Publications by authors named "Angelo Keramidas"

34Publications

Proteostasis Regulators Restore Function of Epilepsy-Associated GABA Receptors.

Cell Chem Biol 2020 Sep 1. Epub 2020 Sep 1.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2020.08.012DOI Listing
September 2020

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors.

Neurobiol Dis 2020 07 1;140:104850. Epub 2020 Apr 1.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2020.104850DOI Listing
July 2020

The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae.

Br J Pharmacol 2020 01 31;177(1):175-187. Epub 2019 Oct 31.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976876PMC
January 2020

SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA Receptor γ2 Subunit.

Front Mol Neurosci 2018 23;11:89. Epub 2018 Mar 23.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876238PMC
March 2018

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus.

PLoS Pathog 2017 Oct 2;13(10):e1006663. Epub 2017 Oct 2.

Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638611PMC
October 2017

Inhibitory synapse deficits caused by familial α1 GABA receptor mutations in epilepsy.

Neurobiol Dis 2017 Dec 1;108:213-224. Epub 2017 Sep 1.

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2017.08.020DOI Listing
December 2017

Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABA receptors.

Neuropharmacology 2017 Oct 27;125:243-253. Epub 2017 Jul 27.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2017.07.027DOI Listing
October 2017

Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function.

Front Mol Neurosci 2017 23;10:158. Epub 2017 May 23.

Queensland Brain Institute, The University of QueenslandBrisbane, QLD, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2017.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440463PMC
May 2017

Probing the Structural Mechanism of Partial Agonism in Glycine Receptors Using the Fluorescent Artificial Amino Acid, ANAP.

ACS Chem Biol 2017 03 2;12(3):805-813. Epub 2017 Feb 2.

Queensland Brain Institute, The University of Queensland , Brisbane, Queensland 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.6b00926DOI Listing
March 2017

The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μM.

Front Mol Neurosci 2016 22;9:88. Epub 2016 Sep 22.

Queensland Brain Institute, The University of Queensland, BrisbaneQLD, Australia; School of Biomedical Sciences, The University of Queensland, BrisbaneQLD, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2016.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031599PMC
September 2016

Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

ACS Chem Neurosci 2016 12 27;7(12):1647-1657. Epub 2016 Sep 27.

Queensland Brain Institute, The University of Queensland , Brisbane, QLD 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.6b00168DOI Listing
December 2016

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia.

J Biol Chem 2016 07 18;291(29):15332-41. Epub 2016 May 18.

From the Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia 4072

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.728592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946944PMC
July 2016

Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.

Br J Pharmacol 2015 Jul 11;172(14):3522-36. Epub 2015 May 11.

Queensland Brain Institute, University of Queensland, Brisbane, Qld, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.13142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507157PMC
July 2015

Correlating structural and energetic changes in glycine receptor activation.

J Biol Chem 2015 Feb 8;290(9):5621-34. Epub 2015 Jan 8.

From the Queensland Brain Institute and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.616573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342475PMC
February 2015

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.

Neuropharmacology 2015 Feb;89:391-7

Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2014.10.026DOI Listing
February 2015

GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.

J Biol Chem 2014 Feb 14;289(9):5399-411. Epub 2014 Jan 14.

From the Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia 4072.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.514695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937617PMC
February 2014

An outline of desensitization in pentameric ligand-gated ion channel receptors.

Cell Mol Life Sci 2013 Apr 31;70(7):1241-53. Epub 2012 Aug 31.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-012-1133-zDOI Listing
April 2013

The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors.

J Gen Physiol 2010 Jan;135(1):59-75

Department of Anesthesiology, Columbia University, New York, NY 10032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1085/jgp.200910317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806416PMC
January 2010

Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors.

J Gen Physiol 2008 Feb;131(2):163-81

CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College of Cornell University, NY, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1085/jgp.200709871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213567PMC
February 2008

Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.

J Neurosci 2008 Jan;28(1):106-15

C. V. Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Cornell Medical College, New York, New York 10065-4897, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3996-07.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671153PMC
January 2008

The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.

J Physiol 2006 Aug 8;575(Pt 1):11-22. Epub 2006 Jun 8.

CV Starr Laboratory for Molecular Pharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, A-1040, 1300 York Avenue, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/jphysiol.2005.102756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819431PMC
August 2006

Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs.

J Neurosci 2005 Nov;25(46):10617-26

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
https://pdfs.semanticscholar.org/5471/17a1922dde77d1e758164d
Web Search
http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2015-05.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2015-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725845PMC
November 2005

Ligand-gated ion channels: mechanisms underlying ion selectivity.

Prog Biophys Mol Biol 2004 Oct;86(2):161-204

Department of Physiology and Pharmacology, School of Medical Sciences, The University of New South Wales, UNSW Sydney, NSW 2052, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbiomolbio.2003.09.002DOI Listing
October 2004

The contribution of proline 250 (P-2') to pore diameter and ion selectivity in the human glycine receptor channel.

Neurosci Lett 2003 Nov;351(3):196-200

Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2003.08.005DOI Listing
November 2003

Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels.

J Gen Physiol 2002 May;119(5):411-25

Department of Physiology and Pharmacology, University of New South Wales, Sydney 2052, Australia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233819PMC
http://dx.doi.org/10.1085/jgp.20028553DOI Listing
May 2002