Ann Hammarstedt

Ann Hammarstedt

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Ann Hammarstedt

Ann Hammarstedt

Publications by authors named "Ann Hammarstedt"

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42Publications

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The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and Is Increased in Type 2 Diabetes and NAFLD/NASH.

Diabetes 2020 Mar 27;69(3):331-341. Epub 2019 Dec 27.

Department of Molecular and Clinical Medicine, The Lundberg Laboratory for Diabetes Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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http://dx.doi.org/10.2337/db19-0701DOI Listing
March 2020

A metabolomics-based molecular pathway analysis of how the sodium-glucose co-transporter-2 inhibitor dapagliflozin may slow kidney function decline in patients with diabetes.

Diabetes Obes Metab 2020 Mar 1. Epub 2020 Mar 1.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1111/dom.14018DOI Listing
March 2020

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice.

Mol Metab 2020 Feb 17;32:15-26. Epub 2019 Dec 17.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933264PMC
February 2020

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity.

Physiol Rev 2018 10;98(4):1911-1941

Department of Molecular and Clinical Medicine, The Lundberg Laboratory for Diabetes Research, the Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.

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http://dx.doi.org/10.1152/physrev.00034.2017DOI Listing
October 2018

Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.

Sci Rep 2018 10 25;8(1):15757. Epub 2018 Oct 25.

The Lundberg Laboratory for Diabetes Research, Departments of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://www.nature.com/articles/s41598-018-34113-3
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http://dx.doi.org/10.1038/s41598-018-34113-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202399PMC
October 2018

CCN5/WISP2 and metabolic diseases.

J Cell Commun Signal 2018 Mar 15;12(1):309-318. Epub 2017 Dec 15.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, 405 30, Gothenburg, Sweden.

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http://link.springer.com/10.1007/s12079-017-0437-z
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http://dx.doi.org/10.1007/s12079-017-0437-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842198PMC
March 2018

Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes.

PLoS One 2017 13;12(3):e0173654. Epub 2017 Mar 13.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348013PMC
August 2017

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue.

Cell Rep 2017 08;20(5):1038-1049

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173097
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http://dx.doi.org/10.1016/j.celrep.2017.07.020DOI Listing
August 2017

Metabolic characteristics of individuals at a high risk of type 2 diabetes - a comparative cross-sectional study.

BMC Endocr Disord 2017 Jul 14;17(1):40. Epub 2017 Jul 14.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, 413 45, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s12902-017-0191-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513347PMC
July 2017

Metabolic predictors of impaired glucose tolerance and type 2 diabetes in a predisposed population--A prospective cohort study.

BMC Endocr Disord 2015 Sep 25;15:51. Epub 2015 Sep 25.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s12902-015-0048-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583989PMC
September 2015

Adipocyte hypertrophy, inflammation and fibrosis characterize subcutaneous adipose tissue of healthy, non-obese subjects predisposed to type 2 diabetes.

PLoS One 2014 22;9(8):e105262. Epub 2014 Aug 22.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105262PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141784PMC
May 2015

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis.

Diabetes 2015 May 20;64(5):1670-81. Epub 2015 Jan 20.

Lundberg Laboratory for Diabetes Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden Department of Molecular and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

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http://dx.doi.org/10.2337/db14-1127DOI Listing
May 2015

Insulin resistance and impaired adipogenesis.

Trends Endocrinol Metab 2015 Apr 18;26(4):193-200. Epub 2015 Feb 18.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, SE-41345 Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2015.01.006DOI Listing
April 2015

The Novel Secreted Adipokine WNT1-inducible Signaling Pathway Protein 2 (WISP2) Is a Mesenchymal Cell Activator of Canonical WNT.

J Biol Chem 2014 Mar 22;289(10):6899-907. Epub 2014 Jan 22.

From the Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Center of Excellence for Cardiovascular and Metabolic Research, The Sahlgrenska Academy at the University of Gothenburg, SE-413 45 Gothenburg, Sweden.

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http://dx.doi.org/10.1074/jbc.M113.511964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945351PMC
March 2014

Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4.

Diabetes 2013 Sep;62(9):2997-3004

Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.2337/db13-0473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749334PMC
September 2013

WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.

Proc Natl Acad Sci U S A 2013 Feb 28;110(7):2563-8. Epub 2013 Jan 28.

Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

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http://dx.doi.org/10.1073/pnas.1211255110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574913PMC
February 2013

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.

Diabetol Metab Syndr 2012 Sep 19;4(1):42. Epub 2012 Sep 19.

The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SE-413 45, Sweden.

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http://dx.doi.org/10.1186/1758-5996-4-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523053PMC
September 2012

Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis.

PLoS One 2011 Apr 12;6(4):e18284. Epub 2011 Apr 12.

Department of Medicine, Karolinska Institute at Karolinska Hospital, Huddinge, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018284PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075240PMC
April 2011

Antagonistic effects of thiazolidinediones and cytokines in lipotoxicity.

Biochim Biophys Acta 2010 Mar 24;1801(3):377-80. Epub 2009 Nov 24.

The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, SE-413 45 Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.bbalip.2009.11.006DOI Listing
March 2010

Inflammation and impaired adipogenesis in hypertrophic obesity in man.

Am J Physiol Endocrinol Metab 2009 Nov 21;297(5):E999-E1003. Epub 2009 Jul 21.

Dept. of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Blå Stråket 3, 413 45 Gothenburg, Sweden.

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http://dx.doi.org/10.1152/ajpendo.00377.2009DOI Listing
November 2009

Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese individuals.

J Clin Endocrinol Metab 2009 Nov 9;94(11):4508-16. Epub 2009 Oct 9.

Department of Molecular and Clinical Medicine, The Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy at Göteborg University, Center of Excellence for Cardiovascular and Metabolic Research, SE-413 45 Göteborg, Sweden.

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http://dx.doi.org/10.1210/jc.2009-0431DOI Listing
November 2009

Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation.

Diabetes 2009 Jul 7;58(7):1550-7. Epub 2009 Apr 7.

Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.2337/db08-1770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699851PMC
July 2009

Inflamed adipose tissue, insulin resistance and vascular injury.

Diabetes Metab Res Rev 2008 Nov-Dec;24(8):595-603

The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine/Diabetes, The Sahlgrenska Academy at Göteborg University, Sweden.

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http://dx.doi.org/10.1002/dmrr.889DOI Listing
February 2009

Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis.

Arterioscler Thromb Vasc Biol 2007 Nov 6;27(11):2276-83. Epub 2007 Sep 6.

The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.

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http://dx.doi.org/10.1161/ATVBAHA.107.147835DOI Listing
November 2007

Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin.

J Clin Endocrinol Metab 2007 Jul 24;92(7):2688-95. Epub 2007 Apr 24.

The Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy at Göteborg University, S-413 45 Göteborg, Sweden.

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http://dx.doi.org/10.1210/jc.2006-2814DOI Listing
July 2007

Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and resistin.

Biochem Biophys Res Commun 2007 Jun 10;357(3):700-6. Epub 2007 Apr 10.

Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine/Diabetes, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2007.03.202DOI Listing
June 2007

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

N Engl J Med 2006 Jun;354(24):2552-63

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1056/NEJMoa054862DOI Listing
June 2006

Visfatin is an adipokine, but it is not regulated by thiazolidinediones.

J Clin Endocrinol Metab 2006 Mar 4;91(3):1181-4. Epub 2006 Jan 4.

Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, SE-413 45 Goteborg, Sweden.

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http://dx.doi.org/10.1210/jc.2005-1395DOI Listing
March 2006

Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males.

Atherosclerosis 2005 May 5;180(1):119-25. Epub 2005 Jan 5.

The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital, Blå Stråket 5, SE-413 45 Göteborg, Sweden.

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http://dx.doi.org/10.1016/j.atherosclerosis.2004.11.006DOI Listing
May 2005

High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator.

Obes Res 2004 Mar;12(3):454-60

The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

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http://dx.doi.org/10.1038/oby.2004.51DOI Listing
March 2004