Publications by authors named "Anita Boelen"

88Publications

Thyroid Hormone and Deiodination in Innate Immune Cells.

Endocrinology 2021 Jan;162(1)

Amsterdam UMC, University of Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology Endocrinology & Metabolism, AZ Amsterdam, the Netherlands.

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January 2021

Cognitive and motor outcome in patients with early-detected central congenital hypothyroidism compared with siblings.

J Clin Endocrinol Metab 2020 Dec 4. Epub 2020 Dec 4.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, department of Pediatric Endocrinology, Amsterdam, the Netherlands.

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December 2020

The Role of Thyroid Hormone in the Innate and Adaptive Immune Response during Infection.

Compr Physiol 2020 09 24;10(4):1277-1287. Epub 2020 Sep 24.

Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam Gastroenterology Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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September 2020

Critical evaluation of the newborn screening for congenital hypothyroidism in the Netherlands.

Eur J Endocrinol 2020 Sep;183(3):265-273

Endocrinology Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

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September 2020

Regulation of type 3 deiodinase in rodent liver and adipose tissue during fasting.

Endocr Connect 2020 Jun;9(6):552-562

Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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June 2020

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity.

Cell Mol Gastroenterol Hepatol 2020 21;10(3):451-466. Epub 2020 Apr 21.

Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

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April 2020

Thyroid function in preterm infants and neurodevelopment at 2 years.

Arch Dis Child Fetal Neonatal Ed 2020 Sep 20;105(5):504-509. Epub 2020 Feb 20.

Department of Paediatric Endocrinology, Institute of Human Genetics, Newcastle upon Tyne, UK.

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September 2020

hypercalcaemia due to a calcitriol-producing neuroendocrine tumour.

J Surg Case Rep 2019 Dec 9;2019(12):rjz346. Epub 2019 Dec 9.

Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

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December 2019

Downregulation of Type 3 Deiodinase in the Hypothalamus During Inflammation.

Thyroid 2019 09 15;29(9):1336-1343. Epub 2019 Aug 15.

Endocrine Laboratory, Research Institute Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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September 2019

TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold.

Eur Thyroid J 2018 Nov 31;7(6):279-288. Epub 2018 Oct 31.

Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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November 2018

One-Week Exposure to a Free-Choice High-Fat High-Sugar Diet Does Not Interfere With the Lipopolysaccharide-Induced Acute Phase Response in the Hypothalamus of Male Rats.

Front Endocrinol (Lausanne) 2018 30;9:186. Epub 2018 Apr 30.

Department of Endocrinology and Metabolism, Academic Medical Centre, Amsterdam, Netherlands.

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April 2018

Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.

Stem Cell Reports 2018 06 26;10(6):1959-1974. Epub 2018 Apr 26.

Leibniz Institute on Aging/Fritz Lipmann Institute, Jena, Germany. Electronic address:

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June 2018

Recommendations for newborn screening for galactokinase deficiency: A systematic review and evaluation of Dutch newborn screening data.

Mol Genet Metab 2018 05 21;124(1):50-56. Epub 2018 Mar 21.

Department of Pediatrics, Division of Metabolic Disorders, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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May 2018

13th International Workshop on Resistance to Thyroid Hormone and Thyroid Hormone Action.

Thyroid 2018 06 2;28(6):690-691. Epub 2018 May 2.

3 Departments of Medicine and Pediatrics and Committee on Genetics, The University of Chicago , Chicago, Illinois.

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June 2018

Regulatory aspects of the human hypothalamus-pituitary-thyroid axis.

Best Pract Res Clin Endocrinol Metab 2017 10 1;31(5):487-503. Epub 2017 Oct 1.

Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands. Electronic address:

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October 2017

Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats.

Chronobiol Int 2017 13;34(10):1339-1353. Epub 2017 Oct 13.

a Department Endocrinology and Metabolism , Academic Medical Centre, University of Amsterdam , Amsterdam , The Netherlands.

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February 2019

The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model.

Appetite 2018 Jan 5;120:527-535. Epub 2017 Oct 5.

Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands; Laboratory of Endocrinology, Department of Clinical Chemistry, AMC, UvA, Amsterdam, The Netherlands; Metabolism and Reward Group, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands. Electronic address:

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January 2018

Transhepatic bile acid kinetics in pigs and humans.

Clin Nutr 2018 08 19;37(4):1406-1414. Epub 2017 Jun 19.

Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: http://metabolism.maartensoeters.nl.

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August 2018

Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers.

Front Neurosci 2017 15;11:270. Epub 2017 May 15.

Laboratory of Endocrinology, Department of Clinical Chemistry and Department of Endocrinology and Metabolism, Academic Medical Center, University of AmsterdamAmsterdam, Netherlands.

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May 2017

An evaluation of the TREC assay with regard to the integration of SCID screening into the Dutch newborn screening program.

Clin Immunol 2017 07 6;180:106-110. Epub 2017 May 6.

Centre for Infectious Diseases Research, Diagnostics and Screening, Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address:

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July 2017

Tissue thyroid hormone metabolism is differentially regulated during illness in mice.

J Endocrinol 2017 04 27;233(1):25-36. Epub 2017 Jan 27.

Department of Endocrinology & MetabolismLaboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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April 2017

The classic pathways of thyroid hormone metabolism.

Mol Cell Endocrinol 2017 Dec 18;458:29-38. Epub 2017 Jan 18.

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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December 2017

Hypothalamic effects of thyroid hormone.

Mol Cell Endocrinol 2017 Dec 12;458:143-148. Epub 2017 Jan 12.

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands. Electronic address:

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December 2017

Thyroid hormone metabolism in innate immune cells.

J Endocrinol 2017 02 16;232(2):R67-R81. Epub 2016 Nov 16.

Department of Endocrinology and MetabolismAcademic Medical Center, Amsterdam, The Netherlands

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February 2017

Quantitative Method for Simultaneous Analysis of a 5-Probe Cocktail for Cytochrome P450 Enzymes.

Ther Drug Monit 2016 12;38(6):761-768

Departments of *Hospital Pharmacy, †Medicine, ‡Endocrinology and Metabolism, and §Medical Oncology, Academic Medical Center, Amsterdam, the Netherlands.

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December 2016

Mutations in TBL1X Are Associated With Central Hypothyroidism.

J Clin Endocrinol Metab 2016 12 7;101(12):4564-4573. Epub 2016 Sep 7.

Department of Endocrinology and Metabolism (C.A.H., O.V.S., A.B., E.F.), Clinical Genetics (M.A.), and Clinical and Experimental Audiology (W.A.D.), Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands; Departments of Paediatric Endocrinology (C.A.H., N.Z.-S., A.S.P.v.T.), Radiology (R.R.v.R.), and Paediatrics (R.C.H.), Emma Children's Hospital, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands; Departments of Clinical Genetics (M.L., Y.S., G.W.E.S.), Paediatrics (S.D.J., W.O., J.M.W.), and Endocrinology and Metabolism (S.D.J., N.R.B.), Leiden University Medical Centre, 2300 RC Leiden, The Netherlands; Henry Wellcome Laboratories of Structural Biology (P.J.W., L.F., J.W.R.S.), Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, United Kingdom; and Department of Paediatric Endocrinology (E.L.T.v.d.A.), Erasmus Medical Centre, 3000 CB Rotterdam, The Netherlands.

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December 2016

Metabolic Effects of Chronic T Administration in the Hypothalamic Paraventricular and Ventromedial Nucleus in Male Rats.

Endocrinology 2016 Oct 17;157(10):4076-4085. Epub 2016 Aug 17.

Department of Endocrinology and Metabolism (Z.Z., E.Fo., Y.S., P.H.B., A.K., E.Fl., A.B.), Academic Medical Center (AMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; and Hypothalamic Integration Mechanisms (A.K.), Netherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands.

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October 2016

The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils.

Endocrinology 2016 08 29;157(8):3293-305. Epub 2016 Jun 29.

Department of Endocrinology and Metabolism (A.H.v.d.S., F.F.B., E.F., A.B.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Cell Biology and Histology (W.T., N.N.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and Department of Clinical Medicine and Surgery (M.D., D.S.), University of Naples Federico II, Naples, Italy.

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August 2016

The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents.

Physiol Behav 2016 08 12;162:61-8. Epub 2016 Apr 12.

Department of Endocrinology & Metabolism, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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August 2016

Differential Effects of Sepsis and Chronic Inflammation on Diaphragm Muscle Fiber Type, Thyroid Hormone Metabolism, and Mitochondrial Function.

Thyroid 2016 Apr 16;26(4):600-9. Epub 2016 Mar 16.

1 Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam , Amsterdam, The Netherlands .

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April 2016

Determination of a steroid profile in heel prick blood using LC-MS/MS.

Bioanalysis 2016 19;8(5):375-84. Epub 2016 Feb 19.

Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, The Netherlands.

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December 2016

Thyroid function in critically ill patients.

Lancet Diabetes Endocrinol 2015 Oct 10;3(10):816-25. Epub 2015 Jun 10.

Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, AZ, Amsterdam, Netherlands. Electronic address:

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October 2015

Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.

Endocrinology 2015 09 27;156(9):3098-113. Epub 2015 May 27.

Molecular Endocrinology Laboratory (J.H.D.B., J.G.L., A.G., J.B.C., E.M., G.R.W.), Department of Medicine, Imperial College London, London, W12 0NN United Kingdom; Department of Endocrinology (A.v.d.S., C.v.Z., A.Boe.), Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands; Bone Biology Program (J.D., P.I.C.), Garvan Institute of Medical Research, Sydney, NSW 2010 Australia; and Centre for Oral Growth and Development (A.Boy.), Queen Mary, University of London, London, E1 4NS United Kingdom.

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September 2015

The immediate and late effects of thyroid hormone (triiodothyronine) on murine coagulation gene transcription.

PLoS One 2015 26;10(5):e0127469. Epub 2015 May 26.

Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.

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April 2016

The molecular basis of the non-thyroidal illness syndrome.

J Endocrinol 2015 Jun 13;225(3):R67-81. Epub 2015 May 13.

Department of Endocrinology and Metabolism Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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June 2015

Short-term fasting alters cytochrome P450-mediated drug metabolism in humans.

Drug Metab Dispos 2015 Jun 20;43(6):819-28. Epub 2015 Mar 20.

Departments of Hospital Pharmacy (L.A.L., R.A.A.M.), Medicine (R.A., J.A.R.), Endocrinology and Metabolism (E.M.d.V., F.S.v.N., M.R.S., A.B.), and Medical Oncology (H.-J.K.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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June 2015

Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness.

Am J Physiol Endocrinol Metab 2014 Sep 12;307(6):E527-37. Epub 2014 Aug 12.

Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; and

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September 2014

Beyond the fixed setpoint of the hypothalamus-pituitary-thyroid axis.

Eur J Endocrinol 2014 Nov 8;171(5):R197-208. Epub 2014 Jul 8.

Department of Endocrinology and MetabolismAcademic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The NetherlandsHypothalamic Integration MechanismsNetherlands Institute for Neuroscience, Amsterdam, The Netherlands.

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November 2014

Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency.

Endocrinology 2014 Jan 20;155(1):315-25. Epub 2013 Dec 20.

Leibniz Institute for Age Research/Fritz Lipmann Institute (J.M., S.M., L.F., H.H.), Jena, Germany; Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands; Laboratory of Comparative Endocrinology (V.M.D.), Biology Department, Katholieke Universiteit Leuven, Leuven, Belgium; Department of Endocrinology and Metabolism (A.B.), Academic Medical Center, Amsterdam, The Netherlands; Institute of Physiology and Zürich Center for Integrative Human Physiology (L.M., F.V.), University of Zürich, Zürich, Switzerland; and Leibniz Institute for Environmental Medicine (H.H.), Düsseldorf, Germany.

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January 2014

Measuring free thyroxine levels in neonatal heel-prick samples.

Clin Chim Acta 2013 Aug 13;423:51-5. Epub 2013 Apr 13.

Neonatal Screening Laboratory Amsterdam, Laboratory of Endocrinology, Academic Medical Centre, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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August 2013

Impact of early nutrient restriction during critical illness on the nonthyroidal illness syndrome and its relation with outcome: a randomized, controlled clinical study.

J Clin Endocrinol Metab 2013 Mar 24;98(3):1006-13. Epub 2013 Jan 24.

Clinical Department and Laboratory of Intensive Care Medicine, Division Cellular and Molecular Medicine, University of Leuven (KU Leuven), B-3000 Leuven, Belgium.

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March 2013

Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy.

J Clin Endocrinol Metab 2013 Feb 7;98(2):769-76. Epub 2013 Jan 7.

Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

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February 2013

Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism.

Eur J Endocrinol 2012 Dec 18;167(6):809-15. Epub 2012 Sep 18.

Department of Endocrinology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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December 2012

Leptin administration restores the fasting-induced increase of hepatic type 3 deiodinase expression in mice.

Thyroid 2012 Feb 16;22(2):192-9. Epub 2011 Dec 16.

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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February 2012

Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection.

Endocr Rev 2011 Oct 26;32(5):670-93. Epub 2011 Jul 26.

Department of Endocrinology and Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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October 2011

Type 2 deiodinase and brown fat: the heat is on--or off.

Endocrinology 2010 Sep;151(9):4087-9

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F5-171, 1105 AZ Amsterdam, The Netherlands.

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September 2010

Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice.

Mol Cell Endocrinol 2010 Jun 17;321(2):231-8. Epub 2010 Mar 17.

Department of Endocrinology & Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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June 2010

Thyroid hormone receptor {alpha} modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism.

Endocrinology 2010 Apr 1;151(4):1959-69. Epub 2010 Mar 1.

Ph.D. student, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5-165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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April 2010

Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis.

Thyroid 2009 Dec;19(12):1401-6

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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December 2009

Thyroid hormones and glucose metabolism: the story begins before birth.

Authors:
Anita Boelen

Exp Physiol 2009 Oct 31;94(10):1050-1. Epub 2009 Jul 31.

Department of Endocrinology & Metabolism, F5-165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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October 2009

Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver.

Proc Natl Acad Sci U S A 2009 Apr 24;106(14):5966-71. Epub 2009 Mar 24.

Department of Endocrinology and Metabolism, Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands.

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April 2009

Photoperiod and acute energy deficits interact on components of the thyroid hormone system in hypothalamic tanycytes of the Siberian hamster.

Am J Physiol Regul Integr Comp Physiol 2009 May 18;296(5):R1307-15. Epub 2009 Mar 18.

Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, UK.

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May 2009

Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae.

Endocrinology 2009 Apr 26;150(4):1984-90. Epub 2008 Nov 26.

Department of Endocrinology and Metabolism, F5-165, Academic Medical Center, Amsterdam, The Netherlands.

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April 2009

Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection.

Thyroid 2008 Oct;18(10):1095-103

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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October 2008

Fasting-induced changes in the hypothalamus-pituitary-thyroid axis.

Thyroid 2008 Feb;18(2):123-9

Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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February 2008

Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats.

Am J Physiol Endocrinol Metab 2008 Mar 8;294(3):E513-20. Epub 2008 Jan 8.

Academic Medical Center, Univ. of Amsterdam, Dept. of Endocrinology and Metabolism, F5-162, 1105 AZ Amsterdam, The Netherlands.

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March 2008

Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma.

J Med Virol 2003 Jan;69(1):156-62

Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

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January 2003