Publications by authors named "Angus W Thomson"

100Publications

Understanding, predicting and achieving liver transplant tolerance: from bench to bedside.

Nat Rev Gastroenterol Hepatol 2020 Dec 5;17(12):719-739. Epub 2020 Aug 5.

Institute of Liver Studies, Medical Research Council (MRC) Centre for Transplantation, School of Immunology and Infectious Diseases, King's College London University, King's College Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41575-020-0334-4DOI Listing
December 2020

Transplant Tolerance Induction: Insights From the Liver.

Front Immunol 2020 5;11:1044. Epub 2020 Jun 5.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.01044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289953PMC
June 2020

The Fourth International Workshop on Clinical Transplant Tolerance.

Am J Transplant 2020 Jun 12. Epub 2020 Jun 12.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.16139DOI Listing
June 2020

Heterotopic Transplantation of Allogeneic Vertical Rectus Abdominis Myocutaneous Flaps in Miniature Swine.

J Surg Res 2020 10 22;254:175-182. Epub 2020 May 22.

Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; McGowan Institute for Regenerative Medicine (MIRM), University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2020.04.026DOI Listing
October 2020

Kidney transplantation: a safe step forward for regulatory immune cell therapy.

Lancet 2020 05;395(10237):1589-1591

Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15238, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(20)30803-5DOI Listing
May 2020

Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation.

Cell Immunol 2020 05 12;351:104087. Epub 2020 Mar 12.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2020.104087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197030PMC
May 2020

Combined GM-CSF and G-CSF administration mobilizes CD4 CD25 Foxp3 Treg in leukapheresis products of rhesus monkeys.

Am J Transplant 2020 06 20;20(6):1691-1702. Epub 2020 Jan 20.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15761DOI Listing
June 2020

Dendritic Cells as Sensors, Mediators, and Regulators of Ischemic Injury.

Front Immunol 2019 15;10:2418. Epub 2019 Oct 15.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.02418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803430PMC
November 2020

Tolerogenic dendritic cells in organ transplantation.

Transpl Int 2020 Feb 29;33(2):113-127. Epub 2019 Oct 29.

Department of Surgery and Department of Immunology, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tri.13504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983332PMC
February 2020

Plasmacytoid Dendritic Cells and the Spontaneous Acceptance of Kidney Allografts.

Transplantation 2020 01;104(1):15-16

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933082PMC
January 2020

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells.

Front Immunol 2019 2;10:1451. Epub 2019 Jul 2.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626913PMC
July 2020

Preliminary assessment of the feasibility of autologous myeloid-derived suppressor cell infusion in non-human primate kidney transplantation.

Transpl Immunol 2019 10 19;56:101225. Epub 2019 Jul 19.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trim.2019.101225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698203PMC
October 2019

Regulatory dendritic cells for human organ transplantation.

Transplant Rev (Orlando) 2019 07 13;33(3):130-136. Epub 2019 May 13.

Nephropathies Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trre.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599577PMC
July 2019

The "other" mTOR complex: New insights into mTORC2 immunobiology and their implications.

Am J Transplant 2019 06 19;19(6):1614-1621. Epub 2019 Mar 19.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538441PMC
June 2019

Cancer Exacerbates Ischemic Brain Injury Via Nrp1 (Neuropilin 1)-Mediated Accumulation of Regulatory T Cells Within the Tumor.

Stroke 2018 11;49(11):2733-2742

From the Department of Anesthesiology (L.W., Y.Z., J.Y., X.W., D.W., L.Y., P.L., W.Y.), Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.021948
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.118.021948DOI Listing
November 2018

Rictor deficiency in dendritic cells exacerbates acute kidney injury.

Kidney Int 2018 11 4;94(5):951-963. Epub 2018 Sep 4.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Center for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia; Westmead Clinical Medical School, University of Sydney, Camperdown, New South Wales, Australia.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00852538183044
Publisher Site
http://dx.doi.org/10.1016/j.kint.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200603PMC
November 2018

mTORC2 deficiency in cutaneous dendritic cells potentiates CD8 effector T cell responses and accelerates skin graft rejection.

Am J Transplant 2019 03 17;19(3):646-661. Epub 2018 Sep 17.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384165PMC
March 2019

A view of the future of regulatory immune cell therapy in organ transplantation.

Authors:
Angus W Thomson

Curr Opin Organ Transplant 2018 10;23(5):507-508

Starzl Transplantation Institute, Department of Surgery, and Department of Immunology and Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOT.0000000000000570DOI Listing
October 2018

Erratum: Hepatic Dendritic Cells, the Tolerogenic Liver Environment, and Liver Disease.

Semin Liver Dis 2018 08 24;38(3):298. Epub 2018 Jul 24.

Department of Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1667175DOI Listing
August 2018

Regulatory dendritic cells: profiling, targeting, and therapeutic application.

Curr Opin Organ Transplant 2018 10;23(5):538-545

Department of Surgery, Thomas E. Starzl Transplantation Institute.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOT.0000000000000565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620776PMC
October 2018

Promises and limitations of immune cell-based therapies in neurological disorders.

Nat Rev Neurol 2018 09;14(9):559-568

Pittsburgh Institute of Brain Disorders and Recovery and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41582-018-0028-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237550PMC
September 2018

Hepatic Dendritic Cells, the Tolerogenic Liver Environment, and Liver Disease.

Semin Liver Dis 2018 05 5;38(2):170-180. Epub 2018 Jun 5.

Department of Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1646949DOI Listing
May 2018

Monocytic myeloid-derived suppressor cells generated from rhesus macaque bone marrow enrich for regulatory T cells.

Cell Immunol 2018 07 27;329:50-55. Epub 2018 Apr 27.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537105PMC
July 2018

Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4CTLA4 T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.

Front Immunol 2018 19;9:250. Epub 2018 Feb 19.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827543PMC
March 2019

High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation.

Cell Immunol 2018 01 14;323:9-18. Epub 2017 Sep 14.

Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2017.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835175PMC
January 2018

Regulatory dendritic cells for promotion of liver transplant operational tolerance: Rationale for a clinical trial and accompanying mechanistic studies.

Hum Immunol 2018 May 31;79(5):314-321. Epub 2017 Oct 31.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01988859173052
Publisher Site
http://dx.doi.org/10.1016/j.humimm.2017.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924712PMC
May 2018

DHRS9 Is a Stable Marker of Human Regulatory Macrophages.

Transplantation 2017 11;101(11):2731-2738

1 Department of Surgery, University Hospital Regensburg, Regensburg, Germany. 2 San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. 3 Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA. 4 INSERM UMR1064, Center for Research in Transplantation and Immunology, Nantes, France. 5 CHU de Nantes, Institut de Transplantation Urologie Nephrologie (ITUN), Nantes, France. 6 Université de Nantes, Nantes, France. 7 Division of Surgical Oncology, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA. 8 Institute of Pathology, University Hospital Regensburg, Regensburg, Germany. 9 Department of Transfusion Medicine, University Hospital Regensburg, Regensburg, Germany. 10 Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. 11 FinVector Vision Therapies Oy, Microkatu 1S, Kuopio, Finland. 12 Institute for Applied Cell Therapy, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000001814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319563PMC
November 2017

Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks.

Curr Transplant Rep 2016 Dec 25;3(4):265-274. Epub 2016 Oct 25.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40472-016-0114-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435383PMC
December 2016

Regeneration and Cell Recruitment in an Improved Heterotopic Auxiliary Partial Liver Transplantation Model in the Rat.

Transplantation 2017 Jan;101(1):92-100

1 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.2 Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.3 Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.4 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000001511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193171PMC
January 2017

MyD88 Inhibitors and the Continuing Challenge of TLR Antagonism.

Authors:
Angus W Thomson

Transplantation 2017 02;101(2):230-231

1 Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA. 2 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/TP.0000000000001565DOI Listing
February 2017

Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation.

J Leukoc Biol 2017 02 31;101(2):429-438. Epub 2016 Aug 31.

Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.2A0516-239RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235903PMC
February 2017

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.

Nat Rev Nephrol 2016 10 1;12(10):587-609. Epub 2016 Aug 1.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, W1540 BST, Pittsburgh, Pennsylvania 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneph.2016.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553645PMC
October 2016

Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8(+) effector T cell responses.

Oncoimmunology 2016 Jun 23;5(6):e1146841. Epub 2016 Mar 23.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, US; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2016.1146841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938309PMC
June 2016

A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells.

J Immunol 2016 08 11;197(4):1137-47. Epub 2016 Jul 11.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1600696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975979PMC
August 2016

Thyroid hormone: relevance to xenotransplantation.

Xenotransplantation 2016 07 4;23(4):293-9. Epub 2016 Jul 4.

Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988877PMC
July 2016

Regulatory T Cell Therapy for Ischemic Stroke: how far from Clinical Translation?

Transl Stroke Res 2016 10 16;7(5):415-9. Epub 2016 Jun 16.

Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street, SBST 506, Pittsburgh, PA, 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12975-016-0476-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179138PMC
October 2016

CD47 regulates renal tubular epithelial cell self-renewal and proliferation following renal ischemia reperfusion.

Kidney Int 2016 08 1;90(2):334-347. Epub 2016 Jun 1.

Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2016.03.034DOI Listing
August 2016

Orthotopic mouse liver transplantation to study liver biology and allograft tolerance.

Nat Protoc 2016 07 2;11(7):1163-74. Epub 2016 Jun 2.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2016.073DOI Listing
July 2016

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation.

Front Immunol 2016 28;7:15. Epub 2016 Jan 28.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2016.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729892PMC
February 2016

Identity Crisis.

Transplantation 2016 Feb;100(2):258-9

1 Starzl Transplantation Institute, Department of Surgery and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000001078DOI Listing
February 2016

New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation.

Br J Clin Pharmacol 2016 11 6;82(5):1158-1170. Epub 2016 Mar 6.

Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061789PMC
November 2016

Immunomodulating effects of the anti-viral agent Silibinin in liver transplant patients with HCV recurrence.

Transplant Res 2016 20;5. Epub 2016 Jan 20.

Department of Emergency and Organ Transplantation, Unit of Gastroenterology, University Hospital, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13737-016-0030-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721199PMC
January 2016

Liver transplantation in the mouse: Insights into liver immunobiology, tissue injury, and allograft tolerance.

Liver Transpl 2016 Apr;22(4):536-46

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.24394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811737PMC
April 2016

Eomesodermin(lo) CTLA4(hi) Alloreactive CD8+ Memory T Cells Are Associated With Prolonged Renal Transplant Survival Induced by Regulatory Dendritic Cell Infusion in CTLA4 Immunoglobulin-Treated Nonhuman Primates.

Transplantation 2016 Jan;100(1):91-102

1 Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.2 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685739PMC
http://dx.doi.org/10.1097/tp.0000000000000871DOI Listing
January 2016

Cell-based immunosuppression in kidney transplantation: the value of non-human primate studies.

Kidney Int 2015 Nov;88(5):1196-7

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ki.2015.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656114PMC
November 2015

The Ups and Downs of TORKinibs in Transplantation.

Transplantation 2015 Aug;99(8):e117-8

1 Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA. 2 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000000803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552074PMC
August 2015

IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production.

J Immunol 2015 Jun 11;194(12):6045-56. Epub 2015 May 11.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15261

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1402505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458432PMC
June 2015

mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.

J Immunol 2015 May 3;194(10):4767-76. Epub 2015 Apr 3.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1402551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417394PMC
May 2015

Generation, cryopreservation, function and in vivo persistence of ex vivo expanded cynomolgus monkey regulatory T cells.

Cell Immunol 2015 May 14;295(1):19-28. Epub 2015 Feb 14.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2015.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405464PMC
May 2015

CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection.

Transpl Immunol 2015 Mar 7;32(2):76-83. Epub 2015 Feb 7.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09663274150000
Publisher Site
http://dx.doi.org/10.1016/j.trim.2015.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368493PMC
March 2015

Dendritic cells and macrophages in the kidney: a spectrum of good and evil.

Nat Rev Nephrol 2014 Nov 30;10(11):625-43. Epub 2014 Sep 30.

MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneph.2014.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922410PMC
November 2014

Orchestration of transplantation tolerance by regulatory dendritic cell therapy or in-situ targeting of dendritic cells.

Curr Opin Organ Transplant 2014 Aug;19(4):348-56

aDepartment of Surgery, Starzl Transplantation Institute bDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MOT.0000000000000097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204930PMC
August 2014

Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells.

J Immunol 2014 Apr 17;192(8):3470-3. Epub 2014 Mar 17.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1300058
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1300058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994403PMC
April 2014

Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.

J Am Soc Nephrol 2014 Jun 7;25(6):1171-86. Epub 2014 Feb 7.

Vascular Medicine Institute, Starzl Transplantation Institute, Department of Pharmacology and Chemical Biology, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2013040433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033366PMC
June 2014

Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke.

Stroke 2014 Mar 4;45(3):857-64. Epub 2014 Feb 4.

From the State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China (P.L., L.M., X.L., Y. Gao, J.C., X.H.); Center of Cerebrovascular Disease Research (P.L., L.M., Y. Gan, J.Z., J.C., X.H.) and Departments of Surgery and Immunology, Starzl Transplantation Institute (A.W.T.), University of Pittsburgh School of Medicine, PA; Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, PA (P.L., X.H.); and Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, People's Republic of China (X.L.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.113.004100
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.113.004100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939692PMC
March 2014

Plasmacytoid dendritic cell-derived IFN-α promotes murine liver ischemia/reperfusion injury by induction of hepatocyte IRF-1.

Hepatology 2014 Jul 27;60(1):267-77. Epub 2014 May 27.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.27037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077928PMC
July 2014

Regulatory dendritic cell therapy: from rodents to clinical application.

Immunol Lett 2014 Oct 4;161(2):216-21. Epub 2013 Dec 4.

Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2013.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045700PMC
October 2014

IL-12hi rapamycin-conditioned dendritic cells mediate IFN-γ-dependent apoptosis of alloreactive CD4+ T cells in vitro and reduce lethal graft-versus-host disease.

Biol Blood Marrow Transplant 2014 Feb 12;20(2):192-201. Epub 2013 Nov 12.

Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2013.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964782PMC
February 2014

Regulatory myeloid cells in transplantation.

Transplantation 2014 Feb;97(4):367-79

1 Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA. 2 Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA. 3 Address correspondence to: Angus W. Thomson, Ph.D., D.Sc., Departments of Surgery and Immunology, University of Pittsburgh School of Medicine, Thomas E. Starzl Transplantation Institute, 200 Lothrop Street, Biomedical Science Tower W1540, Pittsburgh, PA 15213.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0b013e3182a860deDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944083PMC
February 2014

All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities.

J Leukoc Biol 2013 Nov 29;94(5):981-9. Epub 2013 Jul 29.

3.720 Rutland Ave, Room 755A, Baltimore, MD 21205, USA. or University of Pittsburgh, 3700 O'Hara St., 440 Benedum Hall, Pittsburgh, PA 15261, USA. E-mail: Twitter:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0312167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800062PMC
November 2013

CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice.

Hepatology 2013 Dec 15;58(6):2163-75. Epub 2013 Oct 15.

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.26593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844081PMC
December 2013

Adoptive regulatory T-cell therapy protects against cerebral ischemia.

Ann Neurol 2013 Sep 14;74(3):458-71. Epub 2013 May 14.

Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China; Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.23815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748165PMC
September 2013

Immunology of vascularized composite allografts.

Clin Dev Immunol 2013 18;2013:689071. Epub 2013 Mar 18.

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://www.hindawi.com/journals/jir/2013/689071/
Publisher Site
http://dx.doi.org/10.1155/2013/689071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618934PMC
July 2013

Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation.

Transplant Res 2012 Sep 28;1(1):16. Epub 2012 Sep 28.

Thomas E, Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://transplantationresearch.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/2047-1440-1-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560974PMC
September 2012

Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.

J Immunol 2012 Oct 7;189(8):3848-58. Epub 2012 Sep 7.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1200819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466356PMC
October 2012

Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management.

Am J Physiol Renal Physiol 2012 Oct 8;303(8):F1117-25. Epub 2012 Aug 8.

Vascular Medicine Institute, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00359.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469673PMC
October 2012

Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury.

J Am Soc Nephrol 2012 Sep 2;23(9):1538-50. Epub 2012 Aug 2.

Division of Pulmonary Allergy and Critical Care Medicine, Vascular Medicine Institute, University of Pittsburgh School of Medicine, E1240 Biomedical Science Tower, Room E1258, 200 Lothrop Street, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2012020137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431420PMC
September 2012

Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo.

Adv Mater 2012 Sep 23;24(35):4735-8. Epub 2012 Jul 23.

360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201202513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491880PMC
September 2012

IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells.

J Immunol 2012 Jun 16;188(11):5227-37. Epub 2012 Apr 16.

Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1103382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564546PMC
June 2012

Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity.

Blood 2012 May 7;119(22):5088-103. Epub 2012 Mar 7.

Starzl Transplantation Institute, Departments of Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-11-364091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369606PMC
May 2012

Induced regulatory T cells: mechanisms of conversion and suppressive potential.

Hum Immunol 2012 Apr 14;73(4):328-34. Epub 2012 Jan 14.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humimm.2011.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319286PMC
April 2012

Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.

J Control Release 2012 Apr 21;159(1):78-84. Epub 2012 Jan 21.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2012.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706997PMC
April 2012

Tolerance after solid organ and hematopoietic cell transplantation.

Biol Blood Marrow Transplant 2012 Jan;18(1 Suppl):S193-200

Division of Blood and Marrow Transplantation and Cellular Therapies, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2011.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374726PMC
January 2012

Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo.

J Leukoc Biol 2012 May 25;91(5):701-9. Epub 2011 Oct 25.

University of Pittsburgh School of Medicine, Thomas E. Starzl Transplantation Institute, 200 Lothrop St., Biomedical Science Tower, W1540, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0311119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046249PMC
May 2012

Tolerogenic dendritic cells and their role in transplantation.

Semin Immunol 2011 Aug 7;23(4):252-63. Epub 2011 Jul 7.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S104453231100056
Publisher Site
http://dx.doi.org/10.1016/j.smim.2011.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192911PMC
August 2011

Hepatic antigen-presenting cells and regulation of liver transplant outcome.

Immunol Res 2011 Aug;50(2-3):221-7

Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, W1540 BST, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12026-011-8223-0DOI Listing
August 2011

HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance.

Transplantation 2011 May;91(10):1132-40

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0b013e31821414c9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087844PMC
May 2011

The STATus of PD-L1 (B7-H1) on tolerogenic APCs.

Eur J Immunol 2011 Feb;41(2):286-90

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201041353DOI Listing
February 2011