Anita Ignatius

Anita Ignatius

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Anita Ignatius

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Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling.

Proc Natl Acad Sci U S A 2019 Apr 4. Epub 2019 Apr 4.

Laboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, University of Ulm, 89081 Ulm, Germany;

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http://dx.doi.org/10.1073/pnas.1819218116DOI Listing
April 2019

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions.

Sci Rep 2019 Apr 8;9(1):5785. Epub 2019 Apr 8.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany.

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http://dx.doi.org/10.1038/s41598-019-42254-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453962PMC
April 2019

The mode of interfragmentary movement affects bone formation and revascularization after callus distraction.

PLoS One 2018 23;13(8):e0202702. Epub 2018 Aug 23.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107229PMC
February 2019

The challenge of implant integration in partial meniscal replacement: an experimental study on a silk fibroin scaffold in sheep.

Knee Surg Sports Traumatol Arthrosc 2019 Feb 27;27(2):369-380. Epub 2018 Sep 27.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Helmholtzstraße 14, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00167-018-5160-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394547PMC
February 2019

The effect of knee brace misalignment on the anterior cruciate ligament: An experimental study.

Prosthet Orthot Int 2019 Feb 4:309364618824443. Epub 2019 Feb 4.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany.

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http://dx.doi.org/10.1177/0309364618824443DOI Listing
February 2019

Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing.

Am J Pathol 2019 Jan 17;189(1):147-161. Epub 2018 Oct 17.

Institute of Orthopedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.09.011DOI Listing
January 2019

GEORG SCHMORL PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2018: combined inflammatory and mechanical stress weakens the annulus fibrosus: evidences from a loaded bovine AF organ culture.

Eur Spine J 2019 Jan 28. Epub 2019 Jan 28.

Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre, Ulm University, Helmholtzstraße 14, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00586-019-05901-wDOI Listing
January 2019

C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10.

J Cell Mol Med 2018 Dec 24;22(12):6002-6014. Epub 2018 Sep 24.

Institute of Orthopaedic Research and Biomechanics, Trauma Research Center Ulm, Ulm University Hospital, Ulm, Germany.

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http://dx.doi.org/10.1111/jcmm.13873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237570PMC
December 2018

Do Prophylactic Knee Braces Protect the Knee Against Impacts or Tibial Moments? An In Vitro Multisensory Study.

Orthop J Sports Med 2018 Nov 8;6(11):2325967118805399. Epub 2018 Nov 8.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research, Ulm University Medical Centre, Ulm, Germany.

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http://dx.doi.org/10.1177/2325967118805399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240970PMC
November 2018

Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant Mice.

J Neurotrauma 2018 Oct 5;35(19):2317-2329. Epub 2018 Jun 5.

1 Institute of Physiological Chemistry, Ulm University , Ulm, Germany .

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http://dx.doi.org/10.1089/neu.2017.5593DOI Listing
October 2018

Biomechanical, structural and biological characterisation of a new silk fibroin scaffold for meniscal repair.

J Mech Behav Biomed Mater 2018 Oct 30;86:314-324. Epub 2018 Jun 30.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Helmholtzstr. 14, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.jmbbm.2018.06.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079190PMC
October 2018

Role of the Complement System in the Response to Orthopedic Biomaterials.

Int J Mol Sci 2018 Oct 27;19(11). Epub 2018 Oct 27.

Institute of Orthopedic Research and Biomechanics, Centre for Trauma Research Ulm (ZTF Ulm), University of Ulm, D-89081 Ulm, Germany.

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http://www.mdpi.com/1422-0067/19/11/3367
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http://dx.doi.org/10.3390/ijms19113367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274916PMC
October 2018

The Role of the Intestinal Microbiome in Chronic Psychosocial Stress-Induced Pathologies in Male Mice.

Front Behav Neurosci 2018 26;12:252. Epub 2018 Oct 26.

Laboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3389/fnbeh.2018.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234875PMC
October 2018

Evolution of callus tissue behavior during stable distraction osteogenesis.

J Mech Behav Biomed Mater 2018 Sep 24;85:12-19. Epub 2018 May 24.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Baden-Württemberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183072
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http://dx.doi.org/10.1016/j.jmbbm.2018.05.017DOI Listing
September 2018

New horizons for osteoanabolic treatment?

Nat Rev Endocrinol 2018 Sep;14(9):508-509

Institute of Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1038/s41574-018-0069-2DOI Listing
September 2018

Release of the medial collateral ligament is mandatory in medial open-wedge high tibial osteotomy.

Knee Surg Sports Traumatol Arthrosc 2018 Sep 29. Epub 2018 Sep 29.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany.

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http://dx.doi.org/10.1007/s00167-018-5167-0DOI Listing
September 2018

Autologous Mesenchymal Stroma Cells Are Superior to Allogeneic Ones in Bone Defect Regeneration.

Int J Mol Sci 2018 Aug 25;19(9). Epub 2018 Aug 25.

Institute of Orthopaedic Research and Biomechanics, Trauma Research Center Ulm, University of Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.3390/ijms19092526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163925PMC
August 2018

Correction to: In vivo performance of a novel silk fibroin scaffold for partial meniscal replacement in a sheep model.

Knee Surg Sports Traumatol Arthrosc 2018 07;26(7):2216

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Helmholtzstraße 14, 89081, Ulm, Germany.

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http://link.springer.com/10.1007/s00167-018-4878-6
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http://dx.doi.org/10.1007/s00167-018-4878-6DOI Listing
July 2018

Simulating lateral distraction osteogenesis.

PLoS One 2018 15;13(3):e0194500. Epub 2018 Mar 15.

Scientific Computing Centre Ulm (UZWR), Ulm University, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854389PMC
July 2018

Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture.

J Mol Endocrinol 2018 Jul 27;61(1):R75-R90. Epub 2018 Mar 27.

Institute of Comparative Molecular EndocrinologyUlm University, Ulm, Germany

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http://dx.doi.org/10.1530/JME-18-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976078PMC
July 2018

Intramembranous bone formation after callus distraction is augmented by increasing axial compressive strain.

PLoS One 2018 6;13(4):e0195466. Epub 2018 Apr 6.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Baden-Württemberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195466PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889182PMC
July 2018

Influence of Menopause on Inflammatory Cytokines during Murine and Human Bone Fracture Healing.

Int J Mol Sci 2018 Jul 16;19(7). Epub 2018 Jul 16.

Institute of Orthopedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.3390/ijms19072070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073246PMC
July 2018

Complement involvement in bone homeostasis and bone disorders.

Semin Immunol 2018 06 1;37:53-65. Epub 2018 Feb 1.

Institute of Orthopaedic Research and Biomechanics, Center for Trauma Research Ulm (ZTF Ulm), University Medical Center Ulm, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.01.001DOI Listing
June 2018

Estrogen receptor α- (ERα), but not ERβ-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration.

Bone 2018 05 3;110:11-20. Epub 2018 Feb 3.

Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, Helmholtzstraße 14, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.bone.2018.01.017DOI Listing
May 2018

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.

Naunyn Schmiedebergs Arch Pharmacol 2018 05 1;391(5):523-536. Epub 2018 Mar 1.

Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, University Medical Center Ulm, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00210-018-1483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889421PMC
May 2018

Loss of p53 compensates osteopenia in murine Mysm1 deficiency.

FASEB J 2018 04 5;32(4):1957-1968. Epub 2018 Jan 5.

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1096/fj.201700871RDOI Listing
April 2018

Induced global deletion of glucocorticoid receptor impairs fracture healing.

FASEB J 2018 04 5;32(4):2235-2245. Epub 2018 Jan 5.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre.

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http://www.fasebj.org/doi/10.1096/fj.201700459RR
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http://dx.doi.org/10.1096/fj.201700459RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893166PMC
April 2018

Bone regeneration capacity of magnesium phosphate cements in a large animal model.

Acta Biomater 2018 03 2;69:352-361. Epub 2018 Feb 2.

Institute for Orthopaedic Research and Biomechanics, Trauma Research Center Ulm, University of Ulm, Helmholtzstrasse 14, D-89081 Ulm, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183004
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http://dx.doi.org/10.1016/j.actbio.2018.01.035DOI Listing
March 2018

Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.

Am J Pathol 2018 02 13;188(2):474-490. Epub 2017 Nov 13.

Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.10.011DOI Listing
February 2018

Biomechanics of a cemented short stem: Standard vs. line-to-line cementation techniques. A biomechanical in-vitro study involving six osteoporotic pairs of human cadaver femurs.

Clin Biomech (Bristol, Avon) 2018 02 31;52:86-94. Epub 2018 Jan 31.

Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm, Ulm University - Medical Centre, Helmholtzstr. 14, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiomech.2018.01.004DOI Listing
February 2018

Strontium(II) and mechanical loading additively augment bone formation in calcium phosphate scaffolds.

J Orthop Res 2018 01 26;36(1):106-117. Epub 2017 Jun 26.

Trauma Research Center, Institute of Orthopedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, Ulm 89081, Germany.

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http://dx.doi.org/10.1002/jor.23623DOI Listing
January 2018

Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma.

J Cell Mol Med 2018 01 22;22(1):77-88. Epub 2017 Aug 22.

Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1111/jcmm.13295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742720PMC
January 2018

Novel systems for the application of isolated tensile, compressive, and shearing stimulation of distraction callus tissue.

PLoS One 2017 11;12(12):e0189432. Epub 2017 Dec 11.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Baden-Württemberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189432PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724890PMC
January 2018

Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity.

J Bone Miner Res 2017 Dec 11;32(12):2431-2444. Epub 2017 Sep 11.

Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, Ulm University Medical Center, Ulm, Germany.

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http://dx.doi.org/10.1002/jbmr.3234DOI Listing
December 2017

Chronic psychosocial stress disturbs long-bone growth in adolescent mice.

Dis Model Mech 2017 12 19;10(12):1399-1409. Epub 2017 Dec 19.

Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, 89081 Ulm, Germany

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http://dx.doi.org/10.1242/dmm.030916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769608PMC
December 2017

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair.

Sci Rep 2017 Oct 25;7(1):14061. Epub 2017 Oct 25.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, University of Ulm, D-89081, Ulm, Germany.

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http://dx.doi.org/10.1038/s41598-017-14444-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656620PMC
October 2017

Characterization of interfragmentary motion associated with common osteosynthesis devices for rat fracture healing studies.

PLoS One 2017 28;12(4):e0176735. Epub 2017 Apr 28.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Baden-Württemberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176735PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409164PMC
September 2017

Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

Am J Pathol 2017 Aug 12;187(8):1686-1699. Epub 2017 Jun 12.

Experimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany; Department of Trauma, Hand and Reconstructive Surgery, University Hospital of Giessen-Marburg, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.005DOI Listing
August 2017

The effect of a combined thoracic and soft-tissue trauma on blood flow and tissue formation in fracture healing in rats.

Arch Orthop Trauma Surg 2017 Jul 20;137(7):945-952. Epub 2017 Apr 20.

Institute for Rehabilitation Research at Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1007/s00402-017-2695-xDOI Listing
July 2017

Spinal fusion without instrumentation - Experimental animal study.

Clin Biomech (Bristol, Avon) 2017 Jul 25;46:6-14. Epub 2017 Apr 25.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.clinbiomech.2017.04.008DOI Listing
July 2017

The inflammatory phase of fracture healing is influenced by oestrogen status in mice.

Eur J Med Res 2017 Jul 6;22(1):23. Epub 2017 Jul 6.

Institute of Orthopaedic Research and Biomechanics, University Medical Centre Ulm, Helmholtzstraße 9, 89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s40001-017-0264-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501454PMC
July 2017

Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.

EBioMedicine 2017 Jun 5;20:240-254. Epub 2017 May 5.

Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University (LMU), 80336 Munich, Germany; Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Centre, 93053 Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478207PMC
June 2017

ACL double-bundle reconstruction with one tibial tunnel provides equal stability compared to two tibial tunnels.

Knee Surg Sports Traumatol Arthrosc 2017 May 13;25(5):1646-1652. Epub 2016 Jun 13.

Center of Musculoskeletal Research, Institute of Orthopedic Research and Biomechanics, University of Ulm, Helmholtzstraße 14, 89081, Ulm, Germany.

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http://link.springer.com/10.1007/s00167-016-4199-6
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http://dx.doi.org/10.1007/s00167-016-4199-6DOI Listing
May 2017

Dissection of mechanoresponse elements in promoter sites of the mechanoresponsive CYR61 gene.

Exp Cell Res 2017 05 16;354(2):103-111. Epub 2017 Mar 16.

Orthopedic Center for Musculoskeletal Research, Orthopedic Department, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2017.03.031DOI Listing
May 2017

Mg:Ca ratio as regulating factor for osteoclastic in vitro resorption of struvite biocements.

Mater Sci Eng C Mater Biol Appl 2017 Apr 7;73:111-119. Epub 2016 Dec 7.

Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2016.12.002DOI Listing
April 2017

Sheep model for osteoporosis: The effects of peripheral hormone therapy on centrally induced systemic bone loss in an osteoporotic sheep model.

Injury 2017 Apr 20;48(4):841-848. Epub 2017 Feb 20.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.injury.2017.02.009DOI Listing
April 2017

Phytic acid as alternative setting retarder enhanced biological performance of dicalcium phosphate cement in vitro.

Sci Rep 2017 04 3;7(1):558. Epub 2017 Apr 3.

Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.

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http://dx.doi.org/10.1038/s41598-017-00731-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429644PMC
April 2017

Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure.

Clin Oral Investig 2016 Dec 28;20(9):2361-2370. Epub 2016 Jan 28.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00784-016-1727-1DOI Listing
December 2016

Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.

J Orthop Res 2016 11 14;34(11):1914-1921. Epub 2016 Mar 14.

Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, Helmholtzstraße 14, Ulm, 89081, Germany.

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http://dx.doi.org/10.1002/jor.23221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157780PMC
November 2016

The influence of the test setup on knee joint kinematics - A meta-analysis of tibial rotation.

J Biomech 2016 09 30;49(13):2982-2988. Epub 2016 Jul 30.

Institute of Orthopaedic Research and Biomechanics, Centre of Trauma Research, University of Ulm, University Medical Centre, Germany.

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http://dx.doi.org/10.1016/j.jbiomech.2016.07.025DOI Listing
September 2016

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus.

Br J Pharmacol 2016 07 29;173(14):2237-49. Epub 2016 May 29.

Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1111/bph.13503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919577PMC
July 2016

Primary stability of a shoulderless Zweymüller hip stem: a comparative in vitro micromotion study.

J Orthop Surg Res 2016 Jul 5;11(1):73. Epub 2016 Jul 5.

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/s13018-016-0410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934007PMC
July 2016

Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma.

PLoS One 2015 6;10(7):e0131194. Epub 2015 Jul 6.

Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131194PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492600PMC
April 2016

Comparison between different methods for biomechanical assessment of ex vivo fracture callus stiffness in small animal bone healing studies.

PLoS One 2015 17;10(3):e0119603. Epub 2015 Mar 17.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363594PMC
February 2016

A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: An Ex Vivo Model for Anti-inflammatory Drug and Cell Therapy.

Tissue Eng Part C Methods 2016 Jan 13;22(1):8-19. Epub 2015 Nov 13.

1 Institute of Orthopaedic Research and Biomechanics, Center for Musculoskeletal Research, University of Ulm , Ulm, Germany .

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http://dx.doi.org/10.1089/ten.tec.2015.0195DOI Listing
January 2016

Prediction of the time course of callus stiffness as a function of mechanical parameters in experimental rat fracture healing studies--a numerical study.

PLoS One 2014 22;9(12):e115695. Epub 2014 Dec 22.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274111PMC
December 2015

Role of Complement on Broken Surfaces After Trauma.

Adv Exp Med Biol 2015 ;865:43-55

Department of Orthopedic Trauma, Hand-, Plastic-, and Reconstructive Surgery, University of Ulm, Ulm, Germany,

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http://dx.doi.org/10.1007/978-3-319-18603-0_3DOI Listing
December 2015

Bone status of acetylcholinesterase-knockout mice.

Int Immunopharmacol 2015 Nov 4;29(1):222-30. Epub 2015 Aug 4.

Laboratory of Experimental Trauma Surgery, Justus-Liebig-University Giessen, Schubertstr. 81, 35392 Giessen, Germany.

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http://dx.doi.org/10.1016/j.intimp.2015.07.046DOI Listing
November 2015

Differential Interactive Effects of Cartilage Traumatization and Blood Exposure In Vitro and In Vivo.

Am J Sports Med 2015 Nov 11;43(11):2822-32. Epub 2015 Sep 11.

Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany

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http://dx.doi.org/10.1177/0363546515602248DOI Listing
November 2015

Numerical simulation of callus healing for optimization of fracture fixation stiffness.

PLoS One 2014 3;9(7):e101370. Epub 2014 Jul 3.

Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University Hospital Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101370PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081589PMC
October 2015

In vivo performance of a novel silk fibroin scaffold for partial meniscal replacement in a sheep model.

Knee Surg Sports Traumatol Arthrosc 2015 Aug 26;23(8):2218-2229. Epub 2014 Apr 26.

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Helmholtzstraße 14, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00167-014-3009-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661201PMC
August 2015

Analgesia via blockade of NGF/TrkA signaling does not influence fracture healing in mice.

J Orthop Res 2015 Aug 7;33(8):1235-41. Epub 2015 May 7.

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research Ulm (zmfu), University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/jor.22892DOI Listing
August 2015

The molecular fingerprint of lung inflammation after blunt chest trauma.

Eur J Med Res 2015 Aug 25;20:70. Epub 2015 Aug 25.

Department of Traumatology, Hand-, Plastic-, and Reconstructive Surgery, Center of Surgery, University of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548898PMC
August 2015

Material properties of individual menisci and their attachments obtained through inverse FE-analysis.

J Biomech 2015 Jun 20;48(8):1343-9. Epub 2015 Mar 20.

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research Ulm, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.jbiomech.2015.03.014DOI Listing
June 2015

Mechanical stimulation of human tendon stem/progenitor cells results in upregulation of matrix proteins, integrins and MMPs, and activation of p38 and ERK1/2 kinases.

BMC Mol Biol 2015 Mar 13;16. Epub 2015 Mar 13.

Department of Surgery, Experimental Surgery and Regenerative Medicine, Ludwig-Maximilians-University (LMU), Nussbaumstr. 20, D-80336, Munich, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373449PMC
March 2015

Phosphorylation and turnover of paxillin in focal contacts is controlled by force and defines the dynamic state of the adhesion site.

Cytoskeleton (Hoboken) 2015 Feb 7;72(2):101-12. Epub 2015 Feb 7.

Department of Internal Medicine I, University of Ulm, Albert Einstein Allee 23, Ulm, Germany.

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http://dx.doi.org/10.1002/cm.21209DOI Listing
February 2015

Influence of partial meniscectomy on attachment forces, superficial strain and contact mechanics in porcine knee joints.

Knee Surg Sports Traumatol Arthrosc 2015 Jan 27;23(1):74-82. Epub 2014 Mar 27.

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Helmholtzstr. 14, 89081, Ulm, Germany,

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January 2015

The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice.

Dis Model Mech 2015 Jan 7;8(1):93-104. Epub 2014 Nov 7.

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.1242/dmm.018622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283653PMC
January 2015

In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams.

Acta Biomater 2015 Jan 29;12:242-249. Epub 2014 Oct 29.

Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, D-89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2014.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298359PMC
January 2015

Temporal delimitation of the healing phases via monitoring of fracture callus stiffness in rats.

J Orthop Res 2014 Dec 2;32(12):1589-95. Epub 2014 Sep 2.

Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, Ulm University, Helmholtzstrasse 14, 89081, Ulm, Germany.

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http://dx.doi.org/10.1002/jor.22721DOI Listing
December 2014

Increase or decrease in stability after nucleotomy? Conflicting in vitro and in vivo results in the sheep model.

J R Soc Interface 2014 Nov;11(100):20140650

Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1098/rsif.2014.0650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191091PMC
November 2014

Improved anchorage of Ti6Al4V orthopaedic bone implants through oligonucleotide mediated immobilization of BMP-2 in osteoporotic rats.

PLoS One 2014 21;9(1):e86151. Epub 2014 Jan 21.

Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopaedic Surgery, Centre of Musculoskeletal Research, University of Ulm, Ulm, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897651PMC
October 2014

Delayed bone healing following high tibial osteotomy related to increased implant stiffness in locked plating.

Injury 2014 Oct 16;45(10):1648-52. Epub 2014 Apr 16.

Ulm University, Institute of Orthopaedic Research and Biomechanics, Ulm, Germany.

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http://dx.doi.org/10.1016/j.injury.2014.04.018DOI Listing
October 2014

H2S during circulatory shock: some unresolved questions.

Nitric Oxide 2014 Sep 18;41:48-61. Epub 2014 Mar 18.

Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästhesiologie, Universitätsklinikum, Helmholtzstrasse 8-1, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.niox.2014.03.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229245PMC
September 2014

Distinct frequency dependent effects of whole-body vibration on non-fractured bone and fracture healing in mice.

J Orthop Res 2014 Aug 14;32(8):1006-13. Epub 2014 Apr 14.

Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Helmholtzstr.14, 89081 Ulm, Germany.

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http://dx.doi.org/10.1002/jor.22629DOI Listing
August 2014

Molecular interactions between human cartilaginous endplates and nucleus pulposus cells: a preliminary investigation.

Spine (Phila Pa 1976) 2014 Aug;39(17):1355-64

*Institute of Orthopaedic Research and Biomechanics, Centre of Musculoskeletal Research, University of Ulm, Ulm, Baden-Württemberg, Germany †REPAIR-lab, Institute of Pathology, University of Mainz, Germany ‡Istituto Ortopedico Galeazzi, Milano, Italy §Klinik fur Orthopadie und Unfallchirurgie, Baden-Baden, Germany ¶Galenus-Klinik Stuttgart ∥Department of Orthopaedic Trauma, Hand Plastic and Reconstruction Surgery, Centre of Musculoskeletal Research, University of Ulm, Ulm, Baden-Wurttemberg, Germany; and **National Center for Spinal Disorders, Budapest, Hungary.

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http://dx.doi.org/10.1097/BRS.0000000000000372DOI Listing
August 2014

Disadvantages of interfragmentary shear on fracture healing--mechanical insights through numerical simulation.

J Orthop Res 2014 Jul 20;32(7):865-72. Epub 2014 Mar 20.

Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research Ulm, University of Ulm, Ulm, Germany.

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http://doi.wiley.com/10.1002/jor.22617
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July 2014

Control of in vivo mineral bone cement degradation.

Acta Biomater 2014 Jul 24;10(7):3279-87. Epub 2014 Apr 24.

Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070 Würzburg, Germany. Electronic address:

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July 2014

Demineralization after balloon kyphoplasty with calcium phosphate cement: a histological evaluation in ten patients.

Eur Spine J 2014 Jun 25;23(6):1361-8. Epub 2014 Feb 25.

Department of Traumatology, Medical University Graz (MUG), Auenbruggerplatz 5, 8036, Graz, Austria.

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http://dx.doi.org/10.1007/s00586-014-3239-5DOI Listing
June 2014

Finite element modeling of soft tissues: material models, tissue interaction and challenges.

Clin Biomech (Bristol, Avon) 2014 Apr 23;29(4):363-72. Epub 2014 Jan 23.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

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http://dx.doi.org/10.1016/j.clinbiomech.2014.01.006DOI Listing
April 2014