Publications by authors named "Anibal Francone"

13 Publications

  • Page 1 of 1

Evaluation of non-exudative microcystoid macular abnormalities secondary to retinal vein occlusion.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 22. Epub 2021 Jun 22.

Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: We aimed to investigate non-exudative microcystoid macular abnormalities for visual and anatomical outcome in patients with retinal vein occlusion (RVO) with and without glaucomatous optic neuropathy (GON).

Methods: Medical records of 124 eyes (105 patients) with RVO were reviewed and analyzed. Eyes demonstrating microcystoid macular abnormalities were divided into 2 groups, those with evidence of glaucoma (group A) and those without glaucoma (group B). Best-corrected visual acuity (BCVA), the prevalence and number of microcystoid macular abnormalities, and number of intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections were compared at baseline and follow-up.

Results: Seventy-one out of 105 eyes (67.6%) with RVO displayed microcystoid macular abnormalities. Thirty-eight out of 71 eyes (53.5%) presented with concomitant glaucoma (group A), while the remaining 33 eyes (42.6%) had no history of glaucoma (group B). At the end of the follow-up period, mean BCVA was worse in group A versus group B (20/80 versus 20/40, respectively; p = .003). The mean number of anti-VEGF injections was 10.1 ± 9.2 in group A versus 5.9 ± 6.9 in group B (p = .03).

Conclusion: Eyes with RVO and concomitant glaucoma exhibited a significantly higher number of microcystoid macular abnormalities and worse BCVA versus eyes with RVO without glaucoma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-021-05250-9DOI Listing
June 2021

Near-Infrared Reflectance Imaging to Detect an Incipient Retinal Arterial Macroaneurysm.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):150-153. Epub 2021 Apr 12.

Retina Division, Centro Oftalmológico Dr. Charles, Ciudad Autónoma de Buenos Aires, Argentina.

Retinal arterial macroaneurysms (RAM) are characterized by a saccular or fusiform dilation of the retinal artery wall. An 84-year-old Caucasian woman with a medical history of poorly controlled hypertension was diagnosed with RAM in the left eye. Previous macular spectral-domain optical coherence tomography images from the patient were available for comparison. Near-infrared reflectance imaging (NIR-R), taken 3 years before, demonstrated a cuff-type thickening of the arteriolar vessel wall at the site of the current complicated RAM that had gone completely unnoticed. These findings suggest that NIR-R may contribute to the detection of early damage of the arterial wall that may predict arterial aneurysm formation in hypertensive patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000513344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077541PMC
April 2021

Comparison of vitreoretinal disorders in fellow eyes of lamellar macular holes versus epiretinal membrane foveoschisis.

Graefes Arch Clin Exp Ophthalmol 2020 Dec 3;258(12):2611-2619. Epub 2020 Oct 3.

Retina Division, Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, USA.

Purpose: To evaluate and compare the rate and characteristics of vitreoretinal disorders in fellow eyes of lamellar macular holes (LMH) versus epiretinal membrane foveoschisis (ERMF).

Methods: Included patients in this retrospective study were divided into two groups based on spectral-domain optical coherence tomography (SD-OCT) features of their primary eye: LMH (group A) and ERMF (group B).

Results: Ninety-four patients were enrolled: 59 (62.8%) in group A and 35 (37.2%) in group B. Fellow eyes in group A had a higher rate of retinal detachment (8/59 [13.6%] vs. 0/35 [0%], P = 0.024), and full-thickness macular hole (FTMH) (11/59 [18.6%] vs. 2/35 [5.7%], P = 0.079), compared with fellow eyes in group B. In group A, 4/59 patients (6.8%) showed a bilateral LMH while none from group B had a LMH in their fellow eye (0/35 [0%]), P = 0.293. Additionally, epiretinal proliferation was noted in 30/59 (50.8%) fellow eyes in group A versus 3/35 (8.6%) fellow eyes in group B, P < 0.001. Longitudinal data were available for 80/94 patients. Over a mean follow-up of 37.4 ± 29.9 months, 1/48 (2.1%) fellow eyes from group A developed a FTMH and 2/48 (4.2%) developed a LMH, while no FTMH or LMH occurred in fellow eyes of group B.

Conclusions: Fellow eyes of LMH showed a high rate of macular and peripheral vitreoretinal disorders. In addition, epiretinal proliferation was detected in a higher number of fellow eyes of LMH versus ERMF. These findings suggest a bilateral process in eyes of patients with LMH.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-020-04950-yDOI Listing
December 2020

Semiautomated optical coherence tomography-guided robotic surgery for porcine lens removal.

J Cataract Refract Surg 2019 11;45(11):1665-1669

Stein Eye Institute, University of California, Los Angeles, USA.

Purpose: To evaluate semiautomated surgical lens extraction procedures using the optical coherence tomography (OCT)-integrated Intraocular Robotic Interventional Surgical System.

Setting: Stein Eye Institute and Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, USA.

Design: Experimental study.

Methods: Semiautomated lens extraction was performed on postmortem pig eyes using a robotic platform integrated with an OCT imaging system. Lens extraction was performed using a series of automated steps including robot-to-eye alignment, irrigation/aspiration (I/A) handpiece insertion, anatomic modeling, surgical path planning, and I/A handpiece navigation. Intraoperative surgical supervision and human intervention were enabled by real-time OCT image feedback to the surgeon via a graphical user interface. Manual preparation of the pig-eye models, including the corneal incision and capsulorhexis, was performed by a trained cataract surgeon before the semiautomated lens extraction procedures. A scoring system was used to assess surgical complications in a postoperative evaluation.

Results: Complete lens extraction was achieved in 25 of 30 eyes. In the remaining 5 eyes, small lens pieces (≤1.0 mm) were detected near the lens equator, where transpupillary OCT could not image. No posterior capsule rupture or corneal leakage occurred. The mean surgical duration was 277 seconds ± 42 (SD). Based on a 3-point scale (0 = no damage), damage to the iris was 0.33 ± 0.20, damage to the cornea was 1.47 ± 0.20 (due to tissue dehydration), and stress at the incision was 0.97 ± 0.11.

Conclusions: No posterior capsule rupture was reported. Complete lens removal was achieved in 25 trials without significant surgical complications. Refinements to the procedures are required before fully automated lens extraction can be realized.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrs.2019.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941892PMC
November 2019

Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery.

PLoS One 2019 7;14(11):e0224981. Epub 2019 Nov 7.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America.

Purpose: To compare the intraocular lens calculation formulas and evaluate postoperative refractive results of patients with previous hyperopic corneal refractive surgery.

Design: Retrospective, comparative, observational study.

Setting: Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Methods: Clinical charts and optical biometric data of 39 eyes from 24 consecutive patients diagnosed with previous hyperopic laser vision correction and cataract surgery were reviewed and analyzed. The Intraocular lens (IOL) power calculation using the Holladay 2 formula (Lenstar) and the American Society of Cataract and Refractive Surgery (ASCRS) Post-Refractive IOL Calculator (version 4.9, 2017) were compared to the actual manifest refractive spherical equivalent (MRSE) following cataract surgery. No pre-Lasik / PRK or post-Lasik / PRK information was used in any of the calculations. The IOL prediction error, the mean IOL prediction error, the median absolute refractive prediction error, and the percentages of eyes within ±0.50 diopter (D) and ±1.00 D of the predicted refraction were calculated.

Results: The Holladay 2 formula produced a mean arithmetic IOL prediction error significantly different from zero (P = 0.003). Surprisingly, the mean arithmetic IOL prediction errors generated by Shammas, Haigis-L and Barret True K No History formulas were not significantly different from zero (P = 0.14, P = 0.49, P = 0.81, respectively).There were no significant differences in the median absolute refractive prediction error or percentage of eyes within ± 0.50 D or ± 1.00 D of the predicted refraction between formulas or methods.

Conclusion: In eyes with previous hyperopic LASIK/PRK and no prior data, there were no significant differences in the accuracy of IOL power calculation between the Holladay 2 formula and the ASCRS Post-refractive IOL calculator.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224981PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837514PMC
March 2020

EFFECT OF LASER PHOTOCOAGULATION ON MACULAR EDEMA ASSOCIATED WITH MACULAR HOLES.

Retin Cases Brief Rep 2019 Sep 10. Epub 2019 Sep 10.

Division of Retina, Stein Eye Institute, University of California Los Angeles Geffen School of Medicine, Los Angeles, CA.

Purpose: To report the outcomes of laser therapy to barricade eccentric full-thickness macular hole with associated cystoid macular edema.

Methods: We report two patients who developed an eccentric full-thickness macular hole with persistent cystoid macular edema after pars plan vitrectomy with and without internal limiting membrane peel for epiretinal membrane and the results of argon laser therapy.

Results: Barricade argon laser therapy was applied concentric to the full-thickness macular hole. Associated cystoid macular edema was noted to resolve within 1 to 3 months of therapy in both cases.

Conclusion: Barricade laser therapy surrounding a macular hole can lead to resolution of associated cystoid macular edema. Pathogenic mechanisms to explain this favorable outcome are discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICB.0000000000000901DOI Listing
September 2019

DETECTION OF NEUROSENSORY RETINAL DETACHMENT COMPLICATING DEGENERATIVE RETINOSCHISIS BY ULTRA-WIDEFIELD FUNDUS AUTOFLUORESCENCE IMAGING.

Retina 2020 May;40(5):819-824

Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California.

Purpose: To determine whether neurosensory retinal detachment complicating degenerative retinoschisis (RS) can be reliably detected with ultra-widefield fundus autofluorescence evaluation.

Methods: Consecutive patients diagnosed with RS who had ultra-widefield fundus autofluorescence imaging were included in this retrospective case series. According to the fundus autofluorescence patterns, we divided the eyes into two groups: 1) eyes with RS and a hyperautofluorescent leading edge and 2) eyes with RS and without hyperautofluorescence. Peripheral spectral domain optical coherence tomography images at the level of RS were obtained.

Results: Thirty-eight eyes that met eligibility criteria were identified. Review of ultra-widefield fundus autofluorescence demonstrated 21/39 (55%) eyes with distinctive hyperautofluorescence over the area of RS (Group A) and 17/38 (45%) eyes without any form of hyperautofluorescence (Group B). Spectral domain optical coherence tomography images confirmed the presence of full-thickness neurosensory retina separation from the underlying retinal pigment epithelium in the areas of hyperautofluorescence in 10/10 eyes (100%) from Group A. None (0/11; 0%) of the eyes from Group B showed full-thickness neurosensory retina separation on the spectral domain optical coherence tomography imaging of the retina-RS interface.

Conclusion: Hyperautofluorescent findings suggest the presence of a neurosensory retinal detachment. Retinal detachment associated with RS can be reliably detected on ultra-widefield fundus autofluorescence and may be a useful diagnostic imaging modality.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/IAE.0000000000002488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176347PMC
May 2020

The Effect of Haptic Feedback on Efficiency and Safety During Preretinal Membrane Peeling Simulation.

Transl Vis Sci Technol 2019 3;8(4). Epub 2019 Jul 3.

University of California Los Angeles Stein Eye Institute, Los Angeles, CA, USA.

Purpose: We determine whether haptic feedback improves surgical performance and outcome during simulated a preretinal membrane peeling procedure.

Methods: A haptic-enabled virtual reality preretinal membrane peeling simulator was developed using a surgical cockpit with two multifinger haptic devices. Six subjects (three trained retina surgeons and three nonsurgeons) performed the preretinal membrane peeling surgical procedure using two modes of operation: visual and haptic feedback, and visual feedback only.

Results: Task completion time, tool tip path trajectory, tool-retina collision force, and retinal damage were all reduced with haptic feedback used and compared to modes where haptic feedback was disabled.

Conclusions: Haptic feedback improves efficiency and safety during preretinal membrane peeling simulation.

Translational Relevance: These findings highlight the potential benefit of haptic feedback for improving performance and safety of vitreoretinal surgery.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1167/tvst.8.4.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613593PMC
July 2019

LAMELLAR MACULAR HOLES IN THE PRESENCE OF AGE-RELATED MACULAR DEGENERATION.

Retina 2020 Jun;40(6):1079-1086

Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California; and.

Purpose: To investigate whether age-related macular degeneration (AMD) has an influence on the prevalence and anatomical characteristics of lamellar macular holes (LMHs).

Methods: Clinical records and spectral-domain optical coherence tomography images of 756 eyes of 423 consecutive patients diagnosed with AMD were reviewed and analyzed. Spectral-domain optical coherence tomography was used to identify degenerative or tractional LMH subtypes and assess their morphology. The clinical and optical coherence tomography findings of AMD eyes with LMH were compared with those of a control group of eyes with LMH without AMD from a previously published report.

Results: Lamellar macular holes were identified in 25 eyes of 23 patients (3.3%; 25 of 756). Seventeen of 25 eyes (68%) presented with degenerative LMH and underlying late neovascular AMD. Mean best-corrected visual acuity was worse in eyes with AMD and LMH eyes than in those with AMD and no LMH (20/230 vs. 20/98; P = 0.02). The mean outer diameter was greater in the group with degenerative LMH with concomitant AMD than in the control group of degenerative LMH without AMD (1,323.9 ± 999.1 µm vs. 905.9 ± 356.8 µm, respectively; P = 0.01).

Conclusion: The incidence of degenerative LMH increased in advanced forms of AMD, whereas the presence of tractional LMH subtype may be unrelated to AMD evolution.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/IAE.0000000000002532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242169PMC
June 2020

Type III Uveal Effusion Syndrome: Unilateral Idiopathic Serous Detachment.

Ophthalmol Retina 2018 06 6;2(6):637-639. Epub 2018 Feb 6.

Hospital Oftalmologico Dr Pedro Lagleyze, Buenos Aires, Argentina.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oret.2017.12.007DOI Listing
June 2018

Effects of Collagenase type II on Vitreous Humor, an in-situ Rheological Study.

J Biomech Eng 2019 Apr 3. Epub 2019 Apr 3.

Department of Mechanical & Aerospace Engineering, Department of Bioengineering, University of California Los Angeles, Los Angeles, California, 90095.

The purpose of this study is to quantify the impact of enzyme activity on the vitreous humor structure over time to understand the mechanical characteristics of the vitreous humor gel. Changes in the mechanical behavior of the vitreous occur to many reasons including aging, which may lead to many vitreoretinal diseases. The degeneration of the vitreous has been studied; however, in-situ experimental procedures to validate the existing hypotheses are limited. We examined thirty-eight porcine eyes using in-situ rheological creep tests to measure the mechanical properties of the vitreous humor of the eyes prior to, 1 and 24 hours after the intravitreal injection. Eyes in one group were injected with collagenase type II solution and eyes in the control group were injected with Phosphate Buffered Saline solution with calcium and magnesium chloride. Prior to the injection, viscosity and creep compliance intercept values between both groups were not statistically different. At 1 hour and 24 hours after the injection, vitreous properties in eyes from the first group showed a statistically significant increase in the J intercept (representing the inverse of elasticity) values compared with the control group. In addition, 1 and 24 hours after the injection, vitreous viscosity was lower in eyes from the first group than in eyes from the control group. These findings are a foundation for future studies on the effectiveness of intravitreal drugs to modify the mechanical properties of the vitreous humor.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1115/1.4043358DOI Listing
April 2019

Bilateral Acquired Progressive Retinal Nerve Fiber Layer Myelination.

Ophthalmic Surg Lasers Imaging Retina 2018 10;49(10):e147-e150

The authors present the multimodal imaging findings of an unusual case of bilateral acquired progressive myelination of the optic disc during a 10-year follow-up period in a hyperopic adolescent patient in the absence of an underlying ocular or systemic abnormality. Myelination of the left optic disc was noted at age 7 and of the right optic disc at age 13, but no other ocular or systemic abnormalities were identified. Cross-sectional optical coherence tomography (OCT) and en face OCT angiography confirmed the presence of myelination of the retinal nerve fiber layer and excluded other etiologic possibilities including an astrocytic hamartoma. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:e147-e150.].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3928/23258160-20181002-18DOI Listing
October 2018

Intraocular robotic interventional surgical system (IRISS): Semi-automated OCT-guided cataract removal.

Int J Med Robot 2018 Dec 28;14(6):e1949. Epub 2018 Aug 28.

Mechanical and Aerospace Engineering, University of California, Los Angeles, California, Los Angeles.

Background: With the development of laser-assisted platforms, the outcomes of cataract surgery have been improved by automating several procedures. The cataract-extraction step continues to be manually performed, but due to deficiencies in sensing capabilities, surgical complications such as posterior capsule rupture and incomplete cataract removal remain.

Methods: An optical coherence tomography (OCT) system is integrated into our intraocular robotic interventional surgical system (IRISS) robot. The OCT images are used for preoperative planning and intraoperative intervention in a series of automated procedures. Real-time intervention allows surgeons to evaluate the progress and override the operation.

Results: The developed system was validated by performing lens extraction on 30 postmortem pig eyes. Complete lens extraction was achieved on 25 eyes, and "almost complete" extraction was achieved on the remainder due to an inability to image small lens particles behind the iris. No capsule rupture was found.

Conclusion: The IRISS successfully demonstrated semiautomated OCT-guided lens removal with real-time supervision and intervention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcs.1949DOI Listing
December 2018
-->