Angelo Ghezzi

Angelo Ghezzi

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Angelo Ghezzi

Publications by authors named "Angelo Ghezzi"

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Pharmacokinetics and pharmacodynamics of natalizumab in pediatric patients with RRMS.

Neurol Neuroimmunol Neuroinflamm 2019 Sep 1;6(5):e591. Epub 2019 Jul 1.

Multiple Sclerosis Study Center (A.G.), ASST Valle Olona, Gallarate Hospital (VA); Department of Neurology (G.C., L.M.), Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Department of Neurology (L.M.G.), Fondazione Istituto G. Giglio, Cefalù; Department of Neurology (C.P.), "La Sapienza" University, Rome; Biogen Italia (S.F.), Milan; and Department of Neuroscience DNS, Multiple Sclerosis Centre (P.G.), Università degli Studi di Padova, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624146PMC
September 2019

Pharmacokinetics and pharmacodynamics of natalizumab in pediatric patients with RRMS.

Neurol Neuroimmunol Neuroinflamm 2019 Sep 1;6(5). Epub 2019 Jul 1.

From the Multiple Sclerosis Study Center (A.G.), ASST Valle Olona, Gallarate Hospital (VA); Department of Neurology (G.C., L.M.), Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Department of Neurology (L.M.G.), Fondazione Istituto G. Giglio, Cefalù; Department of Neurology (C.P.), "La Sapienza" University, Rome; Biogen Italia (S.F.), Milan; and Department of Neuroscience DNS, Multiple Sclerosis Centre (P.G.), Università degli Studi di Padova, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000591DOI Listing
September 2019

Aging with multiple sclerosis: prevalence and profile of cognitive impairment.

Neurol Sci 2019 Aug 23;40(8):1651-1657. Epub 2019 Apr 23.

Department NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

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http://dx.doi.org/10.1007/s10072-019-03875-7DOI Listing
August 2019

Different MRI patterns in MS worsening after stopping fingolimod.

Neurol Neuroimmunol Neuroinflamm 2019 Jul 16;6(4):e566. Epub 2019 Apr 16.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics (C.L., M.C., G.B., M.P., G.N., G.L.M., A.U., M.I.), Maternal and Child Health (DiNOGMI), University of Genoa; Multiple Sclerosis Centre (D.B., A.G., M.Z.), Gallarate Hospital, ASST of Valle Olona, Gallarate; Department of Neurology (M.C., G.B., M.P., G.L.M., A.U.), Ospedale Policlinico San Martino-Sistema Sanitario Regione; Liguria -Istituto di Ricovero e Cura a Carattere Scientifico per l'Oncologia; IRCCS Foundation C. Mondino National Neurological Institute (I.C.), Pavia; Department of Health Sciences (DISSAL) (M.P.S., L. R.), Ospedale Policlinico San Martino IRCCS, Genoa, Italy; Department of Radiology and Neuroscience (M.I.), Icahn School of Medicine at Mount Sinai, New York; and Department of Neuroradiology (L.R.), Ospedale Policlinico San Martino IRCCS, Genoa, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481223PMC
July 2019

Dynamic gray matter volume changes in pediatric multiple sclerosis: A 3.5 year MRI study.

Neurology 2019 Apr 13;92(15):e1709-e1723. Epub 2019 Mar 13.

From the Neuroimaging Research Unit (E.D.M., A.M., M.F., M.A.R.) and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience (E.D.M., L.M., M.F., M.A.R.), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Multiple Sclerosis Center (A.G.), Ospedale di Gallarate; Pediatric Neurology Unit (P.V.), V. Buzzi Children's Hospital, Milan; and Biomedical and Clinical Science Department (P.V.), University of Milan, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000007267DOI Listing
April 2019

European and American Guidelines for Multiple Sclerosis Treatment.

Authors:
Angelo Ghezzi

Neurol Ther 2018 Dec 12;7(2):189-194. Epub 2018 Oct 12.

Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy.

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http://link.springer.com/10.1007/s40120-018-0112-1
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http://dx.doi.org/10.1007/s40120-018-0112-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283786PMC
December 2018

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.

N Engl J Med 2018 09;379(11):1017-1027

From the Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston (T.C.); Montreal Neurological Institute, McGill University, and NeuroRx Research - both in Montreal (D.L.A.); Children's Hospital of Philadelphia (B.B.) and the Center for Neuroinflammation and Experimental Neurotherapeutics and the Department of Neurology (A.B.-O.), Perelman School of Medicine, University of Pennsylvania - all in Philadelphia; the Department of Neuropathology (W.B.) and the Department of Pediatrics and Adolescent Medicine, German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medical Center Göttingen, Göttingen, and the Division of Pediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln (K.R.) - all in Germany; Gallarate Hospital, Gallarate, Italy (A.G.); Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London (G.G.); the University of Texas Southwestern Medical Center, Children's Health, Dallas (B.G.), and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.) - both in Texas; Pediatric Multiple Sclerosis Center at NYU Langone, New York (L.K.); Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Paris (M.T.); the Department of Neurology, University of California at San Francisco, San Francisco (E.W.); Novartis Pharmaceuticals, East Hanover, NJ (T.S., Y.C., N.P.); and Novartis Pharma, Basel, Switzerland (M.M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1800149
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http://dx.doi.org/10.1056/NEJMoa1800149DOI Listing
September 2018

Cognitive assessment in multiple sclerosis-an Italian consensus.

Neurol Sci 2018 Aug 15;39(8):1317-1324. Epub 2018 May 15.

Neuropsychology Unit, Spedali Civili of Brescia, Brescia, Italy.

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http://link.springer.com/10.1007/s10072-018-3427-x
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http://dx.doi.org/10.1007/s10072-018-3427-xDOI Listing
August 2018

Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: II: Maternal risks.

Neurology 2018 03 7;90(10):e832-e839. Epub 2018 Feb 7.

From IRCCS Don Gnocchi Foundation (E.P.), Florence; Scientific Institute University Vita-Salute San Raffaele (L.M., V.M., G.C.), Milan; Multiple Sclerosis Study Center (P.A., A.G., M.Z.), ASST Valle Olona, Gallarate Hospital (VA); Department of Neurosciences, Reproductive and Odontostomatological Sciences (R.L., V.B.M.), Federico II University of Naples; Department of Neurosciences (F.R., P.G.), Multiple Sclerosis Centre-Veneto Region (CeSMuV), University Hospital of Padova; Department of Neurology (C.T., D.P., M.T.), University of Bari; Department of Neurology and Psychiatry (C.P., L.D.G.), "La Sapienza" University, Rome; Department of Neurology (P.C.), University of Torino; Department of Medical Sciences and Public Health (E.C., M.G.M.), University of Cagliari; Department of Neurology (C.S.), ASL3 Genovese; Department of Neurology (A.U., A.L.), University of Genova; and Department of NEUROFARBA (L.P., M.G., M.P.A.), University of Florence, Italy.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005068DOI Listing
March 2018

Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: I: Fetal risks.

Neurology 2018 03 7;90(10):e823-e831. Epub 2018 Feb 7.

From IRCCS Don Gnocchi Foundation (E.P.), Florence; Multiple Sclerosis Study Center (P.A., A.G., M.Z.), ASST Valle Olona, Gallarate Hospital (VA); Scientific Institute University Vita-Salute San Raffaele (L.M., V.M., G.C.), Milan; Department of Neurosciences, Reproductive and Odontostomatological Sciences (R.L., V.B.M.), Federico II University of Naples; Department of Neurosciences (F.R., P.G.), Multiple Sclerosis Centre-Veneto Region (CeSMuV), University Hospital of Padova; Department of Neurology (C.T., D.P., M.T.), University of Bari; Department of Neurology and Psychiatry (C.P., L.D.G.), "La Sapienza" University, Rome; Department of Neurology (P.C.), University of Torino; Department of Medical Sciences and Public Health (E.C., M.G.M.), University of Cagliari; Department of Neurology (F.P.), University of Catania; Department of Neurology (C.S.), ASL3 Genovese; Multiple Sclerosis Center (P.B.), IRCCS Neuromed, Pozzilli; Department of Neurology (A.U., A.L.), University of Genova; and Department of NEUROFARBA (L.P., M.G., M.P.A.), University of Florence, Italy.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005067DOI Listing
March 2018

A Comprehensive Review on Copemyl.

Neurol Ther 2017 Dec 31;6(2):161-173. Epub 2017 Jul 31.

Multiple Sclerosis Study Center, ASST Valle Olona, Gallarate, VA, Italy.

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http://dx.doi.org/10.1007/s40120-017-0079-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700901PMC
December 2017

Long-term disability progression in primary progressive multiple sclerosis: a 15-year study.

Brain 2017 Nov;140(11):2814-2819

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1093/brain/awx250DOI Listing
November 2017

Pediatric multiple sclerosis: epidemiology, clinical aspects, diagnosis and treatment.

Authors:
Angelo Ghezzi

Neurodegener Dis Manag 2017 11;7(6s):23-25

Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, 21013, Gallarate, Italy.

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http://dx.doi.org/10.2217/nmt-2017-0037DOI Listing
November 2017

Dramatic rebounds of MS during pregnancy following fingolimod withdrawal.

Neurol Neuroimmunol Neuroinflamm 2017 Sep 27;4(5):e377. Epub 2017 Jul 27.

Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) (N.G., C.L., G.L.M., A.U.), University of Genoa, Italy; Multiple Sclerosis Study Center (A.G., P.A.), Hospital of Gallarate, Italy; San Paolo Hospital (M.P., F.B.), Savona, Italy; and IRCCS AUO San Martino-IST (G.L.M., A.U.), Genoa, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532747PMC
September 2017

MRI substrates of sustained attention system and cognitive impairment in pediatric MS patients.

Neurology 2017 Sep 18;89(12):1265-1273. Epub 2017 Aug 18.

From the Neuroimaging Research Unit (E.D.M., E.P., M.F., M.A.R.) and Department of Neurology (E.D.M., L.M., A. Fiorino, G.C., M.F., M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, and Department of Neuroradiology (A. Falini), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Multiple Sclerosis Center (A.G., L.P.), Ospedale di Gallarate; Department of Child Neurology and Psychiatry (P.V., M.C.P.), C. Mondino National Neurological Institute, Brain and Behaviour Department, University of Pavia; Multiple Sclerosis Center (R.C.), Spedali Civili of Brescia; and Department NEUROFARBA (M.P.A.), Section Neurosciences, University of Florence, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004388DOI Listing
September 2017

Randomized clinical trials (RCTs) in pediatric multiple sclerosis: Are they really necessary?

Authors:
Angelo Ghezzi

Mult Scler 2017 06 21;23(7):1042-1043. Epub 2016 Dec 21.

Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy.

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http://dx.doi.org/10.1177/1352458516684025DOI Listing
June 2017

Country breakout session highlights.

Neurodegener Dis Manag 2016 Dec;6(6s):41-44

Department of Clinical Neuroscience, Institute of Neuroscience & Physiology at Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.2217/nmt-2016-0055DOI Listing
December 2016

What is new in multiple sclerosis spasticity research? Poster session highlights.

Authors:
Angelo Ghezzi

Neurodegener Dis Manag 2016 Dec;6(6s):45-47

Neurologia 2, Centro Studi Sclerosi Multipla, Gallarate Hospital, Gallarate, Italy.

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http://dx.doi.org/10.2217/nmt-2016-0056DOI Listing
December 2016

Natalizumab versus fingolimod in patients with relapsing-remitting multiple sclerosis non-responding to first-line injectable therapies.

Mult Scler 2016 09 26;22(10):1315-26. Epub 2016 May 26.

Department of Neurology, San Raffaele Hospital, Milan, Italy/Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.

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http://journals.sagepub.com/doi/10.1177/1352458516650736
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http://dx.doi.org/10.1177/1352458516650736DOI Listing
September 2016

History of multiple sclerosis in 2 successive pregnancies: A French and Italian cohort.

Neurology 2016 Sep 27;87(13):1360-7. Epub 2016 Jul 27.

From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neuro-oncologie et Neuro-inflammation; Université de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.); Université Lyon 1 et Université de Lyon (A.B., R.C., S.R., R.M., C.C., S.V.), France; Department NEUROFARBA (M.-P.A., E.P.), Section Neurosciences, University of Florence, Italy; Observatoire Français de la Sclérose en Plaques (R.C., C.C., S.V.), Bron, France; Departments of Medical Sciences (M.-G.M.) and Public Health, Clinical and Molecular Medicine (E.C.), University of Cagliari; Hospital of Gallarate (A.G., P.A.), Varese; Department of Basic Medical Sciences (M.T., M.S.), Neurosciences and Sense Organs, University of Bari, Italy; Fondation Eugène Devic EDMUS contre la Sclérose en Plaques (R.M., C.C., S.V.), Bron; and Centre des Neurosciences de Lyon (R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neuro-oncologie et Neuro-inflammation, France.

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http://www.neurology.org/content/early/2016/07/27/WNL.000000
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http://dx.doi.org/10.1212/WNL.0000000000003036DOI Listing
September 2016

Pediatric multiple sclerosis: Escalation and emerging treatments.

Neurology 2016 Aug;87(9 Suppl 2):S103-9

From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000002884DOI Listing
August 2016

International Pediatric MS Study Group Global Members Symposium report.

Neurology 2016 Aug;87(9 Suppl 2):S110-6

From the Department of Neurology (E. Wassmer), Birmingham Children's Hospital, UK; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; Department NEUROFARBA (M.P.A.), Section Neurosciences, University of Florence, Italy; Division of Neurology (A.W.), Perelman School of Medicine (B.B.), The Children's Hospital of Philadelphia, University of Pennsylvania; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (R.Q.H.), MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands; Lourie Center for Pediatric MS (L.B.K.), Stony Brook Children's, Stony Brook University, NY; Departments of Pediatrics and Neurology (N.M.), Yale University School of Medicine, New Haven, CT; Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany; National Reference Center for Inflammatory Diseases of the Brain (M.T.), Hôpitaux Universitaires Paris-Sud, University Paris-Sud, France; Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Pediatric MS Center (E. Waubant), UCSF Benioff Children's Hospital, and Neurology Department, UCSF, San Francisco, CA; and the Department of Neurology (A.J.K.), Royal Children's Hospital, Parkville, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000002880DOI Listing
August 2016

Pediatric multiple sclerosis: Clinical features and outcome.

Neurology 2016 Aug;87(9 Suppl 2):S74-81

From the Division of Neurology, Department of Pediatrics (A.W.), Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania; Department of Pediatrics (J.N.), University of Alabama at Birmingham and Children's of Alabama; Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; Department of Basic Medical Sciences, Neurosciences and Sense Organs (I.L.S.), University of Bari, Italy; Department of Pediatric Neurology (B.A.), Hacettepe University, Ankara, Turkey; Department NEUROFARBA, Section Neurosciences (M.P.A.), University of Florence; and Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000003028DOI Listing
August 2016

Pediatric multiple sclerosis: Conventional first-line treatment and general management.

Neurology 2016 Aug;87(9 Suppl 2):S97-S102

From the Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.

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http://dx.doi.org/10.1212/WNL.0000000000002823DOI Listing
August 2016

Abnormalities of the executive control network in multiple sclerosis phenotypes: An fMRI effective connectivity study.

Hum Brain Mapp 2016 06 9;37(6):2293-304. Epub 2016 Mar 9.

Neuroimaging Research Unit, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1002/hbm.23174DOI Listing
June 2016

Regional hippocampal involvement and cognitive impairment in pediatric multiple sclerosis.

Mult Scler 2016 Apr 18;22(5):628-40. Epub 2015 Aug 18.

Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy/Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy

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http://dx.doi.org/10.1177/1352458515598569DOI Listing
April 2016

Subcutaneous interferon β-1a in pediatric patients with multiple sclerosis: Regional differences in clinical features, disease management, and treatment outcomes in an international retrospective study.

J Neurol Sci 2016 Apr 15;363:33-8. Epub 2016 Jan 15.

The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jns.2016.01.023DOI Listing
April 2016

Abnormal cerebellar functional MRI connectivity in patients with paediatric multiple sclerosis.

Mult Scler 2016 Mar 10;22(3):292-301. Epub 2015 Jul 10.

Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

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http://dx.doi.org/10.1177/1352458515592191DOI Listing
March 2016

Natalizumab discontinuation in patients with multiple sclerosis: Profiling risk and benefits at therapeutic crossroads.

Mult Scler 2015 Nov 19;21(13):1713-22. Epub 2015 Feb 19.

Department of Neurology and Psychiatry, Sapienza University, ItalyMS Centre, S. Antonio Abate Hospital, ItalyNeurologia 2 - CRESM (Centro Riferimento Regionale Sclerosi Multipla), University Hospital San Luigi Gonzaga, ItalyRegional Referring MS Center, Spedali Civili of Brescia, Montichiari Hospital, ItalyDepartment of Neurosciences Tor Vergata University, Italy/IRCCS Neuromed, ItalyDepartment of Neurosciences, S. Camillo-Forlanini Hospital, ItalyDepartment of Neurosciences, S. Camillo-Forlanini Hospital, ItalyNeurology Unit, Department Head and Neck, ASL 3 genovese, Genova, ItalyDepartment of Neurosciences Tor Vergata University, Italy/S. Lucia Foundation IRCCS, ItalyNeurologia 2 - CRESM (Centro Riferimento Regionale Sclerosi Multipla), University Hospital San Luigi Gonzaga, ItalyDepartment of Neurology and Psychiatry, Sapienza University, ItalyMS Centre, S. Antonio Abate Hospital, Italy.

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http://dx.doi.org/10.1177/1352458515570768DOI Listing
November 2015

Pediatric multiple sclerosis: update in diagnosis and management.

Authors:
Angelo Ghezzi

Eur Neurol 2014 26;72 Suppl 1:26-8. Epub 2014 Sep 26.

Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy.

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http://dx.doi.org/10.1159/000367621DOI Listing
June 2015

Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions.

Mult Scler 2015 Jun 12;21(7):956-9. Epub 2014 Nov 12.

Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

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http://dx.doi.org/10.1177/1352458514557303DOI Listing
June 2015

Uhthoff's phenomena and brain MRI suggesting demyelinating lesions: RIS or CIS? A case report.

J Neurol Sci 2014 Oct 16;345(1-2):262-4. Epub 2014 Jul 16.

Multiple Sclerosis Study Center, Sant'Antonio Abate Hospital of Gallarate, Italy.

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http://dx.doi.org/10.1016/j.jns.2014.07.020DOI Listing
October 2014

Neuropsychological features in childhood and juvenile multiple sclerosis: five-year follow-up.

Neurology 2014 Oct 12;83(16):1432-8. Epub 2014 Sep 12.

From the Department of NEUROFARBA (M.P.A., B.G., B.H., C.N., S.L., E.P.), University of Florence; MS Centre (A.G., M.R.), Hospital of Gallarate; Neurological Department (L.M., M.F., V.M., G.C.), IRCCS Hospital San Raffaele, Milano; Department of Neuroscience and Sense Organs (R.G.V., M.T.), University of Bari; Multiple Sclerosis Centre (F.P., S.C.), University Polyclinic Hospital G. Rodolico, Catania; and Department of Neurological Sciences (C.P., V.B.), La Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000000885DOI Listing
October 2014

Multiple sclerosis in children: an update on clinical diagnosis, therapeutic strategies, and research.

Lancet Neurol 2014 Sep;13(9):936-48

Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(14)70093-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443918PMC
September 2014

Intranetwork and internetwork functional connectivity abnormalities in pediatric multiple sclerosis.

Hum Brain Mapp 2014 Aug 7;35(8):4180-92. Epub 2014 Feb 7.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1002/hbm.22469DOI Listing
August 2014

Genetic burden of common variants in progressive and bout-onset multiple sclerosis.

Mult Scler 2014 06 25;20(7):802-11. Epub 2013 Nov 25.

Laboratory of Genetics of Neurological Complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Italy Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Italy

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http://dx.doi.org/10.1177/1352458513512707DOI Listing
June 2014

Posterior brain damage and cognitive impairment in pediatric multiple sclerosis.

Neurology 2014 Apr 19;82(15):1314-21. Epub 2014 Mar 19.

From the Neuroimaging Research Unit (M.A.R., M.A., M.F.), Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience (M.A.R., M.A., L.M., A. Fiorino, G.C., M.F.), and Department of Neurology (M.P.A., E.P.), University of Florence; the Multiple Sclerosis Center (A.G., L.P.), Ospedale di Gallarate; Fondazione "Istituto Neurologico Casimiro Mondino" (P.V., M.C.P.), Pavia; Multiple Sclerosis Center (R.C.), Spedali Civili of Brescia, Italy; Department of Cardiovascular Sciences (M.A.H.), University of Leicester, UK; and the Department of Neuroradiology (A. Falini), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000000309DOI Listing
April 2014

Subcutaneous interferon Beta-1a in pediatric multiple sclerosis: a retrospective study.

J Child Neurol 2013 Jul 10;28(7):849-56. Epub 2013 May 10.

Hospital de Pediatría S.A.M.I.C. Prof Juan P Garrahan, Buenos Aires, Argentina.

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http://dx.doi.org/10.1177/0883073813488828DOI Listing
July 2013

Current recommendations for multiple sclerosis treatment in pregnancy and puerperium.

Expert Rev Clin Immunol 2013 Jul;9(7):683-91; quiz 692

UO Neurologia 2 - Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, 21013 Gallarate, Italy.

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http://dx.doi.org/10.1586/1744666X.2013.811046DOI Listing
July 2013

Funding CCSVI research is/was a waste of valuable time, money and intellectual energy: yes.

Authors:
Angelo Ghezzi

Mult Scler 2013 Jun;19(7):855-7

Ospedale di Gallarate, Centro Studi Sclerosi Multipla, Via Pastori 4, Gallarate 21013, Italy.

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http://dx.doi.org/10.1177/1352458513479825DOI Listing
June 2013

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
Stephen Sawcer Garrett Hellenthal Matti Pirinen Chris C A Spencer Nikolaos A Patsopoulos Loukas Moutsianas Alexander Dilthey Zhan Su Colin Freeman Sarah E Hunt Sarah Edkins Emma Gray David R Booth Simon C Potter An Goris Gavin Band Annette Bang Oturai Amy Strange Janna Saarela Céline Bellenguez Bertrand Fontaine Matthew Gillman Bernhard Hemmer Rhian Gwilliam Frauke Zipp Alagurevathi Jayakumar Roland Martin Stephen Leslie Stanley Hawkins Eleni Giannoulatou Sandra D'alfonso Hannah Blackburn Filippo Martinelli Boneschi Jennifer Liddle Hanne F Harbo Marc L Perez Anne Spurkland Matthew J Waller Marcin P Mycko Michelle Ricketts Manuel Comabella Naomi Hammond Ingrid Kockum Owen T McCann Maria Ban Pamela Whittaker Anu Kemppinen Paul Weston Clive Hawkins Sara Widaa John Zajicek Serge Dronov Neil Robertson Suzannah J Bumpstead Lisa F Barcellos Rathi Ravindrarajah Roby Abraham Lars Alfredsson Kristin Ardlie Cristin Aubin Amie Baker Katharine Baker Sergio E Baranzini Laura Bergamaschi Roberto Bergamaschi Allan Bernstein Achim Berthele Mike Boggild Jonathan P Bradfield David Brassat Simon A Broadley Dorothea Buck Helmut Butzkueven Ruggero Capra William M Carroll Paola Cavalla Elisabeth G Celius Sabine Cepok Rosetta Chiavacci Françoise Clerget-Darpoux Katleen Clysters Giancarlo Comi Mark Cossburn Isabelle Cournu-Rebeix Mathew B Cox Wendy Cozen Bruce A C Cree Anne H Cross Daniele Cusi Mark J Daly Emma Davis Paul I W de Bakker Marc Debouverie Marie Beatrice D'hooghe Katherine Dixon Rita Dobosi Bénédicte Dubois David Ellinghaus Irina Elovaara Federica Esposito Claire Fontenille Simon Foote Andre Franke Daniela Galimberti Angelo Ghezzi Joseph Glessner Refujia Gomez Olivier Gout Colin Graham Struan F A Grant Franca Rosa Guerini Hakon Hakonarson Per Hall Anders Hamsten Hans-Peter Hartung Rob N Heard Simon Heath Jeremy Hobart Muna Hoshi Carmen Infante-Duarte Gillian Ingram Wendy Ingram Talat Islam Maja Jagodic Michael Kabesch Allan G Kermode Trevor J Kilpatrick Cecilia Kim Norman Klopp Keijo Koivisto Malin Larsson Mark Lathrop Jeannette S Lechner-Scott Maurizio A Leone Virpi Leppä Ulrika Liljedahl Izaura Lima Bomfim Robin R Lincoln Jenny Link Jianjun Liu Aslaug R Lorentzen Sara Lupoli Fabio Macciardi Thomas Mack Mark Marriott Vittorio Martinelli Deborah Mason Jacob L McCauley Frank Mentch Inger-Lise Mero Tania Mihalova Xavier Montalban John Mottershead Kjell-Morten Myhr Paola Naldi William Ollier Alison Page Aarno Palotie Jean Pelletier Laura Piccio Trevor Pickersgill Fredrik Piehl Susan Pobywajlo Hong L Quach Patricia P Ramsay Mauri Reunanen Richard Reynolds John D Rioux Mariaemma Rodegher Sabine Roesner Justin P Rubio Ina-Maria Rückert Marco Salvetti Erika Salvi Adam Santaniello Catherine A Schaefer Stefan Schreiber Christian Schulze Rodney J Scott Finn Sellebjerg Krzysztof W Selmaj David Sexton Ling Shen Brigid Simms-Acuna Sheila Skidmore Patrick M A Sleiman Cathrine Smestad Per Soelberg Sørensen Helle Bach Søndergaard Jim Stankovich Richard C Strange Anna-Maija Sulonen Emilie Sundqvist Ann-Christine Syvänen Francesca Taddeo Bruce Taylor Jenefer M Blackwell Pentti Tienari Elvira Bramon Ayman Tourbah Matthew A Brown Ewa Tronczynska Juan P Casas Niall Tubridy Aiden Corvin Jane Vickery Janusz Jankowski Pablo Villoslada Hugh S Markus Kai Wang Christopher G Mathew James Wason Colin N A Palmer H-Erich Wichmann Robert Plomin Ernest Willoughby Anna Rautanen Juliane Winkelmann Michael Wittig Richard C Trembath Jacqueline Yaouanq Ananth C Viswanathan Haitao Zhang Nicholas W Wood Rebecca Zuvich Panos Deloukas Cordelia Langford Audrey Duncanson Jorge R Oksenberg Margaret A Pericak-Vance Jonathan L Haines Tomas Olsson Jan Hillert Adrian J Ivinson Philip L De Jager Leena Peltonen Graeme J Stewart David A Hafler Stephen L Hauser Gil McVean Peter Donnelly Alastair Compston

Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis.

Mult Scler 2011 Jun 12;17(6):702-7. Epub 2011 Jan 12.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, Milan, Italy.

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http://dx.doi.org/10.1177/1352458510395645DOI Listing
June 2011

MGAT5 and disease severity in progressive multiple sclerosis.

J Neuroimmunol 2011 Jan 27;230(1-2):143-7. Epub 2010 Nov 27.

INSPE and Department of Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.jneuroim.2010.10.026DOI Listing
January 2011

Brain macro- and microscopic damage in patients with paediatric MS.

J Neurol Neurosurg Psychiatry 2010 Dec 26;81(12):1357-62. Epub 2010 Jul 26.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy.

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http://dx.doi.org/10.1136/jnnp.2010.205682DOI Listing
December 2010

Therapeutic strategies in childhood multiple sclerosis.

Authors:
Angelo Ghezzi

Ther Adv Neurol Disord 2010 Jul;3(4):217-28

Centro Studi Sclerosi Multipla, Via Pastori 4, 21013 Gallarate, Cagliari, Italy.

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http://dx.doi.org/10.1177/1756285610371251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002659PMC
July 2010

Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis.

Radiology 2010 Feb;254(2):541-50

Neuroimaging Research Unit, Institute of Experimental Neurology, Department of Neurology, University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy.

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http://dx.doi.org/10.1148/radiol.09090463DOI Listing
February 2010

Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis.

Mult Scler 2010 Jan 13;16(1):39-44. Epub 2009 Nov 13.

Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

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http://journals.sagepub.com/doi/10.1177/1352458509350310
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http://dx.doi.org/10.1177/1352458509350310DOI Listing
January 2010

Is a preserved functional reserve a mechanism limiting clinical impairment in pediatric MS patients?

Hum Brain Mapp 2009 Sep;30(9):2844-51

Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1002/hbm.20712DOI Listing
September 2009

Corpus callosum damage and cognitive dysfunction in benign MS.

Hum Brain Mapp 2009 Aug;30(8):2656-66

Scientific Institute, University Ospedale San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1002/hbm.20692DOI Listing
August 2009

Glatiramer acetate is a treatment option in neutralising antibodies to interferon-beta-positive patients.

Neurol Sci 2008 Sep;29 Suppl 2:S227-9

Centro di Riferimento Regionale Sclerosi Multipla e Neurobiologia Clinica, AOU S. Luigi Gonzaga, Regione Gonzole 10, 10043, Orbassano, TO, Italy.

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http://dx.doi.org/10.1007/s10072-008-0945-yDOI Listing
September 2008

Induction and add-on therapy with mitoxantrone and interferon beta in multiple sclerosis.

Neurol Sci 2008 Sep;29 Suppl 2:S230-2

Centro Studi Sclerosi Multipla, Gallarate, Italy.

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http://dx.doi.org/10.1007/s10072-008-0946-xDOI Listing
September 2008

Imaging of cranio-meningeal infectious and inflammatory involvement.

Neurol Sci 2008 Sep;29 Suppl 2:S279-82

Dipartimento di Radiologia, U.O.Neuroradiologia e Radiologia, Az. Ospedaliera S. Antonio Abate, Gallarate, Italy.

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http://link.springer.com/10.1007/s10072-008-0964-8
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http://dx.doi.org/10.1007/s10072-008-0964-8DOI Listing
September 2008

A 3-year diffusion tensor MRI study of grey matter damage progression during the earliest clinical stage of MS.

J Neurol 2008 Aug 13;255(8):1209-14. Epub 2008 Jun 13.

Neuroimaging Research Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00415-008-0877-8DOI Listing
August 2008

Female-specific issues in multiple sclerosis.

Expert Rev Neurother 2008 Jun;8(6):969-77

Centro Studi Sclerosi Multipla Via Pastori, 4, I-21013 Gallarate, Italy.

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http://dx.doi.org/10.1586/14737175.8.6.969DOI Listing
June 2008

The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study.

Neuroimage 2008 Feb 13;39(4):1499-509. Epub 2007 Nov 13.

Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1016/j.neuroimage.2007.11.002DOI Listing
February 2008

Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions.

Lancet Neurol 2007 Oct;6(10):887-902

Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/S1474-4422(07)70242-9DOI Listing
October 2007

A brain magnetization transfer MRI study with a clinical follow up of about four years in patients with clinically isolated syndromes suggestive of multiple sclerosis.

J Neurol 2007 Jan 14;254(1):78-83. Epub 2007 Feb 14.

Neuroimaging Research Unit, Dept. of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00415-006-0283-zDOI Listing
January 2007

Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes.

Lancet Neurol 2005 Oct;4(10):618-26

Neuroimaging Research Unit, University Ospedale San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1016/S1474-4422(05)70171-XDOI Listing
October 2005

Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis.

J Neuroimmunol 2005 May;162(1-2):112-21

Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, 21100 Varese VA, Italy.

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http://dx.doi.org/10.1016/j.jneuroim.2005.01.019DOI Listing
May 2005

A widespread pattern of cortical activations in patients at presentation with clinically isolated symptoms is associated with evolution to definite multiple sclerosis.

AJNR Am J Neuroradiol 2005 May;26(5):1136-9

Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

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May 2005

Childhood-juvenile multiple sclerosis: clinical characteristics and treatment.

Authors:
Angelo Ghezzi

Expert Rev Neurother 2005 May;5(3):403-11

Ospedale di Gallarate, Centro Studi Sclerosi Multipla, via Pastori 4, 21013 Gallarate, Italy.

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http://dx.doi.org/10.1586/14737175.5.3.403DOI Listing
May 2005

A preliminary diffusion tensor and magnetization transfer magnetic resonance imaging study of early-onset multiple sclerosis.

Arch Neurol 2004 Mar;61(3):366-8

Neuroimaging Research Unit and the Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1001/archneur.61.3.366DOI Listing
March 2004