR with real-time PCR.

Biotechniques 2006 Oct;41(4):404, 406, 408

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.2144/000112263DOI Listing
October 2006

Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes.

Nat Immunol 2006 Jun 7;7(6):616-24. Epub 2006 May 7.

Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 35294, USA.

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http://dx.doi.org/10.1038/ni1339DOI Listing
June 2006

The extent of histone acetylation correlates with the differential rearrangement frequency of individual VH genes in pro-B cells.

J Immunol 2005 Nov;175(10):6668-75

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.175.10.6668DOI Listing
November 2005

Many levels of control of V gene rearrangement frequency.

Immunol Rev 2004 Aug;200:44-56

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/j.0105-2896.2004.00163.xDOI Listing
August 2004

V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence.

J Immunol 2003 Nov;171(10):5296-304

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.171.10.5296DOI Listing
November 2003