Publications by authors named "Anh Ng"

3 Publications

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In silico genetics: identification of a functional element regulating H2-Ealpha gene expression.

Science 2004 Oct;306(5696):690-5

Department of Genetics and Genomics, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304-1397, USA.

Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits. It was also used to identify an allele-specific functional genomic element regulating H2-Ealpha gene expression. This functional element, which contained the binding sites for YY1 and a second transcription factor that is probably serum response factor, is located within the first intron of the H2-Ealpha gene. This computational method will greatly improve our ability to identify the genetic basis for a variety of phenotypic traits, ranging from qualitative trait information to quantitative gene expression data, which vary among inbred mouse strains.
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October 2004

Prospective evaluation of self-extubations in a medical intensive care unit.

Intensive Care Med 1993 ;19(6):340-2

Service de Réanimation Polyvalente, Hôpital Saint-Antoine, Paris, France.

Objective: To evaluate the incidence, associated factors and gravity of self-extubations.

Design: Prospective study about all patients intubated over an 8 month period.

Setting: A medical intensive care unit of a University Hospital.

Patients: Patients were divided into two groups: self-extubated and those that did not. The self-extubations were separated into deliberate acts by the patients and accidental.

Results: 24 of the 197 patients included presented a total of 27 extubations (12%). There were 21 deliberate incidents and 6 accidental. The only differences between the cases and the rest of the population were a higher mean age (67 vs 59 years) and a larger proportion of chronic respiratory failure (66% versus 35%). Reintubation was necessary in 20 cases (74%) within 30 min in 16 cases. The main indication for reintubation was acute respiratory distress (90%). Reintubation was associated with one death.

Conclusion: Self-extubation is a frequent and serious complication of mechanical ventilation. Deliberate self-extubation, the most frequent type of incident could possibly be reduced by better sedation of agitated patients and accidental self-extubation by better training of the nursing staff.
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December 1993

[Allergy and olfaction. (Preliminary note)].

Ann Otolaryngol Chir Cervicofac 1969 Sep;86(9):578-80

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September 1969