Ann Ager

Ann Ager

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Ann Ager

Ann Ager

Publications by authors named "Ann Ager"

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Defining High Endothelial Venules and Tertiary Lymphoid Structures in Cancer.

Methods Mol Biol 2018 ;1845:99-118

Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.1007/978-1-4939-8709-2_7DOI Listing
May 2019

Lynch syndrome - cancer pathways, heterogeneity and immune escape.

J Pathol 2018 10 27;246(2):129-133. Epub 2018 Aug 27.

Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK.

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http://dx.doi.org/10.1002/path.5139DOI Listing
October 2018

TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer.

Cell Biol Int 2018 Mar 21;42(3):273-280. Epub 2017 Aug 21.

School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom.

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http://dx.doi.org/10.1002/cbin.10832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836882PMC
March 2018

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Front Immunol 2017 19;8:1830. Epub 2017 Dec 19.

Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742143PMC
December 2017

Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction.

Cancer Immunol Res 2017 11 25;5(11):1005-1015. Epub 2017 Sep 25.

Division of Infection and Immunity, School of Medicine, SIURI, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668144PMC
November 2017

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function.

Authors:
Ann Ager

Front Immunol 2017 3;8:45. Epub 2017 Feb 3.

Division of Infection and Immunity, School of Medicine and Systems Immunity Research Institute, Cardiff University , Cardiff , UK.

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http://dx.doi.org/10.3389/fimmu.2017.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289948PMC
February 2017

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1.

Immunol Cell Biol 2016 09 19;94(8):802-8. Epub 2016 Jul 19.

Division of Infection and Immunity, School of Medicine and Systems Immunity University Research Institute, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/icb.2016.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027373PMC
September 2016

SHP-1: the next checkpoint target for cancer immunotherapy?

Biochem Soc Trans 2016 Apr;44(2):356-62

Systems Immunity University Research Institute and Division of Infection and Immunity, School of Medicine, Henry Wellcome Building, Cardiff University, Heath Park, Cardiff, CF14 4XN, U.K.

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http://dx.doi.org/10.1042/BST20150251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264497PMC
April 2016

Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells.

Biochem Soc Trans 2016 Apr;44(2):377-85

Systems Immunity University Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, CF14 4XN, U.K.

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http://dx.doi.org/10.1042/BST20150254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264496PMC
April 2016

L-selectin Is Essential for Delivery of Activated CD8(+) T Cells to Virus-Infected Organs for Protective Immunity.

Cell Rep 2016 Feb 21;14(4):760-771. Epub 2016 Jan 21.

Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742564PMC
February 2016

Understanding high endothelial venules: Lessons for cancer immunology.

Oncoimmunology 2015 Jun 7;4(6):e1008791. Epub 2015 May 7.

School of Veterinary Medicine; University of Pennsylvania ; Philadelphia, PA, USA.

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http://www.tandfonline.com/doi/full/10.1080/2162402X.2015.10
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http://dx.doi.org/10.1080/2162402X.2015.1008791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485764PMC
June 2015

High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression.

Oncoimmunology 2015 Mar 2;4(3):e974374. Epub 2015 Apr 2.

Infection and Immunity; School of Medicine; Henry Wellcome Building; Cardiff University ; Cardiff, UK.

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http://dx.doi.org/10.4161/2162402X.2014.974374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404788PMC
March 2015

Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation.

J Immunol 2014 Apr 5;192(7):3101-10. Epub 2014 Mar 5.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Whitchurch, Cardiff CF14 2TL, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1302736DOI Listing
April 2014

High endothelial venules: Help or hindrance in the quest for antitumor immunity?

Oncoimmunology 2013 May;2(5):e24272

Institute of Infection and Immunity; School of Medicine; Cardiff University; Cardiff, UK.

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http://dx.doi.org/10.4161/onci.24272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667912PMC
May 2013

Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration.

Cell Biol Int 2011 Oct;35(10):1043-53

Department of Oncology, Cambridge University, Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, U.K.

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http://doi.wiley.com/10.1042/CBI20100885
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http://dx.doi.org/10.1042/CBI20100885DOI Listing
October 2011

Cyclical expression of L-selectin (CD62L) by recirculating T cells.

Int Immunol 2009 Apr 24;21(4):443-55. Epub 2009 Feb 24.

Center for Structural and Cell Biology in Medicine, Institute of Anatomy, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1093/intimm/dxp012DOI Listing
April 2009

CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity.

J Immunol 2008 Jan;180(1):198-206

Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.4049/jimmunol.180.1.198DOI Listing
January 2008

Memory T cells in GVHD and GVL.

Biol Blood Marrow Transplant 2008 Jan;14(1 Suppl 1):19-20

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

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January 2008

T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L-selectin (CD62L).

Eur J Immunol 2007 May;37(5):1243-53

Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London, UK.

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http://dx.doi.org/10.1002/eji.200636481DOI Listing
May 2007

Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering.

J Biol Chem 2004 Aug 3;279(32):33263-72. Epub 2004 Jun 3.

Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M312212200
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http://dx.doi.org/10.1074/jbc.M312212200DOI Listing
August 2004

Inflammation: Border crossings.

Authors:
Ann Ager

Nature 2003 Feb;421(6924):703-5

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http://www.nature.com/articles/421703a
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http://dx.doi.org/10.1038/421703aDOI Listing
February 2003

Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells.

Eur J Immunol 2002 03;32(3):837-47

Division of Cellular Immunology, National Institute for Medical Research, Mill Hill, London, GB.

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http://dx.doi.org/10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-QDOI Listing
March 2002

The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin.

J Biol Chem 2002 Jan 8;277(3):2321-9. Epub 2001 Nov 8.

Divisions of Cellular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109460200DOI Listing
January 2002