Publications

Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity.
J Bone Miner Res 2017 Dec 11;32(12):2431-2444. Epub 2017 Sep 11.
Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, Ulm University Medical Center, Ulm, Germany.


Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.
Am J Pathol 2017 Aug 12;187(8):1686-1699. Epub 2017 Jun 12.
Experimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany; Department of Trauma, Hand and Reconstructive Surgery, University Hospital of Giessen-Marburg, Giessen, Germany. Electronic address:


Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.
EBioMedicine 2017 Jun 5;20:240-254. Epub 2017 May 5.
Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University (LMU), 80336 Munich, Germany; Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, 93053 Regensburg, Germany. Electronic address:

Sheep model for osteoporosis: The effects of peripheral hormone therapy on centrally induced systemic bone loss in an osteoporotic sheep model.
Injury 2017 Apr 20;48(4):841-848. Epub 2017 Feb 20.
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure.
Clin Oral Investig 2016 Dec 28;20(9):2361-2370. Epub 2016 Jan 28.
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: An Ex Vivo Model for Anti-inflammatory Drug and Cell Therapy.
Tissue Eng Part C Methods 2016 Jan 13;22(1):8-19. Epub 2015 Nov 13.
1 Institute of Orthopaedic Research and Biomechanics, Center for Musculoskeletal Research, University of Ulm , Ulm, Germany .



In vivo performance of a novel silk fibroin scaffold for partial meniscal replacement in a sheep model.
Knee Surg Sports Traumatol Arthrosc 2015 Aug 26;23(8):2218-29. Epub 2014 Apr 26.
Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Helmholtzstraße 14, 89081, Ulm, Germany.

The molecular fingerprint of lung inflammation after blunt chest trauma.
Eur J Med Res 2015 Aug 25;20:70. Epub 2015 Aug 25.
Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, Center of Surgery, University of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Mechanical stimulation of human tendon stem/progenitor cells results in upregulation of matrix proteins, integrins and MMPs, and activation of p38 and ERK1/2 kinases.
BMC Mol Biol 2015 Mar 13;16. Epub 2015 Mar 13.
Department of Surgery, Experimental Surgery and Regenerative Medicine, Ludwig-Maximilians-University (LMU), Nussbaumstr. 20, D-80336, Munich, Germany.


The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice.
Dis Model Mech 2015 Jan 7;8(1):93-104. Epub 2014 Nov 7.
Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, 89081 Ulm, Germany.


H2S during circulatory shock: some unresolved questions.
Nitric Oxide 2014 Sep 18;41:48-61. Epub 2014 Mar 18.
Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästhesiologie, Universitätsklinikum, Helmholtzstrasse 8-1, 89081 Ulm, Germany.

Molecular interactions between human cartilaginous endplates and nucleus pulposus cells: a preliminary investigation.
Spine (Phila Pa 1976) 2014 Aug;39(17):1355-64
*Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Ulm, Baden-Württemberg, Germany †REPAIR-lab, Institute of Pathology, University of Mainz, Germany ‡Istituto Ortopedico Galeazzi, Milano, Italy §Klinik fur Orthopadie und Unfallchirurgie, Baden-Baden, Germany ¶Galenus-Klinik Stuttgart ∥Department of Orthopaedic Trauma, Hand Plastic and Reconstruction Surgery, Centre of Musculoskeletal Research, University of Ulm, Ulm, Baden-Wurttemberg, Germany; and **National Center for Spinal Disorders, Budapest, Hungary.

Differences of bone healing in metaphyseal defect fractures between osteoporotic and physiological bone in rats.
Injury 2014 Mar 31;45(3):487-93. Epub 2013 Oct 31.
Department of Trauma Surgery, University Hospital of Giessen-Marburg, Giessen, Germany; Laboratory of Experimental Trauma Surgery, Justus-Liebig University, Giessen, Germany. Electronic address:

Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multiple-deficient diet.
Am J Pathol 2014 Mar 31;184(3):765-77. Epub 2013 Dec 31.
Laboratory of Experimental Trauma Surgery, Justus-Liebig University, Giessen, Germany; Department of Trauma Surgery, University Hospital of Giessen-Marburg, Giessen, Germany. Electronic address:


Metaphyseal fracture healing in a sheep model of low turnover osteoporosis induced by hypothalamic-pituitary disconnection (HPD).
J Orthop Res 2013 Nov 27;31(11):1851-7. Epub 2013 Jun 27.
Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Helmholtzstr. 14, 89081, Ulm, Germany.

Sheep model for osteoporosis: sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection.
J Orthop Res 2013 Jul 25;31(7):1067-74. Epub 2013 Feb 25.
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany.



Improved anchorage of Ti6Al4V orthopaedic bone implants through oligonucleotide mediated immobilization of BMP-2 in osteoporotic rats.
PLoS One 2014 21;9(1):e86151. Epub 2014 Jan 21.
Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopaedic Surgery, Centre of Musculoskeletal Research, University of Ulm, Ulm, Germany.

Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100% O2.
PLoS One 2015 30;10(7):e0132810. Epub 2015 Jul 30.
Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Ulm, Germany; Klinik für Anästhesiologie, Universitätsklinikum, Ulm, Germany.

Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.
J Orthop Res 2016 11 14;34(11):1914-1921. Epub 2016 Mar 14.
Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, Helmholtzstraße 14, Ulm, 89081, Germany.

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