Publications


Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
Neuron 2017 Mar;93(5):1015-1034
Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address:




PICALM modulates autophagy activity and tau accumulation.
Nat Commun 2014 Sep 22;5:4998. Epub 2014 Sep 22.
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.

IGF-1 receptor antagonism inhibits autophagy.
Hum Mol Genet 2013 Nov 25;22(22):4528-44. Epub 2013 Jun 25.
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

Complex inhibitory effects of nitric oxide on autophagy.
Mol Cell 2011 Jul;43(1):19-32
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.
Hum Mol Genet 2010 Sep 21;19(17):3413-29. Epub 2010 Jun 21.
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Nat Chem Biol 2008 May;4(5):295-305
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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