Publications by authors named "Anil K Rustgi"

100Publications

Mesenchymal plasticity regulated by Prrx1 drives aggressive pancreatic cancer biology.

Gastroenterology 2020 Sep 29. Epub 2020 Sep 29.

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, 81675, Germany; German Cancer Consortium (DKTK), partner site Munich, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.09.010DOI Listing
September 2020

Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis.

N Engl J Med 2020 09;383(11):1028-1039

From the Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland (C.A.B., J.C.); the Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam (E.D., F.G.K., V.H.R.); the Department of Gastroenterology, Hepatology, and Nutrition, University of Texas M.D. Anderson Cancer Center, Houston (P.L.); the Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix (N.J.S.), and Cancer Prevention Pharmaceuticals, Tucson (A. Cohen) - both in Arizona; the Department of Gastroenterology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona (F.B., A. Castells); the Department of Internal Medicine I, University of Bonn (R.H., C.P.S.), and the National Center for Hereditary Tumor Syndromes (R.H., C.P.S.), Bonn, Germany; Northern Genetics Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne (J.B., A.H.), and Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Manchester (F.L.) - both in the United Kingdom; Mount Sinai Hospital, Toronto (S. Gallinger, R.G.); the Division of Population Sciences, Dana-Farber Cancer Institute, the Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, and Harvard Medical School - all in Boston (R.L., S.S.); the Division of Gastroenterology, University of Michigan, Ann Arbor (E.M.S.); Veterans Affairs San Diego Healthcare System, San Diego, and the Division of Gastroenterology, University of California San Diego, La Jolla (S. Gupta); Huntsman Cancer Center, Salt Lake City (P.K.); the University of Pennsylvania, Philadelphia (G.G.G., A.K.R.); Mayo Clinic, Rochester, MN (F.A.S.); University Hospital Gasthuisberg, Leuven, Belgium (E.V.C.); Emory University School of Medicine, Atlanta (F.F.W.); Washington University School of Medicine, St. Louis (P.E.W.); University of Washington Medical Center, Seattle (W.M.G.); Vanderbilt University Medical Center, Nashville (M.F.); and the University of Wisconsin School of Medicine and Public Health, Madison (J.M.W.).

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http://dx.doi.org/10.1056/NEJMoa1916063DOI Listing
September 2020

EMT, MET, Plasticity, and Tumor Metastasis.

Trends Cell Biol 2020 10 13;30(10):764-776. Epub 2020 Aug 13.

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2020.07.003DOI Listing
October 2020

Our New President-M. Bishr Omary, MD, PhD, AGAF.

Gastroenterology 2020 05 2;158(6):1811-1821. Epub 2020 Apr 2.

Columbia University, New York, New York.

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http://dx.doi.org/10.1053/j.gastro.2020.03.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194536PMC
May 2020

Associations of sociodemographic and clinical factors with gastrointestinal cancer risk assessment appointment completion.

J Genet Couns 2020 Aug 30;29(4):616-624. Epub 2020 Mar 30.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jgc4.1254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415544PMC
August 2020

Mutant p53 on the Path to Metastasis.

Trends Cancer 2020 01 16;6(1):62-73. Epub 2019 Dec 16.

Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485681PMC
January 2020

Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus.

Development 2019 12 4;146(23). Epub 2019 Dec 4.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA

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http://dx.doi.org/10.1242/dev.178855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918786PMC
December 2019

Mechanisms Underlying Metastatic Pancreatic Cancer.

Adv Exp Med Biol 2019 ;1164:3-10

Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-3-030-22254-3_1DOI Listing
October 2019

ESOPHAGEAL CANCERS AND MODEL SYSTEMS.

Authors:
Anil K Rustgi

Trans Am Clin Climatol Assoc 2019 ;130:266-271

PHILADELPHIA, PENNSYLVANIA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735981PMC
February 2020

Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations.

Clin Gastroenterol Hepatol 2020 02 8;18(2):505-508.e1. Epub 2019 May 8.

Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.cgh.2019.04.064DOI Listing
February 2020

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.

Nat Commun 2019 03 21;10(1):1296. Epub 2019 Mar 21.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1038/s41467-019-09179-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428878PMC
March 2019

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells.

Oncogene 2019 05 31;38(22):4325-4339. Epub 2019 Jan 31.

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41388-019-0725-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542713PMC
May 2019

3D Human Esophageal Epithelium Steps Out from hPSCs.

Authors:
Anil K Rustgi

Cell Stem Cell 2018 10;23(4):460-462

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183044
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http://dx.doi.org/10.1016/j.stem.2018.09.010DOI Listing
October 2018

Earlier Colorectal Cancer Screening May Be Necessary In Patients With Li-Fraumeni Syndrome.

Gastroenterology 2019 01 19;156(1):273-274. Epub 2018 Sep 19.

Division of Gastroenterology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1053/j.gastro.2018.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309491PMC
January 2019

The Molecular Basis of Metastatic Colorectal Cancer.

Curr Colorectal Cancer Rep 2018 Apr 1;14(2):69-79. Epub 2018 Mar 1.

Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1007/s11888-018-0403-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141197PMC
April 2018

Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer.

Dev Cell 2018 06;45(6):696-711.e8

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, 900 Biomedical Research Building II/III, 415 Curie Boulevard, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 900 Biomedical Research Building II/III, 415 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011231PMC
June 2018

The Lung and Esophagus: Developmental and Regenerative Overlap.

Trends Cell Biol 2018 09 2;28(9):738-748. Epub 2018 Jun 2.

Division of Gastroenterology, Departments of Medicine and Genetics, Institute for Regenerative Medicine, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102049PMC
September 2018

Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating.

Stem Cell Reports 2018 06 24;10(6):1947-1958. Epub 2018 May 24.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, 951 BRBII/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993649PMC
June 2018

Identification of a novel GREM1 duplication in a patient with multiple colon polyps.

Fam Cancer 2019 01;18(1):63-66

Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s10689-018-0090-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261785PMC
January 2019

RNA Binding Proteins in Intestinal Epithelial Biology and Colorectal Cancer.

Trends Mol Med 2018 05 5;24(5):490-506. Epub 2018 Apr 5.

Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927824PMC
May 2018

Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer.

Cell Mol Gastroenterol Hepatol 2018 Mar 16;5(3):289-298. Epub 2017 Dec 16.

Division of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jcmgh.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849862PMC
March 2018

Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.

Oncotarget 2018 Feb 15;9(10):8985-8998. Epub 2017 Dec 15.

Department of Otorhinolaryngology, Head and Neck Surgery, The University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.23739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823649PMC
February 2018

Differential Regulation of by LIN28B Isoform-Specific Functions.

Mol Cancer Res 2018 03 12;16(3):403-416. Epub 2018 Jan 12.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835183PMC
March 2018

Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.

Br J Cancer 2017 Nov 21;117(11):1614-1620. Epub 2017 Sep 21.

Department of Public Health Science, College of Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1038/bjc.2017.339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729439PMC
November 2017

Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence.

Nat Rev Cancer 2017 10 1;17(10):594-604. Epub 2017 Sep 1.

University of Pennsylvania Perelman School of Medicine, 951 BRB, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrc.2017.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998678PMC
October 2017

Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries.

PLoS Genet 2017 Aug 7;13(8):e1006938. Epub 2017 Aug 7.

Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560753PMC
August 2017

Dose-response Effects of Aerobic Exercise Among Colon Cancer Survivors: A Randomized Phase II Trial.

Clin Colorectal Cancer 2018 03 17;17(1):32-40. Epub 2017 Jun 17.

Department of Public Health Science, College of Medicine, Penn State College of Medicine, Hershey, PA.

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http://dx.doi.org/10.1016/j.clcc.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733696PMC
March 2018

Modeling Esophagitis Using Human Three-Dimensional Organotypic Culture System.

Am J Pathol 2017 Aug 13;187(8):1787-1799. Epub 2017 Jun 13.

Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974532PMC
August 2017

Barriers to generating PDX models of HPV-related head and neck cancer.

Laryngoscope 2017 12 31;127(12):2777-2783. Epub 2017 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, The University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

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http://dx.doi.org/10.1002/lary.26679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687999PMC
December 2017

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.

Nat Commun 2017 03 17;8:14766. Epub 2017 Mar 17.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms14766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357864PMC
March 2017

Gastric Cancer Genomics: Advances and Future Directions.

Cell Mol Gastroenterol Hepatol 2017 Mar 14;3(2):211-217. Epub 2017 Jan 14.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jcmgh.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331775PMC
March 2017

A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-Onset Diabetes.

Gastroenterology 2017 03 5;152(4):840-850.e3. Epub 2016 Dec 5.

Department of Medicine and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.11.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337138PMC
March 2017

Pancreatic fibroblasts smoothen their activities via AKT-GLI2-TGFα.

Authors:
Anil K Rustgi

Genes Dev 2016 09;30(17):1911-2

Division of Gastroenterology, Department of Medicine, Department of Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.289272.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066234PMC
September 2016

The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells.

Mol Carcinog 2017 03 21;56(3):936-944. Epub 2016 Sep 21.

Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/mc.22547DOI Listing
March 2017

JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers.

Cancer Res 2016 09 3;76(18):5538-49. Epub 2016 Aug 3.

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania. The Wistar Institute, Philadelphia, Pennsylvania. VA Medical Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026599PMC
September 2016

ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer.

Gastroenterology 2016 09 16;151(3):540-553.e14. Epub 2016 Jun 16.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002361PMC
September 2016

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.

Cancer Cell 2016 05;29(5):622-637

Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870309PMC
May 2016

Our New President-Timothy C. Wang, MD.

Gastroenterology 2016 05 24;150(5):1231-1236. Epub 2016 Mar 24.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1053/j.gastro.2016.03.021DOI Listing
May 2016

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization.

Genes Dev 2016 Jan;30(2):233-47

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.263327.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719312PMC
January 2016

Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of in Mice.

Cell Mol Gastroenterol Hepatol 2015 09;1(5):550-569

Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698881PMC
http://dx.doi.org/10.1016/j.jcmgh.2015.06.007DOI Listing
September 2015

Impact of Metformin on Advanced Pancreatic Cancer Survival: Too Little, Too Late?

Clin Cancer Res 2016 Mar 4;22(5):1031-3. Epub 2015 Dec 4.

Division of Gastroenterology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Abramson Cancer Center and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775394PMC
March 2016

Assessing Computational Steps for CLIP-Seq Data Analysis.

Biomed Res Int 2015 11;2015:196082. Epub 2015 Oct 11.

Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA ; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA ; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1155/2015/196082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619761PMC
August 2016

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas.

Cell Mol Gastroenterol Hepatol 2015 Nov;1(6):598-609.e6

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA ; Department of Medicine, Harvard Medical School, 45 Shattuck Street, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X150014
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http://dx.doi.org/10.1016/j.jcmgh.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620585PMC
November 2015

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.

Cancer Cell 2015 Nov 17;28(5):599-609. Epub 2015 Oct 17.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643330PMC
November 2015

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer.

Cancer Res 2015 Oct 20;75(19):4074-85. Epub 2015 Aug 20.

Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592477PMC
October 2015

Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2.

PLoS Genet 2015 Aug 5;11(8):e1005408. Epub 2015 Aug 5.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526516PMC
August 2015

Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.

Mol Cancer Res 2015 Nov 20;13(11):1478-86. Epub 2015 Jul 20.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-15
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-15-0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644674PMC
November 2015

Culturing mouse tumor cells.

Cold Spring Harb Protoc 2015 Jun 1;2015(6):505-7. Epub 2015 Jun 1.

Gastroenterology Division, Department of Medicine, Department of Genetics and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/pdb.top069989DOI Listing
June 2015

Culturing primary mouse pancreatic ductal cells.

Cold Spring Harb Protoc 2015 Jun 1;2015(6):558-61. Epub 2015 Jun 1.

Gastroenterology Division, Department of Medicine and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104;

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http://dx.doi.org/10.1101/pdb.prot078279DOI Listing
June 2015

Radiofrequency Ablation Is Associated With Decreased Neoplastic Progression in Patients With Barrett's Esophagus and Confirmed Low-Grade Dysplasia.

Gastroenterology 2015 Sep 24;149(3):567-76.e3; quiz e13-4. Epub 2015 Apr 24.

Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1053/j.gastro.2015.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550488PMC
September 2015

Three-dimensional organotypic culture of stratified epithelia.

Cold Spring Harb Protoc 2015 Apr 1;2015(4):349-53. Epub 2015 Apr 1.

Gastroenterology Division, Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/pdb.prot078311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161091PMC
April 2015

Culturing adult stem cells from mouse small intestinal crypts.

Cold Spring Harb Protoc 2015 Apr 1;2015(4):354-8. Epub 2015 Apr 1.

Gastroenterology Division, Departments of Medicine and Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania and Abramson Cancer Center, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/pdb.prot078303DOI Listing
April 2015

FBXO4 loss facilitates carcinogen induced papilloma development in mice.

Cancer Biol Ther 2015 ;16(5):750-5

a Institute for Regenerative Medicine; University of Pennsylvania School of Medicine ; Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/15384047.2015.1026512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622573PMC
March 2016

WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma.

Carcinogenesis 2015 May 20;36(5):598-606. Epub 2015 Mar 20.

Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA and Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA

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http://dx.doi.org/10.1093/carcin/bgv025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498148PMC
May 2015

Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-Based Method.

Mol Cancer Res 2015 May 27;13(5):863-9. Epub 2015 Feb 27.

II. Medizinische Klinik, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433420PMC
May 2015