Publications by authors named "Angelo M De Marzo"

100Publications

Genomic and phenotypic heterogeneity in prostate cancer.

Nat Rev Urol 2020 Dec 16. Epub 2020 Dec 16.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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December 2020

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Cancer Cell 2021 Jan 12;39(1):68-82.e9. Epub 2020 Nov 12.

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Università della Svizzera Italiana, Lugano 6900, Switzerland; Department of Medicine, University of Padua, Padua 35128, Italy; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich 8093, Switzerland. Electronic address:

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January 2021

Prostate carcinogenesis: inflammatory storms.

Nat Rev Cancer 2020 08 16;20(8):455-469. Epub 2020 Jun 16.

Institute of Oncology Research, Bellinzona, Switzerland.

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August 2020

Telomere lengths differ significantly between small-cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate.

Hum Pathol 2020 Jul 7;101:70-79. Epub 2020 May 7.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, 21287, USA.

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July 2020

An in Situ Atlas of Mitochondrial DNA in Mammalian Tissues Reveals High Content in Stem and Proliferative Compartments.

Am J Pathol 2020 07 15;190(7):1565-1579. Epub 2020 Apr 15.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Urology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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July 2020

High Extratumoral Mast Cell Counts Are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes.

Cancer Epidemiol Biomarkers Prev 2020 03 13;29(3):668-675. Epub 2020 Jan 13.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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March 2020

IL8 Expression Is Associated with Prostate Cancer Aggressiveness and Androgen Receptor Loss in Primary and Metastatic Prostate Cancer.

Mol Cancer Res 2020 01 11;18(1):153-165. Epub 2019 Oct 11.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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January 2020

Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.

Prostate 2019 12 16;79(16):1837-1851. Epub 2019 Sep 16.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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December 2019

Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis.

Am J Pathol 2019 11 6;189(11):2311-2322. Epub 2019 Sep 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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November 2019

Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease.

Eur Urol Oncol 2019 07 19;2(4):429-436. Epub 2018 Oct 19.

Department of Oncology, Johns Hopkins School of Medicine and The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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July 2019

Serum Urate, Genetic Variation, and Prostate Cancer Risk: Atherosclerosis Risk in Communities (ARIC) Study.

Cancer Epidemiol Biomarkers Prev 2019 07;28(7):1259-1261

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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July 2019

Inflammation-associated pathologies in a case of prostate schistosomiasis: Implications for a causal role in prostate carcinogenesis.

Prostate 2019 08 18;79(11):1316-1325. Epub 2019 Jun 18.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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August 2019

Cancer overdiagnosis: a biological challenge and clinical dilemma.

Nat Rev Cancer 2019 06;19(6):349-358

Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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June 2019

TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer.

Hum Pathol 2019 05 6;87:95-102. Epub 2019 Mar 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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May 2019

A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth.

Prostate 2019 02 21;79(2):215-222. Epub 2018 Oct 21.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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February 2019

Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer.

Arch Pathol Lab Med 2019 03 8;143(3):338-348. Epub 2018 Oct 8.

From the Departments of Pathology (Drs Guedes, Morais, Fedor, Hicks, Gurel, De Marzo, and Lotan), Oncology (Drs Trock, De Marzo, and Lotan), and Urology (Drs Trock and De Marzo), Johns Hopkins University School of Medicine, Baltimore, Maryland; the Department of Pathology, New York University School of Medicine, New York, New York (Drs Melamed and Lee); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Drs Gopalan and Fine); the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California (Dr Knudsen); the Department of Pathology, University of Washington, Seattle (Dr True); and Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York (Dr Scher).

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March 2019

PTEN status assessment in the Johns Hopkins active surveillance cohort.

Prostate Cancer Prostatic Dis 2019 03 2;22(1):176-181. Epub 2018 Oct 2.

Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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March 2019

Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy.

Small 2018 10 17;14(41):e1802565. Epub 2018 Sep 17.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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October 2018

Detection of AR-V7 transcript with RNA in situ hybridization in human salivary duct cancer.

Oral Oncol 2018 09 28;84:134-136. Epub 2018 Jun 28.

Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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September 2018

Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications.

Cold Spring Harb Perspect Med 2019 04 1;9(4). Epub 2019 Apr 1.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231.

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April 2019

Prostatic Adenocarcinoma With Focal Pleomorphic Giant Cell Features: A Series of 30 Cases.

Am J Surg Pathol 2018 10;42(10):1286-1296

Department of Pathology, Johns Hopkins Medical Institute, Baltimore, MD.

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October 2018

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer.

Sci Rep 2018 05 8;8(1):7189. Epub 2018 May 8.

The James Buchanan Brady Urologic Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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May 2018

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer.

Am J Pathol 2018 06 22;188(6):1478-1485. Epub 2018 Mar 22.

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland; Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

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June 2018

Clinical implications of PTEN loss in prostate cancer.

Nat Rev Urol 2018 04 20;15(4):222-234. Epub 2018 Feb 20.

Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

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April 2018

Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminal epithelial cells causes invasive prostate cancer and loss of androgen receptor expression.

Oncotarget 2017 Oct 17;8(46):80265-80277. Epub 2017 May 17.

Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

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October 2017

The inflammatory microenvironment and microbiome in prostate cancer development.

Nat Rev Urol 2018 01 31;15(1):11-24. Epub 2017 Oct 31.

Department of Pathology, Johns Hopkins University School of Medicine.

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January 2018

BET inhibitors in metastatic prostate cancer: therapeutic implications and rational drug combinations.

Expert Opin Investig Drugs 2017 Dec 27;26(12):1391-1397. Epub 2017 Oct 27.

a Department of Oncology , Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore , MD , USA.

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December 2017

CXXC5 expression in prostate cancer: implications for cancer progression.

Int J Exp Pathol 2017 08;98(4):234-243

School of Medicine, University of Cartagena, Cartagena, Colombia.

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August 2017

Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer.

J Urol 2018 01 7;199(1):161-171. Epub 2017 Aug 7.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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January 2018

Novel Assay to Detect RNA Polymerase I Activity .

Mol Cancer Res 2017 05 23;15(5):577-584. Epub 2017 Jan 23.

Department of Pathology, Urology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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May 2017

Differential long-term stability of microRNAs and RNU6B snRNA in 12-20 year old archived formalin-fixed paraffin-embedded specimens.

BMC Cancer 2017 01 6;17(1):32. Epub 2017 Jan 6.

The James Buchanan Brady Urologic Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

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January 2017

Low Intratumoral Mast Cells Are Associated With a Higher Risk of Prostate Cancer Recurrence.

Prostate 2017 03 21;77(4):412-424. Epub 2016 Nov 21.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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March 2017

The molecular underpinnings of prostate cancer: impacts on management and pathology practice.

J Pathol 2017 Jan 1;241(2):173-182. Epub 2016 Dec 1.

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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January 2017

Prevalence and Prognostic Significance of PTEN Loss in African-American and European-American Men Undergoing Radical Prostatectomy.

Eur Urol 2017 05 28;71(5):697-700. Epub 2016 Jul 28.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

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May 2017

ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma.

Hum Pathol 2016 09 14;55:117-25. Epub 2016 May 14.

Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231; Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231. Electronic address:

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September 2016

Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer.

Clin Cancer Res 2016 Sep 10;22(18):4651-63. Epub 2016 May 10.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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September 2016

Regulating NKX3.1 stability and function: Post-translational modifications and structural determinants.

Prostate 2016 May 4;76(6):523-33. Epub 2016 Feb 4.

Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland.

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May 2016

Premalignancy in Prostate Cancer: Rethinking What we Know.

Cancer Prev Res (Phila) 2016 Aug 26;9(8):648-56. Epub 2016 Jan 26.

Departments of Pathology Oncology Urology The Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center The Brady Urological Research Institute at Johns Hopkins, Johns Hopkins University, Baltimore, MD.

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August 2016

Inflammation in Benign Prostate Tissue and Prostate Cancer in the Finasteride Arm of the Prostate Cancer Prevention Trial.

Cancer Epidemiol Biomarkers Prev 2016 Mar 29;25(3):463-9. Epub 2015 Dec 29.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland. Department of Urology and the James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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March 2016

A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer.

J Natl Cancer Inst 2016 Feb 27;108(2). Epub 2015 Nov 27.

Department of Epidemiology (TUA, AP, EME, TG, REG, KMW, JRR, HDS, ELG, MJS, LAM) and Department of Nutrition (ELG, MJS), Harvard T. H. Chan School of Public Health, Boston, MA; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (AP); Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (REG); Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD (CLM, JLH, AMDM, TLL); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (JRR, ELG, MJS, LAM, KMW); Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA (HDS); Pathology Unit, Addarii Institute, S. Orsola-Malpighi Hospital, Bologna, Italy (MF); Department of Histopathology Research, Trinity College, Dublin, Ireland (RF, SF); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (ML); Department of Oncology (AMDM, TLL) and Department of Urology (ADMD), Johns Hopkins University School of Medicine, Baltimore, MD.

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February 2016

A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells.

Cancer Immunol Res 2015 Oct 5;3(10):1175-84. Epub 2015 Jun 5.

Department of Pathology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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October 2015

Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-Induced Cancer at Multiple Sites.

Cancer Prev Res (Phila) 2015 Aug 19;8(8):683-92. Epub 2015 May 19.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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August 2015

Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells.

Cancer Prev Res (Phila) 2015 Aug 19;8(8):737-42. Epub 2015 May 19.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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August 2015

Identification of glycoproteins containing specific glycans using a lectin-chemical method.

Anal Chem 2015 20;87(9):4683-7. Epub 2015 Apr 20.

§Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 100101.

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December 2015