Publications

Long-term disability progression in primary progressive multiple sclerosis: a 15-year study.
Brain 2017 Nov;140(11):2814-2819
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Dramatic rebounds of MS during pregnancy following fingolimod withdrawal.
Neurol Neuroimmunol Neuroinflamm 2017 Sep 27;4(5):e377. Epub 2017 Jul 27.
Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) (N.G., C.L., G.L.M., A.U.), University of Genoa, Italy; Multiple Sclerosis Study Center (A.G., P.A.), Hospital of Gallarate, Italy; San Paolo Hospital (M.P., F.B.), Savona, Italy; and IRCCS AUO San Martino-IST (G.L.M., A.U.), Genoa, Italy.

MRI substrates of sustained attention system and cognitive impairment in pediatric MS patients.
Neurology 2017 Sep 18;89(12):1265-1273. Epub 2017 Aug 18.
From the Neuroimaging Research Unit (E.D.M., E.P., M.F., M.A.R.) and Department of Neurology (E.D.M., L.M., A. Fiorino, G.C., M.F., M.A.R.), Institute of Experimental Neurology, Division of Neuroscience, and Department of Neuroradiology (A. Falini), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Multiple Sclerosis Center (A.G., L.P.), Ospedale di Gallarate; Department of Child Neurology and Psychiatry (P.V., M.C.P.), C. Mondino National Neurological Institute, Brain and Behaviour Department, University of Pavia; Multiple Sclerosis Center (R.C.), Spedali Civili of Brescia; and Department NEUROFARBA (M.P.A.), Section Neurosciences, University of Florence, Italy.





Natalizumab versus fingolimod in patients with relapsing-remitting multiple sclerosis non-responding to first-line injectable therapies.
Mult Scler 2016 Sep 26;22(10):1315-26. Epub 2016 May 26.
Department of Neurology, San Raffaele Hospital, Milan, Italy/Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.

History of multiple sclerosis in 2 successive pregnancies: A French and Italian cohort.
Neurology 2016 Sep 27;87(13):1360-7. Epub 2016 Jul 27.
From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neuro-oncologie et Neuro-inflammation; Université de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.); Université Lyon 1 et Université de Lyon (A.B., R.C., S.R., R.M., C.C., S.V.), France; Department NEUROFARBA (M.-P.A., E.P.), Section Neurosciences, University of Florence, Italy; Observatoire Français de la Sclérose en Plaques (R.C., C.C., S.V.), Bron, France; Departments of Medical Sciences (M.-G.M.) and Public Health, Clinical and Molecular Medicine (E.C.), University of Cagliari; Hospital of Gallarate (A.G., P.A.), Varese; Department of Basic Medical Sciences (M.T., M.S.), Neurosciences and Sense Organs, University of Bari, Italy; Fondation Eugène Devic EDMUS contre la Sclérose en Plaques (R.M., C.C., S.V.), Bron; and Centre des Neurosciences de Lyon (R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neuro-oncologie et Neuro-inflammation, France.

Pediatric multiple sclerosis: Escalation and emerging treatments.
Neurology 2016 Aug;87(9 Suppl 2):S103-9
From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada.

International Pediatric MS Study Group Global Members Symposium report.
Neurology 2016 Aug;87(9 Suppl 2):S110-6
From the Department of Neurology (E. Wassmer), Birmingham Children's Hospital, UK; Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; Department NEUROFARBA (M.P.A.), Section Neurosciences, University of Florence, Italy; Division of Neurology (A.W.), Perelman School of Medicine (B.B.), The Children's Hospital of Philadelphia, University of Pennsylvania; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (R.Q.H.), MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands; Lourie Center for Pediatric MS (L.B.K.), Stony Brook Children's, Stony Brook University, NY; Departments of Pediatrics and Neurology (N.M.), Yale University School of Medicine, New Haven, CT; Department of Pediatric Neurology (K.R.), Children's Hospital Datteln, University Witten/Herdecke, Germany; National Reference Center for Inflammatory Diseases of the Brain (M.T.), Hôpitaux Universitaires Paris-Sud, University Paris-Sud, France; Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Ciudad de Buenos Aires, Argentina; Pediatric MS Center (E. Waubant), UCSF Benioff Children's Hospital, and Neurology Department, UCSF, San Francisco, CA; and the Department of Neurology (A.J.K.), Royal Children's Hospital, Parkville, Australia.

Pediatric multiple sclerosis: Clinical features and outcome.
Neurology 2016 Aug;87(9 Suppl 2):S74-81
From the Division of Neurology, Department of Pediatrics (A.W.), Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania; Department of Pediatrics (J.N.), University of Alabama at Birmingham and Children's of Alabama; Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada; Department of Basic Medical Sciences, Neurosciences and Sense Organs (I.L.S.), University of Bari, Italy; Department of Pediatric Neurology (B.A.), Hacettepe University, Ankara, Turkey; Department NEUROFARBA, Section Neurosciences (M.P.A.), University of Florence; and Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy.

Pediatric multiple sclerosis: Conventional first-line treatment and general management.
Neurology 2016 Aug;87(9 Suppl 2):S97-S102
From the Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.

Regional hippocampal involvement and cognitive impairment in pediatric multiple sclerosis.
Mult Scler 2016 Apr 18;22(5):628-40. Epub 2015 Aug 18.
Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy/Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Italy


Abnormal cerebellar functional MRI connectivity in patients with paediatric multiple sclerosis.
Mult Scler 2016 Mar 10;22(3):292-301. Epub 2015 Jul 10.
Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Natalizumab discontinuation in patients with multiple sclerosis: Profiling risk and benefits at therapeutic crossroads.
Mult Scler 2015 Nov 19;21(13):1713-22. Epub 2015 Feb 19.
Department of Neurology and Psychiatry, Sapienza University, ItalyMS Centre, S. Antonio Abate Hospital, ItalyNeurologia 2 - CRESM (Centro Riferimento Regionale Sclerosi Multipla), University Hospital San Luigi Gonzaga, ItalyRegional Referring MS Center, Spedali Civili of Brescia, Montichiari Hospital, ItalyDepartment of Neurosciences Tor Vergata University, Italy/IRCCS Neuromed, ItalyDepartment of Neurosciences, S. Camillo-Forlanini Hospital, ItalyDepartment of Neurosciences, S. Camillo-Forlanini Hospital, ItalyNeurology Unit, Department Head and Neck, ASL 3 genovese, Genova, ItalyDepartment of Neurosciences Tor Vergata University, Italy/S. Lucia Foundation IRCCS, ItalyNeurologia 2 - CRESM (Centro Riferimento Regionale Sclerosi Multipla), University Hospital San Luigi Gonzaga, ItalyDepartment of Neurology and Psychiatry, Sapienza University, ItalyMS Centre, S. Antonio Abate Hospital, Italy.



Cognitive impairment in paediatric multiple sclerosis patients is not related to cortical lesions.
Mult Scler 2015 Jun 12;21(7):956-9. Epub 2014 Nov 12.
Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Neuropsychological features in childhood and juvenile multiple sclerosis: five-year follow-up.
Neurology 2014 Oct 12;83(16):1432-8. Epub 2014 Sep 12.
From the Department of NEUROFARBA (M.P.A., B.G., B.H., C.N., S.L., E.P.), University of Florence; MS Centre (A.G., M.R.), Hospital of Gallarate; Neurological Department (L.M., M.F., V.M., G.C.), IRCCS Hospital San Raffaele, Milano; Department of Neuroscience and Sense Organs (R.G.V., M.T.), University of Bari; Multiple Sclerosis Centre (F.P., S.C.), University Polyclinic Hospital G. Rodolico, Catania; and Department of Neurological Sciences (C.P., V.B.), La Sapienza University, Rome, Italy.


Intranetwork and internetwork functional connectivity abnormalities in pediatric multiple sclerosis.
Hum Brain Mapp 2014 Aug 7;35(8):4180-92. Epub 2014 Feb 7.
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.


Genetic burden of common variants in progressive and bout-onset multiple sclerosis.
Mult Scler 2014 Jun 25;20(7):802-11. Epub 2013 Nov 25.
Laboratory of Genetics of Neurological Complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Italy Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Italy


Posterior brain damage and cognitive impairment in pediatric multiple sclerosis.
Neurology 2014 Apr 19;82(15):1314-21. Epub 2014 Mar 19.
From the Neuroimaging Research Unit (M.A.R., M.A., M.F.), Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience (M.A.R., M.A., L.M., A. Fiorino, G.C., M.F.), and Department of Neurology (M.P.A., E.P.), University of Florence; the Multiple Sclerosis Center (A.G., L.P.), Ospedale di Gallarate; Fondazione "Istituto Neurologico Casimiro Mondino" (P.V., M.C.P.), Pavia; Multiple Sclerosis Center (R.C.), Spedali Civili of Brescia, Italy; Department of Cardiovascular Sciences (M.A.H.), University of Leicester, UK; and the Department of Neuroradiology (A. Falini), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.








Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

MGAT5 and disease severity in progressive multiple sclerosis.
J Neuroimmunol 2011 Jan 27;230(1-2):143-7. Epub 2010 Nov 27.
INSPE and Department of Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.


Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis.
Mult Scler 2010 Jan 13;16(1):39-44. Epub 2009 Nov 13.
Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.




Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis.
J Neuroimmunol 2005 May;162(1-2):112-21
Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, 21100 Varese VA, Italy.


A widespread pattern of cortical activations in patients at presentation with clinically isolated symptoms is associated with evolution to definite multiple sclerosis.
AJNR Am J Neuroradiol 2005 May;26(5):1136-9
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.




Irreversible disability and tissue loss in multiple sclerosis: a conventional and magnetization transfer magnetic resonance imaging study of the optic nerves.
Arch Neurol 2002 Feb;59(2):250-5
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy.




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