Angela Kashuba

Angela Kashuba

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Angela Kashuba

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Differential extracellular, but similar intracellular, disposition of two tenofovir formulations in the male genital tract.

Antivir Ther 2019 ;24(1):45-50

UNC School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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https://www.intmedpress.com/journals/avt/abstract.cfm?id=327
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http://dx.doi.org/10.3851/IMP3277DOI Listing
March 2020

Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis.

Antimicrob Agents Chemother 2020 01 27;64(2). Epub 2020 Jan 27.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/AAC.01729-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985753PMC
January 2020

Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

J Pharmacol Exp Ther 2019 09 24;370(3):360-368. Epub 2019 Jun 24.

Eshelman School of Pharmacy (E.B., J.K.F., N.W., A.P.S., C.S., P.C.S., A.D.M.K.) and School of Medicine (M.K., J.V.G., A.D.M.K.), University of North Carolina, Chapel Hill, North Carolina; School of Medicine, Colorado State University, Fort Collins, Colorado (L.R.-M., R.A.); and School of Medicine, University of California, Davis, California (L.A., P.L.)

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http://dx.doi.org/10.1124/jpet.119.259150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695867PMC
September 2019

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery.

Nat Commun 2019 09 20;10(1):4324. Epub 2019 Sep 20.

International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41467-019-12141-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754500PMC
September 2019

HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood-brain barrier integrity.

J Neurovirol 2019 Aug 17;25(4):560-577. Epub 2019 May 17.

Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, 23298, USA.

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http://dx.doi.org/10.1007/s13365-019-00757-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750988PMC
August 2019

Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging of Human Hair to Characterize Longitudinal Profiles of the Antiretroviral Maraviroc for Adherence Monitoring.

Anal Chem 2019 Aug 6;91(16):10816-10822. Epub 2019 Aug 6.

Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b02464DOI Listing
August 2019

Contemporary Drug-Drug Interactions in HIV Treatment.

Clin Pharmacol Ther 2019 06 25;105(6):1362-1377. Epub 2019 Mar 25.

University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/cpt.1393DOI Listing
June 2019

Estimating Human Immunodeficiency Virus (HIV) Prevention Effects in Low-incidence Settings.

Epidemiology 2019 05;30(3):358-364

From the Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1097/EDE.0000000000000966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456405PMC
May 2019

Injectable long-acting human immunodeficiency virus antiretroviral prodrugs with improved pharmacokinetic profiles.

Int J Pharm 2018 Dec 8;552(1-2):371-377. Epub 2018 Oct 8.

Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583897PMC
December 2018

Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis.

J Am Soc Mass Spectrom 2018 Dec 15;29(12):2467-2470. Epub 2018 Oct 15.

FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.

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http://link.springer.com/10.1007/s13361-018-2073-0
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http://dx.doi.org/10.1007/s13361-018-2073-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250575PMC
December 2018

Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair.

Anal Bioanal Chem 2018 Nov 2;410(29):7773-7781. Epub 2018 Oct 2.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 1099C Genetic Medicine Building, CB# 7361, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s00216-018-1394-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501839PMC
November 2018

Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Nat Commun 2018 10 8;9(1):4156. Epub 2018 Oct 8.

Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, 120 Mason Farm Rd. CB 7042, Chapel Hill, NC 27599, USA.

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http://www.nature.com/articles/s41467-018-06490-w
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http://dx.doi.org/10.1038/s41467-018-06490-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175887PMC
October 2018

Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System.

Clin Pharmacokinet 2018 09;57(9):1059-1074

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, 1094 Genetic Medicine Building, CB# 7361, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA.

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http://link.springer.com/10.1007/s40262-018-0632-y
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http://dx.doi.org/10.1007/s40262-018-0632-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062484PMC
September 2018

Smartphone-Based Contingency Management Intervention to Improve Pre-Exposure Prophylaxis Adherence: Pilot Trial.

JMIR Mhealth Uhealth 2018 Sep 10;6(9):e10456. Epub 2018 Sep 10.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.

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http://dx.doi.org/10.2196/10456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231728PMC
September 2018

Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine.

Am J Pharm Educ 2018 08;82(6):6652

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.5688/ajpe6652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116878PMC
August 2018

Validation of an LC-MS/MS assay to simultaneously monitor the intracellular active metabolites of tenofovir, emtricitabine, and lamivudine in dried blood spots.

J Pharm Biomed Anal 2018 Feb 31;149:40-45. Epub 2017 Oct 31.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC 27599, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173217
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http://dx.doi.org/10.1016/j.jpba.2017.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741486PMC
February 2018

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue.

AIDS 2018 Jan;32(1):11-15

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://Insights.ovid.com/crossref?an=00002030-201801020-0000
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http://dx.doi.org/10.1097/QAD.0000000000001678DOI Listing
January 2018

Darunavir for use in pregnant women with HIV.

Expert Rev Clin Pharmacol 2017 Dec 14;10(12):1317-1327. Epub 2017 Nov 14.

a Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , NC , USA.

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http://dx.doi.org/10.1080/17512433.2017.1390428DOI Listing
December 2017

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact.

Clin Transl Sci 2017 11 10;10(6):443-454. Epub 2017 Aug 10.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1111/cts.12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698804PMC
November 2017

Multimodal analysis of drug transporter expression in gastrointestinal tissue.

AIDS 2017 07;31(12):1669-1678

aEshelman School of Pharmacy bSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina cSchool of Medicine, Colorado State University, Fort Collins, Colorado dSchool of Medicine, University of California, Davis, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546623PMC
July 2017

Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues.

J Antimicrob Chemother 2017 06;72(6):1731-1740

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/jac/dkx064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536328PMC
June 2017

HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities.

AIDS Res Hum Retroviruses 2017 06 16;33(6):513-523. Epub 2017 May 16.

1 Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy , Chapel Hill, North Carolina.

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http://www.liebertpub.com/doi/10.1089/aid.2016.0253
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http://dx.doi.org/10.1089/AID.2016.0253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467125PMC
June 2017

Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers.

J Clin Pharmacol 2017 02 6;57(2):185-193. Epub 2016 Sep 6.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1002/jcph.806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233601PMC
February 2017

Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model.

Sci Rep 2017 02 1;7:41098. Epub 2017 Feb 1.

Division of Infectious Diseases, Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, 27599, United States of America.

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http://www.nature.com/articles/srep41098
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http://dx.doi.org/10.1038/srep41098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286499PMC
February 2017

Effect of HIV infection and menopause status on raltegravir pharmacokinetics in the blood and genital tract.

Antivir Ther 2015 3;20(8):795-803. Epub 2015 Jun 3.

University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3851/IMP2968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242325PMC
November 2016

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses.

Biol Blood Marrow Transplant 2016 10 3;22(10):1829-1835. Epub 2016 Aug 3.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.bbmt.2016.08.001DOI Listing
October 2016

Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design.

J Acquir Immune Defic Syndr 2016 08;72(5):498-506

*Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC; †University of North Carolina at Chapel Hill School of Medicine, Division of Infectious Diseases, Chapel Hill, NC; and ‡University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Biostatistics, Chapel Hill, NC.

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http://dx.doi.org/10.1097/QAI.0000000000000996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942408PMC
August 2016

Saquinavir Loaded Acetalated Dextran Microconfetti - a Long Acting Protease Inhibitor Injectable.

Pharm Res 2016 08 6;33(8):1998-2009. Epub 2016 May 6.

Division of Molecular Pharmaceutics, Eshelman College of Pharmacy, University of North Carolina, 4211 Marsico Hall, 125 Mason Farm Road, Chapel Hill, North Carolina, 27599, USA.

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http://dx.doi.org/10.1007/s11095-016-1936-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776024PMC
August 2016

S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and After Induction.

Ther Drug Monit 2016 06;38(3):383-7

*Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD), La Jolla; †Bertino Consulting, Schenectady, New York; ‡Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; §Disposition Safety and Animal Research, Sanofi, Bridgewater, New Jersey; and ¶Section of Clinical Pharmacology, Deptartment of Medicine, The Geisel School of Medicine at Dartmouth and The Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

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http://dx.doi.org/10.1097/FTD.0000000000000277DOI Listing
June 2016

Non-initiation of hepatitis C virus antiviral therapy in patients with human immunodeficiency virus/hepatitis C virus co-infection.

World J Hepatol 2016 Mar;8(7):368-75

Christine U Oramasionwu, Angela DM Kashuba, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.

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http://dx.doi.org/10.4254/wjh.v8.i7.368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779165PMC
March 2016

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis.

Virology 2016 Feb 6;489:173-8. Epub 2016 Jan 6.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906038PMC
February 2016

Brief Report: Significant Decreases in Both Total and Unbound Lopinavir and Amprenavir Exposures During Coadministration: ACTG Protocol A5143/A5147s Results.

J Acquir Immune Defic Syndr 2015 Dec;70(5):510-4

*UNC Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC; †Gillings School of Global Public Health, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC; ‡School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Center for AIDS Research, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ‖Center for Biostatistics in AIDS Research, The Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA; ¶UCSF School of Pharmacy, Department of Clinical Pharmacy, San Francisco, CA; and #University of Washington School of Medicine, Division of Allergy and Infectious Diseases, Seattle, WA.

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http://dx.doi.org/10.1097/QAI.0000000000000777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648657PMC
December 2015

Low Frequency of Drug-Resistant Variants Selected by Long-Acting Rilpivirine in Macaques Infected with Simian Immunodeficiency Virus Containing HIV-1 Reverse Transcriptase.

Antimicrob Agents Chemother 2015 Dec 5;59(12):7762-70. Epub 2015 Oct 5.

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/AAC.01937-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649225PMC
December 2015

Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells.

Antimicrob Agents Chemother 2015 Oct 3;59(10):6395-401. Epub 2015 Aug 3.

School of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/AAC.01148-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576057PMC
October 2015

Tenofovir Gel for the Prevention of Herpes Simplex Virus Type 2 Infection.

N Engl J Med 2015 Aug;373(6):530-9

From the Centre for the AIDS Programme of Research in South Africa (CAPRISA) (S.S.A.K., Q.A.K., A.B.M.K., C.B., A.C.G., L.W., L.E.M., N.S., A.M., T.N.G.) and the University of KwaZulu-Natal (S.S.A.K.) - both in Durban, South Africa; the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York (S.S.A.K., Q.A.K.); and the Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill (A.K.).

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http://dx.doi.org/10.1056/NEJMoa1410649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562018PMC
August 2015

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.

AIDS 2015 Aug;29(13):1597-606

aClinical Research Division, Fred Hutchinson Cancer Research Center bWashington National Primate Research Center, Seattle cVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington dDivision of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, North Carolina eDepartment of Microbiology fDepartment of Pediatrics gDepartment of Laboratory Medicine hDepartment of Medicine iDepartment of Pharmaceutics jDepartment of Pathology, University of Washington, Seattle, Washington, USA. *Christopher W. Peterson and Kevin G. Haworth contributed equally to the writing of this article.

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http://pdfs.journals.lww.com/aidsonline/2015/08240/Lack_of_v
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAD.0000000000000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572605PMC
August 2015

Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.

Nat Rev Microbiol 2015 Jul 8;13(7):414-25. Epub 2015 Jun 8.

1] Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. [2] UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. [3] Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nrmicro3471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793885PMC
July 2015

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness.

J Acquir Immune Defic Syndr 2015 Jul;69(3):264-9

*Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC; †University of North Carolina Center for AIDS Research, Clinical Pharmacology and Analytical Chemistry Core, Eshelman School of Pharmacy, Chapel Hill, NC; ‡Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa; and §Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.

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http://dx.doi.org/10.1097/QAI.0000000000000607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505741PMC
July 2015

Pharmacokinetics of antiretrovirals in mucosal tissue.

Expert Opin Drug Metab Toxicol 2015 Jun 22;11(6):893-905. Epub 2015 Mar 22.

University of North Carolina, UNC Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics , 1094 Genetic Medicine Building, CB# 7361, 120 Mason Farm Road, Chapel Hill, NC 27599 , USA +1 919 966 9998 ; +1 919 962 0644 ;

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http://dx.doi.org/10.1517/17425255.2015.1027682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498566PMC
June 2015

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.

Biomed Opt Express 2015 Jun 8;6(6):2022-35. Epub 2015 May 8.

Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA ; Department of Obstetrics and Gynecology, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1364/BOE.6.002022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473741PMC
June 2015

Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs.

Antimicrob Agents Chemother 2015 May 2;59(5):2944-8. Epub 2015 Mar 2.

W. M. Keck FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA

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http://dx.doi.org/10.1128/AAC.04952-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394831PMC
May 2015

Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.

J Acquir Immune Defic Syndr 2015 Apr;68(4):420-4

*Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC; †Center for AIDS Research, University of North Carolina, Chapel Hill, NC; ‡Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC; §Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC; and ‖Health Sciences Center, University of Tennessee Health, Memphis, TN.

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http://dx.doi.org/10.1097/QAI.0000000000000480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334681PMC
April 2015

Models for predicting effective HIV chemoprevention in women.

J Acquir Immune Defic Syndr 2015 Apr;68(4):369-76

*Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC; †Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC; and ‡Departments of Medicine and §Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC (Melanie R. Nicol is now with the Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN).

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http://dx.doi.org/10.1097/QAI.0000000000000472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334725PMC
April 2015

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.

Anal Bioanal Chem 2015 Mar 16;407(8):2073-84. Epub 2014 Oct 16.

W.M. Keck Fourier Transform Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.

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http://dx.doi.org/10.1007/s00216-014-8220-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495968PMC
March 2015

Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture.

PLoS One 2014 30;9(6):e100863. Epub 2014 Jun 30.

Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076265PMC
February 2015

Mapping antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q Exactive and comparison with LC-MS/MS SRM assay.

J Am Soc Mass Spectrom 2014 Dec 18;25(12):2038-47. Epub 2014 Apr 18.

W. M. Keck FT Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.

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http://dx.doi.org/10.1007/s13361-014-0884-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201889PMC
December 2014

Short communication: cheminformatics analysis to identify predictors of antiviral drug penetration into the female genital tract.

AIDS Res Hum Retroviruses 2014 Nov 13;30(11):1058-64. Epub 2014 Mar 13.

1 Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy , Chapel Hill, North Carolina.

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http://dx.doi.org/10.1089/AID.2013.0254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208595PMC
November 2014

Pharmacokinetics of antiretrovirals in genital secretions and anatomic sites of HIV transmission: implications for HIV prevention.

Clin Pharmacokinet 2014 Jul;53(7):611-24

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 3318 Kerr Hall, CB# 7569, Chapel Hill, NC, 27599-7569, USA.

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http://link.springer.com/10.1007/s40262-014-0148-z
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http://dx.doi.org/10.1007/s40262-014-0148-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094112PMC
July 2014

FEM-PrEP: adherence patterns and factors associated with adherence to a daily oral study product for pre-exposure prophylaxis.

J Acquir Immune Defic Syndr 2014 Jul;66(3):324-31

Departments of *Social and Behavioral Health Sciences, †Clinical Sciences, and ‡Quantitative Sciences, FHI 360, Durham, NC; §Setshaba Research Centre, Soshanguve, South Africa; ‖Impact Research and Development Organization, Kisumu, Kenya; ¶Josha Research, Bloemfontein, South Africa; #Kilimanjaro Christian Medical Center, Moshi, Tanzania; and **Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC (Van Damme is now with the Bill & Melinda Gates Foundation, Seattle, WA).

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https://insights.ovid.com/crossref?an=00126334-201407010-000
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http://dx.doi.org/10.1097/QAI.0000000000000158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059551PMC
July 2014

Topical microbicides and HIV prevention in the female genital tract.

J Clin Pharmacol 2014 Jun 28;54(6):603-15. Epub 2014 Mar 28.

University of North Carolina at Chapel Hill, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1002/jcph.292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144014PMC
June 2014

Measuring adherence by visual inspection of returned empty gel applicators in the CAPRISA 004 microbicide trial.

AIDS Behav 2014 May;18(5):820-5

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute (2nd Floor), University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa,

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http://dx.doi.org/10.1007/s10461-014-0749-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036812PMC
May 2014

Unreported antiretroviral use by HIV-1-infected participants enrolling in a prospective research study.

J Acquir Immune Defic Syndr 2014 Feb;65(2):e90-4

*Department of Epidemiology, University of Washington, Seattle, WA †Division of Pharmacotherapy and Experimental Therapeutics, Echelman School of Pharmacy, University of North Carolina, Chapel Hill, NC Departments of ‡Global Health; §Medicine, University of Washington, Seattle, WA ‖Department of Medicine, Indiana University, Indianapolis, IN ¶Department of Immunology and Infectious Disease, Harvard School of Public Health, Harvard University, Cambridge, MA #Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, Republic of South Africa **Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA ††Department of Pediatrics, University of Washington, Seattle, WA ‡‡Wits Reproductive Health and HIV Institute, University of Witwatersrand, Johannesburg, Republic of South Africa §§Department of Obstetrics and Gynecology, University of Nairobi and Kenyatta National Hospital, Nairobi, Kenya.

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http://dx.doi.org/10.1097/QAI.0b013e3182a2db02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898592PMC
February 2014

Targeted cytotoxic therapy kills persisting HIV infected cells during ART.

PLoS Pathog 2014 Jan 9;10(1):e1003872. Epub 2014 Jan 9.

Division of Infectious Diseases, Department of Medicine, UNC Center for AIDS Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887103PMC
January 2014