Ann Depicker

Ann Depicker

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Author Correction: Using GlycoDelete to produce proteins lacking plant-specific N-glycan modification in seeds.

Nat Biotechnol 2020 Mar 5. Epub 2020 Mar 5.

Medical Biotechnology Center, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1038/s41587-020-0464-9DOI Listing
March 2020

Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.

Curr Opin Biotechnol 2020 Feb 4;61:96-101. Epub 2019 Dec 4.

Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium; VIB Center for Plant Systems Biology, 9052 Gent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2019.11.006DOI Listing
February 2020

Evaluating single-domain antibodies as carriers for targeted vaccine delivery to the small intestinal epithelium.

J Control Release 2020 Jan 22;321:416-429. Epub 2020 Jan 22.

Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium; VIB Center for Plant Systems Biology, 9052 Gent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.01.033DOI Listing
January 2020

Transformation strategies for stable expression of complex hetero-multimeric proteins like secretory immunoglobulin A in plants.

Plant Biotechnol J 2019 09 5;17(9):1760-1769. Epub 2019 Mar 5.

Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.

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http://dx.doi.org/10.1111/pbi.13098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686127PMC
September 2019

A two-amino acid mutation in murine IgA enables downstream processing and purification on staphylococcal superantigen-like protein 7.

J Biotechnol 2019 Mar 13;294:26-29. Epub 2019 Feb 13.

Ghent University, Department of Plant Biotechnology and Bioinformatics, and VIB Center for Plant Systems Biology, 9052 Ghent, Belgium; Instituto de Biología Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Científicas (CSIC), Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2019.01.020DOI Listing
March 2019

High accumulation in tobacco seeds of hemagglutinin antigen from avian (H5N1) influenza.

Transgenic Res 2017 12 6;26(6):775-789. Epub 2017 Oct 6.

Plant Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), PO Box 6162, 10600, Havana, Havana, Cuba.

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http://dx.doi.org/10.1007/s11248-017-0047-9DOI Listing
December 2017

Biomanufacturing of protective antibodies and other therapeutics in edible plant tissues for oral applications.

Plant Biotechnol J 2016 09 13;14(9):1791-9. Epub 2016 Feb 13.

Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1111/pbi.12541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067594PMC
September 2016

Recombinant IgA production for mucosal passive immunization, advancing beyond the hurdles.

Cell Mol Life Sci 2016 Feb 28;73(3):535-45. Epub 2015 Oct 28.

Department of Plant Systems Biology, VIB, 9052, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00018-015-2074-0DOI Listing
February 2016

Plant expression systems for early stage discovery and development of lead therapeutic antibodies.

Hum Antibodies 2015 Dec;23(3-4):37-43

Department of Plant Systems Biology, VIB, Ghent, Belgium.

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http://dx.doi.org/10.3233/HAB-150285DOI Listing
December 2015

Using GlycoDelete to produce proteins lacking plant-specific N-glycan modification in seeds.

Nat Biotechnol 2015 Nov;33(11):1135-7

Medical Biotechnology Center, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1038/nbt.3359DOI Listing
November 2015

Trafficking of endoplasmic reticulum-retained recombinant proteins is unpredictable in Arabidopsis thaliana.

Front Plant Sci 2014 15;5:473. Epub 2014 Sep 15.

Department of Plant Systems Biology, VIB, Plant-made Antibodies and Immunogens Gent, Belgium ; Department of Plant Biotechnology and Bioinformatics, Ghent University Gent, Belgium.

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http://dx.doi.org/10.3389/fpls.2014.00473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163989PMC
October 2014

Detection and investigation of transitive gene silencing in plants.

Methods Mol Biol 2014 ;1112:219-41

Department of Plant Systems Biology, VIB, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-62703-773-0_15DOI Listing
September 2014

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

J Virol 2014 Aug 14;88(15):8278-96. Epub 2014 May 14.

VIB Inflammation Research Center, Ghent, Belgium Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium

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http://dx.doi.org/10.1128/JVI.03178-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135927PMC
August 2014

Role of plant expression systems in antibody production for passive immunization.

Int J Dev Biol 2013 ;57(6-8):587-93

Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.

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http://dx.doi.org/10.1387/ijdb.130266adDOI Listing
June 2014

Nanobody-based products as research and diagnostic tools.

Trends Biotechnol 2014 May 1;32(5):263-70. Epub 2014 Apr 1.

Department of Plant Systems Biology, VIB, 9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01677799140004
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http://dx.doi.org/10.1016/j.tibtech.2014.03.001DOI Listing
May 2014

Generation of VHH antibodies against the Arabidopsis thaliana seed storage proteins.

Plant Mol Biol 2014 Jan 21;84(1-2):83-93. Epub 2013 Aug 21.

Department of Plant Systems Biology, VIB, 9052, Ghent, Belgium.

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http://dx.doi.org/10.1007/s11103-013-0118-0DOI Listing
January 2014

T-DNA transfer and T-DNA integration efficiencies upon Arabidopsis thaliana root explant cocultivation and floral dip transformation.

Planta 2013 Dec 24;238(6):1025-37. Epub 2013 Aug 24.

Department Plant Systems Biology, VIB, Ghent University, Technologiepark 927, 9052, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00425-013-1948-3DOI Listing
December 2013

Fusion of an Fc chain to a VHH boosts the accumulation levels in Arabidopsis seeds.

Plant Biotechnol J 2013 Oct 6;11(8):1006-16. Epub 2013 Aug 6.

Department of Plant Systems Biology, VIB, Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.

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http://dx.doi.org/10.1111/pbi.12094DOI Listing
October 2013

Site-specific T-DNA integration in Arabidopsis thaliana mediated by the combined action of CRE recombinase and ϕC31 integrase.

Plant J 2013 Jul 15;75(1):172-184. Epub 2013 May 15.

Department of Plant Systems Biology, VIB, Technologiepark 927, B-9052, Gent, Belgium.

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http://dx.doi.org/10.1111/tpj.12202DOI Listing
July 2013

The efficiency of Arabidopsis thaliana floral dip transformation is determined not only by the Agrobacterium strain used but also by the physiology and the ecotype of the dipped plant.

Mol Plant Microbe Interact 2013 Jul;26(7):823-32

Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.

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http://dx.doi.org/10.1094/MPMI-11-12-0267-RDOI Listing
July 2013

Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection.

Proc Natl Acad Sci U S A 2013 Jul 25;110(29):11809-14. Epub 2013 Jun 25.

Department of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, 9052 Ghent, Belgium.

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http://dx.doi.org/10.1073/pnas.1301975110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718133PMC
July 2013

Transitive RNA silencing signals induce cytosine methylation of a transgenic but not an endogenous target.

Plant J 2013 Jun 6;74(5):867-79. Epub 2013 May 6.

Department of Plant Systems Biology, VIB, 9052 Gent, Belgium.

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http://dx.doi.org/10.1111/tpj.12172DOI Listing
June 2013

Epigenetic switches of tobacco transgenes associate with transient redistribution of histone marks in callus culture.

Epigenetics 2013 Jun 26;8(6):666-76. Epub 2013 Apr 26.

Institute of Biophysics, Academy of Sciences; Královopolská, Brno, Czech Republic.

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http://dx.doi.org/10.4161/epi.24613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857346PMC
June 2013

Recombinant antibody production in Arabidopsis seeds triggers an unfolded protein response.

Plant Physiol 2013 Feb 27;161(2):1021-33. Epub 2012 Nov 27.

Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1104/pp.112.209718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561000PMC
February 2013

Production of camel-like antibodies in plants.

Methods Mol Biol 2012 ;911:305-24

Department of Plant Systems Biology, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-61779-968-6_19DOI Listing
December 2012

High frequency of single-copy T-DNA transformants produced after floral dip in CRE-expressing Arabidopsis plants.

Methods Mol Biol 2012 ;847:317-33

Department of Plant Systems Biology, VIB, Department of Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-61779-558-9_26DOI Listing
July 2012

Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds.

Transgenic Res 2011 Oct 25;20(5):1033-42. Epub 2010 Dec 25.

Business Unit Bioscience, Plant Research International BV, Wageningen University and Research Centre, Droevendaalsesteeg 1, 6700 AA Wageningen, The Netherlands.

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http://dx.doi.org/10.1007/s11248-010-9475-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174376PMC
October 2011

Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana.

Plant Biotechnol J 2011 Feb;9(2):179-92

Department of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1467-7652.2010.00540.xDOI Listing
February 2011

Introns reduce transitivity proportionally to their length, suggesting that silencing spreads along the pre-mRNA.

Plant J 2010 Nov;64(3):392-401

Department Plant Systems Biology, VIB, B-9052 Gent, Belgium.

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http://dx.doi.org/10.1111/j.1365-313x.2010.04335.xDOI Listing
November 2010

The T-DNA integration pattern in Arabidopsis transformants is highly determined by the transformed target cell.

Plant J 2009 Oct 5;60(1):134-45. Epub 2009 Jun 5.

Department of Plant Systems Biology, VIB, B-9052 Gent, Belgium.

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http://dx.doi.org/10.1111/j.1365-313X.2009.03942.xDOI Listing
October 2009

Evaluation of seven promoters to achieve germline directed Cre-lox recombination in Arabidopsis thaliana.

Plant Cell Rep 2009 Oct 4;28(10):1509-20. Epub 2009 Aug 4.

Laboratory of Plant Genetics, Institute for Molecular Biology and Biotechnology, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium.

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http://dx.doi.org/10.1007/s00299-009-0750-yDOI Listing
October 2009

Cell culture-induced gradual and frequent epigenetic reprogramming of invertedly repeated tobacco transgene epialleles.

Plant Physiol 2009 Mar 7;149(3):1493-504. Epub 2009 Jan 7.

Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic.

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http://dx.doi.org/10.1104/pp.108.133165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649402PMC
March 2009

Production of antibody fragments in Arabidopsis seeds.

Methods Mol Biol 2009 ;483:89-101

Department Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Gent, Belgium.

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http://dx.doi.org/10.1007/978-1-59745-407-0_6DOI Listing
February 2009

Generation of single-copy T-DNA transformants in Arabidopsis by the CRE/loxP recombination-mediated resolution system.

Plant Physiol 2007 Dec 10;145(4):1171-82. Epub 2007 Aug 10.

Department of Plant Systems Biology, Flanders Institute for Biotechnology, and Department of Molecular Genetics, Ghent University, 9052 Gent, Belgium.

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http://dx.doi.org/10.1104/pp.107.104067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151725PMC
December 2007

Recombinational cloning with plant gateway vectors.

Plant Physiol 2007 Dec;145(4):1144-54

Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, 9052 Ghent, Belgium.

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http://www.plantphysiol.org/cgi/doi/10.1104/pp.107.106989
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http://dx.doi.org/10.1104/pp.107.106989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151728PMC
December 2007

The influence of matrix attachment regions on transgene expression in Arabidopsis thaliana wild type and gene silencing mutants.

Plant Mol Biol 2007 Mar;63(4):533-43

Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark 20, B-3001 Leuven, Belgium.

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http://dx.doi.org/10.1007/s11103-006-9107-xDOI Listing
March 2007

Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds.

Proc Natl Acad Sci U S A 2007 Jan 16;104(4):1430-5. Epub 2007 Jan 16.

Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1073/pnas.0609997104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783127PMC
January 2007

Sequence stability of the T-DNA - plant junctions in tissue culture in Arabidopsis transgenic lines.

Plant Cell Rep 2006 Dec 30;25(12):1362-8. Epub 2006 Jun 30.

Unit Technology and Food, Institute for Agricultural and Fisheries Research, 9820, Merelbeke, Belgium.

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http://dx.doi.org/10.1007/s00299-006-0192-8DOI Listing
December 2006

Introduction of silencing-inducing transgenes does not affect expression of known transcripts.

FEBS Lett 2006 Jul 30;580(17):4154-9. Epub 2006 Jun 30.

Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.febslet.2006.06.063DOI Listing
July 2006

T-DNA integration in Arabidopsis chromosomes. Presence and origin of filler DNA sequences.

Plant Physiol 2003 Dec 26;133(4):2061-8. Epub 2003 Nov 26.

Department of Plant Genetics and Breeding, Center of Agricultural Research-Gent, Caritasstraat 21, B-9090 Melle, Belgium.

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http://dx.doi.org/10.1104/pp.103.027532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC300757PMC
December 2003

Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences.

Nat Biotechnol 2002 Dec 4;20(12):1265-8. Epub 2002 Nov 4.

Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, K.L. Ledeganckstraat 35, B 9000 Gent, Belgium.

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http://dx.doi.org/10.1038/nbt755DOI Listing
December 2002

GATEWAY vectors for Agrobacterium-mediated plant transformation.

Trends Plant Sci 2002 May;7(5):193-5

Dept of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, K.L. Ledeganckstraat 35, B-9000, Gent, Belgium.

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http://dx.doi.org/10.1016/s1360-1385(02)02251-3DOI Listing
May 2002