Mr Anil K Giri, M Sc - CSIR-Institute of genomics and Integrative Biology

Mr Anil K Giri

M Sc

CSIR-Institute of genomics and Integrative Biology

New Delhi, 110025 | India

Main Specialties: Other

Additional Specialties: Data Analytics

Mr Anil K Giri, M Sc - CSIR-Institute of genomics and Integrative Biology

Mr Anil K Giri

M Sc

Introduction

Primary Affiliation: CSIR-Institute of genomics and Integrative Biology - New Delhi, 110025 , India

Specialties:

Additional Specialties:

Publications

1Publications

-Reads

5Profile Views

53PubMed Central Citations

Acute Radiation Syndrome at Crossroads of Protection and Therapy

Indian Journal of Oncology Radiation Biology

Exposure to radiation (>1Gy) induced acute radiation syndrome (ARS), reducing individual defense against exogenous and endogenous factors, resulting in infections and organs dysfunction. Since < 40% of cancer patients require radiation therapy for management, developing acute radiation toxicity, manifesting during or developing months to years after completion. The development of radiation countermeasure to treat ARS patient has been the subject of intense research since World War II. Individual radiation toxicity is assessed by the time gap of onset, severity of nausea and vomiting, and decline in absolute lymphocyte count, over several hours or days after exposure. Numerous synthetic and natural products though evaluated, however, unwanted toxicity even with optimal doses has precluded their usage. Therefore, systematic screening approach is recommended to identify potential new drugs for mitigation of radiation injury. Sincere efforts have been put in the current review to process preclinical to clinical trials, FDA approved treatment modalities and drugs. Therapy includes treatment with hematopoietic cytokines; blood transfusion; and, stem-cell transplantation, in selected cases. Discussions on medical management, of presenting clinical symptoms and signs, envisage the use of radiomimetic, immune-modulatory and anti-inflammatory agents.

View Article
June 2013
2 Reads

Top co-authors

Dwaipayan Bharadwaj
Dwaipayan Bharadwaj

Institute of Genomics and Integrative Biology

5
Nikhil Tandon
Nikhil Tandon

All India Institute of Medical Sciences

4
Nazir M Khan
Nazir M Khan

CSIR-Institute of Genomics & Integrative Biology

3
Ismeet Kaur
Ismeet Kaur

CSIR-Institute of Genomics & Integrative Biology

2
Saurabh Ghosh
Saurabh Ghosh

Indian Statistical Institute

2
Priyanka Banerjee
2
Vinod Scaria
Vinod Scaria

GN Ramachandran Knowledge Center for Genome Informatics

2
Analabha Basu
Analabha Basu

Institute for Human Genetics

2
Andre G Uitterlinden
Andre G Uitterlinden

Erasmus Medical Center

1
Dhananjay Vaidya
Dhananjay Vaidya

Johns Hopkins University School of Medicine

1